PubMed

Age-dependent effects of RPE65 gene therapy for Leber's congenital amaurosis: a phase 1 dose-escalation trial.

Maguire AM, High KA, Auricchio A, Wright JF, Pierce EA, Testa F, Mingozzi F, Bennicelli JL, Ying GS, Rossi S, Fulton A, Marshall KA, Banfi S, Chung DC, Morgan JI, Hauck B, Zelenaia O, Zhu X, Raffini L, Coppieters F, De Baere E, Shindler KS, Volpe NJ, Surace EM, Acerra C, Lyubarsky A, Redmond TM, Stone E, Sun J, McDonnell JW, Leroy BP, Simonelli F, Bennett J.

Lancet. 2009 Nov 7;374(9701):1597-605. Epub 2009 Oct 23.PMID: 19854499 [PubMed - in process]Related articles

Oncogenic KRAS and BRAF differentially regulate hypoxia-inducible factor-1alpha and -2alpha in colon cancer.

Kikuchi H, Pino MS, Zeng M, Shirasawa S, Chung DC.

Cancer Res. 2009 Nov 1;69(21):8499-506. Epub 2009 Oct 20.PMID: 19843849 [PubMed - in process]Related articles

Recent breakthroughs in gene therapy for inherited retinal degeneration.

Revere KE, Chung DC.

Discov Med. 2009 Oct;8(42):125-9.PMID: 19833058 [PubMed - in process]Related articles

Direct evidence that bevacizumab, an anti-VEGF antibody, up-regulates SDF1alpha, CXCR4, CXCL6, and neuropilin 1 in tumors from patients with rectal cancer.

Xu L, Duda DG, di Tomaso E, Ancukiewicz M, Chung DC, Lauwers GY, Samuel R, Shellito P, Czito BG, Lin PC, Poleski M, Bentley R, Clark JW, Willett CG, Jain RK.

Cancer Res. 2009 Oct 15;69(20):7905-10. Epub 2009 Oct 13.PMID: 19826039 [PubMed - in process]Related articles

Cost-effectiveness of prophylactic surgery for duodenal cancer in familial adenomatous polyposis.

Greenblatt WH, Hur C, Knudsen AB, Evans JA, Chung DC, Gazelle GS.

Cancer Epidemiol Biomarkers Prev. 2009 Oct;18(10):2677-84. Epub 2009 Sep 29.PMID: 19789369 [PubMed - in process]Related articles

Recent advances in ocular gene therapy.

Chung DC, Lee V, Maguire AM.

Curr Opin Ophthalmol. 2009 Sep;20(5):377-81. Review.PMID: 19667988 [PubMed - indexed for MEDLINE]Related articles

Colorectal cancer risk perception on the basis of genetic test results in individuals at risk for Lynch syndrome.

Grover S, Stoffel EM, Mercado RC, Ford BM, Kohlman WK, Shannon KM, Conrad PG, Blanco AM, Terdiman JP, Gruber SB, Chung DC, Syngal S.

J Clin Oncol. 2009 Aug 20;27(24):3981-6. Epub 2009 Jul 20.PMID: 19620492 [PubMed - indexed for MEDLINE]Related articles

An integrative genomics approach identifies Hypoxia Inducible Factor-1 (HIF-1)-target genes that form the core response to hypoxia.

Benita Y, Kikuchi H, Smith AD, Zhang MQ, Chung DC, Xavier RJ.

Nucleic Acids Res. 2009 Aug;37(14):4587-602. Epub 2009 Jun 2.PMID: 19491311 [PubMed - indexed for MEDLINE]Related articlesFree article

Efficacy, safety, and biomarkers of neoadjuvant bevacizumab, radiation therapy, and fluorouracil in rectal cancer: a multidisciplinary phase II study.

Willett CG, Duda DG, di Tomaso E, Boucher Y, Ancukiewicz M, Sahani DV, Lahdenranta J, Chung DC, Fischman AJ, Lauwers GY, Shellito P, Czito BG, Wong TZ, Paulson E, Poleski M, Vujaskovic Z, Bentley R, Chen HX, Clark JW, Jain RK.

J Clin Oncol. 2009 Jun 20;27(18):3020-6. Epub 2009 May 26.PMID: 19470921 [PubMed - indexed for MEDLINE]Related articles

Five-year efficacy and safety analysis of the Adenoma Prevention with Celecoxib Trial.

Bertagnolli MM, Eagle CJ, Zauber AG, Redston M, Breazna A, Kim K, Tang J, Rosenstein RB, Umar A, Bagheri D, Collins NT, Burn J, Chung DC, Dewar T, Foley TR, Hoffman N, Macrae F, Pruitt RE, Saltzman JR, Salzberg B, Sylwestrowicz T, Hawk ET; Adenoma Prevention with Celecoxib Study Investigators.

Cancer Prev Res (Phila Pa). 2009 Apr;2(4):310-21. Epub 2009 Mar 31.PMID: 19336730 [PubMed - indexed for MEDLINE]Related articles

Deficient DNA mismatch repair is common in Lynch syndrome-associated colorectal adenomas.

Pino MS, Mino-Kenudson M, Wildemore BM, Ganguly A, Batten J, Sperduti I, Iafrate AJ, Chung DC.

J Mol Diagn. 2009 May;11(3):238-47. Epub 2009 Mar 26.PMID: 19324997 [PubMed - indexed for MEDLINE]Related articles

HIF-1alpha and HIF-2alpha have divergent roles in colon cancer.

Imamura T, Kikuchi H, Herraiz MT, Park DY, Mizukami Y, Mino-Kenduson M, Lynch MP, Rueda BR, Benita Y, Xavier RJ, Chung DC.

Int J Cancer. 2009 Feb 15;124(4):763-71.PMID: 19030186 [PubMed - indexed for MEDLINE]Related articlesFree article

Stool DNA testing and colon cancer prevention: another step forward.

Chung DC.

Ann Intern Med. 2008 Oct 7;149(7):509-10. No abstract available. PMID: 18838731 [PubMed - indexed for MEDLINE]Related articlesFree article

Priorities for improving the management of gastroenteropancreatic neuroendocrine tumors.

Modlin IM, Moss SF, Chung DC, Jensen RT, Snyderwine E.

J Natl Cancer Inst. 2008 Sep 17;100(18):1282-9. Epub 2008 Sep 9.PMID: 18780869 [PubMed - indexed for MEDLINE]Related articlesFree article

Hoxc6 is overexpressed in gastrointestinal carcinoids and interacts with JunD to regulate tumor growth.

Fujiki K, Duerr EM, Kikuchi H, Ng A, Xavier RJ, Mizukami Y, Imamura T, Kulke MH, Chung DC.

Gastroenterology. 2008 Sep;135(3):907-16, 916.e1-2. Epub 2008 Jul 23.PMID: 18655788 [PubMed - indexed for MEDLINE]Related articles

Pseudocoarctation of the aorta associated with the anomalous origin of the left vertebral artery: a case report.

Son JS, Hong KB, Chung DC.

Korean J Radiol. 2008 May-Jun;9(3):283-5. Review.PMID: 18525233 [PubMed - indexed for MEDLINE]Related articlesFree article

Sonic hedgehog derived from human pancreatic cancer cells augments angiogenic function of endothelial progenitor cells.

Yamazaki M, Nakamura K, Mizukami Y, Ii M, Sasajima J, Sugiyama Y, Nishikawa T, Nakano Y, Yanagawa N, Sato K, Maemoto A, Tanno S, Okumura T, Karasaki H, Kono T, Fujiya M, Ashida T, Chung DC, Kohgo Y.

Cancer Sci. 2008 Jun;99(6):1131-8. Epub 2008 Apr 14.PMID: 18422746 [PubMed - indexed for MEDLINE]Related articles

Defining molecular classifications and targets in gastroenteropancreatic neuroendocrine tumors through DNA microarray analysis.

Duerr EM, Mizukami Y, Ng A, Xavier RJ, Kikuchi H, Deshpande V, Warshaw AL, Glickman J, Kulke MH, Chung DC.

Endocr Relat Cancer. 2008 Mar;15(1):243-56.PMID: 18310291 [PubMed - indexed for MEDLINE]Related articlesFree article

Sharing genetic test results in Lynch syndrome: communication with close and distant relatives.

Stoffel EM, Ford B, Mercado RC, Punglia D, Kohlmann W, Conrad P, Blanco A, Shannon KM, Powell M, Gruber SB, Terdiman J, Chung DC, Syngal S.

Clin Gastroenterol Hepatol. 2008 Mar;6(3):333-8. Epub 2008 Feb 7.PMID: 18258490 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of CD95 and CD95L on astrocytes in the CA1 area of the immature rat hippocampus after hypoxia-ischemia injury.

Kim MJ, Lim HS, Yoo YB, Lee YI, Hahm DH, Lee HJ, Jung KW, Kim JW, Yoe SM, Chung DC, Chang YP.

Comp Med. 2007 Dec;57(6):581-9.PMID: 18246871 [PubMed - indexed for MEDLINE]Related articles

Gastroenteropancreatic neuroendocrine tumours.

Modlin IM, Oberg K, Chung DC, Jensen RT, de Herder WW, Thakker RV, Caplin M, Delle Fave G, Kaltsas GA, Krenning EP, Moss SF, Nilsson O, Rindi G, Salazar R, Ruszniewski P, Sundin A.

Lancet Oncol. 2008 Jan;9(1):61-72. Review.PMID: 18177818 [PubMed - indexed for MEDLINE]Related articles

Mechanisms of Cables 1 gene inactivation in human ovarian cancer development.

Sakamoto H, Friel AM, Wood AW, Guo L, Ilic A, Seiden MV, Chung DC, Lynch MP, Serikawa T, Munro E, Oliva E, Orsulic S, Kirley SD, Foster R, Zukerberg LR, Rueda BR.

Cancer Biol Ther. 2008 Feb;7(2):180-88. Epub 2007 Nov 15.PMID: 18059193 [PubMed - indexed for MEDLINE]Related articlesFree article

The Cables gene on chromosome 18q is silenced by promoter hypermethylation and allelic loss in human colorectal cancer.

Park do Y, Sakamoto H, Kirley SD, Ogino S, Kawasaki T, Kwon E, Mino-Kenudson M, Lauwers GY, Chung DC, Rueda BR, Zukerberg LR.

Am J Pathol. 2007 Nov;171(5):1509-19.PMID: 17982127 [PubMed - indexed for MEDLINE]Related articlesFree article

Knowledge and attitudes about microsatellite instability testing among high-risk individuals diagnosed with colorectal cancer.

Manne SL, Chung DC, Weinberg DS, Vig HS, Catts Z, Cabral MK, Shannon K, Meropol NJ.

Cancer Epidemiol Biomarkers Prev. 2007 Oct;16(10):2110-7.PMID: 17932359 [PubMed - indexed for MEDLINE]Related articlesFree article

Hypoxia inducible factor-1 independent pathways in tumor angiogenesis.

Mizukami Y, Kohgo Y, Chung DC.

Clin Cancer Res. 2007 Oct 1;13(19):5670-4. Review.PMID: 17908955 [PubMed - indexed for MEDLINE]Related articlesFree article

Microsatellite instability is frequently observed in rectal cancer and influenced by neoadjuvant chemoradiation.

Choi MY, Lauwers GY, Hur C, Willett CG, Chung DC.

Int J Radiat Oncol Biol Phys. 2007 Aug 1;68(5):1584. No abstract available. PMID: 17674996 [PubMed - indexed for MEDLINE]Related articles

Case records of the Massachusetts General Hospital. Case 22-2007. A woman with a family history of gastric and breast cancer.

Chung DC, Yoon SS, Lauwers GY, Patel D.

N Engl J Med. 2007 Jul 19;357(3):283-91. No abstract available. PMID: 17634464 [PubMed - indexed for MEDLINE]Related articles

Pressure on the neck during laryngoscopy.

Ho AM, Chung DC.

Paediatr Anaesth. 2007 Jun;17(6):601; author reply 601. No abstract available. PMID: 17498031 [PubMed - indexed for MEDLINE]Related articles

Molecular genetics of neuroendocrine tumors.

Duerr EM, Chung DC.

Best Pract Res Clin Endocrinol Metab. 2007 Mar;21(1):1-14. Review.PMID: 17382262 [PubMed - indexed for MEDLINE]Related articles

Hereditary colorectal cancer syndromes: an overview.

Kwak EL, Chung DC.

Clin Colorectal Cancer. 2007 Jan;6(5):340-4. Review.PMID: 17311698 [PubMed - indexed for MEDLINE]Related articles

The management of small polyps found by virtual colonoscopy: results of a decision analysis.

Hur C, Chung DC, Schoen RE, Gazelle GS.

Clin Gastroenterol Hepatol. 2007 Feb;5(2):237-44.PMID: 17296532 [PubMed - indexed for MEDLINE]Related articles

Prevalence of thyroid cancer in familial adenomatous polyposis syndrome and the role of screening ultrasound examinations.

Herraiz M, Barbesino G, Faquin W, Chan-Smutko G, Patel D, Shannon KM, Daniels GH, Chung DC.

Clin Gastroenterol Hepatol. 2007 Mar;5(3):367-73. Epub 2007 Jan 26.PMID: 17258512 [PubMed - indexed for MEDLINE]Related articles

Gene transfer to ocular stem cells by early gestational intraamniotic injection of lentiviral vector.

Endo M, Zoltick PW, Chung DC, Bennett J, Radu A, Muvarak N, Flake AW.

Mol Ther. 2007 Mar;15(3):579-87. Epub 2007 Jan 23.PMID: 17245352 [PubMed - indexed for MEDLINE]Related articles

Case records of the Massachusetts General Hospital. Case 37-2006. A 19-year-old woman with thyroid cancer and lower gastrointestinal bleeding.

Chung DC, Maher MM, Faquin WC.

N Engl J Med. 2006 Nov 30;355(22):2349-57. No abstract available. PMID: 17135589 [PubMed - indexed for MEDLINE]Related articles

The serrated polyp comes of age.

Lauwers GY, Chung DC.

Gastroenterology. 2006 Nov;131(5):1631-4. No abstract available. PMID: 17067594 [PubMed - indexed for MEDLINE]Related articles

Celecoxib for the prevention of sporadic colorectal adenomas.

Bertagnolli MM, Eagle CJ, Zauber AG, Redston M, Solomon SD, Kim K, Tang J, Rosenstein RB, Wittes J, Corle D, Hess TM, Woloj GM, Boisserie F, Anderson WF, Viner JL, Bagheri D, Burn J, Chung DC, Dewar T, Foley TR, Hoffman N, Macrae F, Pruitt RE, Saltzman JR, Salzberg B, Sylwestrowicz T, Gordon GB, Hawk ET; APC Study Investigators.

N Engl J Med. 2006 Aug 31;355(9):873-84.PMID: 16943400 [PubMed - indexed for MEDLINE]Related articlesFree article

Dynamic airflow limitation after topical anaesthesia of the upper airway.

Ho AM, Chung DC, Karmakar MK, Gomersall CD, Peng Z, Tay BA.

Anaesth Intensive Care. 2006 Apr;34(2):211-5.PMID: 16617642 [PubMed - indexed for MEDLINE]Related articles

Colorectal cancer screening: today and tomorrow.

Hung KE, Chung DC.

South Med J. 2006 Mar;99(3):240-6; quiz 247-9. Review.PMID: 16553098 [PubMed - indexed for MEDLINE]Related articles

Hypoxic regulation of vascular endothelial growth factor through the induction of phosphatidylinositol 3-kinase/Rho/ROCK and c-Myc.

Mizukami Y, Fujiki K, Duerr EM, Gala M, Jo WS, Zhang X, Chung DC.

J Biol Chem. 2006 May 19;281(20):13957-63. Epub 2006 Mar 16.PMID: 16543245 [PubMed - indexed for MEDLINE]Related articlesFree article

Wnt signaling can repress thrombospondin-1 expression in colonic tumorigenesis.

Jo WS, Mizukami Y, Duerr EM, Zukerberg LR, Chung DC.

Cancer Biol Ther. 2005 Dec;4(12):1361-6. Epub 2005 Dec 22.PMID: 16258261 [PubMed - indexed for MEDLINE]Related articlesFree article

Surrogate markers for antiangiogenic therapy and dose-limiting toxicities for bevacizumab with radiation and chemotherapy: continued experience of a phase I trial in rectal cancer patients.

Willett CG, Boucher Y, Duda DG, di Tomaso E, Munn LL, Tong RT, Kozin SV, Petit L, Jain RK, Chung DC, Sahani DV, Kalva SP, Cohen KS, Scadden DT, Fischman AJ, Clark JW, Ryan DP, Zhu AX, Blaszkowsky LS, Shellito PC, Mino-Kenudson M, Lauwers GY.

J Clin Oncol. 2005 Nov 1;23(31):8136-9. No abstract available. PMID: 16258121 [PubMed - indexed for MEDLINE]Related articles

Case records of the Massachusetts General Hospital. Case 33-2005. A 43-year-old man with lower gastrointestinal bleeding.

Korzenik J, Chung DC, Digumarthy S, Badizadegan K.

N Engl J Med. 2005 Oct 27;353(17):1836-44. No abstract available. PMID: 16251540 [PubMed - indexed for MEDLINE]Related articles

Correlation of polyp number and family history of colon cancer with germline MYH mutations.

Jo WS, Bandipalliam P, Shannon KM, Niendorf KB, Chan-Smutko G, Hur C, Syngal S, Chung DC.

Clin Gastroenterol Hepatol. 2005 Oct;3(10):1022-8.PMID: 16234049 [PubMed - indexed for MEDLINE]Related articles

The Cables gene on chromosome 18Q regulates colon cancer progression in vivo.

Kirley SD, D'Apuzzo M, Lauwers GY, Graeme-Cook F, Chung DC, Zukerberg LR.

Cancer Biol Ther. 2005 Aug;4(8):861-3.PMID: 16210915 [PubMed - indexed for MEDLINE]Related articlesFree article

Induction of interleukin-8 preserves the angiogenic response in HIF-1alpha-deficient colon cancer cells.

Mizukami Y, Jo WS, Duerr EM, Gala M, Li J, Zhang X, Zimmer MA, Iliopoulos O, Zukerberg LR, Kohgo Y, Lynch MP, Rueda BR, Chung DC.

Nat Med. 2005 Sep;11(9):992-7. Epub 2005 Aug 28. Erratum in: Nat Med. 2006 Feb;12(2):253. PMID: 16127434 [PubMed - indexed for MEDLINE]Related articles

Oncogenic K-ras stimulates Wnt signaling in colon cancer through inhibition of GSK-3beta.

Li J, Mizukami Y, Zhang X, Jo WS, Chung DC.

Gastroenterology. 2005 Jun;128(7):1907-18.PMID: 15940626 [PubMed - indexed for MEDLINE]Related articles

Increased growth rate, delayed senescense and decreased serum dependence characterize cables-deficient cells.

Kirley SD, Rueda BR, Chung DC, Zukerberg LR.

Cancer Biol Ther. 2005 Jun;4(6):654-8. Epub 2005 Jun 11.PMID: 15908791 [PubMed - indexed for MEDLINE]Related articlesFree article

Mutational analysis of PPARG as a candidate tumour suppressor gene in enteropancreatic endocrine tumours.

Costa-Guda J, Rosen ED, Jensen RT, Chung DC, Arnold A.

Clin Endocrinol (Oxf). 2005 May;62(5):603-6.PMID: 15853832 [PubMed - indexed for MEDLINE]Related articles

Low rate of microsatellite instability in young patients with adenomas: reassessing the Bethesda guidelines.

Velayos FS, Allen BA, Conrad PG, Gum J Jr, Kakar S, Chung DC, Truta B, Sleisenger MH, Kim YS, Terdiman JP.

Am J Gastroenterol. 2005 May;100(5):1143-9.PMID: 15842591 [PubMed - indexed for MEDLINE]Related articles

Overexpression of cyclin D1 in pancreatic beta-cells in vivo results in islet hyperplasia without hypoglycemia.

Zhang X, Gaspard JP, Mizukami Y, Li J, Graeme-Cook F, Chung DC.

Diabetes. 2005 Mar;54(3):712-9.PMID: 15734847 [PubMed - indexed for MEDLINE]Related articlesFree article