PubMed

Prevention of hepatic steatosis and hepatic insulin resistance by knockdown of cAMP response element-binding protein.

Erion DM, Ignatova ID, Yonemitsu S, Nagai Y, Chatterjee P, Weismann D, Hsiao JJ, Zhang D, Iwasaki T, Stark R, Flannery C, Kahn M, Carmean CM, Yu XX, Murray SF, Bhanot S, Monia BP, Cline GW, Samuel VT, Shulman GI.

Cell Metab. 2009 Dec;10(6):499-506.PMID: 19945407 [PubMed - in process]Related articles

Altered brain mitochondrial metabolism in healthy aging as assessed by in vivo magnetic resonance spectroscopy.

Boumezbeur F, Mason GF, de Graaf RA, Behar KL, Cline GW, Shulman GI, Rothman DL, Petersen KF.

J Cereb Blood Flow Metab. 2009 Sep 30. [Epub ahead of print]PMID: 19794401 [PubMed - as supplied by publisher]Related articles

Liver-specific loss of long chain acyl-CoA synthetase-1 decreases triacylglycerol synthesis and beta-oxidation and alters phospholipid fatty acid composition.

Li LO, Ellis JM, Paich HA, Wang S, Gong N, Altshuller G, Thresher RJ, Koves TR, Watkins SM, Muoio DM, Cline GW, Shulman GI, Coleman RA.

J Biol Chem. 2009 Oct 9;284(41):27816-26. Epub 2009 Aug 1.PMID: 19648649 [PubMed - indexed for MEDLINE]Related articles

Phosphoenolpyruvate cycling via mitochondrial phosphoenolpyruvate carboxykinase links anaplerosis and mitochondrial GTP with insulin secretion.

Stark R, Pasquel F, Turcu A, Pongratz RL, Roden M, Cline GW, Shulman GI, Kibbey RG.

J Biol Chem. 2009 Sep 25;284(39):26578-90. Epub 2009 Jul 27.PMID: 19635791 [PubMed - indexed for MEDLINE]Related articlesFree article

Investigating the roles of mitochondrial and cytosolic malic enzyme in insulin secretion.

Pongratz RL, Kibbey RG, Cline GW.

Methods Enzymol. 2009;457:425-50.PMID: 19426882 [PubMed - indexed for MEDLINE]Related articles

Mitochondrial dysfunction contributes to impaired insulin secretion in INS-1 cells with dominant-negative mutations of HNF-1alpha and in HNF-1alpha-deficient islets.

Pongratz RL, Kibbey RG, Kirkpatrick CL, Zhao X, Pontoglio M, Yaniv M, Wollheim CB, Shulman GI, Cline GW.

J Biol Chem. 2009 Jun 19;284(25):16808-21. Epub 2009 Apr 17.PMID: 19376774 [PubMed - indexed for MEDLINE]Related articles

Role for malic enzyme, pyruvate carboxylation, and mitochondrial malate import in glucose-stimulated insulin secretion.

Heart E, Cline GW, Collis LP, Pongratz RL, Gray JP, Smith PJ.

Am J Physiol Endocrinol Metab. 2009 Jun;296(6):E1354-62. Epub 2009 Mar 17.PMID: 19293334 [PubMed - indexed for MEDLINE]Related articles

Matrix alkalinization: a novel mitochondrial signal for sustained pancreatic beta-cell activation.

Wiederkehr A, Park KS, Dupont O, Demaurex N, Pozzan T, Cline GW, Wollheim CB.

EMBO J. 2009 Feb 18;28(4):417-28. Epub 2009 Jan 22.PMID: 19165153 [PubMed - indexed for MEDLINE]Related articles

Paradoxical effects of increased expression of PGC-1alpha on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism.

Choi CS, Befroy DE, Codella R, Kim S, Reznick RM, Hwang YJ, Liu ZX, Lee HY, Distefano A, Samuel VT, Zhang D, Cline GW, Handschin C, Lin J, Petersen KF, Spiegelman BM, Shulman GI.

Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19926-31. Epub 2008 Dec 9.PMID: 19066218 [PubMed - indexed for MEDLINE]Related articlesFree article

N-acylphosphatidylethanolamine, a gut- derived circulating factor induced by fat ingestion, inhibits food intake.

Gillum MP, Zhang D, Zhang XM, Erion DM, Jamison RA, Choi C, Dong J, Shanabrough M, Duenas HR, Frederick DW, Hsiao JJ, Horvath TL, Lo CM, Tso P, Cline GW, Shulman GI.

Cell. 2008 Nov 28;135(5):813-24.PMID: 19041747 [PubMed - indexed for MEDLINE]Related articlesFree article

The ATP/DNA ratio is a better indicator of islet cell viability than the ADP/ATP ratio.

Suszynski TM, Wildey GM, Falde EJ, Cline GW, Maynard KS, Ko N, Sotiris J, Naji A, Hering BJ, Papas KK.

Transplant Proc. 2008 Mar;40(2):346-50.PMID: 18374063 [PubMed - indexed for MEDLINE]Related articles

Mitochondrial dysfunction due to long-chain Acyl-CoA dehydrogenase deficiency causes hepatic steatosis and hepatic insulin resistance.

Zhang D, Liu ZX, Choi CS, Tian L, Kibbey R, Dong J, Cline GW, Wood PA, Shulman GI.

Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):17075-80. Epub 2007 Oct 16.PMID: 17940018 [PubMed - indexed for MEDLINE]Related articlesFree article

Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity.

Choi CS, Savage DB, Abu-Elheiga L, Liu ZX, Kim S, Kulkarni A, Distefano A, Hwang YJ, Reznick RM, Codella R, Zhang D, Cline GW, Wakil SJ, Shulman GI.

Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16480-5. Epub 2007 Oct 8.PMID: 17923673 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased hypothalamic-pituitary-adrenal axis activity and hepatic insulin resistance in low-birth-weight rats.

Buhl ES, Neschen S, Yonemitsu S, Rossbacher J, Zhang D, Morino K, Flyvbjerg A, Perret P, Samuel V, Kim J, Cline GW, Petersen KF.

Am J Physiol Endocrinol Metab. 2007 Nov;293(5):E1451-8. Epub 2007 Sep 25.PMID: 17895287 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome.

Petersen KF, Dufour S, Savage DB, Bilz S, Solomon G, Yonemitsu S, Cline GW, Befroy D, Zemany L, Kahn BB, Papademetris X, Rothman DL, Shulman GI.

Proc Natl Acad Sci U S A. 2007 Jul 31;104(31):12587-94. Epub 2007 Jul 18.PMID: 17640906 [PubMed - indexed for MEDLINE]Related articlesFree article

Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance.

Choi CS, Savage DB, Kulkarni A, Yu XX, Liu ZX, Morino K, Kim S, Distefano A, Samuel VT, Neschen S, Zhang D, Wang A, Zhang XM, Kahn M, Cline GW, Pandey SK, Geisler JG, Bhanot S, Monia BP, Shulman GI.

J Biol Chem. 2007 Aug 3;282(31):22678-88. Epub 2007 May 27.PMID: 17526931 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of gluconeogenesis by Krüppel-like factor 15.

Gray S, Wang B, Orihuela Y, Hong EG, Fisch S, Haldar S, Cline GW, Kim JK, Peroni OD, Kahn BB, Jain MK.

Cell Metab. 2007 Apr;5(4):305-12.PMID: 17403374 [PubMed - indexed for MEDLINE]Related articlesFree article

Mitochondrial GTP regulates glucose-stimulated insulin secretion.

Kibbey RG, Pongratz RL, Romanelli AJ, Wollheim CB, Cline GW, Shulman GI.

Cell Metab. 2007 Apr;5(4):253-64.PMID: 17403370 [PubMed - indexed for MEDLINE]Related articlesFree article

Hepatic overexpression of glycerol-sn-3-phosphate acyltransferase 1 in rats causes insulin resistance.

Nagle CA, An J, Shiota M, Torres TP, Cline GW, Liu ZX, Wang S, Catlin RL, Shulman GI, Newgard CB, Coleman RA.

J Biol Chem. 2007 May 18;282(20):14807-15. Epub 2007 Mar 27.PMID: 17389595 [PubMed - indexed for MEDLINE]Related articlesFree article

IGF-1 stimulates de novo fatty acid biosynthesis by Schwann cells during myelination.

Liang G, Cline GW, Macica CM.

Glia. 2007 Apr 15;55(6):632-41.PMID: 17299765 [PubMed - indexed for MEDLINE]Related articles

n-3 Fatty acids preserve insulin sensitivity in vivo in a peroxisome proliferator-activated receptor-alpha-dependent manner.

Neschen S, Morino K, Dong J, Wang-Fischer Y, Cline GW, Romanelli AJ, Rossbacher JC, Moore IK, Regittnig W, Munoz DS, Kim JH, Shulman GI.

Diabetes. 2007 Apr;56(4):1034-41. Epub 2007 Jan 24.PMID: 17251275 [PubMed - indexed for MEDLINE]Related articlesFree article

Cytosolic and mitochondrial malic enzyme isoforms differentially control insulin secretion.

Pongratz RL, Kibbey RG, Shulman GI, Cline GW.

J Biol Chem. 2007 Jan 5;282(1):200-7. Epub 2006 Nov 13.PMID: 17102138 [PubMed - indexed for MEDLINE]Related articlesFree article

Tough love: left out in the cold, but not abandoned, by UCP3.

Cline GW.

J Appl Physiol. 2006 Jul;101(1):12-3. No abstract available. PMID: 16782833 [PubMed - indexed for MEDLINE]Related articlesFree article

Fish oil regulates adiponectin secretion by a peroxisome proliferator-activated receptor-gamma-dependent mechanism in mice.

Neschen S, Morino K, Rossbacher JC, Pongratz RL, Cline GW, Sono S, Gillum M, Shulman GI.

Diabetes. 2006 Apr;55(4):924-8.PMID: 16567512 [PubMed - indexed for MEDLINE]Related articlesFree article

Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2.

Savage DB, Choi CS, Samuel VT, Liu ZX, Zhang D, Wang A, Zhang XM, Cline GW, Yu XX, Geisler JG, Bhanot S, Monia BP, Shulman GI.

J Clin Invest. 2006 Mar;116(3):817-24. Epub 2006 Feb 16.PMID: 16485039 [PubMed - indexed for MEDLINE]Related articlesFree article

Lipid metabolism and adipokine levels in fatty acid-binding protein null and transgenic mice.

Hertzel AV, Smith LA, Berg AH, Cline GW, Shulman GI, Scherer PE, Bernlohr DA.

Am J Physiol Endocrinol Metab. 2006 May;290(5):E814-23. Epub 2005 Nov 22.PMID: 16303844 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of a sustained reduction in plasma free fatty acid concentration on intramuscular long-chain fatty Acyl-CoAs and insulin action in type 2 diabetic patients.

Bajaj M, Suraamornkul S, Romanelli A, Cline GW, Mandarino LJ, Shulman GI, DeFronzo RA.

Diabetes. 2005 Nov;54(11):3148-53.PMID: 16249438 [PubMed - indexed for MEDLINE]Related articlesFree article

Cardiac-specific overexpression of peroxisome proliferator-activated receptor-alpha causes insulin resistance in heart and liver.

Park SY, Cho YR, Finck BN, Kim HJ, Higashimori T, Hong EG, Lee MK, Danton C, Deshmukh S, Cline GW, Wu JJ, Bennett AM, Rothermel B, Kalinowski A, Russell KS, Kim YB, Kelly DP, Kim JK.

Diabetes. 2005 Sep;54(9):2514-24.PMID: 16123338 [PubMed - indexed for MEDLINE]Related articlesFree article

Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 knockout mice.

Neschen S, Morino K, Hammond LE, Zhang D, Liu ZX, Romanelli AJ, Cline GW, Pongratz RL, Zhang XM, Choi CS, Coleman RA, Shulman GI.

Cell Metab. 2005 Jul;2(1):55-65.PMID: 16054099 [PubMed - indexed for MEDLINE]Related articles

Acute inhibition of lipolysis does not affect postprandial suppression of endogenous glucose production.

Carey PE, Gerrard J, Cline GW, Dalla Man C, English PT, Firbank MJ, Cobelli C, Taylor R.

Am J Physiol Endocrinol Metab. 2005 Dec;289(6):E941-7. Epub 2005 Jul 5.PMID: 15998660 [PubMed - indexed for MEDLINE]Related articlesFree article

Adipocyte-specific overexpression of FOXC2 prevents diet-induced increases in intramuscular fatty acyl CoA and insulin resistance.

Kim JK, Kim HJ, Park SY, Cederberg A, Westergren R, Nilsson D, Higashimori T, Cho YR, Liu ZX, Dong J, Cline GW, Enerback S, Shulman GI.

Diabetes. 2005 Jun;54(6):1657-63.PMID: 15919786 [PubMed - indexed for MEDLINE]Related articlesFree article

Mitochondrial glycerol-3-phosphate acyltransferase-1 is essential in liver for the metabolism of excess acyl-CoAs.

Hammond LE, Neschen S, Romanelli AJ, Cline GW, Ilkayeva OR, Shulman GI, Muoio DM, Coleman RA.

J Biol Chem. 2005 Jul 8;280(27):25629-36. Epub 2005 May 6.PMID: 15878874 [PubMed - indexed for MEDLINE]Related articlesFree article

Alterations in postprandial hepatic glycogen metabolism in type 2 diabetes.

Krssak M, Brehm A, Bernroider E, Anderwald C, Nowotny P, Dalla Man C, Cobelli C, Cline GW, Shulman GI, Waldhäusl W, Roden M.

Diabetes. 2004 Dec;53(12):3048-56.PMID: 15561933 [PubMed - indexed for MEDLINE]Related articlesFree article

PKC-theta knockout mice are protected from fat-induced insulin resistance.

Kim JK, Fillmore JJ, Sunshine MJ, Albrecht B, Higashimori T, Kim DW, Liu ZX, Soos TJ, Cline GW, O'Brien WR, Littman DR, Shulman GI.

J Clin Invest. 2004 Sep;114(6):823-7.PMID: 15372106 [PubMed - indexed for MEDLINE]Related articlesFree article

13C NMR isotopomer analysis of anaplerotic pathways in INS-1 cells.

Cline GW, Lepine RL, Papas KK, Kibbey RG, Shulman GI.

J Biol Chem. 2004 Oct 22;279(43):44370-5. Epub 2004 Aug 9.PMID: 15304488 [PubMed - indexed for MEDLINE]Related articlesFree article

Nonacute effects of H-FABP deficiency on skeletal muscle glucose uptake in vitro.

Erol E, Cline GW, Kim JK, Taegtmeyer H, Binas B.

Am J Physiol Endocrinol Metab. 2004 Nov;287(5):E977-82. Epub 2004 Jun 15.PMID: 15198933 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of rexinoids on glucose transport and insulin-mediated signaling in skeletal muscles of diabetic (db/db) mice.

Shen Q, Cline GW, Shulman GI, Leibowitz MD, Davies PJ.

J Biol Chem. 2004 May 7;279(19):19721-31. Epub 2004 Mar 2.PMID: 14998989 [PubMed - indexed for MEDLINE]Related articlesFree article

Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance.

An J, Muoio DM, Shiota M, Fujimoto Y, Cline GW, Shulman GI, Koves TR, Stevens R, Millington D, Newgard CB.

Nat Med. 2004 Mar;10(3):268-74. Epub 2004 Feb 8.PMID: 14770177 [PubMed - indexed for MEDLINE]Related articles

Liver fatty acid binding protein is required for high rates of hepatic fatty acid oxidation but not for the action of PPARalpha in fasting mice.

Erol E, Kumar LS, Cline GW, Shulman GI, Kelly DP, Binas B.

FASEB J. 2004 Feb;18(2):347-9. Epub 2003 Dec 4.PMID: 14656998 [PubMed - indexed for MEDLINE]Related articlesFree article

Phosphoinositide profiling in complex lipid mixtures using electrospray ionization mass spectrometry.

Wenk MR, Lucast L, Di Paolo G, Romanelli AJ, Suchy SF, Nussbaum RL, Cline GW, Shulman GI, McMurray W, De Camilli P.

Nat Biotechnol. 2003 Jul;21(7):813-7. Epub 2003 Jun 15.PMID: 12808461 [PubMed - indexed for MEDLINE]Related articles

Mitochondrial dysfunction in the elderly: possible role in insulin resistance.

Petersen KF, Befroy D, Dufour S, Dziura J, Ariyan C, Rothman DL, DiPietro L, Cline GW, Shulman GI.

Science. 2003 May 16;300(5622):1140-2.PMID: 12750520 [PubMed - indexed for MEDLINE]Related articlesFree article

Skeletal muscle lipid metabolism with obesity.

Hulver MW, Berggren JR, Cortright RN, Dudek RW, Thompson RP, Pories WJ, MacDonald KG, Cline GW, Shulman GI, Dohm GL, Houmard JA.

Am J Physiol Endocrinol Metab. 2003 Apr;284(4):E741-7. Epub 2002 Dec 27.PMID: 12626325 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of a novel glycogen synthase kinase-3 inhibitor on insulin-stimulated glucose metabolism in Zucker diabetic fatty (fa/fa) rats.

Cline GW, Johnson K, Regittnig W, Perret P, Tozzo E, Xiao L, Damico C, Shulman GI.

Diabetes. 2002 Oct;51(10):2903-10.PMID: 12351425 [PubMed - indexed for MEDLINE]Related articlesFree article

Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy.

Petersen KF, Oral EA, Dufour S, Befroy D, Ariyan C, Yu C, Cline GW, DePaoli AM, Taylor SI, Gorden P, Shulman GI.

J Clin Invest. 2002 May;109(10):1345-50.PMID: 12021250 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle.

Yu C, Chen Y, Cline GW, Zhang D, Zong H, Wang Y, Bergeron R, Kim JK, Cushman SW, Cooney GJ, Atcheson B, White MF, Kraegen EW, Shulman GI.

J Biol Chem. 2002 Dec 27;277(52):50230-6. Epub 2002 Nov 14.PMID: 12006582 [PubMed - indexed for MEDLINE]Related articlesFree article

Astroglial contribution to brain energy metabolism in humans revealed by 13C nuclear magnetic resonance spectroscopy: elucidation of the dominant pathway for neurotransmitter glutamate repletion and measurement of astrocytic oxidative metabolism.

Lebon V, Petersen KF, Cline GW, Shen J, Mason GF, Dufour S, Behar KL, Shulman GI, Rothman DL.

J Neurosci. 2002 Mar 1;22(5):1523-31.PMID: 11880482 [PubMed - indexed for MEDLINE]Related articlesFree article

The effects of rosiglitazone on insulin sensitivity, lipolysis, and hepatic and skeletal muscle triglyceride content in patients with type 2 diabetes.

Mayerson AB, Hundal RS, Dufour S, Lebon V, Befroy D, Cline GW, Enocksson S, Inzucchi SE, Shulman GI, Petersen KF.

Diabetes. 2002 Mar;51(3):797-802.PMID: 11872682 [PubMed - indexed for MEDLINE]Related articlesFree article

NMR spectroscopy in beta cell engineering and islet transplantation.

Papas KK, Colton CK, Gounarides JS, Roos ES, Jarema MA, Shapiro MJ, Cheng LL, Cline GW, Shulman GI, Wu H, Bonner-Weir S, Weir GC.

Ann N Y Acad Sci. 2001 Nov;944:96-119.PMID: 11797699 [PubMed - indexed for MEDLINE]Related articles

Glutamine is the major precursor for GABA synthesis in rat neocortex in vivo following acute GABA-transaminase inhibition.

Patel AB, Rothman DL, Cline GW, Behar KL.

Brain Res. 2001 Nov 23;919(2):207-20.PMID: 11701133 [PubMed - indexed for MEDLINE]Related articles

Effect of triiodothyronine on mitochondrial energy coupling in human skeletal muscle.

Lebon V, Dufour S, Petersen KF, Ren J, Jucker BM, Slezak LA, Cline GW, Rothman DL, Shulman GI.

J Clin Invest. 2001 Sep;108(5):733-7.PMID: 11544279 [PubMed - indexed for MEDLINE]Related articlesFree article