PubMed

PathGen: A Transitive Gene Pathway Generator.

Clement K, Gustafson N, Berbert A, Carroll H, Merris C, Olsen A, Clement M, Snell Q, Allen J, Roper RJ.

Bioinformatics. 2009 Dec 4. [Epub ahead of print]PMID: 19965882 [PubMed - as supplied by publisher]Related articles

Metabolite profiling identifies candidate markers reflecting the clinical adaptations associated with Roux-en-Y gastric bypass surgery.

Mutch DM, Fuhrmann JC, Rein D, Wiemer JC, Bouillot JL, Poitou C, Clément K.

PLoS One. 2009 Nov 19;4(11):e7905.PMID: 19936240 [PubMed - in process]Related articlesFree article

CCL5 Promotes Macrophage Recruitment and Survival in Human Adipose Tissue.

Keophiphath M, Rouault C, Divoux A, Clément K, Lacasa D.

Arterioscler Thromb Vasc Biol. 2009 Nov 5. [Epub ahead of print]PMID: 19893003 [PubMed - as supplied by publisher]Related articles

Obesity and low-grade inflammation: a paediatric perspective.

Tam CS, Clément K, Baur LA, Tordjman J.

Obes Rev. 2009 Oct 21. [Epub ahead of print]PMID: 19845868 [PubMed - as supplied by publisher]Related articles

Human adipose tissue macrophages: m1 and m2 cell surface markers in subcutaneous and omental depots and after weight loss.

Aron-Wisnewsky J, Tordjman J, Poitou C, Darakhshan F, Hugol D, Basdevant A, Aissat A, Guerre-Millo M, Clément K.

J Clin Endocrinol Metab. 2009 Nov;94(11):4619-23. Epub 2009 Oct 16.PMID: 19837929 [PubMed - in process]Related articles

1,2-vinyldithiin from garlic inhibits differentiation and inflammation of human preadipocytes.

Keophiphath M, Priem F, Jacquemond-Collet I, Clément K, Lacasa D.

J Nutr. 2009 Nov;139(11):2055-60. Epub 2009 Sep 16.PMID: 19759245 [PubMed - in process]Related articles

Pharmacology of morphine in obese patients: clinical implications.

Lloret Linares C, Declèves X, Oppert JM, Basdevant A, Clement K, Bardin C, Scherrmann JM, Lepine JP, Bergmann JF, Mouly S.

Clin Pharmacokinet. 2009;48(10):635-51. doi: 10.2165/11317150-000000000-00000.PMID: 19743886 [PubMed - in process]Related articles

Effects of bed-time insulin versus pioglitazone on abdominal fat accumulation, inflammation and gene expression in adipose tissue in patients with type 2 diabetes.

Hartemann-Heurtier A, Halbron M, Golmard JL, Jacqueminet S, Bastard JP, Rouault C, Ayed A, Pieroni L, Clément K, Grimaldi A.

Diabetes Res Clin Pract. 2009 Oct;86(1):37-43. Epub 2009 Aug 15.PMID: 19683825 [PubMed - in process]Related articles

The case for developing consensus standards for research in microbial pathogenesis: Bacillus anthracis toxins as an example.

Hughes MA, Burns DL, Juris SJ, Tang WJ, Clement KH, Eaton LJ, Kelly-Cirino CD, McKee ML, Powell BS, Bishop BL, Rudge TL, Shine N, Verma A, Willis MS, Morse SA.

Infect Immun. 2009 Oct;77(10):4182-6. Epub 2009 Aug 3. No abstract available. PMID: 19651858 [PubMed - indexed for MEDLINE]Related articles

Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice.

Liu J, Divoux A, Sun J, Zhang J, Clément K, Glickman JN, Sukhova GK, Wolters PJ, Du J, Gorgun CZ, Doria A, Libby P, Blumberg RS, Kahn BB, Hotamisligil GS, Shi GP.

Nat Med. 2009 Aug;15(8):940-5. Epub 2009 Jul 26.PMID: 19633655 [PubMed - indexed for MEDLINE]Related articles

Wilderness first aid: is there an "industry standard"?

Welch TR, Clement K, Berman D.

Wilderness Environ Med. 2009 Summer;20(2):113-7.PMID: 19594213 [PubMed - indexed for MEDLINE]Related articles

Microarray analysis of genes with impaired insulin regulation in the skeletal muscle of type 2 diabetic patients indicates the involvement of basic helix-loop-helix domain-containing, class B, 2 protein (BHLHB2).

Rome S, Meugnier E, Lecomte V, Berbe V, Besson J, Cerutti C, Pesenti S, Granjon A, Disse E, Clement K, Lefai E, Laville M, Vidal H.

Diabetologia. 2009 Sep;52(9):1899-912. Epub 2009 Jul 10.PMID: 19590847 [PubMed - in process]Related articles

Error in vaccine article.

Clement K.

MCN Am J Matern Child Nurs. 2009 Jul-Aug;34(4):255; author reply 255. No abstract available. PMID: 19587571 [PubMed - indexed for MEDLINE]Related articles

Association between omental adipose tissue macrophages and liver histopathology in morbid obesity: influence of glycemic status.

Tordjman J, Poitou C, Hugol D, Bouillot JL, Basdevant A, Bedossa P, Guerre-Millo M, Clement K.

J Hepatol. 2009 Aug;51(2):354-62. Epub 2009 Apr 24.PMID: 19464069 [PubMed - indexed for MEDLINE]Related articles

[Inflammation, adipokines and obesity]

Clément K, Vignes S.

Rev Med Interne. 2009 Sep;30(9):824-32. Epub 2009 Apr 25. Review. French. PMID: 19394723 [PubMed - indexed for MEDLINE]Related articles

Weight of pericardial fat on coronaropathy.

Clément K, Basdevant A, Dutour A.

Arterioscler Thromb Vasc Biol. 2009 May;29(5):615-6. No abstract available. PMID: 19369652 [PubMed - indexed for MEDLINE]Related articles

Potential contribution of adipose tissue to elevated serum cystatin C in human obesity.

Naour N, Fellahi S, Renucci JF, Poitou C, Rouault C, Basdevant A, Dutour A, Alessi MC, Bastard JP, Clément K, Guerre-Millo M.

Obesity (Silver Spring). 2009 Dec;17(12):2121-6. Epub 2009 Apr 9.PMID: 19360013 [PubMed - in process]Related articles

Using gene expression to predict the secretome of differentiating human preadipocytes.

Mutch DM, Rouault C, Keophiphath M, Lacasa D, Clément K.

Int J Obes (Lond). 2009 Mar;33(3):354-63. Epub 2009 Feb 17.PMID: 19223850 [PubMed - in process]Related articles

Role of serum amyloid a in adipocyte-macrophage cross talk and adipocyte cholesterol efflux.

Poitou C, Divoux A, Faty A, Tordjman J, Hugol D, Aissat A, Keophiphath M, Henegar C, Commans S, Clément K.

J Clin Endocrinol Metab. 2009 May;94(5):1810-7. Epub 2009 Feb 17.PMID: 19223523 [PubMed - indexed for MEDLINE]Related articles

Adipose tissue inflammation and liver pathology in human obesity.

Tordjman J, Guerre-Millo M, Clément K.

Diabetes Metab. 2008 Dec;34(6 Pt 2):658-63. Review.PMID: 19195627 [PubMed - indexed for MEDLINE]Related articlesFree article

In obese and non-obese adults, the cis-regulatory rs361072 promoter variant of PIK3CB is associated with insulin resistance not with type 2 diabetes.

Clément K, Le Stunff C, Meirhaeghe A, Dechartres A, Ferrieres J, Basdevant A, Boitard C, Amouyel P, Bougnères P.

Mol Genet Metab. 2009 Mar;96(3):129-32. Epub 2008 Dec 18.PMID: 19097921 [PubMed - indexed for MEDLINE]Related articles

Needle and surgical biopsy techniques differentially affect adipose tissue gene expression profiles.

Mutch DM, Tordjman J, Pelloux V, Hanczar B, Henegar C, Poitou C, Veyrie N, Zucker JD, Clément K.

Am J Clin Nutr. 2009 Jan;89(1):51-7. Epub 2008 Dec 3.PMID: 19056587 [PubMed - indexed for MEDLINE]Related articles

Elevated expression of osteopontin may be related to adipose tissue macrophage accumulation and liver steatosis in morbid obesity.

Bertola A, Deveaux V, Bonnafous S, Rousseau D, Anty R, Wakkach A, Dahman M, Tordjman J, Clément K, McQuaid SE, Frayn KN, Huet PM, Gugenheim J, Lotersztajn S, Le Marchand-Brustel Y, Tran A, Gual P.

Diabetes. 2009 Jan;58(1):125-33. Epub 2008 Oct 24.PMID: 18952835 [PubMed - indexed for MEDLINE]Related articlesFree article

Macrophage-secreted factors promote a profibrotic phenotype in human preadipocytes.

Keophiphath M, Achard V, Henegar C, Rouault C, Clément K, Lacasa D.

Mol Endocrinol. 2009 Jan;23(1):11-24. Epub 2008 Oct 22.PMID: 18945811 [PubMed - indexed for MEDLINE]Related articles

Retinol-binding protein 4 and prediction of incident coronary events in healthy men and women.

Mallat Z, Simon T, Benessiano J, Clément K, Taleb S, Wareham NJ, Luben R, Khaw KT, Tedgui A, Boekholdt SM.

J Clin Endocrinol Metab. 2009 Jan;94(1):255-60. Epub 2008 Oct 14.PMID: 18854400 [PubMed - indexed for MEDLINE]Related articles

Deficiency and inhibition of cathepsin K reduce body weight gain and increase glucose metabolism in mice.

Yang M, Sun J, Zhang T, Liu J, Zhang J, Shi MA, Darakhshan F, Guerre-Millo M, Clement K, Gelb BD, Dolgnov G, Shi GP.

Arterioscler Thromb Vasc Biol. 2008 Dec;28(12):2202-8. Epub 2008 Sep 25.PMID: 18818416 [PubMed - indexed for MEDLINE]Related articlesFree article

FunNet: an integrative tool for exploring transcriptional interactions.

Prifti E, Zucker JD, Clement K, Henegar C.

Bioinformatics. 2008 Nov 15;24(22):2636-8. Epub 2008 Sep 17.PMID: 18799481 [PubMed - indexed for MEDLINE]Related articlesFree article

Contribution of energy restriction and macronutrient composition to changes in adipose tissue gene expression during dietary weight-loss programs in obese women.

Capel F, Viguerie N, Vega N, Dejean S, Arner P, Klimcakova E, Martinez JA, Saris WH, Holst C, Taylor M, Oppert JM, Sørensen TI, Clément K, Vidal H, Langin D.

J Clin Endocrinol Metab. 2008 Nov;93(11):4315-22. Epub 2008 Sep 9.PMID: 18782868 [PubMed - indexed for MEDLINE]Related articlesFree article

Unexpected endocrine features and normal pigmentation in a young adult patient carrying a novel homozygous mutation in the POMC gene.

Clément K, Dubern B, Mencarelli M, Czernichow P, Ito S, Wakamatsu K, Barsh GS, Vaisse C, Leger J.

J Clin Endocrinol Metab. 2008 Dec;93(12):4955-62. Epub 2008 Sep 2.PMID: 18765507 [PubMed - indexed for MEDLINE]Related articlesFree article

Epicardial adipose tissue extent: relationship with age, body fat distribution, and coronaropathy.

Silaghi A, Piercecchi-Marti MD, Grino M, Leonetti G, Alessi MC, Clement K, Dadoun F, Dutour A.

Obesity (Silver Spring). 2008 Nov;16(11):2424-30. Epub 2008 Aug 14.PMID: 18719675 [PubMed - indexed for MEDLINE]Related articles

Gene expression profiling of human skeletal muscle in response to stabilized weight loss.

Larrouy D, Barbe P, Valle C, Déjean S, Pelloux V, Thalamas C, Bastard JP, Le Bouil A, Diquet B, Clément K, Langin D, Viguerie N.

Am J Clin Nutr. 2008 Jul;88(1):125-32.PMID: 18614732 [PubMed - indexed for MEDLINE]Related articlesFree article

Cathepsin S genotypes are associated with Apo-A1 and HDL-cholesterol in lean and obese French populations.

Spielmann N, Mutch DM, Rousseau F, Tores F, Hager J, Bertrais S, Basdevant A, Tounian P, Dubern B, Galan P, Clément K.

Clin Genet. 2008 Aug;74(2):155-63. Epub 2008 Jun 28.PMID: 18565099 [PubMed - indexed for MEDLINE]Related articles

Gamma-synuclein is an adipocyte-neuron gene coordinately expressed with leptin and increased in human obesity.

Oort PJ, Knotts TA, Grino M, Naour N, Bastard JP, Clément K, Ninkina N, Buchman VL, Permana PA, Luo X, Pan G, Dunn TN, Adams SH.

J Nutr. 2008 May;138(5):841-8.PMID: 18424589 [PubMed - indexed for MEDLINE]Related articlesFree article

Interlaboratory comparison of results of an anthrax lethal toxin neutralization assay for assessment of functional antibodies in multiple species.

Omland KS, Brys A, Lansky D, Clement K, Lynn F; Participating Laboratories.

Clin Vaccine Immunol. 2008 Jun;15(6):946-53. Epub 2008 Apr 16.PMID: 18417668 [PubMed - indexed for MEDLINE]Related articlesFree article

Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity.

Henegar C, Tordjman J, Achard V, Lacasa D, Cremer I, Guerre-Millo M, Poitou C, Basdevant A, Stich V, Viguerie N, Langin D, Bedossa P, Zucker JD, Clement K.

Genome Biol. 2008 Jan 21;9(1):R14. [Epub ahead of print]PMID: 18208606 [PubMed - as supplied by publisher]Related articlesFree article

Adipose gene expression prior to weight loss can differentiate and weakly predict dietary responders.

Mutch DM, Temanni MR, Henegar C, Combes F, Pelloux V, Holst C, Sørensen TI, Astrup A, Martinez JA, Saris WH, Viguerie N, Langin D, Zucker JD, Clément K.

PLoS One. 2007 Dec 19;2(12):e1344.PMID: 18094752 [PubMed - indexed for MEDLINE]Related articlesFree article

Mutational analysis of the pro-opiomelanocortin gene in French obese children led to the identification of a novel deleterious heterozygous mutation located in the alpha-melanocyte stimulating hormone domain.

Dubern B, Lubrano-Berthelier C, Mencarelli M, Ersoy B, Frelut ML, Bouglé D, Costes B, Simon C, Tounian P, Vaisse C, Clement K.

Pediatr Res. 2008 Feb;63(2):211-6.PMID: 18091355 [PubMed - indexed for MEDLINE]Related articles

Leptin therapy for partial lipodystrophy linked to a PPAR-gamma mutation.

Guettier JM, Park JY, Cochran EK, Poitou C, Basdevant A, Meier M, Clément K, Magré J, Gorden P.

Clin Endocrinol (Oxf). 2008 Apr;68(4):547-54. Epub 2007 Dec 10.PMID: 18076675 [PubMed - indexed for MEDLINE]Related articlesFree article

Promoter adiponectin polymorphisms and waist/hip ratio variation in a prospective French adults study.

Dolley G, Bertrais S, Frochot V, Bebel JF, Guerre-Millo M, Tores F, Rousseau F, Hager J, Basdevant A, Hercberg S, Galan P, Oppert JM, Lacorte JM, Clément K.

Int J Obes (Lond). 2008 Apr;32(4):669-75. Epub 2007 Dec 11.PMID: 18071343 [PubMed - indexed for MEDLINE]Related articles

Treatment for 2 mo with n 3 polyunsaturated fatty acids reduces adiposity and some atherogenic factors but does not improve insulin sensitivity in women with type 2 diabetes: a randomized controlled study.

Kabir M, Skurnik G, Naour N, Pechtner V, Meugnier E, Rome S, Quignard-Boulangé A, Vidal H, Slama G, Clément K, Guerre-Millo M, Rizkalla SW.

Am J Clin Nutr. 2007 Dec;86(6):1670-9.PMID: 18065585 [PubMed - indexed for MEDLINE]Related articlesFree article

Safety, reactogenicity and immunogenicity of a recombinant protective antigen anthrax vaccine given to healthy adults.

Campbell JD, Clement KH, Wasserman SS, Donegan S, Chrisley L, Kotloff KL.

Hum Vaccin. 2007 Sep-Oct;3(5):205-11. Epub 2007 May 18.PMID: 17881903 [PubMed - indexed for MEDLINE]Related articles

Expression of adrenomedullin in human epicardial adipose tissue: role of coronary status.

Silaghi A, Achard V, Paulmyer-Lacroix O, Scridon T, Tassistro V, Duncea I, Clément K, Dutour A, Grino M.

Am J Physiol Endocrinol Metab. 2007 Nov;293(5):E1443-50. Epub 2007 Sep 18.PMID: 17878224 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of inflammation-related genes in human adipose tissue.

Clement K, Langin D.

J Intern Med. 2007 Oct;262(4):422-30. Review.PMID: 17875178 [PubMed - indexed for MEDLINE]Related articles

Defective leptin/leptin receptor signaling improves regulatory T cell immune response and protects mice from atherosclerosis.

Taleb S, Herbin O, Ait-Oufella H, Verreth W, Gourdy P, Barateau V, Merval R, Esposito B, Clément K, Holvoet P, Tedgui A, Mallat Z.

Arterioscler Thromb Vasc Biol. 2007 Dec;27(12):2691-8. Epub 2007 Aug 9.PMID: 17690315 [PubMed - indexed for MEDLINE]Related articlesFree article

The transcriptional coactivator peroxisome proliferator activated receptor (PPAR)gamma coactivator-1 alpha and the nuclear receptor PPAR alpha control the expression of glycerol kinase and metabolism genes independently of PPAR gamma activation in human white adipocytes.

Mazzucotelli A, Viguerie N, Tiraby C, Annicotte JS, Mairal A, Klimcakova E, Lepin E, Delmar P, Dejean S, Tavernier G, Lefort C, Hidalgo J, Pineau T, Fajas L, Clément K, Langin D.

Diabetes. 2007 Oct;56(10):2467-75. Epub 2007 Jul 23.PMID: 17646210 [PubMed - indexed for MEDLINE]Related articlesFree article

Cathepsin L activity controls adipogenesis and glucose tolerance.

Yang M, Zhang Y, Pan J, Sun J, Liu J, Libby P, Sukhova GK, Doria A, Katunuma N, Peroni OD, Guerre-Millo M, Kahn BB, Clement K, Shi GP.

Nat Cell Biol. 2007 Aug;9(8):970-7. Epub 2007 Jul 22.PMID: 17643114 [PubMed - indexed for MEDLINE]Related articles

Homozygous null mutation of the melanocortin-4 receptor and severe early-onset obesity.

Dubern B, Bisbis S, Talbaoui H, Le Beyec J, Tounian P, Lacorte JM, Clément K.

J Pediatr. 2007 Jun;150(6):613-7, 617.e1.PMID: 17517245 [PubMed - indexed for MEDLINE]Related articles

[Genetic aspects of obesity]

Dubern B, Clément K.

Presse Med. 2007 Nov;36(11 Pt 2):1598-605. Epub 2007 May 21. Review. French. PMID: 17513079 [PubMed - indexed for MEDLINE]Related articles

Emerging role of cathepsin S in obesity and its associated diseases.

Taleb S, Clément K.

Clin Chem Lab Med. 2007;45(3):328-32. Review.PMID: 17378727 [PubMed - indexed for MEDLINE]Related articles

Acute hyperglycemia induces a global downregulation of gene expression in adipose tissue and skeletal muscle of healthy subjects.

Meugnier E, Faraj M, Rome S, Beauregard G, Michaut A, Pelloux V, Chiasson JL, Laville M, Clement K, Vidal H, Rabasa-Lhoret R.

Diabetes. 2007 Apr;56(4):992-9. Epub 2007 Feb 15.PMID: 17303805 [PubMed - indexed for MEDLINE]Related articlesFree article