PubMed

Adenovirus E3 MHC inhibitory genes but not TNF/Fas apoptotic inhibitory genes expressed in {beta} cells prevent autoimmune diabetes.

Horwitz MS, Efrat S, Christen U, von Herrath MG, Oldstone MB.

Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19450-19454. Epub 2009 Nov 3.PMID: 19887639 [PubMed - as supplied by publisher]Related articles

Viral triggers for autoimmunity: Is the 'glass of molecular mimicry' half full or half empty?

Christen U, Hintermann E, Holdener M, von Herrath MG.

J Autoimmun. 2009 Aug 26. [Epub ahead of print]PMID: 19716269 [PubMed - as supplied by publisher]Related articles

New animal models for autoimmune hepatitis.

Christen U, Hintermann E, Jaeckel E.

Semin Liver Dis. 2009 Aug;29(3):262-72. Epub 2009 Aug 12. Review.PMID: 19675999 [PubMed - indexed for MEDLINE]Related articles

Breaking tolerance to the natural human liver autoantigen cytochrome P450 2D6 by virus infection.

Holdener M, Hintermann E, Bayer M, Rhode A, Rodrigo E, Hintereder G, Johnson EF, Gonzalez FJ, Pfeilschifter J, Manns MP, Herrath MG, Christen U.

J Exp Med. 2008 Jun 9;205(6):1409-22. Epub 2008 May 12.PMID: 18474629 [PubMed - indexed for MEDLINE]Related articlesFree article

Viral infection--a cure for type 1 diabetes?

Hintermann E, Christen U.

Curr Med Chem. 2007;14(19):2048-52. Review.PMID: 17691946 [PubMed - indexed for MEDLINE]Related articles

Systemic anti-TNFalpha treatment restores diabetes-impaired skin repair in ob/ob mice by inactivation of macrophages.

Goren I, Müller E, Schiefelbein D, Christen U, Pfeilschifter J, Mühl H, Frank S.

J Invest Dermatol. 2007 Sep;127(9):2259-67. Epub 2007 Apr 26.PMID: 17460730 [PubMed - indexed for MEDLINE]Related articlesFree article

Animal models for autoimmune hepatitis.

Christen U, Holdener M, Hintermann E.

Autoimmun Rev. 2007 Apr;6(5):306-11. Epub 2006 May 6. Review.PMID: 17412303 [PubMed - indexed for MEDLINE]Related articles

Minimal impact of a de novo-expressed beta-cell autoantigen on spontaneous diabetes development in NOD mice.

Martinic MM, Juedes AE, Bresson D, Homann D, Skak K, Huber C, Ling E, Ejrnaes M, Wolfe T, Togher L, Christen U, von Herrath MG.

Diabetes. 2007 Apr;56(4):1059-68.PMID: 17395746 [PubMed - indexed for MEDLINE]Related articlesFree article

Chemokines as drug targets in type 1 diabetes.

Christen U.

Endocr Metab Immune Disord Drug Targets. 2007 Mar;7(1):7-12. Review.PMID: 17346199 [PubMed - indexed for MEDLINE]Related articles

Cure of chronic viral infection and virus-induced type 1 diabetes by neutralizing antibodies.

Ejrnaes M, von Herrath MG, Christen U.

Clin Dev Immunol. 2006 Jun-Dec;13(2-4):337-47. Review.PMID: 17162375 [PubMed - indexed for MEDLINE]Related articlesFree article

SOCS-1 protects from virally-induced CD8 T cell mediated type 1 diabetes.

Barral AM, Thomas HE, Ling EM, Darwiche R, Rodrigo E, Christen U, Ejrnaes M, Wolfe T, Kay TW, von Herrath MG.

J Autoimmun. 2006 Nov;27(3):166-73. Epub 2006 Oct 10.PMID: 17045460 [PubMed - indexed for MEDLINE]Related articles

Cure of chronic viral infection and virus-induced type 1 diabetes by neutralizing antibodies.

Ejrnaes M, von Herrath MG, Christen U.

Clin Dev Immunol. 2006 Mar;13(1):67-77. Review.PMID: 16603445 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular mimicry, bystander activation, or viral persistence: infections and autoimmune disease.

Fujinami RS, von Herrath MG, Christen U, Whitton JL.

Clin Microbiol Rev. 2006 Jan;19(1):80-94. Review.PMID: 16418524 [PubMed - indexed for MEDLINE]Related articlesFree article

Islet-specific expression of CXCL10 causes spontaneous islet infiltration and accelerates diabetes development.

Rhode A, Pauza ME, Barral AM, Rodrigo E, Oldstone MB, von Herrath MG, Christen U.

J Immunol. 2005 Sep 15;175(6):3516-24.PMID: 16148094 [PubMed - indexed for MEDLINE]Related articlesFree article

Infections and autoimmunity--good or bad?

Christen U, von Herrath MG.

J Immunol. 2005 Jun 15;174(12):7481-6. Review.PMID: 15944245 [PubMed - indexed for MEDLINE]Related articlesFree article

Different diabetogenic potential of autoaggressive CD8+ clones associated with IFN-gamma-inducible protein 10 (CXC chemokine ligand 10) production but not cytokine expression, cytolytic activity, or homing characteristics.

Ejrnaes M, Videbaek N, Christen U, Cooke A, Michelsen BK, von Herrath M.

J Immunol. 2005 Mar 1;174(5):2746-55.PMID: 15728483 [PubMed - indexed for MEDLINE]Related articlesFree article

IP-10 and type 1 diabetes: a question of time and location.

Christen U, Von Herrath MG.

Autoimmunity. 2004 Aug;37(5):273-82. Review.PMID: 15672495 [PubMed - indexed for MEDLINE]Related articles

Manipulating the type 1 vs type 2 balance in type 1 diabetes.

Christen U, von Herrath MG.

Immunol Res. 2004;30(3):309-25. Review.PMID: 15531772 [PubMed - indexed for MEDLINE]Related articles

A viral epitope that mimics a self antigen can accelerate but not initiate autoimmune diabetes.

Christen U, Edelmann KH, McGavern DB, Wolfe T, Coon B, Teague MK, Miller SD, Oldstone MB, von Herrath MG.

J Clin Invest. 2004 Nov;114(9):1290-8.PMID: 15520861 [PubMed - indexed for MEDLINE]Related articlesFree article

IP-10 and type 1 diabetes: a question of time and location.

Christen U, von Herrath MG.

Autoimmunity. 2004 Jun;37(4):273-82. Review. Corrected and republished in: Autoimmunity. 2004 Aug;37(5):273-82. PMID: 15518041 [PubMed - indexed for MEDLINE]Related articles

Initiation of autoimmunity.

Christen U, von Herrath MG.

Curr Opin Immunol. 2004 Dec;16(6):759-67. Review.PMID: 15511670 [PubMed - indexed for MEDLINE]Related articles

CD8alphaalpha-mediated survival and differentiation of CD8 memory T cell precursors.

Madakamutil LT, Christen U, Lena CJ, Wang-Zhu Y, Attinger A, Sundarrajan M, Ellmeier W, von Herrath MG, Jensen P, Littman DR, Cheroutre H.

Science. 2004 Apr 23;304(5670):590-3.PMID: 15105501 [PubMed - indexed for MEDLINE]Related articlesFree article

Virally induced inflammation and therapeutic avenues in type 1 diabetes.

Christen U, Juedes A, Homann D, von Herrath MG.

Endocrinol Metab Clin North Am. 2004 Mar;33(1):45-58, viii. Review. No abstract available. PMID: 15053894 [PubMed - indexed for MEDLINE]Related articles

Induction, acceleration or prevention of autoimmunity by molecular mimicry.

Christen U, von Herrath MG.

Mol Immunol. 2004 Feb;40(14-15):1113-20. Review.PMID: 15036917 [PubMed - indexed for MEDLINE]Related articles

Virally induced inflammation triggers fratricide of Fas-ligand-expressing beta-cells.

Christen U, Darwiche R, Thomas HE, Wolfe T, Rodrigo E, Chervonsky A, Flavell RA, von Herrath MG.

Diabetes. 2004 Mar;53(3):591-6.PMID: 14988242 [PubMed - indexed for MEDLINE]Related articlesFree article

Cure of prediabetic mice by viral infections involves lymphocyte recruitment along an IP-10 gradient.

Christen U, Benke D, Wolfe T, Rodrigo E, Rhode A, Hughes AC, Oldstone MB, von Herrath MG.

J Clin Invest. 2004 Jan;113(1):74-84.PMID: 14702111 [PubMed - indexed for MEDLINE]Related articlesFree article

Among CXCR3 chemokines, IFN-gamma-inducible protein of 10 kDa (CXC chemokine ligand (CXCL) 10) but not monokine induced by IFN-gamma (CXCL9) imprints a pattern for the subsequent development of autoimmune disease.

Christen U, McGavern DB, Luster AD, von Herrath MG, Oldstone MB.

J Immunol. 2003 Dec 15;171(12):6838-45.PMID: 14662890 [PubMed - indexed for MEDLINE]Related articlesFree article

Cytokines and chemokines in virus-induced autoimmunity.

Christen U, von Herrath MG.

Adv Exp Med Biol. 2003;520:203-20. Review. No abstract available. PMID: 12613580 [PubMed - indexed for MEDLINE]Related articles

CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes.

Janssen EM, Lemmens EE, Wolfe T, Christen U, von Herrath MG, Schoenberger SP.

Nature. 2003 Feb 20;421(6925):852-6. Epub 2003 Feb 9.PMID: 12594515 [PubMed - indexed for MEDLINE]Related articles

Transgenic animal models for type 1 diabetes: linking a tetracycline-inducible promoter with a virus-inducible mouse model.

Christen U, von Herrath MG.

Transgenic Res. 2002 Dec;11(6):587-95. Review.PMID: 12509133 [PubMed - indexed for MEDLINE]Related articles

Molecular anatomy of antigen-specific CD8(+) T cell engagement and synapse formation in vivo.

McGavern DB, Christen U, Oldstone MB.

Nat Immunol. 2002 Oct;3(10):918-25. Epub 2002 Sep 23.PMID: 12352968 [PubMed - indexed for MEDLINE]Related articlesFree article

Discrete proteolysis of focal contact and adherens junction components in Porphyromonas gingivalis-infected oral keratinocytes: a strategy for cell adhesion and migration disabling.

Hintermann E, Haake SK, Christen U, Sharabi A, Quaranta V.

Infect Immun. 2002 Oct;70(10):5846-56.PMID: 12228316 [PubMed - indexed for MEDLINE]Related articlesFree article

Apoptosis of autoreactive CD8 lymphocytes as a potential mechanism for the abrogation of type 1 diabetes by islet-specific TNF-alpha expression at a time when the autoimmune process is already ongoing.

Christen U, Von Herrath MG.

Ann N Y Acad Sci. 2002 Apr;958:166-9.PMID: 12021099 [PubMed - indexed for MEDLINE]Related articles

Is activation of autoreactive lymphocytes always detrimental? Viral infections and regulatory circuits in autoimmunity.

von Herrath MG, Oldstone M, Homann D, Christen U.

Curr Dir Autoimmun. 2001;4:91-122. Review. No abstract available. PMID: 11569412 [PubMed - indexed for MEDLINE]Related articles

Identification of candidate genes for controlling development of the basilar pons by differential display PCR.

Gesemann M, Litwack ED, Yee KT, Christen U, O'Leary DD.

Mol Cell Neurosci. 2001 Jul;18(1):1-12.PMID: 11461149 [PubMed - indexed for MEDLINE]Related articles

A dual role for TNF-alpha in type 1 diabetes: islet-specific expression abrogates the ongoing autoimmune process when induced late but not early during pathogenesis.

Christen U, Wolfe T, Möhrle U, Hughes AC, Rodrigo E, Green EA, Flavell RA, von Herrath MG.

J Immunol. 2001 Jun 15;166(12):7023-32.PMID: 11390446 [PubMed - indexed for MEDLINE]Related articlesFree article

Lipopolysaccharide is in close proximity to each of the proteins in its membrane receptor complex. transfer from CD14 to TLR4 and MD-2.

da Silva Correia J, Soldau K, Christen U, Tobias PS, Ulevitch RJ.

J Biol Chem. 2001 Jun 15;276(24):21129-35. Epub 2001 Mar 26.PMID: 11274165 [PubMed - indexed for MEDLINE]Related articlesFree article

Virus-induced autoimmune diabetes: most beta-cells die through inflammatory cytokines and not perforin from autoreactive (anti-viral) cytotoxic T-lymphocytes.

Seewaldt S, Thomas HE, Ejrnaes M, Christen U, Wolfe T, Rodrigo E, Coon B, Michelsen B, Kay TW, von Herrath MG.

Diabetes. 2000 Nov;49(11):1801-9.PMID: 11078446 [PubMed - indexed for MEDLINE]Related articlesFree article

Cost of institute was small change to Roche.

Christen U.

Nature. 2000 Aug 3;406(6795):455. No abstract available. PMID: 10952286 [PubMed - indexed for MEDLINE]Related articles

Local IL-4 expression in the lung reduces pulmonary influenza-virus-specific secondary cytotoxic T cell responses.

Bot A, Holz A, Christen U, Wolfe T, Temann A, Flavell R, von Herrath M.

Virology. 2000 Mar 30;269(1):66-77.PMID: 10725199 [PubMed - indexed for MEDLINE]Related articles

Immune response to a recombinant human TNFR55-IgG1 fusion protein: auto-antibodies in rheumatoid arthritis (RA) and multiple sclerosis (MS) patients have neither neutralizing nor agonist activities.

Christen U, Thuerkauf R, Stevens R, Lesslauer W.

Hum Immunol. 1999 Sep;60(9):774-90.PMID: 10527384 [PubMed - indexed for MEDLINE]Related articles

Rat GTP cyclohydrolase I is a homodecameric protein complex containing high-affinity calcium-binding sites.

Steinmetz MO, Plüss C, Christen U, Wolpensinger B, Lustig A, Werner ER, Wachter H, Engel A, Aebi U, Pfeilschifter J, Kammerer RA.

J Mol Biol. 1998 May 29;279(1):189-99.PMID: 9636709 [PubMed - indexed for MEDLINE]Related articles

The lipoic acid containing components of the 2-oxoacid dehydrogenase complexes mimic trifluoroacetylated proteins and are autoantigens associated with halothane hepatitis.

Frey N, Christen U, Jenö P, Yeaman SJ, Shimomura Y, Kenna JG, Gandolfi AJ, Ranek L, Gut J.

Chem Res Toxicol. 1995 Jul-Aug;8(5):736-46.PMID: 7548757 [PubMed - indexed for MEDLINE]Related articles

Molecular mimicry in halothane hepatitis: biochemical and structural characterization of lipoylated autoantigens.

Gut J, Christen U, Frey N, Koch V, Stoffler D.

Toxicology. 1995 Mar 31;97(1-3):199-224. Review.PMID: 7716787 [PubMed - indexed for MEDLINE]Related articles

Identification of the dihydrolipoamide acetyltransferase subunit of the human pyruvate dehydrogenase complex as an autoantigen in halothane hepatitis. Molecular mimicry of trifluoroacetyl-lysine by lipoic acid.

Christen U, Quinn J, Yeaman SJ, Kenna JG, Clarke JB, Gandolfi AJ, Gut J.

Eur J Biochem. 1994 Aug 1;223(3):1035-47.PMID: 7519986 [PubMed - indexed for MEDLINE]Related articlesFree article

Halothane metabolism: the dihydrolipoamide acetyltransferase subunit of the pyruvate dehydrogenase complex molecularly mimics trifluoroacetyl-protein adducts.

Christen U, Jenö P, Gut J.

Biochemistry. 1993 Feb 16;32(6):1492-9.PMID: 8431428 [PubMed - indexed for MEDLINE]Related articles

Mechanisms of halothane toxicity: novel insights.

Gut J, Christen U, Huwyler J.

Pharmacol Ther. 1993;58(2):133-55. Review.PMID: 8415876 [PubMed - indexed for MEDLINE]Related articles

Molecular mimicry of trifluoroacetylated human liver protein adducts by constitutive proteins and immunochemical evidence for its impairment in halothane hepatitis.

Gut J, Christen U, Huwyler J, Bürgin M, Kenna JG.

Eur J Biochem. 1992 Dec 1;210(2):569-76.PMID: 1459138 [PubMed - indexed for MEDLINE]Related articlesFree article

The kidney as a novel target tissue for protein adduct formation associated with metabolism of halothane and the candidate chlorofluorocarbon replacement 2,2-dichloro-1,1,1-trifluoroethane.

Huwyler J, Aeschlimann D, Christen U, Gut J.

Eur J Biochem. 1992 Jul 1;207(1):229-38.PMID: 1628651 [PubMed - indexed for MEDLINE]Related articlesFree article

Halothane metabolism: immunochemical evidence for molecular mimicry of trifluoroacetylated liver protein adducts by constitutive polypeptides.

Christen U, Bürgin M, Gut J.

Mol Pharmacol. 1991 Sep;40(3):390-400.PMID: 1716732 [PubMed - indexed for MEDLINE]Related articles