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Neonatal hemochromatosis and Martinez-Frias syndrome of intestinal atresia and diabetes mellitus in a consanguineous newborn.

Martinovici D, Ransy V, Serge Eijnden V, Ridremont C, Pardou A, Cassart M, Avni F, Donner C, Lingier P, Mathieu A, Gulbis B, De Brouckère V, Cnop M, Abramowicz M, Désir J.

Eur J Med Genet. 2009 Nov 1. [Epub ahead of print]PMID: 19887127 [PubMed - as supplied by publisher]Related articles

The long lifespan and low turnover of human islet beta cells estimated by mathematical modelling of lipofuscin accumulation.

Cnop M, Hughes SJ, Igoillo-Esteve M, Hoppa MB, Sayyed F, van de Laar L, Gunter JH, de Koning EJ, Walls GV, Gray DW, Johnson PR, Hansen BC, Morris JF, Pipeleers-Marichal M, Cnop I, Clark A.

Diabetologia. 2009 Oct 24. [Epub ahead of print]PMID: 19855953 [PubMed - as supplied by publisher]Related articles

Glucagon-Like Peptide-1 Agonists Protect Pancreatic {beta}-Cells From Lipotoxic Endoplasmic Reticulum Stress Through Upregulation of BiP and JunB.

Cunha DA, Ladrière L, Ortis F, Igoillo-Esteve M, Gurzov EN, Lupi R, Marchetti P, Eizirik DL, Cnop M.

Diabetes. 2009 Dec;58(12):2851-62. Epub 2009 Aug 31.PMID: 19720788 [PubMed - in process]Related articles

Transient oxidative stress damages mitochondrial machinery inducing persistent beta-cell dysfunction.

Li N, Brun T, Cnop M, Cunha DA, Eizirik DL, Maechler P.

J Biol Chem. 2009 Aug 28;284(35):23602-12. Epub 2009 Jun 22.PMID: 19546218 [PubMed - indexed for MEDLINE]Related articles

Functional genomic analysis of frataxin deficiency reveals tissue-specific alterations and identifies the PPARgamma pathway as a therapeutic target in Friedreich's ataxia.

Coppola G, Marmolino D, Lu D, Wang Q, Cnop M, Rai M, Acquaviva F, Cocozza S, Pandolfo M, Geschwind DH.

Hum Mol Genet. 2009 Jul 1;18(13):2452-61. Epub 2009 Apr 17.PMID: 19376812 [PubMed - indexed for MEDLINE]Related articlesFree article

PTPN2, a candidate gene for type 1 diabetes, modulates interferon-gamma-induced pancreatic beta-cell apoptosis.

Moore F, Colli ML, Cnop M, Esteve MI, Cardozo AK, Cunha DA, Bugliani M, Marchetti P, Eizirik DL.

Diabetes. 2009 Jun;58(6):1283-91. Epub 2009 Mar 31.PMID: 19336676 [PubMed - indexed for MEDLINE]Related articlesFree article

An update on lipotoxic endoplasmic reticulum stress in pancreatic beta-cells.

Cnop M, Igoillo-Esteve M, Cunha DA, Ladrière L, Eizirik DL.

Biochem Soc Trans. 2008 Oct;36(Pt 5):909-15. Review.PMID: 18793160 [PubMed - indexed for MEDLINE]Related articles

Initiation and execution of lipotoxic ER stress in pancreatic beta-cells.

Cunha DA, Hekerman P, Ladrière L, Bazarra-Castro A, Ortis F, Wakeham MC, Moore F, Rasschaert J, Cardozo AK, Bellomo E, Overbergh L, Mathieu C, Lupi R, Hai T, Herchuelz A, Marchetti P, Rutter GA, Eizirik DL, Cnop M.

J Cell Sci. 2008 Jul 15;121(Pt 14):2308-18. Epub 2008 Jun 17.PMID: 18559892 [PubMed - indexed for MEDLINE]Related articlesFree article

Fatty acids and glucolipotoxicity in the pathogenesis of Type 2 diabetes.

Cnop M.

Biochem Soc Trans. 2008 Jun;36(Pt 3):348-52. Review.PMID: 18481955 [PubMed - indexed for MEDLINE]Related articles

The role for endoplasmic reticulum stress in diabetes mellitus.

Eizirik DL, Cardozo AK, Cnop M.

Endocr Rev. 2008 Feb;29(1):42-61. Epub 2007 Nov 29. Review.PMID: 18048764 [PubMed - indexed for MEDLINE]Related articlesFree article

The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients.

Marchetti P, Bugliani M, Lupi R, Marselli L, Masini M, Boggi U, Filipponi F, Weir GC, Eizirik DL, Cnop M.

Diabetologia. 2007 Dec;50(12):2486-94. Epub 2007 Sep 30.PMID: 17906960 [PubMed - indexed for MEDLINE]Related articles

Loss of PPAR gamma in immune cells impairs the ability of abscisic acid to improve insulin sensitivity by suppressing monocyte chemoattractant protein-1 expression and macrophage infiltration into white adipose tissue.

Guri AJ, Hontecillas R, Ferrer G, Casagran O, Wankhade U, Noble AM, Eizirik DL, Ortis F, Cnop M, Liu D, Si H, Bassaganya-Riera J.

J Nutr Biochem. 2008 Apr;19(4):216-28. Epub 2007 Jul 6.PMID: 17618105 [PubMed - indexed for MEDLINE]Related articles

Transcriptional regulation of the endoplasmic reticulum stress gene chop in pancreatic insulin-producing cells.

Pirot P, Ortis F, Cnop M, Ma Y, Hendershot LM, Eizirik DL, Cardozo AK.

Diabetes. 2007 Apr;56(4):1069-77.PMID: 17395747 [PubMed - indexed for MEDLINE]Related articlesFree article

Progressive loss of beta-cell function leads to worsening glucose tolerance in first-degree relatives of subjects with type 2 diabetes.

Cnop M, Vidal J, Hull RL, Utzschneider KM, Carr DB, Schraw T, Scherer PE, Boyko EJ, Fujimoto WY, Kahn SE.

Diabetes Care. 2007 Mar;30(3):677-82.PMID: 17327340 [PubMed - indexed for MEDLINE]Related articlesFree article

Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis.

Cnop M, Ladriere L, Hekerman P, Ortis F, Cardozo AK, Dogusan Z, Flamez D, Boyce M, Yuan J, Eizirik DL.

J Biol Chem. 2007 Feb 9;282(6):3989-97. Epub 2006 Dec 8.PMID: 17158450 [PubMed - indexed for MEDLINE]Related articlesFree article

BCL-6: a possible missing link for anti-inflammatory PPAR-delta signalling in pancreatic beta cells.

Kharroubi I, Lee CH, Hekerman P, Darville MI, Evans RM, Eizirik DL, Cnop M.

Diabetologia. 2006 Oct;49(10):2350-8. Epub 2006 Aug 5.PMID: 16896941 [PubMed - indexed for MEDLINE]Related articles

Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities.

Cnop M, Welsh N, Jonas JC, Jörns A, Lenzen S, Eizirik DL.

Diabetes. 2005 Dec;54 Suppl 2:S97-107. Review.PMID: 16306347 [PubMed - indexed for MEDLINE]Related articlesFree article

Is there a role for locally produced interleukin-1 in the deleterious effects of high glucose or the type 2 diabetes milieu to human pancreatic islets?

Welsh N, Cnop M, Kharroubi I, Bugliani M, Lupi R, Marchetti P, Eizirik DL.

Diabetes. 2005 Nov;54(11):3238-44.PMID: 16249450 [PubMed - indexed for MEDLINE]Related articlesFree article

Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress.

Kharroubi I, Ladrière L, Cardozo AK, Dogusan Z, Cnop M, Eizirik DL.

Endocrinology. 2004 Nov;145(11):5087-96. Epub 2004 Aug 5.PMID: 15297438 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of adiponectin receptors in pancreatic beta cells.

Kharroubi I, Rasschaert J, Eizirik DL, Cnop M.

Biochem Biophys Res Commun. 2003 Dec 26;312(4):1118-22.PMID: 14651988 [PubMed - indexed for MEDLINE]Related articles

Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex.

Cnop M, Havel PJ, Utzschneider KM, Carr DB, Sinha MK, Boyko EJ, Retzlaff BM, Knopp RH, Brunzell JD, Kahn SE.

Diabetologia. 2003 Apr;46(4):459-69. Epub 2003 Apr 10.PMID: 12687327 [PubMed - indexed for MEDLINE]Related articles

The effect of apolipoprotein E deficiency on islet amyloid deposition in human islet amyloid polypeptide transgenic mice.

Vidal J, Verchere CB, Andrikopoulos S, Wang F, Hull RL, Cnop M, Olin KL, LeBoeuf RC, O'Brien KD, Chait A, Kahn SE.

Diabetologia. 2003 Jan;46(1):71-9. Epub 2003 Jan 9.PMID: 12637985 [PubMed - indexed for MEDLINE]Related articles

Increased dietary fat promotes islet amyloid formation and beta-cell secretory dysfunction in a transgenic mouse model of islet amyloid.

Hull RL, Andrikopoulos S, Verchere CB, Vidal J, Wang F, Cnop M, Prigeon RL, Kahn SE.

Diabetes. 2003 Feb;52(2):372-9.PMID: 12540610 [PubMed - indexed for MEDLINE]Related articlesFree article

The atherogenic lipoprotein profile associated with obesity and insulin resistance is largely attributable to intra-abdominal fat.

Nieves DJ, Cnop M, Retzlaff B, Walden CE, Brunzell JD, Knopp RH, Kahn SE.

Diabetes. 2003 Jan;52(1):172-9.PMID: 12502509 [PubMed - indexed for MEDLINE]Related articlesFree article

Low density lipoprotein can cause death of islet beta-cells by its cellular uptake and oxidative modification.

Cnop M, Hannaert JC, Grupping AY, Pipeleers DG.

Endocrinology. 2002 Sep;143(9):3449-53.PMID: 12193557 [PubMed - indexed for MEDLINE]Related articlesFree article

Beta-cell function is a major contributor to oral glucose tolerance in high-risk relatives of four ethnic groups in the U.S.

Jensen CC, Cnop M, Hull RL, Fujimoto WY, Kahn SE; American Diabetes Association GENNID Study Group.

Diabetes. 2002 Jul;51(7):2170-8.PMID: 12086947 [PubMed - indexed for MEDLINE]Related articlesFree article

Troglitazone does not protect rat pancreatic beta cells against free fatty acid-induced cytotoxicity.

Cnop M, Hannaert JC, Pipeleers DG.

Biochem Pharmacol. 2002 Apr 1;63(7):1281-5.PMID: 11960604 [PubMed - indexed for MEDLINE]Related articles

The concurrent accumulation of intra-abdominal and subcutaneous fat explains the association between insulin resistance and plasma leptin concentrations : distinct metabolic effects of two fat compartments.

Cnop M, Landchild MJ, Vidal J, Havel PJ, Knowles NG, Carr DR, Wang F, Hull RL, Boyko EJ, Retzlaff BM, Walden CE, Knopp RH, Kahn SE.

Diabetes. 2002 Apr;51(4):1005-15.PMID: 11916919 [PubMed - indexed for MEDLINE]Related articlesFree article

Islet amyloid develops diffusely throughout the pancreas before becoming severe and replacing endocrine cells.

Wang F, Hull RL, Vidal J, Cnop M, Kahn SE.

Diabetes. 2001 Nov;50(11):2514-20.PMID: 11679429 [PubMed - indexed for MEDLINE]Related articlesFree article

Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation.

Cnop M, Hannaert JC, Hoorens A, Eizirik DL, Pipeleers DG.

Diabetes. 2001 Aug;50(8):1771-7.PMID: 11473037 [PubMed - indexed for MEDLINE]Related articlesFree article

Endocytosis of low-density lipoprotein by human pancreatic beta cells and uptake in lipid-storing vesicles, which increase with age.

Cnop M, Grupping A, Hoorens A, Bouwens L, Pipeleers-Marichal M, Pipeleers D.

Am J Pathol. 2000 Jan;156(1):237-44.PMID: 10623672 [PubMed - indexed for MEDLINE]Related articlesFree article

Low density lipoprotein binding and uptake by human and rat islet beta cells.

Grupping AY, Cnop M, Van Schravendijk CF, Hannaert JC, Van Berkel TJ, Pipeleers DG.

Endocrinology. 1997 Oct;138(10):4064-8.PMID: 9322913 [PubMed - indexed for MEDLINE]Related articlesFree article