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Preadipocyte Factor-1 Is Associated with Marrow Adiposity and Bone Mineral Density in Women with Anorexia Nervosa.

Fazeli PK, Bredella MA, Misra M, Meenaghan E, Rosen CJ, Clemmons DR, Breggia A, Miller KK, Klibanski A.

J Clin Endocrinol Metab. 2009 Oct 22. [Epub ahead of print]PMID: 19850693 [PubMed - as supplied by publisher]Related articles

The current status of IGF-I assays - A 2009 update.

Frystyk J, Freda P, Clemmons DR.

Growth Horm IGF Res. 2009 Oct 7. [Epub ahead of print]PMID: 19818658 [PubMed - as supplied by publisher]Related articles

Role of IGF-I in skeletal muscle mass maintenance.

Clemmons DR.

Trends Endocrinol Metab. 2009 Sep;20(7):349-56. Epub 2009 Sep 2. Review.PMID: 19729319 [PubMed - indexed for MEDLINE]Related articles

Occurrence of impaired fasting glucose in GH-deficient adults receiving GH replacement compared to untreated subjects.

Woodmansee WW, Hartman ML, Lamberts SW, Zagar AJ, Clemmons DR; on behalf of the International HypoCCS Advisory Board.

Clin Endocrinol (Oxf). 2009 May 4. [Epub ahead of print]PMID: 19438908 [PubMed - as supplied by publisher]Related articles

Identification of novel SHPS-1-associated proteins and their roles in regulation of insulin-like growth factor-dependent responses in vascular smooth muscle cells.

Shen X, Xi G, Radhakrishnan Y, Clemmons DR.

Mol Cell Proteomics. 2009 Jul;8(7):1539-51. Epub 2009 Mar 18.PMID: 19299420 [PubMed - in process]Related articles

Glucose-oxidized low-density lipoproteins enhance insulin-like growth factor I-stimulated smooth muscle cell proliferation by inhibiting integrin-associated protein cleavage.

Allen LB, Capps BE, Miller EC, Clemmons DR, Maile LA.

Endocrinology. 2009 Mar;150(3):1321-9. Epub 2008 Oct 30.PMID: 18974270 [PubMed - indexed for MEDLINE]Related articles

Complement 1s is the serine protease that cleaves IGFBP-5 in human osteoarthritic joint fluid.

Busby WH Jr, Yocum SA, Rowland M, Kellner D, Lazerwith S, Sverdrup F, Yates M, Radabaugh M, Clemmons DR.

Osteoarthritis Cartilage. 2009 Apr;17(4):547-55. Epub 2008 Oct 18.PMID: 18930415 [PubMed - in process]Related articles

Follow-up of pituitary tumor volume in patients with acromegaly treated with pegvisomant in clinical trials.

Jimenez C, Burman P, Abs R, Clemmons DR, Drake WM, Hutson KR, Messig M, Thorner MO, Trainer PJ, Gagel RF.

Eur J Endocrinol. 2008 Nov;159(5):517-23. Epub 2008 Aug 15.PMID: 18708436 [PubMed - indexed for MEDLINE]Related articlesFree article

Integrin-associated protein association with SRC homology 2 domain containing tyrosine phosphatase substrate 1 regulates igf-I signaling in vivo.

Maile LA, Capps BE, Miller EC, Aday AW, Clemmons DR.

Diabetes. 2008 Oct;57(10):2637-43. Epub 2008 Jul 15.PMID: 18633106 [PubMed - indexed for MEDLINE]Related articlesFree article

Modulation of integrin antagonist signaling by ligand binding of the heparin-binding domain of vitronectin to the alphaVbeta3 integrin.

Maile LA, Aday AW, Busby WH, Sanghani R, Veluvolu U, Clemmons DR.

J Cell Biochem. 2008 Oct 1;105(2):437-46.PMID: 18615592 [PubMed - indexed for MEDLINE]Related articlesFree article

p66shc negatively regulates insulin-like growth factor I signal transduction via inhibition of p52shc binding to Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 leading to impaired growth factor receptor-bound protein-2 membrane recruitment.

Xi G, Shen X, Clemmons DR.

Mol Endocrinol. 2008 Sep;22(9):2162-75. Epub 2008 Jul 7.PMID: 18606861 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin-like growth factor-I stimulates Shc-dependent phosphatidylinositol 3-kinase activation via Grb2-associated p85 in vascular smooth muscle cells.

Radhakrishnan Y, Maile LA, Ling Y, Graves LM, Clemmons DR.

J Biol Chem. 2008 Jun 13;283(24):16320-31. Epub 2008 Apr 16.PMID: 18420583 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulatory Actions of Insulin-like Growth Factor-binding Proteins.

Rechler MM, Clemmons DR.

Trends Endocrinol Metab. 1998 Jul;9(5):176-83.PMID: 18406262 [PubMed - in process]Related articles

Glucose regulation of integrin-associated protein cleavage controls the response of vascular smooth muscle cells to insulin-like growth factor-I.

Maile LA, Capps BE, Miller EC, Allen LB, Veluvolu U, Aday AW, Clemmons DR.

Mol Endocrinol. 2008 May;22(5):1226-37. Epub 2008 Feb 21.PMID: 18292237 [PubMed - indexed for MEDLINE]Related articlesFree article

Gender-specific changes in bone turnover and skeletal architecture in igfbp-2-null mice.

DeMambro VE, Clemmons DR, Horton LG, Bouxsein ML, Wood TL, Beamer WG, Canalis E, Rosen CJ.

Endocrinology. 2008 May;149(5):2051-61. Epub 2008 Feb 14.PMID: 18276763 [PubMed - indexed for MEDLINE]Related articlesFree article

Long-acting forms of growth hormone-releasing hormone and growth hormone: effects in normal volunteers and adults with growth hormone deficiency.

Clemmons DR.

Horm Res. 2007;68 Suppl 5:178-81. Epub 2007 Dec 10. Review.PMID: 18174751 [PubMed - indexed for MEDLINE]Related articles

Modifying IGF1 activity: an approach to treat endocrine disorders, atherosclerosis and cancer.

Clemmons DR.

Nat Rev Drug Discov. 2007 Oct;6(10):821-33. Review.PMID: 17906644 [PubMed - indexed for MEDLINE]Related articles

Regulation of igf-I signaling in retinal endothelial cells by hyperglycemia.

Miller EC, Capps BE, Sanghani RR, Clemmons DR, Maile LA.

Invest Ophthalmol Vis Sci. 2007 Aug;48(8):3878-87.PMID: 17652764 [PubMed - indexed for MEDLINE]Related articlesFree article

Protease-resistant insulin-like growth factor (IGF)-binding protein-4 inhibits IGF-I actions and neointimal expansion in a porcine model of neointimal hyperplasia.

Nichols TC, Busby WH Jr, Merricks E, Sipos J, Rowland M, Sitko K, Clemmons DR.

Endocrinology. 2007 Oct;148(10):5002-10. Epub 2007 Jul 19.PMID: 17640990 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of the human beta3 integrin subunit in mouse smooth muscle cells enhances IGF-I-stimulated signaling and proliferation.

Xi G, Maile LA, Yoo SE, Clemmons DR.

J Cell Physiol. 2008 Feb;214(2):306-15.PMID: 17607710 [PubMed - indexed for MEDLINE]Related articles

IGF-I assays: current assay methodologies and their limitations.

Clemmons DR.

Pituitary. 2007;10(2):121-8. Review.PMID: 17429590 [PubMed - indexed for MEDLINE]Related articles

Effects of combined recombinant insulin-like growth factor (IGF)-I and IGF binding protein-3 in type 2 diabetic patients on glycemic control and distribution of IGF-I and IGF-II among serum binding protein complexes.

Clemmons DR, Sleevi M, Allan G, Sommer A.

J Clin Endocrinol Metab. 2007 Jul;92(7):2652-8. Epub 2007 Apr 10.PMID: 17426090 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of the integrin alphaVbeta3 in mediating increased smooth muscle cell responsiveness to IGF-I in response to hyperglycemic stress.

Clemmons DR, Maile LA, Ling Y, Yarber J, Busby WH.

Growth Horm IGF Res. 2007 Aug;17(4):265-70. Epub 2007 Apr 6. Review.PMID: 17412627 [PubMed - indexed for MEDLINE]Related articlesFree article

Value of insulin-like growth factor system markers in the assessment of growth hormone status.

Clemmons DR.

Endocrinol Metab Clin North Am. 2007 Mar;36(1):109-29. Review.PMID: 17336738 [PubMed - indexed for MEDLINE]Related articles

Hyperglycemia alters the responsiveness of smooth muscle cells to insulin-like growth factor-I.

Maile LA, Capps BE, Ling Y, Xi G, Clemmons DR.

Endocrinology. 2007 May;148(5):2435-43. Epub 2007 Jan 25.PMID: 17255202 [PubMed - indexed for MEDLINE]Related articlesFree article

Involvement of insulin-like growth factor-I in the control of glucose homeostasis.

Clemmons DR.

Curr Opin Pharmacol. 2006 Dec;6(6):620-5. Epub 2006 Oct 9. Review.PMID: 17030015 [PubMed - indexed for MEDLINE]Related articles

Clinical utility of measurements of insulin-like growth factor 1.

Clemmons DR.

Nat Clin Pract Endocrinol Metab. 2006 Aug;2(8):436-46. Review.PMID: 16932333 [PubMed - indexed for MEDLINE]Related articles

The role of Src kinase in insulin-like growth factor-dependent mitogenic signaling in vascular smooth muscle cells.

Lieskovska J, Ling Y, Badley-Clarke J, Clemmons DR.

J Biol Chem. 2006 Sep 1;281(35):25041-53. Epub 2006 Jul 5.PMID: 16825188 [PubMed - indexed for MEDLINE]Related articlesFree article

Evaluation and treatment of adult growth hormone deficiency: an Endocrine Society Clinical Practice Guideline.

Molitch ME, Clemmons DR, Malozowski S, Merriam GR, Shalet SM, Vance ML; Endocrine Society's Clinical Guidelines Subcommittee, Stephens PA.

J Clin Endocrinol Metab. 2006 May;91(5):1621-34. Epub 2006 Apr 24. Review.PMID: 16636129 [PubMed - indexed for MEDLINE]Related articlesFree article

The heparin binding domain of vitronectin is the region that is required to enhance insulin-like growth factor-I signaling.

Maile LA, Busby WH, Sitko K, Capps BE, Sergent T, Badley-Clarke J, Ling Y, Clemmons DR.

Mol Endocrinol. 2006 Apr;20(4):881-92. Epub 2005 Dec 1.PMID: 16322097 [PubMed - indexed for MEDLINE]Related articlesFree article

Recruitment of the tyrosine phosphatase Src homology 2 domain tyrosine phosphatase-2 to the p85 subunit of phosphatidylinositol-3 (PI-3) kinase is required for insulin-like growth factor-I-dependent PI-3 kinase activation in smooth muscle cells.

Kwon M, Ling Y, Maile LA, Badley-Clark J, Clemmons DR.

Endocrinology. 2006 Mar;147(3):1458-65. Epub 2005 Nov 23.PMID: 16306077 [PubMed - indexed for MEDLINE]Related articlesFree article

SOM230 inhibits insulin-like growth factor-I action in mammary gland development by pituitary independent mechanism: mediated through somatostatin subtype receptor 3?

Ruan W, Fahlbusch F, Clemmons DR, Monaco ME, Walden PD, Silva AP, Schmid HA, Kleinberg DL.

Mol Endocrinol. 2006 Feb;20(2):426-36. Epub 2005 Oct 13.PMID: 16223973 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin-like growth factor-I signaling in smooth muscle cells is regulated by ligand binding to the 177CYDMKTTC184 sequence of the beta3-subunit of alphaVbeta3.

Maile LA, Busby WH, Sitko K, Capps BE, Sergent T, Badley-Clarke J, Clemmons DR.

Mol Endocrinol. 2006 Feb;20(2):405-13. Epub 2005 Sep 29.PMID: 16195248 [PubMed - indexed for MEDLINE]Related articlesFree article

Recombinant, nonglycosylated human insulin-like growth factor-binding protein-3 (IGFBP-3) is degraded preferentially after administration to type II diabetics, resulting in increased endogenous glycosylated IGFBP-3.

Clemmons DR, Sleevi M, Busby WH Jr.

J Clin Endocrinol Metab. 2005 Dec;90(12):6561-8. Epub 2005 Sep 27.PMID: 16189247 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose homeostasis and safety in patients with acromegaly converted from long-acting octreotide to pegvisomant.

Barkan AL, Burman P, Clemmons DR, Drake WM, Gagel RF, Harris PE, Trainer PJ, van der Lely AJ, Vance ML.

J Clin Endocrinol Metab. 2005 Oct;90(10):5684-91. Epub 2005 Aug 2.PMID: 16076947 [PubMed - indexed for MEDLINE]Related articlesFree article

Rh/IGF-I/rhIGFBP-3 administration to patients with type 2 diabetes mellitus reduces insulin requirements while also lowering fasting glucose.

Clemmons DR, Moses AC, Sommer A, Jacobson W, Rogol AD, Sleevi MR, Allan G.

Growth Horm IGF Res. 2005 Aug;15(4):265-74.PMID: 16005252 [PubMed - indexed for MEDLINE]Related articles

Role of SHPS-1 in the regulation of insulin-like growth factor I-stimulated Shc and mitogen-activated protein kinase activation in vascular smooth muscle cells.

Ling Y, Maile LA, Lieskovska J, Badley-Clarke J, Clemmons DR.

Mol Biol Cell. 2005 Jul;16(7):3353-64. Epub 2005 May 11.PMID: 15888547 [PubMed - indexed for MEDLINE]Related articlesFree article

Quantitative measurement of IGF-I and its use in diagnosing and monitoring treatment of disorders of growth hormone secretion.

Clemmons DR.

Endocr Dev. 2005;9:55-65. Review.PMID: 15879688 [PubMed - indexed for MEDLINE]Related articles

Role of insulin-like growth factor iin maintaining normal glucose homeostasis.

Clemmons DR.

Horm Res. 2004;62 Suppl 1:77-82.PMID: 15761237 [PubMed - indexed for MEDLINE]Related articles

Role of insulin-like growth factor-I in diagnosis and management of acromegaly.

Clemmons DR.

Endocr Pract. 2004 Jul-Aug;10(4):362-71. Review.PMID: 15760781 [PubMed - indexed for MEDLINE]Related articles

Insulin-like growth factor binding protein-5 (IGFBP-5) interacts with thrombospondin-1 to induce negative regulatory effects on IGF-I actions.

Moralez AM, Maile LA, Clarke J, Busby WH Jr, Clemmons DR.

J Cell Physiol. 2005 May;203(2):328-34.PMID: 15700281 [PubMed - indexed for MEDLINE]Related articles

DOK1 mediates SHP-2 binding to the alphaVbeta3 integrin and thereby regulates insulin-like growth factor I signaling in cultured vascular smooth muscle cells.

Ling Y, Maile LA, Badley-Clarke J, Clemmons DR.

J Biol Chem. 2005 Feb 4;280(5):3151-8. Epub 2004 Nov 15.PMID: 15546884 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression and characterization of a serine protease that preferentially cleaves insulin-like growth factor binding protein-5.

Hou J, Clemmons DR, Smeekens S.

J Cell Biochem. 2005 Feb 15;94(3):470-84.PMID: 15534875 [PubMed - indexed for MEDLINE]Related articles

Monitoring the response to treatment in acromegaly.

Clemmons DR, Strasburger C.

J Clin Endocrinol Metab. 2004 Nov;89(11):5289-91. No abstract available. PMID: 15531471 [PubMed - indexed for MEDLINE]Related articlesFree article

Interaction between insulin-like growth factor-I receptor and alphaVbeta3 integrin linked signaling pathways: cellular responses to changes in multiple signaling inputs.

Clemmons DR, Maile LA.

Mol Endocrinol. 2005 Jan;19(1):1-11. Epub 2004 Nov 4. Review.PMID: 15528274 [PubMed - indexed for MEDLINE]Related articlesFree article

The relative roles of growth hormone and IGF-1 in controlling insulin sensitivity.

Clemmons DR.

J Clin Invest. 2004 Jan;113(1):25-7.PMID: 14702105 [PubMed - indexed for MEDLINE]Related articlesFree article

Integrin-associated protein binding domain of thrombospondin-1 enhances insulin-like growth factor-I receptor signaling in vascular smooth muscle cells.

Maile LA, Clemmons DR.

Circ Res. 2003 Nov 14;93(10):925-31. Epub 2003 Oct 16.PMID: 14563713 [PubMed - indexed for MEDLINE]Related articlesFree article

Optimizing control of acromegaly: integrating a growth hormone receptor antagonist into the treatment algorithm.

Clemmons DR, Chihara K, Freda PU, Ho KK, Klibanski A, Melmed S, Shalet SM, Strasburger CJ, Trainer PJ, Thorner MO.

J Clin Endocrinol Metab. 2003 Oct;88(10):4759-67. Review.PMID: 14557452 [PubMed - indexed for MEDLINE]Related articlesFree article

The association between integrin-associated protein and SHPS-1 regulates insulin-like growth factor-I receptor signaling in vascular smooth muscle cells.

Maile LA, Badley-Clarke J, Clemmons DR.

Mol Biol Cell. 2003 Sep;14(9):3519-28. Epub 2003 May 29.PMID: 12972543 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of vascular smooth muscle cell responses to insulin-like growth factor (IGF)-I by local IGF-binding proteins.

Hsieh T, Gordon RE, Clemmons DR, Busby WH Jr, Duan C.

J Biol Chem. 2003 Oct 31;278(44):42886-92. Epub 2003 Aug 12.PMID: 12917428 [PubMed - indexed for MEDLINE]Related articlesFree article