PubMed

Comparison of Combined Bupropion and Naltrexone Therapy for Obesity with Monotherapy and Placebo.

Greenway FL, Dunayevich E, Tollefson G, Erickson J, Guttadauria M, Fujioka K, Cowley MA; for the NB-201 Study Group.

J Clin Endocrinol Metab. 2009 Dec;94(12):4898-4906. Epub 2009 Oct 21.PMID: 19846734 [PubMed - as supplied by publisher]Related articles

Changes of peripheral alpha-melanocyte-stimulating hormone in childhood obesity.

Roth CL, Enriori PJ, Gebhardt U, Hinney A, Müller HL, Hebebrand J, Reinehr T, Cowley MA.

Metabolism. 2009 Sep 17. [Epub ahead of print] No abstract available. PMID: 19766264 [PubMed - as supplied by publisher]Related articles

The role of thermogenesis in antipsychotic drug-induced weight gain.

Stefanidis A, Verty AN, Allen AM, Owens NC, Cowley MA, Oldfield BJ.

Obesity (Silver Spring). 2009 Jan;17(1):16-24. Epub 2008 Oct 30.PMID: 19107124 [PubMed - indexed for MEDLINE]Related articles

Rational design of a combination medication for the treatment of obesity.

Greenway FL, Whitehouse MJ, Guttadauria M, Anderson JW, Atkinson RL, Fujioka K, Gadde KM, Gupta AK, O'Neil P, Schumacher D, Smith D, Dunayevich E, Tollefson GD, Weber E, Cowley MA.

Obesity (Silver Spring). 2009 Jan;17(1):30-9. Epub 2008 Nov 6.PMID: 18997675 [PubMed - indexed for MEDLINE]Related articles

Suppression of basal spontaneous gonadotropin-releasing hormone neuronal activity during lactation: role of inhibitory effects of neuropeptide Y.

Xu J, Kirigiti MA, Cowley MA, Grove KL, Smith MS.

Endocrinology. 2009 Jan;150(1):333-40. Epub 2008 Aug 21.PMID: 18719019 [PubMed - indexed for MEDLINE]Related articles

Regulation of agouti-related protein messenger ribonucleic acid transcription and peptide secretion by acute and chronic inflammation.

Scarlett JM, Zhu X, Enriori PJ, Bowe DD, Batra AK, Levasseur PR, Grant WF, Meguid MM, Cowley MA, Marks DL.

Endocrinology. 2008 Oct;149(10):4837-45. Epub 2008 Jun 26.PMID: 18583425 [PubMed - indexed for MEDLINE]Related articlesFree article

Feeding induced by cannabinoids is mediated independently of the melanocortin system.

Sinnayah P, Jobst EE, Rathner JA, Caldera-Siu AD, Tonelli-Lemos L, Eusterbrock AJ, Enriori PJ, Pothos EN, Grove KL, Cowley MA.

PLoS One. 2008 May 21;3(5):e2202.PMID: 18493584 [PubMed - indexed for MEDLINE]Related articlesFree article

Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice.

Hill JW, Williams KW, Ye C, Luo J, Balthasar N, Coppari R, Cowley MA, Cantley LC, Lowell BB, Elmquist JK.

J Clin Invest. 2008 May;118(5):1796-805.PMID: 18382766 [PubMed - indexed for MEDLINE]Related articlesFree article

Zonisamide prevents olanzapine-associated hyperphagia, weight gain, and elevated blood glucose in rats.

Wallingford NM, Sinnayah P, Bymaster FP, Gadde KM, Krishnan RK, McKinney AA, Landbloom RP, Tollefson GD, Cowley MA.

Neuropsychopharmacology. 2008 Nov;33(12):2922-33. Epub 2008 Mar 5.PMID: 18322467 [PubMed - indexed for MEDLINE]Related articlesFree article

Starvation after AgRP neuron ablation is independent of melanocortin signaling.

Wu Q, Howell MP, Cowley MA, Palmiter RD.

Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2687-92. Epub 2008 Feb 13.PMID: 18272480 [PubMed - indexed for MEDLINE]Related articlesFree article

Developmental switch in neuropeptide Y and melanocortin effects in the paraventricular nucleus of the hypothalamus.

Melnick I, Pronchuk N, Cowley MA, Grove KL, Colmers WF.

Neuron. 2007 Dec 20;56(6):1103-15.PMID: 18093530 [PubMed - indexed for MEDLINE]Related articles

Characterization of brainstem peptide YY (PYY) neurons.

Glavas MM, Grayson BE, Allen SE, Copp DR, Smith MS, Cowley MA, Grove KL.

J Comp Neurol. 2008 Jan 10;506(2):194-210.PMID: 18022952 [PubMed - indexed for MEDLINE]Related articles

Mechanisms of leptin action and leptin resistance.

Myers MG, Cowley MA, Münzberg H.

Annu Rev Physiol. 2008;70:537-56. Review.PMID: 17937601 [PubMed - indexed for MEDLINE]Related articles

Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity.

Parton LE, Ye CP, Coppari R, Enriori PJ, Choi B, Zhang CY, Xu C, Vianna CR, Balthasar N, Lee CE, Elmquist JK, Cowley MA, Lowell BB.

Nature. 2007 Sep 13;449(7159):228-32. Epub 2007 Aug 29.PMID: 17728716 [PubMed - indexed for MEDLINE]Related articles

Catecholamine reuptake inhibition causes weight loss by increasing locomotor activity and thermogenesis.

Billes SK, Cowley MA.

Neuropsychopharmacology. 2008 May;33(6):1287-97. Epub 2007 Aug 8.PMID: 17687262 [PubMed - indexed for MEDLINE]Related articlesFree article

GLP-1 analogs: satiety without malaise?

Tang-Christensen M, Cowley MA.

Am J Physiol Regul Integr Comp Physiol. 2007 Sep;293(3):R981-2. Epub 2007 Jun 27. No abstract available. PMID: 17596320 [PubMed - indexed for MEDLINE]Related articles

Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production.

Könner AC, Janoschek R, Plum L, Jordan SD, Rother E, Ma X, Xu C, Enriori P, Hampel B, Barsh GS, Kahn CR, Cowley MA, Ashcroft FM, Brüning JC.

Cell Metab. 2007 Jun;5(6):438-49.PMID: 17550779 [PubMed - indexed for MEDLINE]Related articles

Regulation of central melanocortin signaling by interleukin-1 beta.

Scarlett JM, Jobst EE, Enriori PJ, Bowe DD, Batra AK, Grant WF, Cowley MA, Marks DL.

Endocrinology. 2007 Sep;148(9):4217-25. Epub 2007 May 24.PMID: 17525125 [PubMed - indexed for MEDLINE]Related articlesFree article

Excess weight gain during the early postnatal period is associated with permanent reprogramming of brown adipose tissue adaptive thermogenesis.

Xiao XQ, Williams SM, Grayson BE, Glavas MM, Cowley MA, Smith MS, Grove KL.

Endocrinology. 2007 Sep;148(9):4150-9. Epub 2007 May 24.PMID: 17525123 [PubMed - indexed for MEDLINE]Related articlesFree article

Diet-induced obesity causes severe but reversible leptin resistance in arcuate melanocortin neurons.

Enriori PJ, Evans AE, Sinnayah P, Jobst EE, Tonelli-Lemos L, Billes SK, Glavas MM, Grayson BE, Perello M, Nillni EA, Grove KL, Cowley MA.

Cell Metab. 2007 Mar;5(3):181-94.PMID: 17339026 [PubMed - indexed for MEDLINE]Related articles

Appropriate inhibition of orexigenic hypothalamic arcuate nucleus neurons independently of leptin receptor/STAT3 signaling.

Münzberg H, Jobst EE, Bates SH, Jones J, Villanueva E, Leshan R, Björnholm M, Elmquist J, Sleeman M, Cowley MA, Myers MG Jr.

J Neurosci. 2007 Jan 3;27(1):69-74.PMID: 17202473 [PubMed - indexed for MEDLINE]Related articlesFree article

To be or NUCB2, is nesfatin the answer?

Cowley MA, Grove KL.

Cell Metab. 2006 Dec;4(6):421-2. Review.PMID: 17141625 [PubMed - indexed for MEDLINE]Related articles

Using intranasal lidocaine to reduce food intake.

Greenway FL, Martin CK, Gupta AK, Cruickshank S, Whitehouse J, DeYoung L, Kamdar K, Caruso MK, Roberts AT, England M, Dumas K, Laidlaw BJ, Rogers B, Cowley MA.

Int J Obes (Lond). 2007 May;31(5):858-63. Epub 2006 Nov 28.PMID: 17130849 [PubMed - indexed for MEDLINE]Related articles

Physiological evidence for the involvement of peptide YY in the regulation of energy homeostasis in humans.

Guo Y, Ma L, Enriori PJ, Koska J, Franks PW, Brookshire T, Cowley MA, Salbe AD, Delparigi A, Tataranni PA.

Obesity (Silver Spring). 2006 Sep;14(9):1562-70.PMID: 17030967 [PubMed - indexed for MEDLINE]Related articles

Leptin resistance and obesity.

Enriori PJ, Evans AE, Sinnayah P, Cowley MA.

Obesity (Silver Spring). 2006 Aug;14 Suppl 5:254S-258S. Review.PMID: 17021377 [PubMed - indexed for MEDLINE]Related articles

Serotonin reciprocally regulates melanocortin neurons to modulate food intake.

Heisler LK, Jobst EE, Sutton GM, Zhou L, Borok E, Thornton-Jones Z, Liu HY, Zigman JM, Balthasar N, Kishi T, Lee CE, Aschkenasi CJ, Zhang CY, Yu J, Boss O, Mountjoy KG, Clifton PG, Lowell BB, Friedman JM, Horvath T, Butler AA, Elmquist JK, Cowley MA.

Neuron. 2006 Jul 20;51(2):239-49.PMID: 16846858 [PubMed - indexed for MEDLINE]Related articles

Inhibition of dopamine and norepinephrine reuptake produces additive effects on energy balance in lean and obese mice.

Billes SK, Cowley MA.

Neuropsychopharmacology. 2007 Apr;32(4):822-34. Epub 2006 Jul 12.PMID: 16841072 [PubMed - indexed for MEDLINE]Related articlesFree article

Pancreatic polypeptide in obese children before and after weight loss.

Reinehr T, Enriori PJ, Harz K, Cowley MA, Roth CL.

Int J Obes (Lond). 2006 Oct;30(10):1476-81. Epub 2006 May 16.PMID: 16702998 [PubMed - indexed for MEDLINE]Related articles

Hypothalamic regulatory pathways and potential obesity treatment targets.

Jobst EE, Enriori PJ, Sinnayah P, Cowley MA.

Endocrine. 2006 Feb;29(1):33-48. Review.PMID: 16622291 [PubMed - indexed for MEDLINE]Related articles

Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis.

Dhillon H, Zigman JM, Ye C, Lee CE, McGovern RA, Tang V, Kenny CD, Christiansen LM, White RD, Edelstein EA, Coppari R, Balthasar N, Cowley MA, Chua S Jr, Elmquist JK, Lowell BB.

Neuron. 2006 Jan 19;49(2):191-203.PMID: 16423694 [PubMed - indexed for MEDLINE]Related articles

Is ghrelin a signal for the development of metabolic systems?

Grove KL, Cowley MA.

J Clin Invest. 2005 Dec;115(12):3393-7.PMID: 16322785 [PubMed - indexed for MEDLINE]Related articlesFree article

Peptide YY(3-36) inhibits morning, but not evening, food intake and decreases body weight in rhesus macaques.

Koegler FH, Enriori PJ, Billes SK, Takahashi DL, Martin MS, Clark RL, Evans AE, Grove KL, Cameron JL, Cowley MA.

Diabetes. 2005 Nov;54(11):3198-204.PMID: 16249445 [PubMed - indexed for MEDLINE]Related articlesFree article

Peptide YY is a regulator of energy homeostasis in obese children before and after weight loss.

Roth CL, Enriori PJ, Harz K, Woelfle J, Cowley MA, Reinehr T.

J Clin Endocrinol Metab. 2005 Dec;90(12):6386-91. Epub 2005 Oct 4.PMID: 16204364 [PubMed - indexed for MEDLINE]Related articlesFree article

Serotonergic pathways converge upon central melanocortin systems to regulate energy balance.

Zhou L, Williams T, Lachey JL, Kishi T, Cowley MA, Heisler LK.

Peptides. 2005 Oct;26(10):1728-32. Review.PMID: 15993514 [PubMed - indexed for MEDLINE]Related articles

The electrophysiology of feeding circuits.

Jobst EE, Enriori PJ, Cowley MA.

Trends Endocrinol Metab. 2004 Dec;15(10):488-99. Review.PMID: 15541648 [PubMed - indexed for MEDLINE]Related articles

Ghrelin--satisfying a hunger for the mechanism.

Cowley MA, Grove KL.

Endocrinology. 2004 Jun;145(6):2604-6. Review. No abstract available. PMID: 15140838 [PubMed - indexed for MEDLINE]Related articlesFree article

Hypothalamic melanocortin neurons integrate signals of energy state.

Cowley MA.

Eur J Pharmacol. 2003 Nov 7;480(1-3):3-11. Review.PMID: 14623345 [PubMed - indexed for MEDLINE]Related articles

Electrophysiological actions of peripheral hormones on melanocortin neurons.

Cowley MA, Cone RD, Enriori P, Louiselle I, Williams SM, Evans AE.

Ann N Y Acad Sci. 2003 Jun;994:175-86. Review.PMID: 12851314 [PubMed - indexed for MEDLINE]Related articles

Central serotonin and melanocortin pathways regulating energy homeostasis.

Heisler LK, Cowley MA, Kishi T, Tecott LH, Fan W, Low MJ, Smart JL, Rubinstein M, Tatro JB, Zigman JM, Cone RD, Elmquist JK.

Ann N Y Acad Sci. 2003 Jun;994:169-74. Review.PMID: 12851313 [PubMed - indexed for MEDLINE]Related articles

Coenzyme Q induces nigral mitochondrial uncoupling and prevents dopamine cell loss in a primate model of Parkinson's disease.

Horvath TL, Diano S, Leranth C, Garcia-Segura LM, Cowley MA, Shanabrough M, Elsworth JD, Sotonyi P, Roth RH, Dietrich EH, Matthews RT, Barnstable CJ, Redmond DE Jr.

Endocrinology. 2003 Jul;144(7):2757-60.PMID: 12810526 [PubMed - indexed for MEDLINE]Related articlesFree article

The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis.

Cowley MA, Smith RG, Diano S, Tschöp M, Pronchuk N, Grove KL, Strasburger CJ, Bidlingmaier M, Esterman M, Heiman ML, Garcia-Segura LM, Nillni EA, Mendez P, Low MJ, Sotonyi P, Friedman JM, Liu H, Pinto S, Colmers WF, Cone RD, Horvath TL.

Neuron. 2003 Feb 20;37(4):649-61.PMID: 12597862 [PubMed - indexed for MEDLINE]Related articles

Gut hormone PYY(3-36) physiologically inhibits food intake.

Batterham RL, Cowley MA, Small CJ, Herzog H, Cohen MA, Dakin CL, Wren AM, Brynes AE, Low MJ, Ghatei MA, Cone RD, Bloom SR.

Nature. 2002 Aug 8;418(6898):650-4.PMID: 12167864 [PubMed - indexed for MEDLINE]Related articles

Activation of central melanocortin pathways by fenfluramine.

Heisler LK, Cowley MA, Tecott LH, Fan W, Low MJ, Smart JL, Rubinstein M, Tatro JB, Marcus JN, Holstege H, Lee CE, Cone RD, Elmquist JK.

Science. 2002 Jul 26;297(5581):609-11.PMID: 12142539 [PubMed - indexed for MEDLINE]Related articlesFree article

The arcuate nucleus as a conduit for diverse signals relevant to energy homeostasis.

Cone RD, Cowley MA, Butler AA, Fan W, Marks DL, Low MJ.

Int J Obes Relat Metab Disord. 2001 Dec;25 Suppl 5:S63-7. Review.PMID: 11840218 [PubMed - indexed for MEDLINE]Related articlesFree article

Hypothalamic circuitry of neuropeptide Y regulation of neuroendocrine function and food intake via the Y5 receptor subtype.

Campbell RE, ffrench-Mullen JM, Cowley MA, Smith MS, Grove KL.

Neuroendocrinology. 2001 Aug;74(2):106-19.PMID: 11474218 [PubMed - indexed for MEDLINE]Related articles

Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus.

Cowley MA, Smart JL, Rubinstein M, Cerdán MG, Diano S, Horvath TL, Cone RD, Low MJ.

Nature. 2001 May 24;411(6836):480-4.PMID: 11373681 [PubMed - indexed for MEDLINE]Related articles

Neuropeptide Y Y5 receptor protein in the cortical/limbic system and brainstem of the rat: expression on gamma-aminobutyric acid and corticotropin-releasing hormone neurons.

Grove KL, Campbell RE, Ffrench-Mullen JM, Cowley MA, Smith MS.

Neuroscience. 2000;100(4):731-40.PMID: 11036207 [PubMed - indexed for MEDLINE]Related articles

Integration of NPY, AGRP, and melanocortin signals in the hypothalamic paraventricular nucleus: evidence of a cellular basis for the adipostat.

Cowley MA, Pronchuk N, Fan W, Dinulescu DM, Colmers WF, Cone RD.

Neuron. 1999 Sep;24(1):155-63.PMID: 10677034 [PubMed - indexed for MEDLINE]Related articles

Estrogen transiently increases delayed rectifier, voltage-dependent potassium currents in ovine gonadotropes.

Cowley MA, Chen C, Clarke IJ.

Neuroendocrinology. 1999 Apr;69(4):254-60.PMID: 10207277 [PubMed - indexed for MEDLINE]Related articles

Evidence for differential regulation of multiple transcripts of the gonadotropin releasing hormone receptor in the ovine pituitary gland; effect of estrogen.

Cowley MA, Rao A, Wright PJ, Illing N, Millar RP, Clarke IJ.

Mol Cell Endocrinol. 1998 Nov 25;146(1-2):141-9.PMID: 10022772 [PubMed - indexed for MEDLINE]Related articles