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Strategic nonmyeloablative conditioning: CD154:CD40 costimulatory blockade at primary bone marrow transplantation promotes engraftment for secondary bone marrow transplantation after engraftment failure.
Xu H, Huang Y, Chilton PM, Hussain LR, Tanner MK, Yan J, Ildstad ST.
J Immunol. 2008 Nov 1;181(9):6616-24.PMID: 18941252 [PubMed - indexed for MEDLINE]Related articlesFree article
Plasmacytoid precursor dendritic cells from NOD mice exhibit impaired function: are they a component of diabetes pathogenesis?
Huang Y, Fugier-Vivier IJ, Miller T, Elliott MJ, Xu H, Bozulic LD, Chilton PM, Ildstad ST.
Diabetes. 2008 Sep;57(9):2360-70. Epub 2008 Jun 20.PMID: 18567821 [PubMed - indexed for MEDLINE]Related articlesFree article
Impaired Bcl3 up-regulation leads to enhanced lipopolysaccharide-induced interleukin (IL)-23P19 gene expression in IL-10(-/-) mice.
Mühlbauer M, Chilton PM, Mitchell TC, Jobin C.
J Biol Chem. 2008 May 23;283(21):14182-9. Epub 2008 Mar 28.PMID: 18375954 [PubMed - indexed for MEDLINE]Related articlesFree article
Adjuvant induced glucose uptake by activated T cells is not correlated with increased survival.
Sengupta S, Vitale RJ, Chilton PM, Mitchell TC.
Adv Exp Med Biol. 2008;614:65-72.PMID: 18290315 [PubMed - indexed for MEDLINE]Related articles
TNF-alpha is critical to facilitate hemopoietic stem cell engraftment and function.
Rezzoug F, Huang Y, Tanner MK, Wysoczynski M, Schanie CL, Chilton PM, Ratajczak MZ, Fugier-Vivier IJ, Ildstad ST.
J Immunol. 2008 Jan 1;180(1):49-57.PMID: 18097003 [PubMed - indexed for MEDLINE]Related articlesFree article
Costimulatory blockade of CD154-CD40 in combination with T-cell lymphodepletion results in prevention of allogeneic sensitization.
Xu H, Yan J, Huang Y, Chilton PM, Ding C, Schanie CL, Wang L, Ildstad ST.
Blood. 2008 Mar 15;111(6):3266-75. Epub 2007 Sep 7.PMID: 17827394 [PubMed - indexed for MEDLINE]Related articlesFree article
The vaccine adjuvant monophosphoryl lipid A as a TRIF-biased agonist of TLR4.
Mata-Haro V, Cekic C, Martin M, Chilton PM, Casella CR, Mitchell TC.
Science. 2007 Jun 15;316(5831):1628-32.PMID: 17569868 [PubMed - indexed for MEDLINE]Related articlesFree article
Unrestrained glycogen synthase kinase-3 beta activity leads to activated T cell death and can be inhibited by natural adjuvant.
Sengupta S, Jayaraman P, Chilton PM, Casella CR, Mitchell TC.
J Immunol. 2007 May 15;178(10):6083-91.PMID: 17475833 [PubMed - indexed for MEDLINE]Related articlesFree article
Addition of cyclophosphamide to T-cell depletion-based nonmyeloablative conditioning allows donor T-cell engraftment and clonal deletion of alloreactive host T-cells after bone marrow transplantation.
Xu H, Chilton PM, Huang Y, Schanie CL, Yan J, Ildstad ST.
Transplantation. 2007 Apr 15;83(7):954-63.PMID: 17460568 [PubMed - indexed for MEDLINE]Related articles
Humoral immunity is the dominant barrier for allogeneic bone marrow engraftment in sensitized recipients.
Xu H, Chilton PM, Tanner MK, Huang Y, Schanie CL, Dy-Liacco M, Yan J, Ildstad ST.
Blood. 2006 Nov 15;108(10):3611-9. Epub 2006 Aug 3.PMID: 16888094 [PubMed - indexed for MEDLINE]Related articlesFree article
CD8 T cells require Bcl-3 for maximal gamma interferon production upon secondary exposure to antigen.
Chilton PM, Mitchell TC.
Infect Immun. 2006 Jul;74(7):4180-9.PMID: 16790793 [PubMed - indexed for MEDLINE]Related articlesFree article
Adjuvant-induced survival signaling in clonally expanded T cells is associated with transient increases in pAkt levels and sustained uptake of glucose.
Sengupta S, Chilton PM, Mitchell TC.
Immunobiology. 2005;210(9):647-59.PMID: 16325488 [PubMed - indexed for MEDLINE]Related articles
The low-toxicity versions of LPS, MPL adjuvant and RC529, are efficient adjuvants for CD4+ T cells.
Thompson BS, Chilton PM, Ward JR, Evans JT, Mitchell TC.
J Leukoc Biol. 2005 Dec;78(6):1273-80. Epub 2005 Oct 4.PMID: 16204643 [PubMed - indexed for MEDLINE]Related articlesFree article
NK cells play a critical role in the regulation of class I-deficient hemopoietic stem cell engraftment: evidence for NK tolerance correlates with receptor editing.
Huang Y, Rezzoug F, Xu H, Chilton PM, Schanie CL, Fugier-Vivier I, Ildstad ST.
J Immunol. 2005 Sep 15;175(6):3753-61.PMID: 16148121 [PubMed - indexed for MEDLINE]Related articlesFree article
Plasmacytoid precursor dendritic cells facilitate allogeneic hematopoietic stem cell engraftment.
Fugier-Vivier IJ, Rezzoug F, Huang Y, Graul-Layman AJ, Schanie CL, Xu H, Chilton PM, Ildstad ST.
J Exp Med. 2005 Feb 7;201(3):373-83.PMID: 15699072 [PubMed - indexed for MEDLINE]Related articlesFree article
CD45 congenic bone marrow transplantation: evidence for T cell-mediated immunity.
Xu H, Exner BG, Chilton PM, Schanie C, Ildstad ST.
Stem Cells. 2004;22(6):1039-48.PMID: 15536194 [PubMed - indexed for MEDLINE]Related articlesFree article
Hematopoietic stem cells from NOD mice exhibit autonomous behavior and a competitive advantage in allogeneic recipients.
Chilton PM, Rezzoug F, Ratajczak MZ, Fugier-Vivier I, Ratajczak J, Kucia M, Huang Y, Tanner MK, Ildstad ST.
Blood. 2005 Mar 1;105(5):2189-97. Epub 2004 Nov 2.PMID: 15522953 [PubMed - indexed for MEDLINE]Related articlesFree article
Preconditioning of NOD mice with anti-CD8 mAb and costimulatory blockade enhances chimerism and tolerance and prevents diabetes, while depletion of alpha beta-TCR+ and CD4+ cells negates the effect.
Ildstad ST, Chilton PM, Xu H, Domenick MA, Ray MB.
Blood. 2005 Mar 15;105(6):2577-84. Epub 2004 Oct 21.PMID: 15498851 [PubMed - indexed for MEDLINE]Related articlesFree article
Flt3-ligand treatment prevents diabetes in NOD mice.
Chilton PM, Rezzoug F, Fugier-Vivier I, Weeter LA, Xu H, Huang Y, Ray MB, Ildstad ST.
Diabetes. 2004 Aug;53(8):1995-2002.PMID: 15277378 [PubMed - indexed for MEDLINE]Related articlesFree article
A delay in bone marrow transplantation after partial conditioning improves engraftment.
Xu H, Exner BG, Chilton PM, Tanner MK, Mueller YM, Rezzoug F, Ildstad ST.
Transplantation. 2004 Mar 27;77(6):819-26.PMID: 15077020 [PubMed - indexed for MEDLINE]Related articles
Matching at the MHC class I K locus is essential for long-term engraftment of purified hematopoietic stem cells: a role for host NK cells in regulating HSC engraftment.
Huang Y, Rezzoug F, Chilton PM, Grimes HL, Cramer DE, Ildstad ST.
Blood. 2004 Aug 1;104(3):873-80. Epub 2004 Mar 30.PMID: 15054040 [PubMed - indexed for MEDLINE]Related articlesFree article
Production of donor T cells is critical for induction of donor-specific tolerance and maintenance of chimerism.
Xu H, Chilton PM, Huang Y, Schanie CL, Ildstad ST.
J Immunol. 2004 Feb 1;172(3):1463-71.PMID: 14734723 [PubMed - indexed for MEDLINE]Related articlesFree article
The role of alphabeta- and gammadelta-T cells in allogenic donor marrow on engraftment, chimerism, and graft-versus-host disease.
Huang Y, Cramer DE, Ray MB, Chilton PM, Que X, Ildstad ST.
Transplantation. 2001 Dec 27;72(12):1907-14.PMID: 11773887 [PubMed - indexed for MEDLINE]Related articles
Bone marrow cell graft engineering: from bench to bedside.
Chilton PM, Huang Y, Ildstad ST.
Leuk Lymphoma. 2001 Mar;41(1-2):19-34. Review.PMID: 11342354 [PubMed - indexed for MEDLINE]Related articles
Regulation of the production of soluble IL-4 receptors in murine cutaneous leishmaniasis. The roles of IL-12 and IL-4.
Fernandez-Botran R, Chilton PM, Hondowicz BD, Vetvickova J, Yan J, Jones W 3rd, Scott P.
J Leukoc Biol. 1999 Sep;66(3):481-8.PMID: 10496319 [PubMed - indexed for MEDLINE]Related articlesFree article
Regulation of the expression of the soluble and membrane forms of the murine IL-4 receptor.
Chilton PM, Fernandez-Botran R.
Cell Immunol. 1997 Sep 15;180(2):104-15.PMID: 9341740 [PubMed - indexed for MEDLINE]Related articles
The production of soluble interleukin 4 receptors is preferentially regulated by the murine Th2 cell subset.
Fernandez-Botran R, Chilton PM, Ma Y, Windsor JL, Street NE.
Cytokine. 1997 Mar;9(3):166-77.PMID: 9126705 [PubMed - indexed for MEDLINE]Related articles
Control of the production of soluble interleukin-4 receptors: implications in immunoregulation.
J Leukoc Biol. 1996 Apr;59(4):499-504. Review.PMID: 8613696 [PubMed - indexed for MEDLINE]Related articlesFree article
Soluble cytokine receptors: their roles in immunoregulation, disease, and therapy.
Fernandez-Botran R, Chilton PM, Ma Y.
Adv Immunol. 1996;63:269-336. Review. No abstract available. PMID: 8787633 [PubMed - indexed for MEDLINE]Related articles
Linked in vivo expression of soluble interleukin-4 receptor and interleukin-4 in murine schistosomiasis.
Fernandez-Botran R, Wynn TA, Hieny S, Caspar P, Chilton PM, Sher A.
Eur J Immunol. 1995 Mar;25(3):649-56.PMID: 7705393 [PubMed - indexed for MEDLINE]Related articles
Production of soluble IL-4 receptors by murine spleen cells is regulated by T cell activation and IL-4.
J Immunol. 1993 Dec 1;151(11):5907-17.PMID: 8245438 [PubMed - indexed for MEDLINE]Related articles
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J Immunol. 2008 Nov 1; 181(9):6616-24.
[J Immunol. 2008]
Diabetes. 2008 Sep; 57(9):2360-70.
[Diabetes. 2008]
J Biol Chem. 2008 May 23; 283(21):14182-9.
[J Biol Chem. 2008]
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