PubMed

Systemic administration of the potential countermeasure huperzine reversibly inhibits central and peripheral acetylcholinesterase activity without adverse cognitive-behavioral effects.

Myers TM, Sun W, Saxena A, Doctor BP, Bonvillain AJ, Clark MG.

Pharmacol Biochem Behav. 2009 Nov 10. [Epub ahead of print]PMID: 19909771 [PubMed - as supplied by publisher]Related articles

Galantamine is a novel post-exposure therapeutic against lethal VX challenge.

Hilmas CJ, Poole MJ, Finneran K, Clark MG, Williams PT.

Toxicol Appl Pharmacol. 2009 Oct 15;240(2):166-73. Epub 2009 Jul 30.PMID: 19647007 [PubMed - indexed for MEDLINE]Related articles

Decreased microvascular vasomotion and myogenic response in rat skeletal muscle in association with acute insulin resistance.

Newman JM, Dwyer RM, St-Pierre P, Richards SM, Clark MG, Rattigan S.

J Physiol. 2009 Jun 1;587(Pt 11):2579-88. Epub 2009 Apr 29.PMID: 19403615 [PubMed - indexed for MEDLINE]Related articles

Interleukin-6 attenuates insulin-mediated increases in endothelial cell signaling but augments skeletal muscle insulin action via differential effects on tumor necrosis factor-alpha expression.

Yuen DY, Dwyer RM, Matthews VB, Zhang L, Drew BG, Neill B, Kingwell BA, Clark MG, Rattigan S, Febbraio MA.

Diabetes. 2009 May;58(5):1086-95. Epub 2009 Feb 2.PMID: 19188427 [PubMed - indexed for MEDLINE]Related articlesFree article

Impaired microvascular perfusion: a consequence of vascular dysfunction and a potential cause of insulin resistance in muscle.

Clark MG.

Am J Physiol Endocrinol Metab. 2008 Oct;295(4):E732-50. Epub 2008 Jul 8. Review.PMID: 18612041 [PubMed - indexed for MEDLINE]Related articlesFree article

Factors influencing the hemodynamic and metabolic effects of insulin in muscle.

Rattigan S, Zhang L, Mahajan H, Kolka CM, Richards SM, Clark MG.

Curr Diabetes Rev. 2006 Feb;2(1):61-70. Review.PMID: 18220618 [PubMed - indexed for MEDLINE]Related articles

Contrast-enhanced ultrasound measurement of microvascular perfusion relevant to nutrient and hormone delivery in skeletal muscle: a model study in vitro.

Ross RM, Downey K, Newman JM, Richards SM, Clark MG, Rattigan S.

Microvasc Res. 2008 Apr;75(3):323-9. Epub 2007 Nov 28.PMID: 18207201 [PubMed - indexed for MEDLINE]Related articles

Insulin and contraction increase nutritive blood flow in rat muscle in vivo determined by microdialysis of L-[14C]glucose.

Newman JM, Ross RM, Richards SM, Clark MG, Rattigan S.

J Physiol. 2007 Nov 15;585(Pt 1):217-29. Epub 2007 Sep 20.PMID: 17884927 [PubMed - indexed for MEDLINE]Related articlesFree article

Local nitric oxide synthase inhibition reduces skeletal muscle glucose uptake but not capillary blood flow during in situ muscle contraction in rats.

Ross RM, Wadley GD, Clark MG, Rattigan S, McConell GK.

Diabetes. 2007 Dec;56(12):2885-92. Epub 2007 Sep 19.PMID: 17881613 [PubMed - indexed for MEDLINE]Related articlesFree article

Point: There is capillary recruitment in active skeletal muscle during exercise.

Clark MG, Rattigan S, Barrett EJ, Vincent MA.

J Appl Physiol. 2008 Mar;104(3):889-91. Epub 2007 Jul 26. No abstract available. PMID: 17656624 [PubMed - indexed for MEDLINE]Related articlesFree article

Biochemical and genetic analyses provide insight into the structural and mechanistic properties of actin filament disassembly by the Aip1p cofilin complex in Saccharomyces cerevisiae.

Clark MG, Amberg DC.

Genetics. 2007 Jul;176(3):1527-39. Epub 2007 May 4.PMID: 17483419 [PubMed - indexed for MEDLINE]Related articlesFree article

Potential for endothelin-1-mediated impairment of contractile activity in hypertension.

Kolka CM, Rattigan S, Richards SM, Clark MG.

Clin Exp Pharmacol Physiol. 2007 Mar;34(3):217-22.PMID: 17250642 [PubMed - indexed for MEDLINE]Related articles

Requirement for the polarisome and formin function in Ssk2p-mediated actin recovery from osmotic stress in Saccharomyces cerevisiae.

Bettinger BT, Clark MG, Amberg DC.

Genetics. 2007 Apr;175(4):1637-48. Epub 2007 Jan 21.PMID: 17237521 [PubMed - indexed for MEDLINE]Related articlesFree article

Acute blockade by endothelin-1 of haemodynamic insulin action in rats.

Ross RM, Kolka CM, Rattigan S, Clark MG.

Diabetologia. 2007 Feb;50(2):443-51. Epub 2006 Dec 23.PMID: 17187249 [PubMed - indexed for MEDLINE]Related articles

Graded occlusion of perfused rat muscle vasculature decreases insulin action.

Vollus GC, Bradley EA, Roberts MK, Newman JM, Richards SM, Rattigan S, Barrett EJ, Clark MG.

Clin Sci (Lond). 2007 Apr;112(8):457-66.PMID: 17147515 [PubMed - indexed for MEDLINE]Related articles

Muscle metabolism and control of capillary blood flow: insulin and exercise.

Rattigan S, Bradley EA, Richards SM, Clark MG.

Essays Biochem. 2006;42:133-44. Review.PMID: 17144885 [PubMed - indexed for MEDLINE]Related articles

Serial-probe recognition in rhesus macaques: effects of midazolam.

Myers TM, Clark MG.

Pharmacol Biochem Behav. 2006 Nov;85(3):555-61. Epub 2006 Dec 1.PMID: 17141303 [PubMed - indexed for MEDLINE]Related articles

Acute effects of wortmannin on insulin's hemodynamic and metabolic actions in vivo.

Bradley EA, Clark MG, Rattigan S.

Am J Physiol Endocrinol Metab. 2007 Mar;292(3):E779-87. Epub 2006 Nov 14.PMID: 17106063 [PubMed - indexed for MEDLINE]Related articlesFree article

Nutritive blood flow as an essential element supporting muscle anabolism.

Clark MG, Rattigan S, Barrett EJ.

Curr Opin Clin Nutr Metab Care. 2006 May;9(3):185-9. Review.PMID: 16607114 [PubMed - indexed for MEDLINE]Related articles

Vascular and metabolic effects of methacholine in relation to insulin action in muscle.

Mahajan H, Kolka CM, Newman JM, Rattigan S, Richards SM, Clark MG.

Diabetologia. 2006 Apr;49(4):713-23. Epub 2006 Feb 1.PMID: 16477439 [PubMed - indexed for MEDLINE]Related articles

A genetic dissection of Aip1p's interactions leads to a model for Aip1p-cofilin cooperative activities.

Clark MG, Teply J, Haarer BK, Viggiano SC, Sept D, Amberg DC.

Mol Biol Cell. 2006 Apr;17(4):1971-84. Epub 2006 Jan 18.PMID: 16421248 [PubMed - indexed for MEDLINE]Related articlesFree article

Endothelial Na+-D-glucose cotransporter: no role in insulin-mediated glucose uptake.

Kolka CM, Rattigan S, Richards SM, Barrett EJ, Clark MG.

Horm Metab Res. 2005 Nov;37(11):657-61.PMID: 16308832 [PubMed - indexed for MEDLINE]Related articles

Comment to: Grassi G, Dell'oro R, Quarti-Trevano F et al (2005) neuroadrenergic and reflex abnormalities in patients with metabolic syndrome. Diabetologia 48:1359-1365.

Clark MG.

Diabetologia. 2005 Dec;48(12):2689-90. Epub 2005 Nov 4. No abstract available. PMID: 16270196 [PubMed - indexed for MEDLINE]Related articles

The microvasculature in insulin resistance and type 2 diabetes.

Clark MG, Barrett EJ, Wallis MG, Vincent MA, Rattigan S.

Semin Vasc Med. 2002 Feb;2(1):21-31. Review.PMID: 16222593 [PubMed - indexed for MEDLINE]Related articles

Acute glucosamine-induced insulin resistance in muscle in vivo is associated with impaired capillary recruitment.

Wallis MG, Smith ME, Kolka CM, Zhang L, Richards SM, Rattigan S, Clark MG.

Diabetologia. 2005 Oct;48(10):2131-9. Epub 2005 Jul 30.PMID: 16059714 [PubMed - indexed for MEDLINE]Related articles

Microvascular flow routes in muscle controlled by vasoconstrictors.

Zhang L, Newman JM, Richards SM, Rattigan S, Clark MG.

Microvasc Res. 2005 Jul;70(1-2):7-16. Epub 2005 Jul 5.PMID: 15993903 [PubMed - indexed for MEDLINE]Related articles

Effects of physostigmine and human butyrylcholinesterase on acoustic startle reflex and prepulse inhibition in C57BL/6J mice.

Clark MG, Sun W, Myers TM, Bansal R, Doctor BP, Saxena A.

Pharmacol Biochem Behav. 2005 Jul;81(3):497-505.PMID: 15913750 [PubMed - indexed for MEDLINE]Related articles

Metabolic and vascular actions of endothelin-1 are inhibited by insulin-mediated vasodilation in perfused rat hindlimb muscle.

Kolka CM, Rattigan S, Richards S, Clark MG.

Br J Pharmacol. 2005 Aug;145(7):992-1000.PMID: 15895101 [PubMed - indexed for MEDLINE]Related articlesFree article

Active role for the vasculature in the delivery of insulin to skeletal muscle.

Vincent MA, Clerk LH, Rattigan S, Clark MG, Barrett EJ.

Clin Exp Pharmacol Physiol. 2005 Apr;32(4):302-7. Review.PMID: 15810996 [PubMed - indexed for MEDLINE]Related articles

Exercise and insulin-mediated capillary recruitment in muscle.

Rattigan S, Wheatley C, Richards SM, Barrett EJ, Clark MG.

Exerc Sport Sci Rev. 2005 Jan;33(1):43-8. Review.PMID: 15640720 [PubMed - indexed for MEDLINE]Related articles

Axially symmetric semi-infinite domain models of microdialysis and their application to the determination of nutritive flow in rat muscle.

Roberts JL, Newman JM, Warner R, Rattigan S, Clark MG.

J Physiol. 2005 Feb 15;563(Pt 1):213-28. Epub 2004 Dec 20.PMID: 15611039 [PubMed - indexed for MEDLINE]Related articlesFree article

Local methacholine but not bradykinin potentiates insulin-mediated glucose uptake in muscle in vivo by augmenting capillary recruitment.

Mahajan H, Richards SM, Rattigan S, Clark MG.

Diabetologia. 2004 Dec;47(12):2226-34. Epub 2004 Dec 16.PMID: 15602653 [PubMed - indexed for MEDLINE]Related articles

Age and experience-related improvements in gap detection in the rat.

Friedman JT, Peiffer AM, Clark MG, Benasich AA, Fitch RH.

Brain Res Dev Brain Res. 2004 Sep 17;152(2):83-91.PMID: 15351495 [PubMed - indexed for MEDLINE]Related articles

Skeletal muscle contraction stimulates capillary recruitment and glucose uptake in insulin-resistant obese Zucker rats.

Wheatley CM, Rattigan S, Richards SM, Barrett EJ, Clark MG.

Am J Physiol Endocrinol Metab. 2004 Oct;287(4):E804-9. Epub 2004 Jun 22.PMID: 15213062 [PubMed - indexed for MEDLINE]Related articlesFree article

Microvascular recruitment is an early insulin effect that regulates skeletal muscle glucose uptake in vivo.

Vincent MA, Clerk LH, Lindner JR, Klibanov AL, Clark MG, Rattigan S, Barrett EJ.

Diabetes. 2004 Jun;53(6):1418-23.PMID: 15161743 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin sensitivity of muscle capillary recruitment in vivo.

Zhang L, Vincent MA, Richards SM, Clerk LH, Rattigan S, Clark MG, Barrett EJ.

Diabetes. 2004 Feb;53(2):447-53.PMID: 14747297 [PubMed - indexed for MEDLINE]Related articlesFree article

The vasodilatory actions of insulin on resistance and terminal arterioles and their impact on muscle glucose uptake.

Clerk LH, Vincent MA, Lindner JR, Clark MG, Rattigan S, Barrett EJ.

Diabetes Metab Res Rev. 2004 Jan-Feb;20(1):3-12. Review.PMID: 14737741 [PubMed - indexed for MEDLINE]Related articles

T-1032, a cyclic GMP phosphodiesterase-5 inhibitor, acutely blocks physiologic insulin-mediated muscle haemodynamic effects and glucose uptake in vivo.

Mahajan H, Richards SM, Rattigan S, Clark MG.

Br J Pharmacol. 2003 Dec;140(7):1283-91. Epub 2003 Oct 27.PMID: 14581178 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibiting NOS blocks microvascular recruitment and blunts muscle glucose uptake in response to insulin.

Vincent MA, Barrett EJ, Lindner JR, Clark MG, Rattigan S.

Am J Physiol Endocrinol Metab. 2003 Jul;285(1):E123-9.PMID: 12791603 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin-mediated capillary recruitment in skeletal muscle: is this a mediator of insulin action on glucose metabolism?

Rattigan S, Barrett EJ, Clark MG.

Curr Diab Rep. 2003 Jun;3(3):195-200. Review.PMID: 12762965 [PubMed - indexed for MEDLINE]Related articles

TNF-alpha acutely inhibits vascular effects of physiological but not high insulin or contraction.

Zhang L, Wheatley CM, Richards SM, Barrett EJ, Clark MG, Rattigan S.

Am J Physiol Endocrinol Metab. 2003 Sep;285(3):E654-60. Epub 2003 May 20.PMID: 12759220 [PubMed - indexed for MEDLINE]Related articlesFree article

Air and shock two-way shuttlebox avoidance in C57BL/6J and 129X1/SvJ mice.

Clark MG, Vasilevsky S, Myers TM.

Physiol Behav. 2003 Jan;78(1):117-23.PMID: 12536018 [PubMed - indexed for MEDLINE]Related articles

Blood flow and muscle metabolism: a focus on insulin action.

Clark MG, Wallis MG, Barrett EJ, Vincent MA, Richards SM, Clerk LH, Rattigan S.

Am J Physiol Endocrinol Metab. 2003 Feb;284(2):E241-58. Review.PMID: 12531739 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin-mediated hemodynamic changes are impaired in muscle of Zucker obese rats.

Wallis MG, Wheatley CM, Rattigan S, Barrett EJ, Clark AD, Clark MG.

Diabetes. 2002 Dec;51(12):3492-8.PMID: 12453905 [PubMed - indexed for MEDLINE]Related articlesFree article

Nonnutritive flow impairs uptake of fatty acid by white muscles of the perfused rat hindlimb.

Clerk LH, Smith ME, Rattigan S, Clark MG.

Am J Physiol Endocrinol Metab. 2003 Mar;284(3):E611-7. Epub 2002 Nov 26.PMID: 12453824 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of anticholinergics on serial-probe recognition accuracy of rhesus macaques (Macaca mulatta).

Myers TM, Galbicka G, Sipos ML, Varadi S, Oubre JL, Clark MG.

Pharmacol Biochem Behav. 2002 Nov;73(4):829-34.PMID: 12213528 [PubMed - indexed for MEDLINE]Related articles

Nutritive blood flow improves interstitial glucose and lactate exchange in perfused rat hindlimb.

Newman JM, Rattigan S, Clark MG.

Am J Physiol Heart Circ Physiol. 2002 Jul;283(1):H186-92.PMID: 12063290 [PubMed - indexed for MEDLINE]Related articlesFree article

Lipid infusion impairs physiologic insulin-mediated capillary recruitment and muscle glucose uptake in vivo.

Clerk LH, Rattigan S, Clark MG.

Diabetes. 2002 Apr;51(4):1138-45.PMID: 11916937 [PubMed - indexed for MEDLINE]Related articlesFree article

Skeletal muscle microvascular recruitment by physiological hyperinsulinemia precedes increases in total blood flow.

Vincent MA, Dawson D, Clark AD, Lindner JR, Rattigan S, Clark MG, Barrett EJ.

Diabetes. 2002 Jan;51(1):42-8.PMID: 11756321 [PubMed - indexed for MEDLINE]Related articlesFree article

Exercise training improves insulin-mediated capillary recruitment in association with glucose uptake in rat hindlimb.

Rattigan S, Wallis MG, Youd JM, Clark MG.

Diabetes. 2001 Dec;50(12):2659-65.PMID: 11723047 [PubMed - indexed for MEDLINE]Related articlesFree article