PubMed

WNK kinases and blood pressure control.

Deaton SL, Sengupta S, Cobb MH.

Curr Hypertens Rep. 2009 Dec;11(6):421-6.PMID: 19895753 [PubMed - in process]Related articles

MAP-ping unconventional protein-DNA interactions.

Dioum EM, Wauson EM, Cobb MH.

Cell. 2009 Oct 30;139(3):462-3.PMID: 19879834 [PubMed - in process]Related articles

Radial spoke protein 3 is a mammalian protein kinase A-anchoring protein that binds ERK1/2.

Jivan A, Earnest S, Juang YC, Cobb MH.

J Biol Chem. 2009 Oct 23;284(43):29437-45. Epub 2009 Aug 14.PMID: 19684019 [PubMed - in process]Related articles

FAK phosphorylation by ERK primes ras-induced tyrosine dephosphorylation of FAK mediated by PIN1 and PTP-PEST.

Zheng Y, Xia Y, Hawke D, Halle M, Tremblay ML, Gao X, Zhou XZ, Aldape K, Cobb MH, Xie K, He J, Lu Z.

Mol Cell. 2009 Jul 10;35(1):11-25.PMID: 19595712 [PubMed - indexed for MEDLINE]Related articles

Crystal structure of domain-swapped STE20 OSR1 kinase domain.

Lee SJ, Cobb MH, Goldsmith EJ.

Protein Sci. 2009 Feb;18(2):304-13.PMID: 19177573 [PubMed - indexed for MEDLINE]Related articles

The structure of the MAP2K MEK6 reveals an autoinhibitory dimer.

Min X, Akella R, He H, Humphreys JM, Tsutakawa SE, Lee SJ, Tainer JA, Cobb MH, Goldsmith EJ.

Structure. 2009 Jan 14;17(1):96-104.PMID: 19141286 [PubMed - indexed for MEDLINE]Related articles

PTMap--a sequence alignment software for unrestricted, accurate, and full-spectrum identification of post-translational modification sites.

Chen Y, Chen W, Cobb MH, Zhao Y.

Proc Natl Acad Sci U S A. 2009 Jan 20;106(3):761-6. Epub 2009 Jan 9.PMID: 19136633 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of a third conserved phosphorylation site in SGK1.

Chen W, Chen Y, Xu BE, Juang YC, Stippec S, Zhao Y, Cobb MH.

J Biol Chem. 2009 Feb 6;284(6):3453-60. Epub 2008 Dec 9.PMID: 19068477 [PubMed - indexed for MEDLINE]Related articles

Sumoylation regulates the transcriptional activity of MafA in pancreatic beta cells.

Shao C, Cobb MH.

J Biol Chem. 2009 Jan 30;284(5):3117-24. Epub 2008 Nov 22.PMID: 19029092 [PubMed - indexed for MEDLINE]Related articles

Chromatin-bound mitogen-activated protein kinases transmit dynamic signals in transcription complexes in beta-cells.

Lawrence MC, McGlynn K, Shao C, Duan L, Naziruddin B, Levy MF, Cobb MH.

Proc Natl Acad Sci U S A. 2008 Sep 9;105(36):13315-20. Epub 2008 Aug 28.PMID: 18755896 [PubMed - indexed for MEDLINE]Related articlesFree article

The roles of MAPKs in disease.

Lawrence MC, Jivan A, Shao C, Duan L, Goad D, Zaganjor E, Osborne J, McGlynn K, Stippec S, Earnest S, Chen W, Cobb MH.

Cell Res. 2008 Apr;18(4):436-42. Review.PMID: 18347614 [PubMed - indexed for MEDLINE]Related articlesFree article

The protein kinases ERK1/2 and their roles in pancreatic beta cells.

Lawrence M, Shao C, Duan L, McGlynn K, Cobb MH.

Acta Physiol (Oxf). 2008 Jan;192(1):11-7. Review.PMID: 18171425 [PubMed - indexed for MEDLINE]Related articles

WNKs: protein kinases with a unique kinase domain.

Huang CL, Cha SK, Wang HR, Xie J, Cobb MH.

Exp Mol Med. 2007 Oct 31;39(5):565-73. Review.PMID: 18059132 [PubMed - indexed for MEDLINE]Related articlesFree article

WNK1 is a novel regulator of Munc18c-syntaxin 4 complex formation in soluble NSF attachment protein receptor (SNARE)-mediated vesicle exocytosis.

Oh E, Heise CJ, English JM, Cobb MH, Thurmond DC.

J Biol Chem. 2007 Nov 9;282(45):32613-22. Epub 2007 Sep 11.PMID: 17848561 [PubMed - indexed for MEDLINE]Related articlesFree article

Mutations in ERK2 binding sites affect nuclear entry.

Yazicioglu MN, Goad DL, Ranganathan A, Whitehurst AW, Goldsmith EJ, Cobb MH.

J Biol Chem. 2007 Sep 28;282(39):28759-67. Epub 2007 Jul 26.PMID: 17656361 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential regulation of CHOP-10/GADD153 gene expression by MAPK signaling in pancreatic beta-cells.

Lawrence MC, McGlynn K, Naziruddin B, Levy MF, Cobb MH.

Proc Natl Acad Sci U S A. 2007 Jul 10;104(28):11518-25. Epub 2007 Jul 5.PMID: 17615236 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential regulation and properties of MAPKs.

Raman M, Chen W, Cobb MH.

Oncogene. 2007 May 14;26(22):3100-12. Review.PMID: 17496909 [PubMed - indexed for MEDLINE]Related articles

TAO kinases mediate activation of p38 in response to DNA damage.

Raman M, Earnest S, Zhang K, Zhao Y, Cobb MH.

EMBO J. 2007 Apr 18;26(8):2005-14. Epub 2007 Mar 29.PMID: 17396146 [PubMed - indexed for MEDLINE]Related articlesFree article

Biological cross-talk between WNK1 and the transforming growth factor beta-Smad signaling pathway.

Lee BH, Chen W, Stippec S, Cobb MH.

J Biol Chem. 2007 Jun 22;282(25):17985-96. Epub 2007 Mar 28.PMID: 17392271 [PubMed - indexed for MEDLINE]Related articlesFree article

Mxi2 promotes stimulus-independent ERK nuclear translocation.

Casar B, Sanz-Moreno V, Yazicioglu MN, Rodríguez J, Berciano MT, Lafarga M, Cobb MH, Crespo P.

EMBO J. 2007 Feb 7;26(3):635-46. Epub 2007 Jan 25.PMID: 17255949 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of mitogen-activated protein kinase (MAPK) dimers.

Wilsbacher JL, Juang YC, Khokhlatchev AV, Gallagher E, Binns D, Goldsmith EJ, Cobb MH.

Biochemistry. 2006 Nov 7;45(44):13175-82.PMID: 17073439 [PubMed - indexed for MEDLINE]Related articles

Expression and characterization of MAP kinases in bacteria.

Heise CJ, Cobb MH.

Methods. 2006 Nov;40(3):209-12.PMID: 16908184 [PubMed - indexed for MEDLINE]Related articles

WNK1 and OSR1 regulate the Na+, K+, 2Cl- cotransporter in HeLa cells.

Anselmo AN, Earnest S, Chen W, Juang YC, Kim SC, Zhao Y, Cobb MH.

Proc Natl Acad Sci U S A. 2006 Jul 18;103(29):10883-8. Epub 2006 Jul 10.PMID: 16832045 [PubMed - indexed for MEDLINE]Related articlesFree article

The transcriptional ETS2 repressor factor associates with active and inactive Erks through distinct FXF motifs.

Polychronopoulos S, Verykokakis M, Yazicioglu MN, Sakarellos-Daitsiotis M, Cobb MH, Mavrothalassitis G.

J Biol Chem. 2006 Sep 1;281(35):25601-11. Epub 2006 Jun 23.PMID: 16799155 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of with-no-lysine [K] kinases in the pathogenesis of Gordon's syndrome.

Xie J, Craig L, Cobb MH, Huang CL.

Pediatr Nephrol. 2006 Sep;21(9):1231-6. Epub 2006 May 9. Review.PMID: 16683163 [PubMed - indexed for MEDLINE]Related articles

The MAP kinase ERK5 binds to and phosphorylates p90 RSK.

Ranganathan A, Pearson GW, Chrestensen CA, Sturgill TW, Cobb MH.

Arch Biochem Biophys. 2006 May 15;449(1-2):8-16. Epub 2006 Mar 13.PMID: 16626623 [PubMed - indexed for MEDLINE]Related articles

The nuclear localization of ERK2 occurs by mechanisms both independent of and dependent on energy.

Ranganathan A, Yazicioglu MN, Cobb MH.

J Biol Chem. 2006 Jun 9;281(23):15645-52. Epub 2006 Apr 4.PMID: 16595679 [PubMed - indexed for MEDLINE]Related articlesFree article

Cyclic AMP selectively uncouples mitogen-activated protein kinase cascades from activating signals.

Pearson GW, Earnest S, Cobb MH.

Mol Cell Biol. 2006 Apr;26(8):3039-47.PMID: 16581779 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of glucose-stimulated activation of extracellular signal-regulated protein kinases 1 and 2 by epinephrine in pancreatic beta-cells.

Gibson TB, Lawrence MC, Gibson CJ, Vanderbilt CA, McGlynn K, Arnette D, Chen W, Collins J, Naziruddin B, Levy MF, Ehrlich BE, Cobb MH.

Diabetes. 2006 Apr;55(4):1066-73.PMID: 16567530 [PubMed - indexed for MEDLINE]Related articlesFree article

TGF-beta regulation by Emilin1: new links in the etiology of hypertension.

Raman M, Cobb MH.

Cell. 2006 Mar 10;124(5):893-5.PMID: 16530037 [PubMed - indexed for MEDLINE]Related articles

Activation of MEKK1 by Rho GTPases.

Chen Z, Cobb MH.

Methods Enzymol. 2006;406:468-78.PMID: 16472679 [PubMed - indexed for MEDLINE]Related articles

WNK1 activates SGK1 by a phosphatidylinositol 3-kinase-dependent and non-catalytic mechanism.

Xu BE, Stippec S, Lazrak A, Huang CL, Cobb MH.

J Biol Chem. 2005 Oct 7;280(40):34218-23. Epub 2005 Aug 4.PMID: 16081417 [PubMed - indexed for MEDLINE]Related articlesFree article

WNK1 activates SGK1 to regulate the epithelial sodium channel.

Xu BE, Stippec S, Chu PY, Lazrak A, Li XJ, Lee BH, English JM, Ortega B, Huang CL, Cobb MH.

Proc Natl Acad Sci U S A. 2005 Jul 19;102(29):10315-20. Epub 2005 Jul 8.PMID: 16006511 [PubMed - indexed for MEDLINE]Related articlesFree article

ERK1/2-dependent activation of transcription factors required for acute and chronic effects of glucose on the insulin gene promoter.

Lawrence MC, McGlynn K, Park BH, Cobb MH.

J Biol Chem. 2005 Jul 22;280(29):26751-9. Epub 2005 May 16.PMID: 15899886 [PubMed - indexed for MEDLINE]Related articlesFree article

Properties of WNK1 and implications for other family members.

Lenertz LY, Lee BH, Min X, Xu BE, Wedin K, Earnest S, Goldsmith EJ, Cobb MH.

J Biol Chem. 2005 Jul 22;280(29):26653-8. Epub 2005 May 9.PMID: 15883153 [PubMed - indexed for MEDLINE]Related articlesFree article

Context-dependent regulation of NeuroD activity and protein accumulation.

Dufton C, Marcora E, Chae JH, McCullough J, Eby J, Hausburg M, Stein GH, Khoo S, Cobb MH, Lee JE.

Mol Cell Neurosci. 2005 Apr;28(4):727-36.PMID: 15797719 [PubMed - indexed for MEDLINE]Related articles

WNK1: analysis of protein kinase structure, downstream targets, and potential roles in hypertension.

Xu BE, Lee BH, Min X, Lenertz L, Heise CJ, Stippec S, Goldsmith EJ, Cobb MH.

Cell Res. 2005 Jan;15(1):6-10. Review.PMID: 15686619 [PubMed - indexed for MEDLINE]Related articlesFree article

Stimulus-coupled spatial restriction of extracellular signal-regulated kinase 1/2 activity contributes to the specificity of signal-response pathways.

Whitehurst A, Cobb MH, White MA.

Mol Cell Biol. 2004 Dec;24(23):10145-50.PMID: 15542825 [PubMed - indexed for MEDLINE]Related articlesFree article

Crystal structure of the TAO2 kinase domain: activation and specificity of a Ste20p MAP3K.

Zhou T, Raman M, Gao Y, Earnest S, Chen Z, Machius M, Cobb MH, Goldsmith EJ.

Structure. 2004 Oct;12(10):1891-900.PMID: 15458637 [PubMed - indexed for MEDLINE]Related articles

WNK1 phosphorylates synaptotagmin 2 and modulates its membrane binding.

Lee BH, Min X, Heise CJ, Xu BE, Chen S, Shu H, Luby-Phelps K, Goldsmith EJ, Cobb MH.

Mol Cell. 2004 Sep 10;15(5):741-51.PMID: 15350218 [PubMed - indexed for MEDLINE]Related articles

MAP kinases and their roles in pancreatic beta-cells.

Khoo S, Gibson TB, Arnette D, Lawrence M, January B, McGlynn K, Vanderbilt CA, Griffen SC, German MS, Cobb MH.

Cell Biochem Biophys. 2004;40(3 Suppl):191-200. Review.PMID: 15289654 [PubMed - indexed for MEDLINE]Related articles

Protein kinase function and glutathionylation.

Anselmo AN, Cobb MH.

Biochem J. 2004 Aug 1;381(Pt 3):e1-2. Review.PMID: 15270699 [PubMed - indexed for MEDLINE]Related articlesFree article

Crystal structure of the kinase domain of WNK1, a kinase that causes a hereditary form of hypertension.

Min X, Lee BH, Cobb MH, Goldsmith EJ.

Structure. 2004 Jul;12(7):1303-11.PMID: 15242606 [PubMed - indexed for MEDLINE]Related articles

Structure of MAPKs.

Goldsmith EJ, Cobb MH, Chang CI.

Methods Mol Biol. 2004;250:127-44. No abstract available. PMID: 14755085 [PubMed - indexed for MEDLINE]Related articles

The death effector domain protein PEA-15 prevents nuclear entry of ERK2 by inhibiting required interactions.

Whitehurst AW, Robinson FL, Moore MS, Cobb MH.

J Biol Chem. 2004 Mar 26;279(13):12840-7. Epub 2004 Jan 5.PMID: 14707138 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of OSR1, a member of the mammalian Ste20p/germinal center kinase subfamily.

Chen W, Yazicioglu M, Cobb MH.

J Biol Chem. 2004 Mar 19;279(12):11129-36. Epub 2004 Jan 5.PMID: 14707132 [PubMed - indexed for MEDLINE]Related articlesFree article

WNK1 activates ERK5 by an MEKK2/3-dependent mechanism.

Xu BE, Stippec S, Lenertz L, Lee BH, Zhang W, Lee YK, Cobb MH.

J Biol Chem. 2004 Feb 27;279(9):7826-31. Epub 2003 Dec 16.PMID: 14681216 [PubMed - indexed for MEDLINE]Related articlesFree article

MAP kinase modules: many roads home.

Raman M, Cobb MH.

Curr Biol. 2003 Nov 11;13(22):R886-8. Review. No abstract available. PMID: 14614847 [PubMed - indexed for MEDLINE]Related articles

RhoA binds to the amino terminus of MEKK1 and regulates its kinase activity.

Gallagher ED, Gutowski S, Sternweis PC, Cobb MH.

J Biol Chem. 2004 Jan 16;279(3):1872-7. Epub 2003 Oct 27.PMID: 14581471 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of insulin gene transcription by ERK1 and ERK2 in pancreatic beta cells.

Khoo S, Griffen SC, Xia Y, Baer RJ, German MS, Cobb MH.

J Biol Chem. 2003 Aug 29;278(35):32969-77. Epub 2003 Jun 16.PMID: 12810726 [PubMed - indexed for MEDLINE]Related articlesFree article