PubMed

The tissue-type plasminogen activator story.

Collen D, Lijnen HR.

Arterioscler Thromb Vasc Biol. 2009 Aug;29(8):1151-5.PMID: 19605778 [PubMed - indexed for MEDLINE]Related articles

Emerging treatments for thrombocytopenia: increasing platelet production.

Peeters K, Stassen JM, Collen D, Van Geet C, Freson K.

Drug Discov Today. 2008 Sep;13(17-18):798-806. Epub 2008 Jul 17. Review.PMID: 18602017 [PubMed - indexed for MEDLINE]Related articles

Sustained endothelial progenitor cell dysfunction after chronic hypoxia-induced pulmonary hypertension.

Marsboom G, Pokreisz P, Gheysens O, Vermeersch P, Gillijns H, Pellens M, Liu X, Collen D, Janssens S.

Stem Cells. 2008 Apr;26(4):1017-26. Epub 2008 Feb 7.PMID: 18258720 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of Gas6 in erythropoiesis and anemia in mice.

Angelillo-Scherrer A, Burnier L, Lambrechts D, Fish RJ, Tjwa M, Plaisance S, Sugamele R, DeMol M, Martinez-Soria E, Maxwell PH, Lemke G, Goff SP, Matsushima GK, Earp HS, Chanson M, Collen D, Izui S, Schapira M, Conway EM, Carmeliet P.

J Clin Invest. 2008 Feb;118(2):583-96.PMID: 18188450 [PubMed - indexed for MEDLINE]Related articlesFree article

Urokinase-type plasminogen activator receptor (uPAR) augments brain damage in a murine model of ischemic stroke.

Nagai N, Okada K, Kawao N, Ishida C, Ueshima S, Collen D, Matsuo O.

Neurosci Lett. 2008 Feb 13;432(1):46-9. Epub 2007 Dec 8.PMID: 18164548 [PubMed - indexed for MEDLINE]Related articles

Ttrap is an essential modulator of Smad3-dependent Nodal signaling during zebrafish gastrulation and left-right axis determination.

Esguerra CV, Nelles L, Vermeire L, Ibrahimi A, Crawford AD, Derua R, Janssens E, Waelkens E, Carmeliet P, Collen D, Huylebroeck D.

Development. 2007 Dec;134(24):4381-93.PMID: 18039968 [PubMed - indexed for MEDLINE]Related articlesFree article

Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels.

Fischer C, Jonckx B, Mazzone M, Zacchigna S, Loges S, Pattarini L, Chorianopoulos E, Liesenborghs L, Koch M, De Mol M, Autiero M, Wyns S, Plaisance S, Moons L, van Rooijen N, Giacca M, Stassen JM, Dewerchin M, Collen D, Carmeliet P.

Cell. 2007 Nov 2;131(3):463-75.PMID: 17981115 [PubMed - indexed for MEDLINE]Related articles

Soluble guanylate cyclase-alpha1 deficiency selectively inhibits the pulmonary vasodilator response to nitric oxide and increases the pulmonary vascular remodeling response to chronic hypoxia.

Vermeersch P, Buys E, Pokreisz P, Marsboom G, Ichinose F, Sips P, Pellens M, Gillijns H, Swinnen M, Graveline A, Collen D, Dewerchin M, Brouckaert P, Bloch KD, Janssens S.

Circulation. 2007 Aug 21;116(8):936-43. Epub 2007 Aug 6.PMID: 17679618 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of vascular endothelial growth factor receptor tyrosine kinases impairs adipose tissue development in mouse models of obesity.

Lijnen HR, Van Hoef B, Kemp D, Collen D.

Biochim Biophys Acta. 2007 Sep;1770(9):1369-73. Epub 2007 Jun 15.PMID: 17616257 [PubMed - indexed for MEDLINE]Related articles

Stromelysin-1 (MMP-3) is critical for intracranial bleeding after t-PA treatment of stroke in mice.

Suzuki Y, Nagai N, Umemura K, Collen D, Lijnen HR.

J Thromb Haemost. 2007 Aug;5(8):1732-9. Epub 2007 May 21.PMID: 17596135 [PubMed - indexed for MEDLINE]Related articles

Lack of endothelial cell survivin causes embryonic defects in angiogenesis, cardiogenesis, and neural tube closure.

Zwerts F, Lupu F, De Vriese A, Pollefeyt S, Moons L, Altura RA, Jiang Y, Maxwell PH, Hill P, Oh H, Rieker C, Collen D, Conway SJ, Conway EM.

Blood. 2007 Jun 1;109(11):4742-52. Epub 2007 Feb 13.PMID: 17299096 [PubMed - indexed for MEDLINE]Related articlesFree article

A dose-finding clinical trial of staphylokinase SY162 in patients with long-term venous access catheter thrombotic occlusion.

Verhamme P, Goossens G, Maleux G, Collen D, Stas M.

J Thromb Thrombolysis. 2007 Aug;24(1):1-5. Epub 2007 Feb 3.PMID: 17278000 [PubMed - indexed for MEDLINE]Related articles

Species differences in transgene DNA uptake in hepatocytes after adenoviral transfer correlate with the size of endothelial fenestrae.

Snoeys J, Lievens J, Wisse E, Jacobs F, Duimel H, Collen D, Frederik P, De Geest B.

Gene Ther. 2007 Apr;14(7):604-12. Epub 2007 Jan 18.PMID: 17235290 [PubMed - indexed for MEDLINE]Related articles

Tiplaxtinin impairs nutritionally induced obesity in mice.

Lijnen HR, Alessi MC, Frederix L, Collen D, Juhan-Vague I.

Thromb Haemost. 2006 Dec;96(6):731-7.PMID: 17139366 [PubMed - indexed for MEDLINE]Related articles

Expression of aggrecan(ases) during murine preadipocyte differentiation and adipose tissue development.

Voros G, Sandy JD, Collen D, Lijnen HR.

Biochim Biophys Acta. 2006 Dec;1760(12):1837-44. Epub 2006 Aug 26.PMID: 17011710 [PubMed - indexed for MEDLINE]Related articles

Impaired adipose tissue development in mice with inactivation of placental growth factor function.

Lijnen HR, Christiaens V, Scroyen I, Voros G, Tjwa M, Carmeliet P, Collen D.

Diabetes. 2006 Oct;55(10):2698-704.PMID: 17003333 [PubMed - indexed for MEDLINE]Related articlesFree article

Efficacy and safety of adeno-associated viral vectors based on serotype 8 and 9 vs. lentiviral vectors for hemophilia B gene therapy.

Vandendriessche T, Thorrez L, Acosta-Sanchez A, Petrus I, Wang L, Ma L, DE Waele L, Iwasaki Y, Gillijns V, Wilson JM, Collen D, Chuah MK.

J Thromb Haemost. 2007 Jan;5(1):16-24. Epub 2006 Sep 26.PMID: 17002653 [PubMed - indexed for MEDLINE]Related articles

The lectin-like domain of thrombomodulin interferes with complement activation and protects against arthritis.

Van de Wouwer M, Plaisance S, De Vriese A, Waelkens E, Collen D, Persson J, Daha MR, Conway EM.

J Thromb Haemost. 2006 Aug;4(8):1813-24.PMID: 16879225 [PubMed - indexed for MEDLINE]Related articles

Angiogenesis enhances factor IX delivery and persistence from retrievable human bioengineered muscle implants.

Thorrez L, Vandenburgh H, Callewaert N, Mertens N, Shansky J, Wang L, Arnout J, Collen D, Chuah M, Vandendriessche T.

Mol Ther. 2006 Sep;14(3):442-51. Epub 2006 Jun 5.PMID: 16750937 [PubMed - indexed for MEDLINE]Related articles

Overexpression of tissue inhibitor of matrix metalloproteinases-1 (TIMP-1) in mice does not affect adipogenesis or adipose tissue development.

Demeulemeester D, Scroyen I, Voros G, Snoeys J, De Geest B, Collen D, Lijnen HR.

Thromb Haemost. 2006 Jun;95(6):1019-24.PMID: 16732382 [PubMed - indexed for MEDLINE]Related articles

Variable region heavy chain glycosylation determines the anticoagulant activity of a factor VIII antibody.

Jacquemin M, Radcliffe CM, Lavend'homme R, Wormald MR, Vanderelst L, Wallays G, Dewaele J, Collen D, Vermylen J, Dwek RA, Saint-Remy JM, Rudd PM, Dewerchin M.

J Thromb Haemost. 2006 May;4(5):1047-55.PMID: 16689758 [PubMed - indexed for MEDLINE]Related articles

Impairment of adipose tissue development by hypoxia is not mediated by plasminogen activator inhibitor-1.

Semeraro F, Voros G, Collen D, Lijnen HR.

Thromb Haemost. 2006 Jan;95(1):174-81.PMID: 16543977 [PubMed - indexed for MEDLINE]Related articles

Cytochrome P450 epoxygenase gene function in hypoxic pulmonary vasoconstriction and pulmonary vascular remodeling.

Pokreisz P, Fleming I, Kiss L, Barbosa-Sicard E, Fisslthaler B, Falck JR, Hammock BD, Kim IH, Szelid Z, Vermeersch P, Gillijns H, Pellens M, Grimminger F, van Zonneveld AJ, Collen D, Busse R, Janssens S.

Hypertension. 2006 Apr;47(4):762-70. Epub 2006 Feb 27.PMID: 16505204 [PubMed - indexed for MEDLINE]Related articlesFree article

Phenotypic correction of von Willebrand disease type 3 blood-derived endothelial cells with lentiviral vectors expressing von Willebrand factor.

De Meyer SF, Vanhoorelbeke K, Chuah MK, Pareyn I, Gillijns V, Hebbel RP, Collen D, Deckmyn H, VandenDriessche T.

Blood. 2006 Jun 15;107(12):4728-36. Epub 2006 Feb 14.PMID: 16478886 [PubMed - indexed for MEDLINE]Related articlesFree article

Plasminogen activation: a mediator of vascular smooth muscle cell apoptosis in atherosclerotic plaques.

Rossignol P, Luttun A, Martin-Ventura JL, Lupu F, Carmeliet P, Collen D, Anglès-Cano E, Lijnen HR.

J Thromb Haemost. 2006 Mar;4(3):664-70.PMID: 16460449 [PubMed - indexed for MEDLINE]Related articlesFree article

Elimination of innate immune responses and liver inflammation by PEGylation of adenoviral vectors and methylprednisolone.

De Geest B, Snoeys J, Van Linthout S, Lievens J, Collen D.

Hum Gene Ther. 2005 Dec;16(12):1439-51.PMID: 16390275 [PubMed - indexed for MEDLINE]Related articles

Efficient lentiviral transduction and improved engraftment of human bone marrow mesenchymal cells.

Van Damme A, Thorrez L, Ma L, Vandenburgh H, Eyckmans J, Dell'Accio F, De Bari C, Luyten F, Lillicrap D, Collen D, VandenDriessche T, Chuah MK.

Stem Cells. 2006 Apr;24(4):896-907. Epub 2005 Dec 9.PMID: 16339997 [PubMed - indexed for MEDLINE]Related articlesFree article

A genetic Xenopus laevis tadpole model to study lymphangiogenesis.

Ny A, Koch M, Schneider M, Neven E, Tong RT, Maity S, Fischer C, Plaisance S, Lambrechts D, Héligon C, Terclavers S, Ciesiolka M, Kälin R, Man WY, Senn I, Wyns S, Lupu F, Brändli A, Vleminckx K, Collen D, Dewerchin M, Conway EM, Moons L, Jain RK, Carmeliet P.

Nat Med. 2005 Sep;11(9):998-1004. Epub 2005 Aug 14.PMID: 16116431 [PubMed - indexed for MEDLINE]Related articles

Lipid emulsions potently increase transgene expression in hepatocytes after adenoviral transfer.

Snoeys J, Mertens G, Lievens J, van Berkel T, Collen D, Biessen EA, De Geest B.

Mol Ther. 2006 Jan;13(1):98-107. Epub 2005 Aug 19.PMID: 16112619 [PubMed - indexed for MEDLINE]Related articles

Genetic evidence for a tumor suppressor role of HIF-2alpha.

Acker T, Diez-Juan A, Aragones J, Tjwa M, Brusselmans K, Moons L, Fukumura D, Moreno-Murciano MP, Herbert JM, Burger A, Riedel J, Elvert G, Flamme I, Maxwell PH, Collen D, Dewerchin M, Jain RK, Plate KH, Carmeliet P.

Cancer Cell. 2005 Aug;8(2):131-41.PMID: 16098466 [PubMed - indexed for MEDLINE]Related articles

Modulation of angiogenesis during adipose tissue development in murine models of obesity.

Voros G, Maquoi E, Demeulemeester D, Clerx N, Collen D, Lijnen HR.

Endocrinology. 2005 Oct;146(10):4545-54. Epub 2005 Jul 14.PMID: 16020476 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of plasminogen activator inhibitor-1 on ischemic brain injury in permanent and thrombotic middle cerebral artery occlusion models in mice.

Nagai N, Suzuki Y, Van Hoef B, Lijnen HR, Collen D.

J Thromb Haemost. 2005 Jul;3(7):1379-84.PMID: 15978095 [PubMed - indexed for MEDLINE]Related articles

Thrombophilia in mice expressing a tissue factor variant lacking its transmembrane and cytosolic domain.

Melis E, Moons L, Arnout J, Hoylaerts MF, Collen D, Carmeliet P, Dewerchin M.

Biochem Biophys Res Commun. 2005 Jul 29;333(2):488-95.PMID: 15961065 [PubMed - indexed for MEDLINE]Related articles

On the role of plasminogen activator inhibitor-1 in adipose tissue development and insulin resistance in mice.

Lijnen HR, Alessi MC, Van Hoef B, Collen D, Juhan-Vague I.

J Thromb Haemost. 2005 Jun;3(6):1174-9.PMID: 15946208 [PubMed - indexed for MEDLINE]Related articles

Low expression VEGF haplotype increases the risk for tetralogy of Fallot: a family based association study.

Lambrechts D, Devriendt K, Driscoll DA, Goldmuntz E, Gewillig M, Vlietinck R, Collen D, Carmeliet P.

J Med Genet. 2005 Jun;42(6):519-22. No abstract available. PMID: 15937089 [PubMed - indexed for MEDLINE]Related articlesFree article

Placental growth factor promotes atherosclerotic intimal thickening and macrophage accumulation.

Khurana R, Moons L, Shafi S, Luttun A, Collen D, Martin JF, Carmeliet P, Zachary IC.

Circulation. 2005 May 31;111(21):2828-36. Epub 2005 May 23.PMID: 15911697 [PubMed - indexed for MEDLINE]Related articlesFree article

Unconventional intronic splice site mutation in SCN5A associates with cardiac sodium channelopathy.

Rossenbacker T, Schollen E, Kuipéri C, de Ravel TJ, Devriendt K, Matthijs G, Collen D, Heidbüchel H, Carmeliet P.

J Med Genet. 2005 May;42(5):e29.PMID: 15863661 [PubMed - indexed for MEDLINE]Related articlesFree article

Relationship between inflammation and venous thromboembolism as studied by microparticle assessment in plasma.

Collen D, Hoylaerts MF.

J Am Coll Cardiol. 2005 May 3;45(9):1472-3. No abstract available. PMID: 15862421 [PubMed - indexed for MEDLINE]Related articles

Thrombolytic agents.

Collen D, Lijnen HR.

Thromb Haemost. 2005 Apr;93(4):627-30. Review.PMID: 15841305 [PubMed - indexed for MEDLINE]Related articles

Role of Gas-6 in adipogenesis and nutritionally induced adipose tissue development in mice.

Maquoi E, Vörös G, Carmeliet P, Collen D, Lijnen HR.

Arterioscler Thromb Vasc Biol. 2005 May;25(5):1002-7. Epub 2005 Feb 24.PMID: 15731491 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of matrix metalloproteinase inhibition on adipose tissue development.

Demeulemeester D, Collen D, Lijnen HR.

Biochem Biophys Res Commun. 2005 Apr 1;329(1):105-10.PMID: 15721280 [PubMed - indexed for MEDLINE]Related articles

Novel mutation in the Per-Arnt-Sim domain of KCNH2 causes a malignant form of long-QT syndrome.

Rossenbacker T, Mubagwa K, Jongbloed RJ, Vereecke J, Devriendt K, Gewillig M, Carmeliet E, Collen D, Heidbüchel H, Carmeliet P.

Circulation. 2005 Mar 1;111(8):961-8. Epub 2005 Feb 7.PMID: 15699249 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy.

Angelillo-Scherrer A, Burnier L, Flores N, Savi P, DeMol M, Schaeffer P, Herbert JM, Lemke G, Goff SP, Matsushima GK, Earp HS, Vesin C, Hoylaerts MF, Plaisance S, Collen D, Conway EM, Wehrle-Haller B, Carmeliet P.

J Clin Invest. 2005 Feb;115(2):237-46.PMID: 15650770 [PubMed - indexed for MEDLINE]Related articlesFree article

Loss or inhibition of uPA or MMP-9 attenuates LV remodeling and dysfunction after acute pressure overload in mice.

Heymans S, Lupu F, Terclavers S, Vanwetswinkel B, Herbert JM, Baker A, Collen D, Carmeliet P, Moons L.

Am J Pathol. 2005 Jan;166(1):15-25.PMID: 15631996 [PubMed - indexed for MEDLINE]Related articlesFree article

Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors.

Li X, Tjwa M, Moons L, Fons P, Noel A, Ny A, Zhou JM, Lennartsson J, Li H, Luttun A, Pontén A, Devy L, Bouché A, Oh H, Manderveld A, Blacher S, Communi D, Savi P, Bono F, Dewerchin M, Foidart JM, Autiero M, Herbert JM, Collen D, Heldin CH, Eriksson U, Carmeliet P.

J Clin Invest. 2005 Jan;115(1):118-27.PMID: 15630451 [PubMed - indexed for MEDLINE]Related articlesFree article

A novel role for vascular endothelial growth factor as an autocrine survival factor for embryonic stem cells during hypoxia.

Brusselmans K, Bono F, Collen D, Herbert JM, Carmeliet P, Dewerchin M.

J Biol Chem. 2005 Feb 4;280(5):3493-9. Epub 2004 Nov 29.PMID: 15572379 [PubMed - indexed for MEDLINE]Related articlesFree article

Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS.

Storkebaum E, Lambrechts D, Dewerchin M, Moreno-Murciano MP, Appelmans S, Oh H, Van Damme P, Rutten B, Man WY, De Mol M, Wyns S, Manka D, Vermeulen K, Van Den Bosch L, Mertens N, Schmitz C, Robberecht W, Conway EM, Collen D, Moons L, Carmeliet P.

Nat Neurosci. 2005 Jan;8(1):85-92. Epub 2004 Nov 28.PMID: 15568021 [PubMed - indexed for MEDLINE]Related articles

Preclinical and clinical gene therapy for haemophilia.

Chuah MK, Collen D, Vandendriessche T.

Haemophilia. 2004 Oct;10 Suppl 4:119-25. Review.PMID: 15479384 [PubMed - indexed for MEDLINE]Related articles

Comparative effects of microplasmin and tissue-type plasminogen activator (tPA) on cerebral hemorrhage in a middle cerebral artery occlusion model in mice.

Suzuki Y, Nagai N, Collen D.

J Thromb Haemost. 2004 Sep;2(9):1617-21.PMID: 15333039 [PubMed - indexed for MEDLINE]Related articles

Microplasmin reduces ischemic brain damage and improves neurological function in a rat stroke model monitored with MRI.

Suzuki Y, Chen F, Ni Y, Marchal G, Collen D, Nagai N.

Stroke. 2004 Oct;35(10):2402-6. Epub 2004 Aug 19.PMID: 15322296 [PubMed - indexed for MEDLINE]Related articlesFree article