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Disruption of the allosteric phosphorylase a regulation of the hepatic glycogen-targeted protein phosphatase 1 improves glucose tolerance in vivo.

Kelsall IR, Rosenzweig D, Cohen PT.

Cell Signal. 2009 Jul;21(7):1123-34. Epub 2009 Mar 9.PMID: 19275933 [PubMed - indexed for MEDLINE]Related articles

The post-opium scenario and rubber in northern Laos: Alternative Western and Chinese models of development.

Cohen PT.

Int J Drug Policy. 2009 Sep;20(5):424-30. Epub 2009 Feb 23.PMID: 19231150 [PubMed - indexed for MEDLINE]Related articles

Characterization of the role of a trimeric protein phosphatase complex in recovery from cisplatin-induced versus noncrosslinking DNA damage.

Vázquez-Martin C, Rouse J, Cohen PT.

FEBS J. 2008 Aug;275(16):4211-21. Epub 2008 Jul 18. Erratum in: FEBS J. 2008 Nov;275(22):5745. PMID: 18647348 [PubMed - indexed for MEDLINE]Related articles

Depletion of protein phosphatase 4 in human cells reveals essential roles in centrosome maturation, cell migration and the regulation of Rho GTPases.

Martin-Granados C, Philp A, Oxenham SK, Prescott AR, Cohen PT.

Int J Biochem Cell Biol. 2008;40(10):2315-32. Epub 2008 Apr 8.PMID: 18487071 [PubMed - indexed for MEDLINE]Related articles

Disruption of the striated muscle glycogen-targeting subunit of protein phosphatase 1: influence of the genetic background.

Paterson J, Kelsall IR, Cohen PT.

J Mol Endocrinol. 2008 Feb;40(2):47-59.PMID: 18234908 [PubMed - indexed for MEDLINE]Related articlesFree article

The hepatic PP1 glycogen-targeting subunit interaction with phosphorylase a can be blocked by C-terminal tyrosine deletion or an indole drug.

Kelsall IR, Munro S, Hallyburton I, Treadway JL, Cohen PT.

FEBS Lett. 2007 Oct 2;581(24):4749-53. Epub 2007 Sep 6.PMID: 17870073 [PubMed - indexed for MEDLINE]Related articles

The skeletal muscle-specific glycogen-targeted protein phosphatase 1 plays a major role in the regulation of glycogen metabolism by adrenaline in vivo.

Toole BJ, Cohen PT.

Cell Signal. 2007 May;19(5):1044-55. Epub 2006 Dec 5.PMID: 17257813 [PubMed - indexed for MEDLINE]Related articles

SARP, a new alternatively spliced protein phosphatase 1 and DNA interacting protein.

Browne GJ, Fardilha M, Oxenham SK, Wu W, Helps NR, da Cruz E Silva OA, Cohen PT, da Cruz E Silva EF.

Biochem J. 2007 Feb 15;402(1):187-96.PMID: 17123353 [PubMed - indexed for MEDLINE]Related articlesFree article

The Saccharomyces cerevisiae orthologue of the human protein phosphatase 4 core regulatory subunit R2 confers resistance to the anticancer drug cisplatin.

Hastie CJ, Vázquez-Martin C, Philp A, Stark MJ, Cohen PT.

FEBS J. 2006 Jul;273(14):3322-34.PMID: 16857015 [PubMed - indexed for MEDLINE]Related articles

Inhibition of several protein phosphatases by a non-covalently interacting microcystin and a novel cyanobacterial peptide, nostocyclin.

Hastie CJ, Borthwick EB, Morrison LF, Codd GA, Cohen PT.

Biochim Biophys Acta. 2005 Nov 15;1726(2):187-93. Epub 2005 Jun 28.PMID: 16046071 [PubMed - indexed for MEDLINE]Related articles

Protein phosphatase 4--from obscurity to vital functions.

Cohen PT, Philp A, Vázquez-Martin C.

FEBS Lett. 2005 Jun 13;579(15):3278-86. Review.PMID: 15913612 [PubMed - indexed for MEDLINE]Related articles

A novel glycogen-targeting subunit of protein phosphatase 1 that is regulated by insulin and shows differential tissue distribution in humans and rodents.

Munro S, Ceulemans H, Bollen M, Diplexcito J, Cohen PT.

FEBS J. 2005 Mar;272(6):1478-89.PMID: 15752363 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular basis for TPR domain-mediated regulation of protein phosphatase 5.

Yang J, Roe SM, Cliff MJ, Williams MA, Ladbury JE, Cohen PT, Barford D.

EMBO J. 2005 Jan 12;24(1):1-10. Epub 2004 Dec 2.PMID: 15577939 [PubMed - indexed for MEDLINE]Related articlesFree article

Human protein phosphatase 5 dissociates from heat-shock proteins and is proteolytically activated in response to arachidonic acid and the microtubule-depolymerizing drug nocodazole.

Zeke T, Morrice N, Vázquez-Martin C, Cohen PT.

Biochem J. 2005 Jan 1;385(Pt 1):45-56.PMID: 15383005 [PubMed - indexed for MEDLINE]Related articlesFree article

Assay of protein phosphatase 1 complexes.

Cohen PT, Browne GJ, Delibegovic M, Munro S.

Methods Enzymol. 2003;366:135-44. No abstract available. PMID: 14674246 [PubMed - indexed for MEDLINE]Related articles

Male preponderance in early diagnosed type 2 diabetes is associated with the ARE insertion/deletion polymorphism in the PPP1R3A locus.

Doney AS, Fischer B, Cecil JE, Cohen PT, Boyle DI, Leese G, Morris AD, Palmer CN.

BMC Genet. 2003 Jun 28;4:11.PMID: 12831406 [PubMed - indexed for MEDLINE]Related articlesFree article

Harm reduction and alternative development in the Golden Triangle.

Lyttleton C, Cohen PT.

Drug Alcohol Rev. 2003 Mar;22(1):83-91. Review.PMID: 12745362 [PubMed - indexed for MEDLINE]Related articles

Protein phosphatase 4 interacts with the Survival of Motor Neurons complex and enhances the temporal localisation of snRNPs.

Carnegie GK, Sleeman JE, Morrice N, Hastie CJ, Peggie MW, Philp A, Lamond AI, Cohen PT.

J Cell Sci. 2003 May 15;116(Pt 10):1905-13. Epub 2003 Mar 18.PMID: 12668731 [PubMed - indexed for MEDLINE]Related articlesFree article

Disruption of the striated muscle glycogen targeting subunit PPP1R3A of protein phosphatase 1 leads to increased weight gain, fat deposition, and development of insulin resistance.

Delibegovic M, Armstrong CG, Dobbie L, Watt PW, Smith AJ, Cohen PT.

Diabetes. 2003 Mar;52(3):596-604.PMID: 12606498 [PubMed - indexed for MEDLINE]Related articlesFree article

Human skeletal muscle expresses a glycogen-targeting subunit of PP1 that is identical to the insulin-sensitive glycogen-targeting subunit G(L) of liver.

Munro S, Cuthbertson DJ, Cunningham J, Sales M, Cohen PT.

Diabetes. 2002 Mar;51(3):591-8.PMID: 11872655 [PubMed - indexed for MEDLINE]Related articlesFree article

Protein phosphatase 1--targeted in many directions.

Cohen PT.

J Cell Sci. 2002 Jan 15;115(Pt 2):241-56. Review.PMID: 11839776 [PubMed - indexed for MEDLINE]Related articlesFree article

The level of the glycogen targetting regulatory subunit R5 of protein phosphatase 1 is decreased in the livers of insulin-dependent diabetic rats and starved rats.

Browne GJ, Delibegovic M, Keppens S, Stalmans W, Cohen PT.

Biochem J. 2001 Dec 1;360(Pt 2):449-59.PMID: 11716774 [PubMed - indexed for MEDLINE]Related articlesFree article

Nuclear localization of protein phosphatase 5 is dependent on the carboxy-terminal region.

Borthwick EB, Zeke T, Prescott AR, Cohen PT.

FEBS Lett. 2001 Mar 2;491(3):279-84.PMID: 11240142 [PubMed - indexed for MEDLINE]Related articles

Interaction with protein phosphatase 1 Is essential for bifocal function during the morphogenesis of the Drosophila compound eye.

Helps NR, Cohen PT, Bahri SM, Chia W, Babu K.

Mol Cell Biol. 2001 Mar;21(6):2154-64.PMID: 11238949 [PubMed - indexed for MEDLINE]Related articlesFree article

Adenovirus-mediated expression of a naturally occurring Asp905Tyr variant of the glycogen-associated regulatory subunit of protein phosphatase-1 in L6 myotubes.

Rasmussen SK, Hansen L, Frevert EU, Cohen PT, Kahn BB, Pedersen O.

Diabetologia. 2000 Jun;43(6):718-22.PMID: 10907117 [PubMed - indexed for MEDLINE]Related articles

Drosophila protein phosphatase 5 is encoded by a single gene that is most highly expressed during embryonic development.

Brown L, Borthwick EB, Cohen PT.

Biochim Biophys Acta. 2000 Jul 24;1492(2-3):470-6.PMID: 10899584 [PubMed - indexed for MEDLINE]Related articles

NIMA-related kinase 2 (Nek2), a cell-cycle-regulated protein kinase localized to centrosomes, is complexed to protein phosphatase 1.

Helps NR, Luo X, Barker HM, Cohen PT.

Biochem J. 2000 Jul 15;349(Pt 2):509-18.PMID: 10880350 [PubMed - indexed for MEDLINE]Related articlesFree article

A novel 50 kDa protein forms complexes with protein phosphatase 4 and is located at centrosomal microtubule organizing centres.

Hastie CJ, Carnegie GK, Morrice N, Cohen PT.

Biochem J. 2000 May 1;347 Pt 3:845-55.PMID: 10769191 [PubMed - indexed for MEDLINE]Related articlesFree article

Cellular mechanisms regulating protein phosphatase-1. A key functional interaction between inhibitor-2 and the type 1 protein phosphatase catalytic subunit.

Connor JH, Frederick D, Huang H, Yang J, Helps NR, Cohen PT, Nairn AC, DePaoli-Roach A, Tatchell K, Shenolikar S.

J Biol Chem. 2000 Jun 23;275(25):18670-5.PMID: 10748125 [PubMed - indexed for MEDLINE]Related articlesFree article

Association of a protein phosphatase 1 activity with the human factor C1 (HCF) complex.

Ajuh PM, Browne GJ, Hawkes NA, Cohen PT, Roberts SG, Lamond AI.

Nucleic Acids Res. 2000 Feb 1;28(3):678-86.PMID: 10637318 [PubMed - indexed for MEDLINE]Related articlesFree article

Drosophila melanogaster protein phosphatase inhibitor-2: identification of a site important for PP1 inhibition.

Helps NR, Cohen PT.

FEBS Lett. 1999 Dec 10;463(1-2):72-6.PMID: 10601641 [PubMed - indexed for MEDLINE]Related articles

HIV RNA and CD4 cell count response to protease inhibitor therapy in an urban AIDS clinic: response to both initial and salvage therapy.

Deeks SG, Hecht FM, Swanson M, Elbeik T, Loftus R, Cohen PT, Grant RM.

AIDS. 1999 Apr 16;13(6):F35-43.PMID: 10397555 [PubMed - indexed for MEDLINE]Related articles

Identification of the separate domains in the hepatic glycogen-targeting subunit of protein phosphatase 1 that interact with phosphorylase a, glycogen and protein phosphatase 1.

Armstrong CG, Doherty MJ, Cohen PT.

Biochem J. 1998 Dec 15;336 ( Pt 3):699-704.PMID: 9841883 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterisation of a novel Drosophila melanogaster testis specific PP1 inhibitor related to mammalian inhibitor-2: identification of the site of interaction with PP1.

Helps NR, Vergidou C, Gaskell T, Cohen PT.

FEBS Lett. 1998 Oct 30;438(1-2):131-6.PMID: 9821974 [PubMed - indexed for MEDLINE]Related articles

Cloning of a novel testis specific protein serine/threonine phosphatase, PPN 58A, from Drosophila melanogaster.

Armstrong CG, Dombradi V, Mann DJ, Cohen PT.

Biochim Biophys Acta. 1998 Aug 20;1399(2-3):234-8.PMID: 9765603 [PubMed - indexed for MEDLINE]Related articles

A common variant in PPP1R3 associated with insulin resistance and type 2 diabetes.

Xia J, Scherer SW, Cohen PT, Majer M, Xi T, Norman RA, Knowler WC, Bogardus C, Prochazka M.

Diabetes. 1998 Sep;47(9):1519-24.PMID: 9726244 [PubMed - indexed for MEDLINE]Related articlesFree article

Purification of protein phosphatase 4 catalytic subunit: inhibition by the antitumour drug fostriecin and other tumour suppressors and promoters.

Hastie CJ, Cohen PT.

FEBS Lett. 1998 Jul 24;431(3):357-61.PMID: 9714542 [PubMed - indexed for MEDLINE]Related articles

Loss of the hepatic glycogen-binding subunit (GL) of protein phosphatase 1 underlies deficient glycogen synthesis in insulin-dependent diabetic rats and in adrenalectomized starved rats.

Doherty MJ, Cadefau J, Stalmans W, Bollen M, Cohen PT.

Biochem J. 1998 Jul 15;333 ( Pt 2):253-7.PMID: 9657963 [PubMed - indexed for MEDLINE]Related articlesFree article

Protein phosphatase 4 is an essential enzyme required for organisation of microtubules at centrosomes in Drosophila embryos.

Helps NR, Brewis ND, Lineruth K, Davis T, Kaiser K, Cohen PT.

J Cell Sci. 1998 May;111 ( Pt 10):1331-40.PMID: 9570751 [PubMed - indexed for MEDLINE]Related articlesFree article

PPP1R6, a novel member of the family of glycogen-targetting subunits of protein phosphatase 1.

Armstrong CG, Browne GJ, Cohen P, Cohen PT.

FEBS Lett. 1997 Nov 24;418(1-2):210-4.PMID: 9414128 [PubMed - indexed for MEDLINE]Related articles

Human immunodeficiency virus disease-related neutropenia and the risk of hospitalization for bacterial infection.

Jacobson MA, Liu RC, Davies D, Cohen PT.

Arch Intern Med. 1997 Sep 8;157(16):1825-31.PMID: 9290541 [PubMed - indexed for MEDLINE]Related articles

Novel protein serine/threonine phosphatases: variety is the spice of life.

Cohen PT.

Trends Biochem Sci. 1997 Jul;22(7):245-51. Review.PMID: 9255065 [PubMed - indexed for MEDLINE]Related articles

Structural basis for the recognition of regulatory subunits by the catalytic subunit of protein phosphatase 1.

Egloff MP, Johnson DF, Moorhead G, Cohen PT, Cohen P, Barford D.

EMBO J. 1997 Apr 15;16(8):1876-87.PMID: 9155014 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of the regions on the M110 subunit of protein phosphatase 1M that interact with the M21 subunit and with myosin.

Johnson D, Cohen P, Chen MX, Chen YH, Cohen PT.

Eur J Biochem. 1997 Mar 15;244(3):931-9.PMID: 9108268 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of protein phosphatase 5 by limited proteolysis or the binding of polyunsaturated fatty acids to the TPR domain.

Chen MX, Cohen PT.

FEBS Lett. 1997 Jan 2;400(1):136-40.PMID: 9000529 [PubMed - indexed for MEDLINE]Related articles

Crystal structure of the protein serine/threonine phosphatase 2C at 2.0 A resolution.

Das AK, Helps NR, Cohen PT, Barford D.

EMBO J. 1996 Dec 16;15(24):6798-809.PMID: 9003755 [PubMed - indexed for MEDLINE]Related articlesFree article

Amino acid sequence of a novel protein phosphatase 1 binding protein (R5) which is related to the liver- and muscle-specific glycogen binding subunits of protein phosphatase 1.

Doherty MJ, Young PR, Cohen PT.

FEBS Lett. 1996 Dec 16;399(3):339-43.PMID: 8985175 [PubMed - indexed for MEDLINE]Related articles

Deficiency of protein phosphatase 2A uncouples the nuclear and centrosome cycles and prevents attachment of microtubules to the kinetochore in Drosophila microtubule star (mts) embryos.

Snaith HA, Armstrong CG, Guo Y, Kaiser K, Cohen PT.

J Cell Sci. 1996 Dec;109 ( Pt 13):3001-12.PMID: 9004035 [PubMed - indexed for MEDLINE]Related articlesFree article

Further evidence that inhibitor-2 acts like a chaperone to fold PP1 into its native conformation.

MacKintosh C, Garton AJ, McDonnell A, Barford D, Cohen PT, Tonks NK, Cohen P.

FEBS Lett. 1996 Nov 18;397(2-3):235-8.PMID: 8955354 [PubMed - indexed for MEDLINE]Related articles

Regions of the 110-kDa regulatory subunit M110 required for regulation of myosin-light-chain-phosphatase activity in smooth muscle.

Gailly P, Wu X, Haystead TA, Somlyo AP, Cohen PT, Cohen P, Somlyo AV.

Eur J Biochem. 1996 Jul 15;239(2):326-32.PMID: 8706736 [PubMed - indexed for MEDLINE]Related articlesFree article