PubMed

Sialic Acid Modification of Adiponectin Is Not Required for Multimerization or Secretion but Determines Half-Life in Circulation.

Richards AA, Colgrave ML, Jialiang Z, Webster J, Simpson F, Preston E, Wilks D, Hoehn KL, Stephenson M, Macdonald GA, Prins JB, Cooney GJ, Xu A, Whitehead JP.

Mol Endocrinol. 2009 Oct 23. [Epub ahead of print]PMID: 19855092 [PubMed - as supplied by publisher]Related articles

Diverse roles for protein kinase C delta and protein kinase C epsilon in the generation of high-fat-diet-induced glucose intolerance in mice: regulation of lipogenesis by protein kinase C delta.

Frangioudakis G, Burchfield JG, Narasimhan S, Cooney GJ, Leitges M, Biden TJ, Schmitz-Peiffer C.

Diabetologia. 2009 Oct 7. [Epub ahead of print]PMID: 19809797 [PubMed - as supplied by publisher]Related articles

Insulin resistance is a cellular antioxidant defense mechanism.

Hoehn KL, Salmon AB, Hohnen-Behrens C, Turner N, Hoy AJ, Maghzal GJ, Stocker R, Van Remmen H, Kraegen EW, Cooney GJ, Richardson AR, James DE.

Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17787-92. Epub 2009 Sep 30.PMID: 19805130 [PubMed - in process]Related articles

Enhancement of muscle mitochondrial oxidative capacity and alterations in insulin action are lipid species dependent: potent tissue-specific effects of medium-chain fatty acids.

Turner N, Hariharan K, TidAng J, Frangioudakis G, Beale SM, Wright LE, Zeng XY, Leslie SJ, Li JY, Kraegen EW, Cooney GJ, Ye JM.

Diabetes. 2009 Nov;58(11):2547-54. Epub 2009 Aug 31.PMID: 19720794 [PubMed - in process]Related articles

Rev-erb beta regulates the Srebp-1c promoter and mRNA expression in skeletal muscle cells.

Ramakrishnan SN, Lau P, Crowther LM, Cleasby ME, Millard S, Leong GM, Cooney GJ, Muscat GE.

Biochem Biophys Res Commun. 2009 Oct 30;388(4):654-9. Epub 2009 Aug 12.PMID: 19682428 [PubMed - indexed for MEDLINE]Related articles

Dual ablation of Grb10 and Grb14 in mice reveals their combined role in regulation of insulin signaling and glucose homeostasis.

Holt LJ, Lyons RJ, Ryan AS, Beale SM, Ward A, Cooney GJ, Daly RJ.

Mol Endocrinol. 2009 Sep;23(9):1406-14. Epub 2009 Jun 18.PMID: 19541746 [PubMed - indexed for MEDLINE]Related articles

Regulation of the nuclear hormone receptor nur77 in muscle: influence of exercise-activated pathways in vitro and obesity in vivo.

Kanzleiter T, Wilks D, Preston E, Ye J, Frangioudakis G, Cooney GJ.

Biochim Biophys Acta. 2009 Aug;1792(8):777-82. Epub 2009 May 15.PMID: 19447175 [PubMed - indexed for MEDLINE]Related articles

Lipid and insulin infusion-induced skeletal muscle insulin resistance is likely due to metabolic feedback and not changes in IRS-1, Akt, or AS160 phosphorylation.

Hoy AJ, Brandon AE, Turner N, Watt MJ, Bruce CR, Cooney GJ, Kraegen EW.

Am J Physiol Endocrinol Metab. 2009 Jul;297(1):E67-75. Epub 2009 Apr 14.PMID: 19366875 [PubMed - indexed for MEDLINE]Related articles

Insulin resistance and fuel homeostasis: the role of AMP-activated protein kinase.

Hegarty BD, Turner N, Cooney GJ, Kraegen EW.

Acta Physiol (Oxf). 2009 May;196(1):129-45. Epub 2009 Feb 19.PMID: 19245658 [PubMed - in process]Related articles

Overexpression of carnitine palmitoyltransferase-1 in skeletal muscle is sufficient to enhance fatty acid oxidation and improve high-fat diet-induced insulin resistance.

Bruce CR, Hoy AJ, Turner N, Watt MJ, Allen TL, Carpenter K, Cooney GJ, Febbraio MA, Kraegen EW.

Diabetes. 2009 Mar;58(3):550-8. Epub 2008 Dec 10.PMID: 19073774 [PubMed - indexed for MEDLINE]Related articlesFree article

Muscle insulin resistance: a case of fat overconsumption, not mitochondrial dysfunction.

Kraegen EW, Cooney GJ, Turner N.

Proc Natl Acad Sci U S A. 2008 Jun 3;105(22):7627-8. Epub 2008 May 28. No abstract available. PMID: 18509057 [PubMed - indexed for MEDLINE]Related articlesFree article

Free fatty acids and skeletal muscle insulin resistance.

Kraegen EW, Cooney GJ.

Curr Opin Lipidol. 2008 Jun;19(3):235-41. Review.PMID: 18460913 [PubMed - indexed for MEDLINE]Related articles

Acute elevation of circulating fatty acids impairs downstream insulin signalling in rat skeletal muscle in vivo independent of effects on stress signalling.

Frangioudakis G, Cooney GJ.

J Endocrinol. 2008 May;197(2):277-85.PMID: 18434357 [PubMed - indexed for MEDLINE]Related articlesFree article

Uteroplacental insufficiency and reducing litter size alters skeletal muscle mitochondrial biogenesis in a sex-specific manner in the adult rat.

Wadley GD, Siebel AL, Cooney GJ, McConell GK, Wlodek ME, Owens JA.

Am J Physiol Endocrinol Metab. 2008 May;294(5):E861-9. Epub 2008 Mar 4.PMID: 18319353 [PubMed - indexed for MEDLINE]Related articlesFree article

Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action.

Turner N, Li JY, Gosby A, To SW, Cheng Z, Miyoshi H, Taketo MM, Cooney GJ, Kraegen EW, James DE, Hu LH, Li J, Ye JM.

Diabetes. 2008 May;57(5):1414-8. Epub 2008 Feb 19.PMID: 18285556 [PubMed - indexed for MEDLINE]Related articlesFree article

An Actn3 knockout mouse provides mechanistic insights into the association between alpha-actinin-3 deficiency and human athletic performance.

MacArthur DG, Seto JT, Chan S, Quinlan KG, Raftery JM, Turner N, Nicholson MD, Kee AJ, Hardeman EC, Gunning PW, Cooney GJ, Head SI, Yang N, North KN.

Hum Mol Genet. 2008 Apr 15;17(8):1076-86. Epub 2008 Jan 4.PMID: 18178581 [PubMed - indexed for MEDLINE]Related articlesFree article

Local activation of the IkappaK-NF-kappaB pathway in muscle does not cause insulin resistance.

Polkinghorne E, Lau Q, Cooney GJ, Kraegen EW, Cleasby ME.

Am J Physiol Endocrinol Metab. 2008 Feb;294(2):E316-25. Epub 2007 Nov 20.PMID: 18029440 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of PKCepsilon improves glucose-stimulated insulin secretion and reduces insulin clearance.

Schmitz-Peiffer C, Laybutt DR, Burchfield JG, Gurisik E, Narasimhan S, Mitchell CJ, Pedersen DJ, Braun U, Cooney GJ, Leitges M, Biden TJ.

Cell Metab. 2007 Oct;6(4):320-8.PMID: 17908560 [PubMed - indexed for MEDLINE]Related articles

Glucose infusion causes insulin resistance in skeletal muscle of rats without changes in Akt and AS160 phosphorylation.

Hoy AJ, Bruce CR, Cederberg A, Turner N, James DE, Cooney GJ, Kraegen EW.

Am J Physiol Endocrinol Metab. 2007 Nov;293(5):E1358-64. Epub 2007 Sep 4.PMID: 17785505 [PubMed - indexed for MEDLINE]Related articlesFree article

Mice with a disruption of the imprinted Grb10 gene exhibit altered body composition, glucose homeostasis, and insulin signaling during postnatal life.

Smith FM, Holt LJ, Garfield AS, Charalambous M, Koumanov F, Perry M, Bazzani R, Sheardown SA, Hegarty BD, Lyons RJ, Cooney GJ, Daly RJ, Ward A.

Mol Cell Biol. 2007 Aug;27(16):5871-86. Epub 2007 Jun 11.PMID: 17562854 [PubMed - indexed for MEDLINE]Related articlesFree article

Excess lipid availability increases mitochondrial fatty acid oxidative capacity in muscle: evidence against a role for reduced fatty acid oxidation in lipid-induced insulin resistance in rodents.

Turner N, Bruce CR, Beale SM, Hoehn KL, So T, Rolph MS, Cooney GJ.

Diabetes. 2007 Aug;56(8):2085-92. Epub 2007 May 22.PMID: 17519422 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of carnitine palmitoyltransferase I in skeletal muscle in vivo increases fatty acid oxidation and reduces triacylglycerol esterification.

Bruce CR, Brolin C, Turner N, Cleasby ME, van der Leij FR, Cooney GJ, Kraegen EW.

Am J Physiol Endocrinol Metab. 2007 Apr;292(4):E1231-7. Epub 2006 Dec 19.PMID: 17179390 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic ablation of the c-Cbl ubiquitin ligase domain results in increased energy expenditure and improved insulin action.

Molero JC, Turner N, Thien CB, Langdon WY, James DE, Cooney GJ.

Diabetes. 2006 Dec;55(12):3411-7.PMID: 17130487 [PubMed - indexed for MEDLINE]Related articlesFree article

Functional studies of Akt isoform specificity in skeletal muscle in vivo; maintained insulin sensitivity despite reduced insulin receptor substrate-1 expression.

Cleasby ME, Reinten TA, Cooney GJ, James DE, Kraegen EW.

Mol Endocrinol. 2007 Jan;21(1):215-28. Epub 2006 Oct 4.PMID: 17021050 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of acyl-CoA synthetase-1 increases lipid deposition in hepatic (HepG2) cells and rodent liver in vivo.

Parkes HA, Preston E, Wilks D, Ballesteros M, Carpenter L, Wood L, Kraegen EW, Furler SM, Cooney GJ.

Am J Physiol Endocrinol Metab. 2006 Oct;291(4):E737-44. Epub 2006 May 16.PMID: 16705061 [PubMed - indexed for MEDLINE]Related articlesFree article

Casitas b-lineage lymphoma-deficient mice are protected against high-fat diet-induced obesity and insulin resistance.

Molero JC, Waring SG, Cooper A, Turner N, Laybutt R, Cooney GJ, James DE.

Diabetes. 2006 Mar;55(3):708-15.PMID: 16505234 [PubMed - indexed for MEDLINE]Related articlesFree article

Y2Y4 receptor double knockout protects against obesity due to a high-fat diet or Y1 receptor deficiency in mice.

Sainsbury A, Bergen HT, Boey D, Bamming D, Cooney GJ, Lin S, Couzens M, Stroth N, Lee NJ, Lindner D, Singewald N, Karl T, Duffy L, Enriquez R, Slack K, Sperk G, Herzog H.

Diabetes. 2006 Jan;55(1):19-26.PMID: 16380472 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased malonyl-CoA and diacylglycerol content and reduced AMPK activity accompany insulin resistance induced by glucose infusion in muscle and liver of rats.

Kraegen EW, Saha AK, Preston E, Wilks D, Hoy AJ, Cooney GJ, Ruderman NB.

Am J Physiol Endocrinol Metab. 2006 Mar;290(3):E471-9. Epub 2005 Oct 18.PMID: 16234268 [PubMed - indexed for MEDLINE]Related articlesFree article

Both saturated and n-6 polyunsaturated fat diets reduce phosphorylation of insulin receptor substrate-1 and protein kinase B in muscle during the initial stages of in vivo insulin stimulation.

Frangioudakis G, Ye JM, Cooney GJ.

Endocrinology. 2005 Dec;146(12):5596-603. Epub 2005 Sep 8.PMID: 16150913 [PubMed - indexed for MEDLINE]Related articlesFree article

Acute bidirectional manipulation of muscle glucose uptake by in vivo electrotransfer of constructs targeting glucose transporter genes.

Cleasby ME, Davey JR, Reinten TA, Graham MW, James DE, Kraegen EW, Cooney GJ.

Diabetes. 2005 Sep;54(9):2702-11.PMID: 16123360 [PubMed - indexed for MEDLINE]Related articlesFree article

Nur77 regulates lipolysis in skeletal muscle cells. Evidence for cross-talk between the beta-adrenergic and an orphan nuclear hormone receptor pathway.

Maxwell MA, Cleasby ME, Harding A, Stark A, Cooney GJ, Muscat GE.

J Biol Chem. 2005 Apr 1;280(13):12573-84. Epub 2005 Jan 6.PMID: 15640143 [PubMed - indexed for MEDLINE]Related articlesFree article

Metformin prevents the development of acute lipid-induced insulin resistance in the rat through altered hepatic signaling mechanisms.

Cleasby ME, Dzamko N, Hegarty BD, Cooney GJ, Kraegen EW, Ye JM.

Diabetes. 2004 Dec;53(12):3258-66.PMID: 15561958 [PubMed - indexed for MEDLINE]Related articlesFree article

c-Cbl-deficient mice have reduced adiposity, higher energy expenditure, and improved peripheral insulin action.

Molero JC, Jensen TE, Withers PC, Couzens M, Herzog H, Thien CB, Langdon WY, Walder K, Murphy MA, Bowtell DD, James DE, Cooney GJ.

J Clin Invest. 2004 Nov;114(9):1326-33.PMID: 15520865 [PubMed - indexed for MEDLINE]Related articlesFree article

Direct demonstration of lipid sequestration as a mechanism by which rosiglitazone prevents fatty-acid-induced insulin resistance in the rat: comparison with metformin.

Ye JM, Dzamko N, Cleasby ME, Hegarty BD, Furler SM, Cooney GJ, Kraegen EW.

Diabetologia. 2004 Jul;47(7):1306-13. Epub 2004 Jul 1.PMID: 15232684 [PubMed - indexed for MEDLINE]Related articles

AMP-activated protein kinase activation by AICAR increases both muscle fatty acid and glucose uptake in white muscle of insulin-resistant rats in vivo.

Iglesias MA, Furler SM, Cooney GJ, Kraegen EW, Ye JM.

Diabetes. 2004 Jul;53(7):1649-54.PMID: 15220186 [PubMed - indexed for MEDLINE]Related articlesFree article

Peroxisome proliferator-activated receptor (PPAR) activation induces tissue-specific effects on fatty acid uptake and metabolism in vivo--a study using the novel PPARalpha/gamma agonist tesaglitazar.

Hegarty BD, Furler SM, Oakes ND, Kraegen EW, Cooney GJ.

Endocrinology. 2004 Jul;145(7):3158-64. Epub 2004 Apr 1.PMID: 15059948 [PubMed - indexed for MEDLINE]Related articlesFree article

Improved glucose homeostasis and enhanced insulin signalling in Grb14-deficient mice.

Cooney GJ, Lyons RJ, Crew AJ, Jensen TE, Molero JC, Mitchell CJ, Biden TJ, Ormandy CJ, James DE, Daly RJ.

EMBO J. 2004 Feb 11;23(3):582-93. Epub 2004 Jan 29.PMID: 14749734 [PubMed - indexed for MEDLINE]Related articlesFree article

Disassociation of muscle triglyceride content and insulin sensitivity after exercise training in patients with Type 2 diabetes.

Bruce CR, Kriketos AD, Cooney GJ, Hawley JA.

Diabetologia. 2004 Jan;47(1):23-30. Epub 2003 Dec 12.PMID: 14673522 [PubMed - indexed for MEDLINE]Related articles

Muscle oxidative capacity is a better predictor of insulin sensitivity than lipid status.

Bruce CR, Anderson MJ, Carey AL, Newman DG, Bonen A, Kriketos AD, Cooney GJ, Hawley JA.

J Clin Endocrinol Metab. 2003 Nov;88(11):5444-51.PMID: 14602787 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of intramuscular lipid in insulin resistance.

Hegarty BD, Furler SM, Ye J, Cooney GJ, Kraegen EW.

Acta Physiol Scand. 2003 Aug;178(4):373-83. Review.PMID: 12864742 [PubMed - indexed for MEDLINE]Related articles

PPARalpha /gamma ragaglitazar eliminates fatty liver and enhances insulin action in fat-fed rats in the absence of hepatomegaly.

Ye JM, Iglesias MA, Watson DG, Ellis B, Wood L, Jensen PB, Sørensen RV, Larsen PJ, Cooney GJ, Wassermann K, Kraegen EW.

Am J Physiol Endocrinol Metab. 2003 Mar;284(3):E531-40.PMID: 12556350 [PubMed - indexed for MEDLINE]Related articlesFree article

Hypothalamic regulation of energy homeostasis.

Sainsbury A, Cooney GJ, Herzog H.

Best Pract Res Clin Endocrinol Metab. 2002 Dec;16(4):623-37. Review.PMID: 12468411 [PubMed - indexed for MEDLINE]Related articles

Prior thiazolidinedione treatment preserves insulin sensitivity in normal rats during acute fatty acid elevation: role of the liver.

Ye JM, Frangioudakis G, Iglesias MA, Furler SM, Ellis B, Dzamko N, Cooney GJ, Kraegen EW.

Endocrinology. 2002 Dec;143(12):4527-35.PMID: 12446579 [PubMed - indexed for MEDLINE]Related articlesFree article

AICAR administration causes an apparent enhancement of muscle and liver insulin action in insulin-resistant high-fat-fed rats.

Iglesias MA, Ye JM, Frangioudakis G, Saha AK, Tomas E, Ruderman NB, Cooney GJ, Kraegen EW.

Diabetes. 2002 Oct;51(10):2886-94. Erratum in: Diabetes 2003 Jan;52(1):223-4. PMID: 12351423 [PubMed - indexed for MEDLINE]Related articlesFree article

Muscle long-chain acyl CoA esters and insulin resistance.

Cooney GJ, Thompson AL, Furler SM, Ye J, Kraegen EW.

Ann N Y Acad Sci. 2002 Jun;967:196-207. Review.PMID: 12079848 [PubMed - indexed for MEDLINE]Related articles

Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle.

Yu C, Chen Y, Cline GW, Zhang D, Zong H, Wang Y, Bergeron R, Kim JK, Cushman SW, Cooney GJ, Atcheson B, White MF, Kraegen EW, Shulman GI.

J Biol Chem. 2002 Dec 27;277(52):50230-6. Epub 2002 Nov 14.PMID: 12006582 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased efficiency of fatty acid uptake contributes to lipid accumulation in skeletal muscle of high fat-fed insulin-resistant rats.

Hegarty BD, Cooney GJ, Kraegen EW, Furler SM.

Diabetes. 2002 May;51(5):1477-84.PMID: 11978645 [PubMed - indexed for MEDLINE]Related articlesFree article

Acyl-CoA binding protein expression is fiber type- specific and elevated in muscles from the obese insulin-resistant Zucker rat.

Franch J, Knudsen J, Ellis BA, Pedersen PK, Cooney GJ, Jensen J.

Diabetes. 2002 Feb;51(2):449-54.PMID: 11812754 [PubMed - indexed for MEDLINE]Related articlesFree article

Chronic central melanocortin-4 receptor antagonism and central neuropeptide-Y infusion in rats produce increased adiposity by divergent pathways.

Baran K, Preston E, Wilks D, Cooney GJ, Kraegen EW, Sainsbury A.

Diabetes. 2002 Jan;51(1):152-8.PMID: 11756335 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of lipids in the pathogenesis of muscle insulin resistance and beta cell failure in type II diabetes and obesity.

Kraegen EW, Cooney GJ, Ye JM, Thompson AL, Furler SM.

Exp Clin Endocrinol Diabetes. 2001;109 Suppl 2:S189-201. Review.PMID: 11460570 [PubMed - indexed for MEDLINE]Related articles