PubMed

The CB1 antagonist rimonabant decreases insulin hypersecretion in rat pancreatic islets.

Getty-Kaushik L, Richard AM, Deeney JT, Krawczyk S, Shirihai O, Corkey BE.

Obesity (Silver Spring). 2009 Oct;17(10):1856-60. Epub 2009 Jul 30.PMID: 19644453 [PubMed - in process]Related articles

Mitochondrial networking protects beta-cells from nutrient-induced apoptosis.

Molina AJ, Wikstrom JD, Stiles L, Las G, Mohamed H, Elorza A, Walzer G, Twig G, Katz S, Corkey BE, Shirihai OS.

Diabetes. 2009 Oct;58(10):2303-15. Epub 2009 Jul 6.PMID: 19581419 [PubMed - indexed for MEDLINE]Related articles

ROS signaling, oxidative stress and Nrf2 in pancreatic beta-cell function.

Pi J, Zhang Q, Fu J, Woods CG, Hou Y, Corkey BE, Collins S, Andersen ME.

Toxicol Appl Pharmacol. 2009 Jun 6. [Epub ahead of print]PMID: 19501608 [PubMed - as supplied by publisher]Related articles

Persistent oxidative stress due to absence of uncoupling protein 2 associated with impaired pancreatic beta-cell function.

Pi J, Bai Y, Daniel KW, Liu D, Lyght O, Edelstein D, Brownlee M, Corkey BE, Collins S.

Endocrinology. 2009 Jul;150(7):3040-8. Epub 2009 Feb 26.PMID: 19246534 [PubMed - indexed for MEDLINE]Related articles

Dual role of proapoptotic BAD in insulin secretion and beta cell survival.

Danial NN, Walensky LD, Zhang CY, Choi CS, Fisher JK, Molina AJ, Datta SR, Pitter KL, Bird GH, Wikstrom JD, Deeney JT, Robertson K, Morash J, Kulkarni A, Neschen S, Kim S, Greenberg ME, Corkey BE, Shirihai OS, Shulman GI, Lowell BB, Korsmeyer SJ.

Nat Med. 2008 Feb;14(2):144-53. Epub 2008 Jan 27.PMID: 18223655 [PubMed - indexed for MEDLINE]Related articles

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy.

Twig G, Elorza A, Molina AJ, Mohamed H, Wikstrom JD, Walzer G, Stiles L, Haigh SE, Katz S, Las G, Alroy J, Wu M, Py BF, Yuan J, Deeney JT, Corkey BE, Shirihai OS.

EMBO J. 2008 Jan 23;27(2):433-46. Epub 2008 Jan 17.PMID: 18200046 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose-dependent insulinotropic polypeptide enhances adipocyte development and glucose uptake in part through Akt activation.

Song DH, Getty-Kaushik L, Tseng E, Simon J, Corkey BE, Wolfe MM.

Gastroenterology. 2007 Dec;133(6):1796-805. Epub 2007 Sep 14.PMID: 18054552 [PubMed - indexed for MEDLINE]Related articlesFree article

The L-type voltage-gated Ca2+ channel is the Ca2+ sensor protein of stimulus-secretion coupling in pancreatic beta cells.

Trus M, Corkey RF, Nesher R, Richard AM, Deeney JT, Corkey BE, Atlas D.

Biochemistry. 2007 Dec 18;46(50):14461-7. Epub 2007 Nov 21.PMID: 18027971 [PubMed - indexed for MEDLINE]Related articles

beta-Cell mitochondria exhibit membrane potential heterogeneity that can be altered by stimulatory or toxic fuel levels.

Wikstrom JD, Katzman SM, Mohamed H, Twig G, Graf SA, Heart E, Molina AJ, Corkey BE, de Vargas LM, Danial NN, Collins S, Shirihai OS.

Diabetes. 2007 Oct;56(10):2569-78. Epub 2007 Aug 8.PMID: 17686943 [PubMed - indexed for MEDLINE]Related articlesFree article

3H-serotonin as a marker of oscillatory insulin secretion in clonal beta-cells (INS-1).

Deeney JT, Bränström R, Corkey BE, Larsson O, Berggren PO.

FEBS Lett. 2007 Aug 21;581(21):4080-4. Epub 2007 Jul 30.PMID: 17686476 [PubMed - indexed for MEDLINE]Related articles

New scanning electron microscopic method for determination of adipocyte size in humans and mice.

Guo W, Bigornia S, Leizerman I, Xie W, McDonnell M, Clemente K, Pirtskhalava T, Kirkland JL, Gokce N, Corkey BE, Sullivan LM, Apovian CM.

Obesity (Silver Spring). 2007 Jul;15(7):1657-65.PMID: 17636083 [PubMed - indexed for MEDLINE]Related articles

Effects of dietary medium-chain triglyceride on weight loss and insulin sensitivity in a group of moderately overweight free-living type 2 diabetic Chinese subjects.

Han JR, Deng B, Sun J, Chen CG, Corkey BE, Kirkland JL, Ma J, Guo W.

Metabolism. 2007 Jul;56(7):985-91.PMID: 17570262 [PubMed - indexed for MEDLINE]Related articles

Single residue (K332A) substitution in Kir6.2 abolishes the stimulatory effect of long-chain acyl-CoA esters: indications for a long-chain acyl-CoA ester binding motif.

Bränström R, Leibiger IB, Leibiger B, Klement G, Nilsson J, Arhem P, Aspinwall CA, Corkey BE, Larsson O, Berggren PO.

Diabetologia. 2007 Aug;50(8):1670-7. Epub 2007 May 24.PMID: 17522836 [PubMed - indexed for MEDLINE]Related articles

Reactive oxygen species as a signal in glucose-stimulated insulin secretion.

Pi J, Bai Y, Zhang Q, Wong V, Floering LM, Daniel K, Reece JM, Deeney JT, Andersen ME, Corkey BE, Collins S.

Diabetes. 2007 Jul;56(7):1783-91. Epub 2007 Mar 30.PMID: 17400930 [PubMed - indexed for MEDLINE]Related articlesFree article

Ca2+, NAD(P)H and membrane potential changes in pancreatic beta-cells by methyl succinate: comparison with glucose.

Heart E, Yaney GC, Corkey RF, Schultz V, Luc E, Liu L, Deeney JT, Shirihai O, Tornheim K, Smith PJ, Corkey BE.

Biochem J. 2007 Apr 1;403(1):197-205.PMID: 17181533 [PubMed - indexed for MEDLINE]Related articlesFree article

Aging results in paradoxical susceptibility of fat cell progenitors to lipotoxicity.

Guo W, Pirtskhalava T, Tchkonia T, Xie W, Thomou T, Han J, Wang T, Wong S, Cartwright A, Hegardt FG, Corkey BE, Kirkland JL.

Am J Physiol Endocrinol Metab. 2007 Apr;292(4):E1041-51. Epub 2006 Dec 5.PMID: 17148751 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose-dependent insulinotropic polypeptide modulates adipocyte lipolysis and reesterification.

Getty-Kaushik L, Song DH, Boylan MO, Corkey BE, Wolfe MM.

Obesity (Silver Spring). 2006 Jul;14(7):1124-31.PMID: 16899793 [PubMed - indexed for MEDLINE]Related articles

Oleate-induced formation of fat cells with impaired insulin sensitivity.

Xie W, Hamilton JA, Kirkland JL, Corkey BE, Guo W.

Lipids. 2006 Mar;41(3):267-71.PMID: 16711601 [PubMed - indexed for MEDLINE]Related articles

Glucose-dependent insulin modulation of oscillatory lipolysis in perifused rat adipocytes.

Getty-Kaushik L, Richard AM, Corkey BE.

Obes Res. 2005 Dec;13(12):2058-65.PMID: 16421338 [PubMed - indexed for MEDLINE]Related articles

Regulation of acetyl CoA carboxylase and carnitine palmitoyl transferase-1 in rat adipocytes.

Zang Y, Wang T, Xie W, Wang-Fischer YL, Getty L, Han J, Corkey BE, Guo W.

Obes Res. 2005 Sep;13(9):1530-9.PMID: 16222055 [PubMed - indexed for MEDLINE]Related articles

Glucose-dependent increase in mitochondrial membrane potential, but not cytoplasmic calcium, correlates with insulin secretion in single islet cells.

Heart E, Corkey RF, Wikstrom JD, Shirihai OS, Corkey BE.

Am J Physiol Endocrinol Metab. 2006 Jan;290(1):E143-E148. Epub 2005 Sep 6.PMID: 16144817 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of lipolytic activity by long-chain acyl-coenzyme A in islets and adipocytes.

Hu L, Deeney JT, Nolan CJ, Peyot ML, Ao A, Richard AM, Luc E, Faergeman NJ, Knudsen J, Guo W, Sorhede-Winzell M, Prentki M, Corkey BE.

Am J Physiol Endocrinol Metab. 2005 Dec;289(6):E1085-92. Epub 2005 Aug 9.PMID: 16091387 [PubMed - indexed for MEDLINE]Related articlesFree article

Free fatty acid regulation of glucose-dependent intrinsic oscillatory lipolysis in perifused isolated rat adipocytes.

Getty-Kaushik L, Richard AM, Corkey BE.

Diabetes. 2005 Mar;54(3):629-37.PMID: 15734837 [PubMed - indexed for MEDLINE]Related articlesFree article

Acyl coenzyme a synthetase regulation: putative role in long-chain acyl coenzyme a partitioning.

Wang YL, Guo W, Zang Y, Yaney GC, Vallega G, Getty-Kaushik L, Pilch P, Kandror K, Corkey BE.

Obes Res. 2004 Nov;12(11):1781-8.PMID: 15601973 [PubMed - indexed for MEDLINE]Related articles

Mitochondrial metabolism reveals a functional architecture in intact islets of Langerhans from normal and diabetic Psammomys obesus.

Katzman SM, Messerli MA, Barry DT, Grossman A, Harel T, Wikstrom JD, Corkey BE, Smith PJ, Shirihai OS.

Am J Physiol Endocrinol Metab. 2004 Dec;287(6):E1090-9. Epub 2004 Aug 31.PMID: 15339741 [PubMed - indexed for MEDLINE]Related articlesFree article

Hormone-sensitive lipase has a role in lipid signaling for insulin secretion but is nonessential for the incretin action of glucagon-like peptide 1.

Peyot ML, Nolan CJ, Soni K, Joly E, Lussier R, Corkey BE, Wang SP, Mitchell GA, Prentki M.

Diabetes. 2004 Jul;53(7):1733-42.PMID: 15220197 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased beta-oxidation in muscle cells enhances insulin-stimulated glucose metabolism and protects against fatty acid-induced insulin resistance despite intramyocellular lipid accumulation.

Perdomo G, Commerford SR, Richard AM, Adams SH, Corkey BE, O'Doherty RM, Brown NF.

J Biol Chem. 2004 Jun 25;279(26):27177-86. Epub 2004 Apr 22.PMID: 15105415 [PubMed - indexed for MEDLINE]Related articlesFree article

Medium-chain Fatty acids attenuate agonist-stimulated lipolysis, mimicking the effects of starvation.

Lei T, Xie W, Han J, Corkey BE, Hamilton JA, Guo W.

Obes Res. 2004 Apr;12(4):599-611.PMID: 15090627 [PubMed - indexed for MEDLINE]Related articles

Long-chain CoA esters activate human pancreatic beta-cell KATP channels: potential role in Type 2 diabetes.

Bränström R, Aspinwall CA, Välimäki S, Ostensson CG, Tibell A, Eckhard M, Brandhorst H, Corkey BE, Berggren PO, Larsson O.

Diabetologia. 2004 Feb;47(2):277-83. Epub 2004 Jan 23.PMID: 14740158 [PubMed - indexed for MEDLINE]Related articles

Sulfonylureas rapidly cross phospholipid bilayer membranes by a free-diffusion mechanism.

Kamp F, Kizilbash N, Corkey BE, Berggren PO, Hamilton JA.

Diabetes. 2003 Oct;52(10):2526-31.PMID: 14514636 [PubMed - indexed for MEDLINE]Related articlesFree article

Fatty acid metabolism and insulin secretion in pancreatic beta cells.

Yaney GC, Corkey BE.

Diabetologia. 2003 Oct;46(10):1297-312. Epub 2003 Sep 12. Review.PMID: 13680127 [PubMed - indexed for MEDLINE]Related articles

Octanoate inhibits triglyceride synthesis in 3T3-L1 and human adipocytes.

Guo W, Lei T, Wang T, Corkey BE, Han J.

J Nutr. 2003 Aug;133(8):2512-8.PMID: 12888629 [PubMed - indexed for MEDLINE]Related articlesFree article

Metabolic partitioning of endogenous fatty acid in adipocytes.

Wang T, Zang Y, Ling W, Corkey BE, Guo W.

Obes Res. 2003 Jul;11(7):880-7.PMID: 12855758 [PubMed - indexed for MEDLINE]Related articles

Medium-chain oil reduces fat mass and down-regulates expression of adipogenic genes in rats.

Han J, Hamilton JA, Kirkland JL, Corkey BE, Guo W.

Obes Res. 2003 Jun;11(6):734-44.PMID: 12805394 [PubMed - indexed for MEDLINE]Related articles

Rapid flip-flop of oleic acid across the plasma membrane of adipocytes.

Kamp F, Guo W, Souto R, Pilch PF, Corkey BE, Hamilton JA.

J Biol Chem. 2003 Mar 7;278(10):7988-95. Epub 2002 Dec 23.PMID: 12499383 [PubMed - indexed for MEDLINE]Related articlesFree article

Potentiation of insulin secretion by phorbol esters is mediated by PKC-alpha and nPKC isoforms.

Yaney GC, Fairbanks JM, Deeney JT, Korchak HM, Tornheim K, Corkey BE.

Am J Physiol Endocrinol Metab. 2002 Nov;283(5):E880-8.PMID: 12376314 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucagon-like peptide 1 and fatty acids amplify pulsatile insulin secretion from perifused rat islets.

Cunningham BA, Richard AM, Dillon JS, Daley JT, Civelek VN, Deeney JT, Yaney GC, Corkey BE, Tornheim K.

Biochem J. 2003 Jan 1;369(Pt 1):173-8.PMID: 12356335 [PubMed - indexed for MEDLINE]Related articlesFree article

Succinate is a preferential metabolic stimulus-coupling signal for glucose-induced proinsulin biosynthesis translation.

Alarcon C, Wicksteed B, Prentki M, Corkey BE, Rhodes CJ.

Diabetes. 2002 Aug;51(8):2496-504.PMID: 12145163 [PubMed - indexed for MEDLINE]Related articlesFree article

Octanoate attenuates adipogenesis in 3T3-L1 preadipocytes.

Han J, Farmer SR, Kirkland JL, Corkey BE, Yoon R, Pirtskhalava T, Ido Y, Guo W.

J Nutr. 2002 May;132(5):904-10.PMID: 11983812 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose-induced metabolic oscillations parallel those of Ca(2+) and insulin release in clonal insulin-secreting cells. A multiwell approach to oscillatory cell behavior.

Deeney JT, Köhler M, Kubik K, Brown G, Schultz V, Tornheim K, Corkey BE, Berggren PO.

J Biol Chem. 2001 Oct 5;276(40):36946-50. Epub 2001 Jul 31.PMID: 11481328 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose-induced toxicity in insulin-producing pituitary cells that coexpress GLUT2 and glucokinase. Implications for metabolic engineering.

Faradji RN, Havari E, Chen Q, Gray J, Tornheim K, Corkey BE, Mulligan RC, Lipes MA.

J Biol Chem. 2001 Sep 28;276(39):36695-702. Epub 2001 Jul 6.PMID: 11443115 [PubMed - indexed for MEDLINE]Related articlesFree article

Negative regulation of ligand-initiated Ca(2+) uptake by PKC-beta II in differentiated HL60 cells.

Korchak HM, Corkey BE, Yaney GC, Kilpatrick LE.

Am J Physiol Cell Physiol. 2001 Aug;281(2):C514-23.PMID: 11443050 [PubMed - indexed for MEDLINE]Related articlesFree article

Fat depot origin affects fatty acid handling in cultured rat and human preadipocytes.

Caserta F, Tchkonia T, Civelek VN, Prentki M, Brown NF, McGarry JD, Forse RA, Corkey BE, Hamilton JA, Kirkland JL.

Am J Physiol Endocrinol Metab. 2001 Feb;280(2):E238-47.PMID: 11158926 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucagon-like peptide 1 stimulates lipolysis in clonal pancreatic beta-cells (HIT).

Yaney GC, Civelek VN, Richard AM, Dillon JS, Deeney JT, Hamilton JA, Korchak HM, Tornheim K, Corkey BE, Boyd AE 3rd.

Diabetes. 2001 Jan;50(1):56-62.PMID: 11147795 [PubMed - indexed for MEDLINE]Related articlesFree article

Dehydroepiandrosterone sulfate and beta-cell function: enhanced glucose-induced insulin secretion and altered gene expression in rodent pancreatic beta-cells.

Dillon JS, Yaney GC, Zhou Y, Voilley N, Bowen S, Chipkin S, Bliss CR, Schultz V, Schuit FC, Prentki M, Waxman DJ, Corkey BE.

Diabetes. 2000 Dec;49(12):2012-20.PMID: 11118002 [PubMed - indexed for MEDLINE]Related articlesFree article

Oxygen consumption oscillates in single clonal pancreatic beta-cells (HIT).

Porterfield DM, Corkey RF, Sanger RH, Tornheim K, Smith PJ, Corkey BE.

Diabetes. 2000 Sep;49(9):1511-6.PMID: 10969835 [PubMed - indexed for MEDLINE]Related articlesFree article

Metabolic control of beta-cell function.

Deeney JT, Prentki M, Corkey BE.

Semin Cell Dev Biol. 2000 Aug;11(4):267-75. Review.PMID: 10966860 [PubMed - indexed for MEDLINE]Related articles

Esterification of free fatty acids in adipocytes: a comparison between octanoate and oleate.

Guo W, Choi JK, Kirkland JL, Corkey BE, Hamilton JA.

Biochem J. 2000 Jul 15;349(Pt 2):463-71.PMID: 10880345 [PubMed - indexed for MEDLINE]Related articlesFree article

Synaptotagmin III isoform is compartmentalized in pancreatic beta-cells and has a functional role in exocytosis.

Brown H, Meister B, Deeney J, Corkey BE, Yang SN, Larsson O, Rhodes CJ, Seino S, Berggren PO, Fried G.

Diabetes. 2000 Mar;49(3):383-91.PMID: 10868959 [PubMed - indexed for MEDLINE]Related articlesFree article

Long-chain acyl CoA regulation of protein kinase C and fatty acid potentiation of glucose-stimulated insulin secretion in clonal beta-cells.

Yaney GC, Korchak HM, Corkey BE.

Endocrinology. 2000 Jun;141(6):1989-98.PMID: 10830281 [PubMed - indexed for MEDLINE]Related articlesFree article