PubMed

Autoantibodies and associated T-cell responses to determinants within the 831-860 region of the autoantigen IA-2 in Type 1 diabetes.

Weenink SM, Lo J, Stephenson CR, McKinney PA, Ananieva-Jordanova R, Rees Smith B, Furmaniak J, Tremble JM, Bodansky HJ, Christie MR.

J Autoimmun. 2009 Sep;33(2):147-54. Epub 2009 May 15.PMID: 19447008 [PubMed - indexed for MEDLINE]Related articles

Somatostatin secreted by islet delta-cells fulfills multiple roles as a paracrine regulator of islet function.

Hauge-Evans AC, King AJ, Carmignac D, Richardson CC, Robinson IC, Low MJ, Christie MR, Persaud SJ, Jones PM.

Diabetes. 2009 Feb;58(2):403-11. Epub 2008 Nov 4.PMID: 18984743 [PubMed - indexed for MEDLINE]Related articlesFree article

Autoantibodies to GAD65 and IA-2 in canine diabetes mellitus.

Davison LJ, Weenink SM, Christie MR, Herrtage ME, Catchpole B.

Vet Immunol Immunopathol. 2008 Nov 15;126(1-2):83-90. Epub 2008 Jul 10.PMID: 18706702 [PubMed - indexed for MEDLINE]Related articles

The lack of anti-idiotypic antibodies, not the presence of the corresponding autoantibodies to glutamate decarboxylase, defines type 1 diabetes.

Oak S, Gilliam LK, Landin-Olsson M, Törn C, Kockum I, Pennington CR, Rowley MJ, Christie MR, Banga JP, Hampe CS.

Proc Natl Acad Sci U S A. 2008 Apr 8;105(14):5471-6. Epub 2008 Mar 26.PMID: 18367670 [PubMed - indexed for MEDLINE]Related articlesFree article

Diet-induced obesity in female mice leads to offspring hyperphagia, adiposity, hypertension, and insulin resistance: a novel murine model of developmental programming.

Samuelsson AM, Matthews PA, Argenton M, Christie MR, McConnell JM, Jansen EH, Piersma AH, Ozanne SE, Twinn DF, Remacle C, Rowlerson A, Poston L, Taylor PD.

Hypertension. 2008 Feb;51(2):383-92. Epub 2007 Dec 17.PMID: 18086952 [PubMed - indexed for MEDLINE]Related articlesFree article

Evidence for the presence of stem cell-like progenitor cells in human adult pancreas.

Zhao M, Amiel SA, Christie MR, Muiesan P, Srinivasan P, Littlejohn W, Rela M, Arno M, Heaton N, Huang GC.

J Endocrinol. 2007 Dec;195(3):407-14.PMID: 18000303 [PubMed - indexed for MEDLINE]Related articlesFree article

GAD autoantibodies and epitope reactivities persist after diagnosis in latent autoimmune diabetes in adults but do not predict disease progression: UKPDS 77.

Desai M, Cull CA, Horton VA, Christie MR, Bonifacio E, Lampasona V, Bingley PJ, Levy JC, Mackay IR, Zimmet P, Holman RR, Clark A.

Diabetologia. 2007 Oct;50(10):2052-60. Epub 2007 Jul 27.PMID: 17657474 [PubMed - indexed for MEDLINE]Related articles

Low levels of glucose transporters and K+ATP channels in human pancreatic beta cells early in development.

Richardson CC, Hussain K, Jones PM, Persaud S, Löbner K, Boehm A, Clark A, Christie MR.

Diabetologia. 2007 May;50(5):1000-5. Epub 2007 Mar 23.PMID: 17380317 [PubMed - indexed for MEDLINE]Related articles

A role for kisspeptin in islet function.

Hauge-Evans AC, Richardson CC, Milne HM, Christie MR, Persaud SJ, Jones PM.

Diabetologia. 2006 Sep;49(9):2131-5. Epub 2006 Jul 7.PMID: 16826407 [PubMed - indexed for MEDLINE]Related articles

Homotypic cell contact enhances insulin but not glucagon secretion.

Brereton HC, Carvell MJ, Asare-Anane H, Roberts G, Christie MR, Persaud SJ, Jones PM.

Biochem Biophys Res Commun. 2006 Jun 9;344(3):995-1000. Epub 2006 Apr 19.PMID: 16643853 [PubMed - indexed for MEDLINE]Related articles

Monoclonal antibody 76F distinguishes IA-2 from IA-2beta and overlaps an autoantibody epitope.

Piquer S, Valera L, Lampasona V, Jardin-Watelet B, Roche S, Granier C, Roquet F, Christie MR, Giordano T, Malosio ML, Bonifacio E, Laune D.

J Autoimmun. 2006 May;26(3):215-22. Epub 2006 Feb 24.PMID: 16503116 [PubMed - indexed for MEDLINE]Related articles

Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice.

Zhao M, Amiel SA, Christie MR, Rela M, Heaton N, Huang GC.

Diabetologia. 2005 Oct;48(10):2051-61. Epub 2005 Aug 17.PMID: 16132961 [PubMed - indexed for MEDLINE]Related articles

The dense core transmembrane vesicle protein IA-2 is a regulator of vesicle number and insulin secretion.

Harashima S, Clark A, Christie MR, Notkins AL.

Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8704-9. Epub 2005 Jun 6.PMID: 15939893 [PubMed - indexed for MEDLINE]Related articlesFree article

Autoantibodies to GAD and IA-2 in Saudi Arabian diabetic patients.

Damanhouri LH, Dromey JA, Christie MR, Nasrat HA, Ardawi MS, Robins RA, Todd I.

Diabet Med. 2005 Apr;22(4):448-52.PMID: 15787671 [PubMed - indexed for MEDLINE]Related articles

Acute tumor necrosis factor alpha signaling via NADPH oxidase in microvascular endothelial cells: role of p47phox phosphorylation and binding to TRAF4.

Li JM, Fan LM, Christie MR, Shah AM.

Mol Cell Biol. 2005 Mar;25(6):2320-30.PMID: 15743827 [PubMed - indexed for MEDLINE]Related articlesFree article

The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes.

Gillespie KM, Bain SC, Barnett AH, Bingley PJ, Christie MR, Gill GV, Gale EA.

Lancet. 2004 Nov 6-12;364(9446):1699-700.PMID: 15530631 [PubMed - indexed for MEDLINE]Related articles

Mapping of epitopes for autoantibodies to the type 1 diabetes autoantigen IA-2 by peptide phage display and molecular modeling: overlap of antibody and T cell determinants.

Dromey JA, Weenink SM, Peters GH, Endl J, Tighe PJ, Todd I, Christie MR.

J Immunol. 2004 Apr 1;172(7):4084-90.PMID: 15034020 [PubMed - indexed for MEDLINE]Related articlesFree article

The development of new density gradient media for purifying human islets and islet-quality assessments.

Huang GC, Zhao M, Jones P, Persaud S, Ramracheya R, Löbner K, Christie MR, Banga JP, Peakman M, Sirinivsan P, Rela M, Heaton N, Amiel S.

Transplantation. 2004 Jan 15;77(1):143-5.PMID: 14724452 [PubMed - indexed for MEDLINE]Related articles

Different regulated expression of the tyrosine phosphatase-like proteins IA-2 and phogrin by glucose and insulin in pancreatic islets: relationship to development of insulin secretory responses in early life.

Löbner K, Steinbrenner H, Roberts GA, Ling Z, Huang GC, Piquer S, Pipeleers DG, Seissler J, Christie MR.

Diabetes. 2002 Oct;51(10):2982-8.PMID: 12351437 [PubMed - indexed for MEDLINE]Related articlesFree article

IA-2 antibody-negative status predicts remission and recovery of C-peptide levels in type 1 diabetic patients treated with cyclosporin.

Christie MR, Mølvig J, Hawkes CJ, Carstensen B, Mandrup-Poulsen T; Canadian-European Randomised Control Trial Group.

Diabetes Care. 2002 Jul;25(7):1192-7.PMID: 12087018 [PubMed - indexed for MEDLINE]Related articlesFree article

Amelioration of streptozotocin-induced diabetes in mice using human islet cells derived from long-term culture in vitro.

Zhao M, Christie MR, Heaton N, George S, Amiel S, Cai Huang G.

Transplantation. 2002 May 15;73(9):1454-60.PMID: 12023624 [PubMed - indexed for MEDLINE]Related articles

Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens.

Bearzatto M, Naserke H, Piquer S, Koczwara K, Lampasona V, Williams A, Christie MR, Bingley PJ, Ziegler AG, Bonifacio E.

J Immunol. 2002 Apr 15;168(8):4202-8.PMID: 11937581 [PubMed - indexed for MEDLINE]Related articlesFree article

Autoantibodies to a 38-kDa glycosylated islet cell membrane-associated antigen in (pre)type 1 diabetes: association with IA-2 and islet cell autoantibodies.

Winnock F, Christie MR, Batstra MR, Aanstoot HJ, Weets I, Decochez K, Jopart P, Nicolaij D, Gorus FK; Belgian Diabetes Registry.

Diabetes Care. 2001 Jul;24(7):1181-6.PMID: 11423499 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of the protein tyrosine phosphatase-like protein IA-2 during pancreatic islet development.

Roberts C, Roberts GA, Löbner K, Bearzatto M, Clark A, Bonifacio E, Christie MR.

J Histochem Cytochem. 2001 Jun;49(6):767-76.PMID: 11373323 [PubMed - indexed for MEDLINE]Related articlesFree article

ss-cell autoantibodies, human leukocyte antigen II alleles, and type 1 diabetes in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy.

Gylling M, Tuomi T, Björses P, Kontiainen S, Partanen J, Christie MR, Knip M, Perheentupa J, Miettinen A.

J Clin Endocrinol Metab. 2000 Dec;85(12):4434-40.PMID: 11134089 [PubMed - indexed for MEDLINE]Related articlesFree article

T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes.

Hawkes CJ, Schloot NC, Marks J, Willemen SJ, Drijfhout JW, Mayer EK, Christie MR, Roep BO.

Diabetes. 2000 Mar;49(3):356-66.PMID: 10868956 [PubMed - indexed for MEDLINE]Related articlesFree article

Recombinant IA-2 expressed in E. coli can be used for the routine detection of autoantibodies in Type-I diabetes.

Morgenthaler NG, Löbner K, Morgenthaler UY, Christie MR, Seissler J, Scherbaum WA.

Horm Metab Res. 1998 Sep;30(9):559-64.PMID: 9808324 [PubMed - indexed for MEDLINE]Related articles

Islet cell antigens in the prediction and prevention of insulin-dependent diabetes mellitus.

Bonifacio E, Christie MR.

Ann Med. 1997 Oct;29(5):405-12. Review.PMID: 9453288 [PubMed - indexed for MEDLINE]Related articles

Cross reactivity between IA-2 and phogrin/IA-2beta in binding of autoantibodies in IDDM.

Hatfield EC, Hawkes CJ, Payton MA, Christie MR.

Diabetologia. 1997 Nov;40(11):1327-33.PMID: 9389426 [PubMed - indexed for MEDLINE]Related articles

Human B cells secreting immunoglobulin G to glutamic acid decarboxylase-65 from a nondiabetic patient with multiple autoantibodies and Graves' disease: a comparison with those present in type 1 diabetes.

Tremble J, Morgenthaler NG, Vlug A, Powers AC, Christie MR, Scherbaum WA, Banga JP.

J Clin Endocrinol Metab. 1997 Aug;82(8):2664-70.PMID: 9253351 [PubMed - indexed for MEDLINE]Related articlesFree article

Value of antibodies to islet protein tyrosine phosphatase-like molecule in predicting type 1 diabetes.

Hawa M, Rowe R, Lan MS, Notkins AL, Pozzilli P, Christie MR, Leslie RD.

Diabetes. 1997 Aug;46(8):1270-5.PMID: 9231650 [PubMed - indexed for MEDLINE]Related articles

Validity of screening for individuals at risk for type I diabetes by combined analysis of antibodies to recombinant proteins.

Christie MR, Roll U, Payton MA, Hatfield EC, Ziegler AG.

Diabetes Care. 1997 Jun;20(6):965-70.PMID: 9167107 [PubMed - indexed for MEDLINE]Related articles

Antibodies to the tyrosine phosphatase-like protein IA-2 are highly associated with IDDM, but not with autoimmune endocrine diseases or stiff man syndrome.

Morgenthaler NG, Seissler J, Achenbach P, Glawe D, Payton M, Meinck HM, Christie MR, Scherbaum WA.

Autoimmunity. 1997;25(4):203-11.PMID: 9344328 [PubMed - indexed for MEDLINE]Related articles

IA-2-autoantibodies complement GAD65-autoantibodies in new-onset IDDM patients and help predict impending diabetes in their siblings. The Belgian Diabetes Registry.

Gorus FK, Goubert P, Semakula C, Vandewalle CL, De Schepper J, Scheen A, Christie MR, Pipeleers DG.

Diabetologia. 1997 Jan;40(1):95-9.PMID: 9028724 [PubMed - indexed for MEDLINE]Related articles

Islet cell autoantigens in type 1 diabetes.

Christie MR.

Eur J Clin Invest. 1996 Oct;26(10):827-38. Review. No abstract available. PMID: 8911854 [PubMed - indexed for MEDLINE]Related articles

Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase-like protein (phogrin) related to IA-2.

Hawkes CJ, Wasmeier C, Christie MR, Hutton JC.

Diabetes. 1996 Sep;45(9):1187-92.PMID: 8772720 [PubMed - indexed for MEDLINE]Related articles

Perinatal autoimmunity in offspring of diabetic parents. The German Multicenter BABY-DIAB study: detection of humoral immune responses to islet antigens in early childhood.

Roll U, Christie MR, Füchtenbusch M, Payton MA, Hawkes CJ, Ziegler AG.

Diabetes. 1996 Jul;45(7):967-73.PMID: 8666150 [PubMed - indexed for MEDLINE]Related articles

Relationship of the 37,000- and 40,000-M(r) tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512).

Payton MA, Hawkes CJ, Christie MR.

J Clin Invest. 1995 Sep;96(3):1506-11.PMID: 7657822 [PubMed - indexed for MEDLINE]Related articlesFree article

Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives.

Bingley PJ, Christie MR, Bonifacio E, Bonfanti R, Shattock M, Fonte MT, Bottazzo GF, Gale EA.

Diabetes. 1994 Nov;43(11):1304-10.PMID: 7926304 [PubMed - indexed for MEDLINE]Related articles

Antibodies to islet 37k antigen, but not to glutamate decarboxylase, discriminate rapid progression to IDDM in endocrine autoimmunity.

Christie MR, Genovese S, Cassidy D, Bosi E, Brown TJ, Lai M, Bonifacio E, Bottazzo GF.

Diabetes. 1994 Oct;43(10):1254-9.PMID: 7926297 [PubMed - indexed for MEDLINE]Related articles

Combined analysis of IDDM-related autoantibodies in healthy schoolchildren.

Genovese S, Bingley PJ, Bonifacio E, Christie MR, Shattock M, Bonfanti R, Foxon R, Gale EA, Bottazzo GF.

Lancet. 1994 Sep 10;344(8924):756. No abstract available. PMID: 7915802 [PubMed - indexed for MEDLINE]Related articles

Lack of immunohistological changes in the islets of nondiabetic, autoimmune, polyendocrine patients with beta-selective GAD-specific islet cell antibodies.

Wagner R, McNally JM, Bonifacio E, Genovese S, Foulis A, McGill M, Christie MR, Betterle C, Bosi E, Bottazzo GF.

Diabetes. 1994 Jul;43(7):851-6.PMID: 7912208 [PubMed - indexed for MEDLINE]Related articles

Inflammatory islet damage in patients bearing HLA-DR 3 and/or DR 4 haplotypes does not lead to islet autoimmunity.

Lampeter EF, Seifert I, Lohmann D, Heise JW, Bertrams J, Christie MR, Kolb-Bachofen V, Kolb H.

Diabetologia. 1994 May;37(5):471-5.PMID: 8056184 [PubMed - indexed for MEDLINE]Related articles

Slow metabolic deterioration towards diabetes in islet cell antibody positive patients with autoimmune polyendocrine disease.

Wagner R, Genovese S, Bosi E, Becker F, Bingley PJ, Bonifacio E, Miles KA, Christie MR, Bottazzo GF, Gale EA.

Diabetologia. 1994 Apr;37(4):365-71.PMID: 8063036 [PubMed - indexed for MEDLINE]Related articles

Associations of anti-GAD antibodies with islet cell antibodies and insulin autoantibodies in first-degree relatives of type I diabetic patients.

Roll U, Christie MR, Standl E, Ziegler AG.

Diabetes. 1994 Jan;43(1):154-60.PMID: 8262311 [PubMed - indexed for MEDLINE]Related articles

Detection of pancreatic islet 64,000 M(r) autoantigens in insulin-dependent diabetes distinct from glutamate decarboxylase.

Christie MR, Hollands JA, Brown TJ, Michelsen BK, Delovitch TL.

J Clin Invest. 1993 Jul;92(1):240-8.PMID: 8325989 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of distinct islet protein autoantigens associated with type 1 diabetes.

Christie MR.

Autoimmunity. 1993;15 Suppl:1-3. Review. No abstract available. PMID: 8218841 [PubMed - indexed for MEDLINE]Related articles

Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM. Studies with identical twins.

Christie MR, Tun RY, Lo SS, Cassidy D, Brown TJ, Hollands J, Shattock M, Bottazzo GF, Leslie RD.

Diabetes. 1992 Jul;41(7):782-7.PMID: 1612192 [PubMed - indexed for MEDLINE]Related articles

Binding of antibodies in sera from Type 1 (insulin-dependent) diabetic patients to glutamate decarboxylase from rat tissues. Evidence for antigenic and non-antigenic forms of the enzyme.

Christie MR, Brown TJ, Cassidy D.

Diabetologia. 1992 Apr;35(4):380-4.PMID: 1516767 [PubMed - indexed for MEDLINE]Related articles

Novel considerations on the antibody/autoantigen system in type I (insulin-dependent) diabetes mellitus.

Bottazzo GF, Genovese S, Bosi E, Dean BM, Christie MR, Bonifacio E.

Ann Med. 1991 Oct;23(4):453-61. Review.PMID: 1930942 [PubMed - indexed for MEDLINE]Related articles