PubMed

Analogues of the NAADP antagonist NED-19 indicate two binding sites on the NAADP receptor.

Rosen D, Lewis AM, Mizote A, Thomas JM, Aley PK, Vasudevan SR, Parkesh R, Galione A, Izumi M, Ganesan A, Churchill GC.

J Biol Chem. 2009 Oct 13. [Epub ahead of print]PMID: 19826006 [PubMed - as supplied by publisher]Related articlesFree article

Recruitment of NAADP-sensitive acidic Ca2+ stores by glutamate.

Pandey V, Chuang CC, Lewis AM, Aley PK, Brailoiu E, Dun NJ, Churchill GC, Patel S.

Biochem J. 2009 Aug 27;422(3):503-12.PMID: 19548879 [PubMed - indexed for MEDLINE]Related articles

NAADP receptors mediate calcium signaling stimulated by endothelin-1 and norepinephrine in renal afferent arterioles.

Thai TL, Churchill GC, Arendshorst WJ.

Am J Physiol Renal Physiol. 2009 Aug;297(2):F510-6. Epub 2009 May 13.PMID: 19439521 [PubMed - indexed for MEDLINE]Related articles

NOD x 129.H2(g7) backcross delineates 129S1/SvImJ-derived genomic regions modulating type 1 diabetes development in mice.

Leiter EH, Reifsnyder PC, Wallace R, Li R, King B, Churchill GC.

Diabetes. 2009 Jul;58(7):1700-3. Epub 2009 Mar 31.PMID: 19336673 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of a chemical probe for NAADP by virtual screening.

Naylor E, Arredouani A, Vasudevan SR, Lewis AM, Parkesh R, Mizote A, Rosen D, Thomas JM, Izumi M, Ganesan A, Galione A, Churchill GC.

Nat Chem Biol. 2009 Apr;5(4):220-6. Epub 2009 Feb 22.PMID: 19234453 [PubMed - indexed for MEDLINE]Related articlesFree article

NAADP-mediated channel 'chatter' in neurons of the rat medulla oblongata.

Brailoiu GC, Brailoiu E, Parkesh R, Galione A, Churchill GC, Patel S, Dun NJ.

Biochem J. 2009 Apr 1;419(1):91-7, 2 p following 97.PMID: 19090786 [PubMed - indexed for MEDLINE]Related articles

Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium.

Lloyd-Evans E, Morgan AJ, He X, Smith DA, Elliot-Smith E, Sillence DJ, Churchill GC, Schuchman EH, Galione A, Platt FM.

Nat Med. 2008 Nov;14(11):1247-55. Epub 2008 Oct 26.PMID: 18953351 [PubMed - indexed for MEDLINE]Related articles

Cellular confocal fluorescence studies and cytotoxic activity of new Zn(II) bis(thiosemicarbazonato) complexes.

Pascu SI, Waghorn PA, Conry TD, Lin B, Betts HM, Dilworth JR, Sim RB, Churchill GC, Aigbirhio FI, Warren JE.

Dalton Trans. 2008 Apr 28;(16):2107-10. Epub 2008 Mar 18.PMID: 18398535 [PubMed - indexed for MEDLINE]Related articles

Sperm express a Ca2+-regulated NAADP synthase.

Vasudevan SR, Galione A, Churchill GC.

Biochem J. 2008 Apr 1;411(1):63-70.PMID: 18215126 [PubMed - indexed for MEDLINE]Related articlesFree article

Designing Zn(II) and Cu(II) derivatives as probes for in vitro fluorescence imaging.

Pascu SI, Waghorn PA, Conry TD, Betts HM, Dilworth JR, Churchill GC, Pokrovska T, Christlieb M, Aigbirhio FI, Warren JE.

Dalton Trans. 2007 Nov 21;(43):4988-97. Epub 2007 Sep 13.PMID: 17992284 [PubMed - indexed for MEDLINE]Related articles

Cell-permeant NAADP: a novel chemical tool enabling the study of Ca2+ signalling in intact cells.

Parkesh R, Lewis AM, Aley PK, Arredouani A, Rossi S, Tavares R, Vasudevan SR, Rosen D, Galione A, Dowden J, Churchill GC.

Cell Calcium. 2008 Jun;43(6):531-8. Epub 2007 Nov 1.PMID: 17935780 [PubMed - indexed for MEDLINE]Related articles

Refinement of a radioreceptor binding assay for nicotinic acid adenine dinucleotide phosphate.

Lewis AM, Masgrau R, Vasudevan SR, Yamasaki M, O'Neill JS, Garnham C, James K, Macdonald A, Ziegler M, Galione A, Churchill GC.

Anal Biochem. 2007 Dec 1;371(1):26-36. Epub 2007 Sep 1.PMID: 17919448 [PubMed - indexed for MEDLINE]Related articlesFree article

NAADP controls cross-talk between distinct Ca2+ stores in the heart.

Macgregor A, Yamasaki M, Rakovic S, Sanders L, Parkesh R, Churchill GC, Galione A, Terrar DA.

J Biol Chem. 2007 May 18;282(20):15302-11. Epub 2007 Mar 26.PMID: 17387177 [PubMed - indexed for MEDLINE]Related articlesFree article

Functionalized bis(thiosemicarbazonato) complexes of zinc and copper: synthetic platforms toward site-specific radiopharmaceuticals.

Holland JP, Aigbirhio FI, Betts HM, Bonnitcha PD, Burke P, Christlieb M, Churchill GC, Cowley AR, Dilworth JR, Donnelly PS, Green JC, Peach JM, Vasudevan SR, Warren JE.

Inorg Chem. 2007 Jan 22;46(2):465-85.PMID: 17279826 [PubMed]Related articles

Chemo-enzymatic synthesis and biological evaluation of photolabile nicotinic acid adenine dinuclotide phosphate (NAADP+).

Parkesh R, Vasudevan SR, Berry A, Galione A, Dowden J, Churchill GC.

Org Biomol Chem. 2007 Feb 7;5(3):441-3. Epub 2006 Dec 11.PMID: 17252124 [PubMed - indexed for MEDLINE]Related articlesFree article

Cell-permeant small-molecule modulators of NAADP-mediated Ca2+ release.

Dowden J, Berridge G, Moreau C, Yamasaki M, Churchill GC, Potter BV, Galione A.

Chem Biol. 2006 Jun;13(6):659-65.PMID: 16793523 [PubMed - indexed for MEDLINE]Related articles

Calcium signalling by nicotinic acid adenine dinucleotide phosphate (NAADP).

Yamasaki M, Churchill GC, Galione A.

FEBS J. 2005 Sep;272(18):4598-606. Review.PMID: 16156782 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of NAADP and cADPR in the induction and maintenance of agonist-evoked Ca2+ spiking in mouse pancreatic acinar cells.

Yamasaki M, Thomas JM, Churchill GC, Garnham C, Lewis AM, Cancela JM, Patel S, Galione A.

Curr Biol. 2005 May 10;15(9):874-8.PMID: 15886108 [PubMed - indexed for MEDLINE]Related articles

Organelle selection determines agonist-specific Ca2+ signals in pancreatic acinar and beta cells.

Yamasaki M, Masgrau R, Morgan AJ, Churchill GC, Patel S, Ashcroft SJ, Galione A.

J Biol Chem. 2004 Feb 20;279(8):7234-40. Epub 2003 Dec 2.PMID: 14660554 [PubMed - indexed for MEDLINE]Related articlesFree article

NAADP: a new second messenger for glucose-induced Ca2+ responses in clonal pancreatic beta cells.

Masgrau R, Churchill GC, Morgan AJ, Ashcroft SJ, Galione A.

Curr Biol. 2003 Feb 4;13(3):247-51.PMID: 12573222 [PubMed - indexed for MEDLINE]Related articles

Sperm deliver a new second messenger: NAADP.

Churchill GC, O'Neill JS, Masgrau R, Patel S, Thomas JM, Genazzani AA, Galione A.

Curr Biol. 2003 Jan 21;13(2):125-8.PMID: 12546785 [PubMed - indexed for MEDLINE]Related articles

Interactions between calcium release pathways: multiple messengers and multiple stores.

Galione A, Churchill GC.

Cell Calcium. 2002 Nov-Dec;32(5-6):343-54. Review.PMID: 12543094 [PubMed - indexed for MEDLINE]Related articles

Calmodulin dissociation mediates desensitization of the cADPR-induced Ca2+ release mechanism.

Thomas JM, Summerhill RJ, Fruen BR, Churchill GC, Galione A.

Curr Biol. 2002 Dec 10;12(23):2018-22.PMID: 12477390 [PubMed - indexed for MEDLINE]Related articles

NAADP mobilizes Ca(2+) from reserve granules, lysosome-related organelles, in sea urchin eggs.

Churchill GC, Okada Y, Thomas JM, Genazzani AA, Patel S, Galione A.

Cell. 2002 Nov 27;111(5):703-8.PMID: 12464181 [PubMed - indexed for MEDLINE]Related articles

Ca(2+) regulation in differentiating lens cells in culture.

Churchill GC, Louis CF.

Exp Eye Res. 2002 Jul;75(1):77-85.PMID: 12123639 [PubMed - indexed for MEDLINE]Related articles

A pivotal role for cADPR-mediated Ca2+ signaling: regulation of endothelin-induced contraction in peritubular smooth muscle cells.

Barone F, Genazzani AA, Conti A, Churchill GC, Palombi F, Ziparo E, Sorrentino V, Galione A, Filippini A.

FASEB J. 2002 May;16(7):697-705.PMID: 11978734 [PubMed - indexed for MEDLINE]Related articlesFree article

Cyclic ADP ribose as a calcium-mobilizing messenger.

Galione A, Churchill GC.

Sci STKE. 2000 Jul 18;2000(41):pe1. Review.PMID: 11752598 [PubMed - indexed for MEDLINE]Related articles

Pharmacological characterization of the putative cADP-ribose receptor.

Thomas JM, Masgrau R, Churchill GC, Galione A.

Biochem J. 2001 Oct 15;359(Pt 2):451-7.PMID: 11583594 [PubMed - indexed for MEDLINE]Related articlesFree article

Coordination of Ca2+ signalling by NAADP.

Patel S, Churchill GC, Galione A.

Trends Biochem Sci. 2001 Aug;26(8):482-9. Review.PMID: 11504624 [PubMed - indexed for MEDLINE]Related articles

Ca(2+) regulation of gap junctional coupling in lens epithelial cells.

Churchill GC, Lurtz MM, Louis CF.

Am J Physiol Cell Physiol. 2001 Sep;281(3):C972-81.PMID: 11502574 [PubMed - indexed for MEDLINE]Related articlesFree article

Distinct pharmacology of 2-hydroxycarbazole-induced Ca2+ release in the sea urchin egg.

Thomas JM, Churchill GC, Patel S, Galione A.

J Pharmacol Exp Ther. 2001 Aug;298(2):644-50.PMID: 11454926 [PubMed - indexed for MEDLINE]Related articlesFree article

NAADP induces Ca2+ oscillations via a two-pool mechanism by priming IP3- and cADPR-sensitive Ca2+ stores.

Churchill GC, Galione A.

EMBO J. 2001 Jun 1;20(11):2666-71.PMID: 11387201 [PubMed - indexed for MEDLINE]Related articlesFree article

Prolonged inactivation of nicotinic acid adenine dinucleotide phosphate-induced Ca2+ release mediates a spatiotemporal Ca2+ memory.

Churchill GC, Galione A.

J Biol Chem. 2001 Apr 6;276(14):11223-5. Epub 2001 Jan 3.PMID: 11139579 [PubMed - indexed for MEDLINE]Related articlesFree article

Unique kinetics of nicotinic acid-adenine dinucleotide phosphate (NAADP) binding enhance the sensitivity of NAADP receptors for their ligand.

Patel S, Churchill GC, Galione A.

Biochem J. 2000 Dec 15;352 Pt 3:725-9.PMID: 11104679 [PubMed - indexed for MEDLINE]Related articlesFree article

NAADP-induced calcium release in sea urchin eggs.

Galione A, Patel S, Churchill GC.

Biol Cell. 2000 Jul;92(3-4):197-204. Review.PMID: 11043408 [PubMed - indexed for MEDLINE]Related articles

Widespread distribution of binding sites for the novel Ca2+-mobilizing messenger, nicotinic acid adenine dinucleotide phosphate, in the brain.

Patel S, Churchill GC, Sharp T, Galione A.

J Biol Chem. 2000 Nov 24;275(47):36495-7.PMID: 11010959 [PubMed - indexed for MEDLINE]Related articlesFree article

Spatial control of Ca2+ signaling by nicotinic acid adenine dinucleotide phosphate diffusion and gradients.

Churchill GC, Galione A.

J Biol Chem. 2000 Dec 8;275(49):38687-92.PMID: 11006280 [PubMed - indexed for MEDLINE]Related articlesFree article

Coordination of agonist-induced Ca2+-signalling patterns by NAADP in pancreatic acinar cells.

Cancela JM, Churchill GC, Galione A.

Nature. 1999 Mar 4;398(6722):74-6.PMID: 10078532 [PubMed - indexed for MEDLINE]Related articles

Imaging of intracellular calcium stores in single permeabilized lens cells.

Churchill GC, Louis CF.

Am J Physiol. 1999 Feb;276(2 Pt 1):C426-34.PMID: 9950770 [PubMed - indexed for MEDLINE]Related articlesFree article

Roles of Ca2+, inositol trisphosphate and cyclic ADP-ribose in mediating intercellular Ca2+ signaling in sheep lens cells.

Churchill GC, Louis CF.

J Cell Sci. 1998 May;111 ( Pt 9):1217-25.PMID: 9547298 [PubMed - indexed for MEDLINE]Related articlesFree article

Stimulation of P2U purinergic or alpha 1A adrenergic receptors mobilizes Ca2+ in lens cells.

Churchill GC, Louis CF.

Invest Ophthalmol Vis Sci. 1997 Apr;38(5):855-65.PMID: 9112981 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanical stimulation initiates cell-to-cell calcium signaling in ovine lens epithelial cells.

Churchill GC, Atkinson MM, Louis CF.

J Cell Sci. 1996 Feb;109 ( Pt 2):355-65.PMID: 8838659 [PubMed - indexed for MEDLINE]Related articlesFree article

Structure-Activity Relationships of Abscisic Acid Analogs Based on the Induction of Freezing Tolerance in Bromegrass (Bromus inermis Leyss) Cell Cultures.

Churchill GC, Ewan B, Reaney MJ, Abrams SR, Gusta LV.

Plant Physiol. 1992 Dec;100(4):2024-2029.PMID: 16653234 [PubMed - as supplied by publisher]Related articlesFree article