PubMed

The vascular and coagulation issues in xenotransplantation.

Cowan PJ, Roussel JC, d'Apice AJ.

Curr Opin Organ Transplant. 2009 Apr;14(2):161-7. Review.PMID: 19469030 [PubMed - indexed for MEDLINE]Related articles

Preservation of cochlear function in Cd39 deficient mice.

Vlajkovic SM, Housley GD, Thorne PR, Gupta R, Enjyoji K, Cowan PJ, Charles Liberman M, Robson SC.

Hear Res. 2009 Jul;253(1-2):77-82. Epub 2009 Mar 25.PMID: 19327391 [PubMed - indexed for MEDLINE]Related articles

Optimizing transduction of pig islet cell clusters for xenotransplantation.

Londrigan SL, Brady JL, Sutherland RM, Cowan PJ, d'Apice AJ, Hawthorne WJ, O'Connell PJ, Lew AM.

Xenotransplantation. 2009 Jan;16(1):45-6. No abstract available. PMID: 19243560 [PubMed - indexed for MEDLINE]Related articles

Monoclonal antibodies generated by DNA immunization recognize CD2 from a broad range of primates.

Brady JL, Mannering SI, Kireta S, Coates PT, Proietto AI, Cowan PJ, D'Apice AJ, Lew AM.

Immunol Cell Biol. 2009 Jul;87(5):413-8. Epub 2009 Feb 10.PMID: 19204736 [PubMed - indexed for MEDLINE]Related articles

Complement activation and coagulation in xenotransplantation.

Cowan PJ, d'Apice AJ.

Immunol Cell Biol. 2009 Mar-Apr;87(3):203-8. Epub 2009 Jan 20. Review.PMID: 19153592 [PubMed - indexed for MEDLINE]Related articles

The impact of purinergic signaling on renal ischemia-reperfusion injury.

Lu B, Rajakumar SV, Robson SC, Lee EK, Crikis S, d'Apice AJ, Cowan PJ, Dwyer KM.

Transplantation. 2008 Dec 27;86(12):1707-12.PMID: 19104409 [PubMed - indexed for MEDLINE]Related articles

Xenotransplantation: the next generation of engineered animals.

d'Apice AJ, Cowan PJ.

Transpl Immunol. 2009 Jun;21(2):111-5. Epub 2008 Oct 28. No abstract available. PMID: 18973810 [PubMed - in process]Related articles

The coagulation barrier in xenotransplantation: incompatibilities and strategies to overcome them.

Cowan PJ, d'Apice AJ.

Curr Opin Organ Transplant. 2008 Apr;13(2):178-83. Review.PMID: 18685300 [PubMed - indexed for MEDLINE]Related articles

Total intravenous anesthesia (TIVA) for carcinoid syndrome--a case report.

Nielsen PT, Cowan PJ.

Middle East J Anesthesiol. 2008 Jun;19(5):949-55. No abstract available. PMID: 18637597 [PubMed - indexed for MEDLINE]Related articles

Recombinant pig TFPI efficiently regulates human tissue factor pathways.

Lee KF, Salvaris EJ, Roussel JC, Robson SC, d'Apice AJ, Cowan PJ.

Xenotransplantation. 2008 May;15(3):191-7.PMID: 18611227 [PubMed - indexed for MEDLINE]Related articlesFree article

Gene-modified pigs.

d'Apice AJ, Cowan PJ.

Xenotransplantation. 2008 Mar;15(2):87-90. No abstract available. PMID: 18447874 [PubMed - indexed for MEDLINE]Related articles

Pig thrombomodulin binds human thrombin but is a poor cofactor for activation of human protein C and TAFI.

Roussel JC, Moran CJ, Salvaris EJ, Nandurkar HH, d'Apice AJ, Cowan PJ.

Am J Transplant. 2008 Jun;8(6):1101-12. Epub 2008 Apr 29.PMID: 18444940 [PubMed - indexed for MEDLINE]Related articles

Enzymatic properties of an ecto-nucleoside triphosphate diphosphohydrolase from Legionella pneumophila: substrate specificity and requirement for virulence.

Sansom FM, Riedmaier P, Newton HJ, Dunstone MA, Müller CE, Stephan H, Byres E, Beddoe T, Rossjohn J, Cowan PJ, d'Apice AJ, Robson SC, Hartland EL.

J Biol Chem. 2008 May 9;283(19):12909-18. Epub 2008 Mar 12.PMID: 18337253 [PubMed - indexed for MEDLINE]Related articlesFree article

Anti-Gal antibody-mediated skin graft rejection requires a threshold level of Gal expression.

Murray-Segal L, Gock H, Cowan PJ, d'Apice AJ.

Xenotransplantation. 2008 Feb;15(1):20-6.PMID: 18333910 [PubMed - indexed for MEDLINE]Related articles

Glycosylation changes in hFUT1 transgenic mice increase TCR signaling and apoptosis resulting in thymocyte maturation arrest.

Moore GT, Brown SJ, Winterhalter AC, Lust M, Salvaris EJ, Selan C, Nandurkar HH, Desmond PV, Cowan PJ, d'Apice AJ.

Mol Immunol. 2008 Apr;45(8):2401-10. Epub 2007 Dec 26.PMID: 18155296 [PubMed - indexed for MEDLINE]Related articles

Production of homozygous alpha-1,3-galactosyltransferase knockout pigs by breeding and somatic cell nuclear transfer.

Nottle MB, Beebe LF, Harrison SJ, McIlfatrick SM, Ashman RJ, O'Connell PJ, Salvaris EJ, Fisicaro N, Pommey S, Cowan PJ, d'Apice AJ.

Xenotransplantation. 2007 Jul;14(4):339-44.PMID: 17669176 [PubMed - indexed for MEDLINE]Related articles

Building on the GalKO platform.

d'Apice AJ, Cowan PJ.

Transplantation. 2007 Jul 15;84(1):10-1. No abstract available. PMID: 17627229 [PubMed - indexed for MEDLINE]Related articles

A bacterial ecto-triphosphate diphosphohydrolase similar to human CD39 is essential for intracellular multiplication of Legionella pneumophila.

Sansom FM, Newton HJ, Crikis S, Cianciotto NP, Cowan PJ, d'Apice AJ, Hartland EL.

Cell Microbiol. 2007 Aug;9(8):1922-35. Epub 2007 Mar 26.PMID: 17388784 [PubMed - indexed for MEDLINE]Related articles

Evaluation of promoters for driving efficient transgene expression in neonatal porcine islets.

Londrigan SL, Brady JL, Sutherland RM, Hawthorne WJ, Thomas HE, Jhala G, Cowan PJ, Kay TW, O'Connell PJ, Lew AM.

Xenotransplantation. 2007 Mar;14(2):119-25.PMID: 17381686 [PubMed - indexed for MEDLINE]Related articles

Blockade of the passive cell death pathway does not prevent tolerance induction to islet grafts.

Lehnert AM, Murray-Segal L, Cowan PJ, d'Apice AJ, O'Connell PJ.

Transplantation. 2007 Mar 15;83(5):653-5.PMID: 17353789 [PubMed - indexed for MEDLINE]Related articles

Coagulation and the xenograft endothelium.

Cowan PJ.

Xenotransplantation. 2007 Jan;14(1):7-12. Review.PMID: 17214700 [PubMed - indexed for MEDLINE]Related articles

Cardiac and skin xenograft survival in different recipient mouse strains.

Gock H, Murray-Segal L, Salvaris E, Fisicaro N, Cowan PJ, d'Apice AJ.

Transplantation. 2006 Nov 27;82(10):1362-9.PMID: 17130786 [PubMed - indexed for MEDLINE]Related articles

Intravascular thrombosis in discordant xenotransplantation.

Crikis S, Cowan PJ, d'Apice AJ.

Transplantation. 2006 Nov 15;82(9):1119-23. Review.PMID: 17102759 [PubMed - indexed for MEDLINE]Related articles

Towards endothelial cell-specific transgene expression in pigs: characterization of the pig ICAM-2 promoter.

Godwin JW, Fisicaro N, d'Apice AJ, Cowan PJ.

Xenotransplantation. 2006 Nov;13(6):514-21.PMID: 17059578 [PubMed - indexed for MEDLINE]Related articles

The transgenic expression of human CD39 on murine islets inhibits clotting of human blood.

Dwyer KM, Mysore TB, Crikis S, Robson SC, Nandurkar H, Cowan PJ, D'Apice AJ.

Transplantation. 2006 Aug 15;82(3):428-32.PMID: 16906044 [PubMed - indexed for MEDLINE]Related articles

Xenotransplantation: past achievements and future promise.

Dwyer KM, Cowan PJ, d'Apice AJ.

Heart Lung Circ. 2002;11(1):32-41.PMID: 16352066 [PubMed]Related articles

Overexpression of glutathione peroxidase with two isoforms of superoxide dismutase protects mouse islets from oxidative injury and improves islet graft function.

Mysore TB, Shinkel TA, Collins J, Salvaris EJ, Fisicaro N, Murray-Segal LJ, Johnson LE, Lepore DA, Walters SN, Stokes R, Chandra AP, O'Connell PJ, d'Apice AJ, Cowan PJ.

Diabetes. 2005 Jul;54(7):2109-16.PMID: 15983212 [PubMed - indexed for MEDLINE]Related articlesFree article

Human factor H-related protein 5 has cofactor activity, inhibits C3 convertase activity, binds heparin and C-reactive protein, and associates with lipoprotein.

McRae JL, Duthy TG, Griggs KM, Ormsby RJ, Cowan PJ, Cromer BA, McKinstry WJ, Parker MW, Murphy BF, Gordon DL.

J Immunol. 2005 May 15;174(10):6250-6.PMID: 15879123 [PubMed - indexed for MEDLINE]Related articlesFree article

Litigation.

Cowan PJ.

Semin Fetal Neonatal Med. 2005 Feb;10(1):11-21. Review.PMID: 15698966 [PubMed - indexed for MEDLINE]Related articles

Altered immune system glycosylation causes colitis in alpha1,2-fucosyltransferase transgenic mice.

Brown SJ, Miller AM, Cowan PJ, Slavin J, Connell WR, Moore GT, Bell S, Elliott PR, Desmond PV, d'Apice AJ.

Inflamm Bowel Dis. 2004 Sep;10(5):546-56.PMID: 15472514 [PubMed - indexed for MEDLINE]Related articles

Transgenic expression of human complement regulators reduces skeletal muscle ischaemia/reperfusion injury in mice.

Knight KR, Shinkel TA, Cowan PJ, Romeo-Meeuw R, d'Apice AJ, Morrison WA.

Clin Sci (Lond). 2005 Jan;108(1):47-53. Retraction in: Morrison WA. Clin Sci (Lond). 2008 Oct;115(8):263. PMID: 15341509 [PubMed - indexed for MEDLINE]Related articles

Fate of alphaGal +/+ pancreatic islet grafts after transplantation into alphaGal knockout mice.

Chandra AP, Salvaris E, Walters SN, Murray-Segal L, Gock H, Lehnert AM, Wong JK, Cowan PJ, d'Apice AJ, O'Connell PJ.

Xenotransplantation. 2004 Jul;11(4):323-31.PMID: 15196126 [PubMed - indexed for MEDLINE]Related articles

Thromboregulatory manifestations in human CD39 transgenic mice and the implications for thrombotic disease and transplantation.

Dwyer KM, Robson SC, Nandurkar HH, Campbell DJ, Gock H, Murray-Segal LJ, Fisicaro N, Mysore TB, Kaczmarek E, Cowan PJ, d'Apice AJ.

J Clin Invest. 2004 May;113(10):1440-6.PMID: 15146241 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of pig intercellular adhesion molecule-2 and its interaction with human LFA-1.

Godwin JW, d'Apice AJ, Cowan PJ.

Am J Transplant. 2004 Apr;4(4):515-25.PMID: 15023143 [PubMed - indexed for MEDLINE]Related articles

Enhanced expression of glutathione peroxidase protects islet beta cells from hypoxia-reoxygenation.

Lepore DA, Shinkel TA, Fisicaro N, Mysore TB, Johnson LE, d'Apice AJ, Cowan PJ.

Xenotransplantation. 2004 Jan;11(1):53-9.PMID: 14962293 [PubMed - indexed for MEDLINE]Related articles

Targeting gene expression to endothelium in transgenic animals: a comparison of the human ICAM-2, PECAM-1 and endoglin promoters.

Cowan PJ, Shinkel TA, Fisicaro N, Godwin JW, Bernabéu C, Almendro N, Rius C, Lonie AJ, Nottle MB, Wigley PL, Paizis K, Pearse MJ, d'Apice AJ.

Xenotransplantation. 2003 May;10(3):223-31.PMID: 12694542 [PubMed - indexed for MEDLINE]Related articles

Gal mismatch alone causes skin graft rejection in mice.

Gock H, Murray-Segal L, Salvaris E, Cowan PJ, D'Apice AJ.

Transplantation. 2002 Sep 15;74(5):637-45.PMID: 12352879 [PubMed - indexed for MEDLINE]Related articles

Transgenic perspectives in xenotransplantation, 2001.

Nottle MB, D'Apice AJ, Cowan PJ, Boquest AC, Harrison SJ, Grupen CG.

Xenotransplantation. 2002 Sep;9(5):305-8. Review. No abstract available. PMID: 12199862 [PubMed - indexed for MEDLINE]Related articles

Protective effects of recombinant human antithrombin III in pig-to-primate renal xenotransplantation.

Cowan PJ, Aminian A, Barlow H, Brown AA, Dwyer K, Filshie RJ, Fisicaro N, Francis DM, Gock H, Goodman DJ, Katsoulis J, Robson SC, Salvaris E, Shinkel TA, Stewart AB, d'Apice AJ.

Am J Transplant. 2002 Jul;2(6):520-5.PMID: 12118895 [PubMed - indexed for MEDLINE]Related articles

Location and structure of the human FHR-5 gene.

McRae JL, Murphy BE, Eyre HJ, Sutherland GR, Crawford J, Cowan PJ.

Genetica. 2002 Mar;114(2):157-61.PMID: 12041828 [PubMed - indexed for MEDLINE]Related articles

Effect of DNA concentration on transgenesis rates in mice and pigs.

Nottle MB, Haskard KA, Verma PJ, Du ZT, Grupen CG, McIlfatrick SM, Ashman RJ, Harrison SJ, Barlow H, Wigley PL, Lyons IG, Cowan PJ, Crawford RJ, Tolstoshev PL, Pearse MJ, Robins AJ, d'Apice AJ.

Transgenic Res. 2001 Dec;10(6):523-31.PMID: 11817540 [PubMed - indexed for MEDLINE]Related articles

Genetic modification for xenotransplantation: transgenics and clones.

d'Apice AJ, Nottle MB, Cowan PJ.

Transplant Proc. 2001 Nov-Dec;33(7-8):3053-4. No abstract available. PMID: 11750316 [PubMed - indexed for MEDLINE]Related articles

Blockade of the CD28 and CD40 pathways result in the acceptance of pig and rat islet xenografts but not rat cardiac grafts in mice.

Lehnert AM, Mottram PL, Han W, Walters SN, Patel AT, Hawthorne WJ, Cowan PJ, d'Apice AJ, O'Connell PJ.

Transpl Immunol. 2001 Oct;9(1):51-6.PMID: 11680572 [PubMed - indexed for MEDLINE]Related articles

Vascular gene transfer driven by endoglin and ICAM-2 endothelial-specific promoters.

Velasco B, Ramírez JR, Relloso M, Li C, Kumar S, Lopez-Bote JP, Pérez-Barriocanal F, López-Novoa JM, Cowan PJ, d'Apice AJ, Bernabéu C.

Gene Ther. 2001 Jun;8(12):897-904.PMID: 11426329 [PubMed - indexed for MEDLINE]Related articlesFree article

ICAM2 maps to porcine chromosome 12.

Godwin J, Lee JH, Cowan PJ, d'Apice AJ, Moran C.

Anim Genet. 2000 Dec;31(6):404. No abstract available. PMID: 11167528 [PubMed - indexed for MEDLINE]Related articles

Profound coagulopathy associated with pig-to-primate xenotransplants: how many transgenes will be required to overcome this new barrier?

D'Apice AJ, Cowan PJ.

Transplantation. 2000 Nov 15;70(9):1273-4. No abstract available. PMID: 11087140 [PubMed - indexed for MEDLINE]Related articles

Hyperacute rejection of vascularized heart transplants in BALB/c Gal knockout mice.

Gock H, Salvaris E, Murray-Segal L, Mottram P, Han W, Pearse MJ, Goodman DJ, Cowan PJ, d'Apice AJ.

Xenotransplantation. 2000 Nov;7(4):237-46.PMID: 11081758 [PubMed - indexed for MEDLINE]Related articles

Human factor H-related protein 5 (FHR-5). A new complement-associated protein.

McRae JL, Cowan PJ, Power DA, Mitchelhill KI, Kemp BE, Morgan BP, Murphy BF.

J Biol Chem. 2001 Mar 2;276(9):6747-54. Epub 2000 Oct 31.PMID: 11058592 [PubMed - indexed for MEDLINE]Related articlesFree article

The pig analogue of CD59 protects transgenic mouse hearts from injury by human complement.

Fisicaro N, Aminian A, Hinchliffe SJ, Morgan BP, Pearse MJ, D'Apice AJ, Cowan PJ.

Transplantation. 2000 Sep 27;70(6):963-8.PMID: 11014650 [PubMed - indexed for MEDLINE]Related articles

Renal xenografts from triple-transgenic pigs are not hyperacutely rejected but cause coagulopathy in non-immunosuppressed baboons.

Cowan PJ, Aminian A, Barlow H, Brown AA, Chen CG, Fisicaro N, Francis DM, Goodman DJ, Han W, Kurek M, Nottle MB, Pearse MJ, Salvaris E, Shinkel TA, Stainsby GV, Stewart AB, d'Apice AJ.

Transplantation. 2000 Jun 27;69(12):2504-15.PMID: 10910270 [PubMed - indexed for MEDLINE]Related articles