PubMed

Triazine and pyrimidine based ROCK inhibitors with efficacy in spontaneous hypertensive rat model.

Ho KK, Beasley JR, Belanger L, Black D, Chan JH, Dunn D, Hu B, Klon A, Kultgen SG, Ohlmeyer M, Parlato SM, Ray PC, Pham Q, Rong Y, Roughton AL, Walker TL, Wright J, Xu K, Xu Y, Zhang L, Webb M.

Bioorg Med Chem Lett. 2009 Nov 1;19(21):6027-31. Epub 2009 Sep 17.PMID: 19800787 [PubMed - in process]Related articles

Case report: Effective treatment of Cotard's syndrome: quetiapine in combination with venlafaxine.

Chan JH, Chen CH, Robson D, Tan HK.

Psychiatry Clin Neurosci. 2009 Feb;63(1):125-6. No abstract available. PMID: 19154221 [PubMed - indexed for MEDLINE]Related articles

Structural basis for the improved drug resistance profile of new generation benzophenone non-nucleoside HIV-1 reverse transcriptase inhibitors.

Ren J, Chamberlain PP, Stamp A, Short SA, Weaver KL, Romines KR, Hazen R, Freeman A, Ferris RG, Andrews CW, Boone L, Chan JH, Stammers DK.

J Med Chem. 2008 Aug 28;51(16):5000-8. Epub 2008 Jul 30.PMID: 18665583 [PubMed - indexed for MEDLINE]Related articles

Idiopathic cervical dystonia: Report of discordance in a pair of monozygotic twins.

Chan JH, Tsui JK.

Parkinsonism Relat Disord. 1997 Nov;3(3):167-9.PMID: 18591071 [PubMed - in process]Related articles

Kinetics of immune cell migration at the human ocular surface.

Chan JH, Amankwah R, Robins RA, Gray T, Dua HS.

Br J Ophthalmol. 2008 Jul;92(7):970-5.PMID: 18577649 [PubMed - indexed for MEDLINE]Related articles

Functional vision with bilateral ReZoom and ReSTOR intraocular lenses 6 months after cataract surgery.

Chiam PJ, Chan JH, Haider SI, Karia N, Kasaby H, Aggarwal RK.

J Cataract Refract Surg. 2007 Dec;33(12):2057-61.PMID: 18053904 [PubMed - indexed for MEDLINE]Related articles

Treatment of lupus-prone mice with a dual inhibitor of TLR7 and TLR9 leads to reduction of autoantibody production and amelioration of disease symptoms.

Barrat FJ, Meeker T, Chan JH, Guiducci C, Coffman RL.

Eur J Immunol. 2007 Dec;37(12):3582-6.PMID: 18034431 [PubMed - indexed for MEDLINE]Related articles

Gab2 antisense oligonucleotide blocks rat basophilic leukemic cell functions.

Chan JH, Liao W, Lau HY, Wong WS.

Int Immunopharmacol. 2007 Jul;7(7):937-44. Epub 2007 Apr 2.PMID: 17499196 [PubMed - indexed for MEDLINE]Related articles

Relationship of potency and resilience to drug resistant mutations for GW420867X revealed by crystal structures of inhibitor complexes for wild-type, Leu100Ile, Lys101Glu, and Tyr188Cys mutant HIV-1 reverse transcriptases.

Ren J, Nichols CE, Chamberlain PP, Weaver KL, Short SA, Chan JH, Kleim JP, Stammers DK.

J Med Chem. 2007 May 17;50(10):2301-9. Epub 2007 Apr 19.PMID: 17441703 [PubMed - indexed for MEDLINE]Related articles

Ciprofloxacin-induced palatal tremor.

Cheung YF, Wong WW, Tang KW, Chan JH, Li PC.

Mov Disord. 2007 May 15;22(7):1038-43.PMID: 17357133 [PubMed - indexed for MEDLINE]Related articles

A prospective randomized double-blind trial of the use of intrathecal fentanyl in patients undergoing lumbar spinal surgery.

Chan JH, Heilpern GN, Packham I, Trehan RK, Marsh GD, Knibb AA.

Spine (Phila Pa 1976). 2006 Oct 15;31(22):2529-33.PMID: 17047539 [PubMed - indexed for MEDLINE]Related articles

ReSTOR intraocular lens implantation in cataract surgery: quality of vision.

Chiam PJ, Chan JH, Aggarwal RK, Kasaby S.

J Cataract Refract Surg. 2006 Sep;32(9):1459-63. Erratum in: J Cataract Refract Surg. 2006 Dec;32(12):1987. PMID: 16931256 [PubMed - indexed for MEDLINE]Related articles

Properties regulating the nature of the plasmacytoid dendritic cell response to Toll-like receptor 9 activation.

Guiducci C, Ott G, Chan JH, Damon E, Calacsan C, Matray T, Lee KD, Coffman RL, Barrat FJ.

J Exp Med. 2006 Aug 7;203(8):1999-2008. Epub 2006 Jul 24.PMID: 16864658 [PubMed - indexed for MEDLINE]Related articlesFree article

Antisense oligonucleotides: from design to therapeutic application.

Chan JH, Lim S, Wong WS.

Clin Exp Pharmacol Physiol. 2006 May-Jun;33(5-6):533-40. Review.PMID: 16700890 [PubMed - indexed for MEDLINE]Related articles

Structure-activity relationship studies of novel benzophenones leading to the discovery of a potent, next generation HIV nonnucleoside reverse transcriptase inhibitor.

Romines KR, Freeman GA, Schaller LT, Cowan JR, Gonzales SS, Tidwell JH, Andrews CW 3rd, Stammers DK, Hazen RJ, Ferris RG, Short SA, Chan JH, Boone LR.

J Med Chem. 2006 Jan 26;49(2):727-39.PMID: 16420058 [PubMed - indexed for MEDLINE]Related articles

Gene transfer of pro-opiomelanocortin prohormone suppressed the growth and metastasis of melanoma: involvement of alpha-melanocyte-stimulating hormone-mediated inhibition of the nuclear factor kappaB/cyclooxygenase-2 pathway.

Liu GS, Liu LF, Lin CJ, Tseng JC, Chuang MJ, Lam HC, Lee JK, Yang LC, Chan JH, Howng SL, Tai MH.

Mol Pharmacol. 2006 Feb;69(2):440-51. Epub 2005 Nov 3.PMID: 16269535 [PubMed - indexed for MEDLINE]Related articlesFree article

Anti-human immunodeficiency virus type 1 activity of the nonnucleoside reverse transcriptase inhibitor GW678248 in combination with other antiretrovirals against clinical isolate viruses and in vitro selection for resistance.

Hazen RJ, Harvey RJ, St Clair MH, Ferris RG, Freeman GA, Tidwell JH, Schaller LT, Cowan JR, Short SA, Romines KR, Chan JH, Boone LR.

Antimicrob Agents Chemother. 2005 Nov;49(11):4465-73.PMID: 16251284 [PubMed - indexed for MEDLINE]Related articlesFree article

Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus.

Barrat FJ, Meeker T, Gregorio J, Chan JH, Uematsu S, Akira S, Chang B, Duramad O, Coffman RL.

J Exp Med. 2005 Oct 17;202(8):1131-9.PMID: 16230478 [PubMed - indexed for MEDLINE]Related articlesFree article

Antiviral activity of GW678248, a novel benzophenone nonnucleoside reverse transcriptase inhibitor.

Ferris RG, Hazen RJ, Roberts GB, St Clair MH, Chan JH, Romines KR, Freeman GA, Tidwell JH, Schaller LT, Cowan JR, Short SA, Weaver KL, Selleseth DW, Moniri KR, Boone LR.

Antimicrob Agents Chemother. 2005 Oct;49(10):4046-51.PMID: 16189079 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibitors of TLR-9 act on multiple cell subsets in mouse and man in vitro and prevent death in vivo from systemic inflammation.

Duramad O, Fearon KL, Chang B, Chan JH, Gregorio J, Coffman RL, Barrat FJ.

J Immunol. 2005 May 1;174(9):5193-200.PMID: 15843514 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhaled p38alpha mitogen-activated protein kinase antisense oligonucleotide attenuates asthma in mice.

Duan W, Chan JH, McKay K, Crosby JR, Choo HH, Leung BP, Karras JG, Wong WS.

Am J Respir Crit Care Med. 2005 Mar 15;171(6):571-8. Epub 2004 Nov 19.PMID: 15557129 [PubMed - indexed for MEDLINE]Related articlesFree article

Transgenic plant-derived siRNAs can suppress propagation of influenza virus in mammalian cells.

Zhou Y, Chan JH, Chan AY, Chak RK, Wong EY, Chye ML, Peiris JS, Poon LL, Lam E.

FEBS Lett. 2004 Nov 19;577(3):345-50. Erratum in: FEBS Lett. 2006 Jul 24;580(17):4302. PMID: 15556607 [PubMed - indexed for MEDLINE]Related articles

Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 2.

Freeman GA, Andrews Iii CW 3rd, Hopkins AL, Lowell GS, Schaller LT, Cowan JR, Gonzales SS, Koszalka GW, Hazen RJ, Boone LR, Ferris RG, Creech KL, Roberts GB, Short SA, Weaver K, Reynolds DJ, Milton J, Ren J, Stuart DI, Stammers DK, Chan JH.

J Med Chem. 2004 Nov 18;47(24):5923-36.PMID: 15537347 [PubMed - indexed for MEDLINE]Related articles

Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 1.

Hopkins AL, Ren J, Milton J, Hazen RJ, Chan JH, Stuart DI, Stammers DK.

J Med Chem. 2004 Nov 18;47(24):5912-22.PMID: 15537346 [PubMed - indexed for MEDLINE]Related articles

Can a less pejorative Chinese translation for schizophrenia reduce stigma? A study of adolescents' attitudes toward people with schizophrenia.

Chung KF, Chan JH.

Psychiatry Clin Neurosci. 2004 Oct;58(5):507-15.PMID: 15482582 [PubMed - indexed for MEDLINE]Related articles

Anti-inflammatory effects of mitogen-activated protein kinase kinase inhibitor U0126 in an asthma mouse model.

Duan W, Chan JH, Wong CH, Leung BP, Wong WS.

J Immunol. 2004 Jun 1;172(11):7053-9.PMID: 15153527 [PubMed - indexed for MEDLINE]Related articlesFree article

Mitochondrial dysfunction and rod-like lesions associated with administration of beta2 adrenoceptor agonist formoterol.

Kiernan MC, Bullpitt P, Chan JH.

Neuromuscul Disord. 2004 Jun;14(6):375-7.PMID: 15145339 [PubMed - indexed for MEDLINE]Related articles

Pseudohypopyon due to malignant infiltration of the anterior chamber in multiple myeloma.

Chan JH, Dua HS, Tranos PG, Jagger JD, Lim FL.

Eye (Lond). 2005 Jan;19(1):112-3. No abstract available. PMID: 15105820 [PubMed - indexed for MEDLINE]Related articles

Identification of a stretch of six divergent amino acids on the alpha5 helix of Galpha16 as a major determinant of the promiscuity and efficiency of receptor coupling.

Ho MK, Chan JH, Wong CS, Wong YH.

Biochem J. 2004 Jun 1;380(Pt 2):361-9.PMID: 15005654 [PubMed - indexed for MEDLINE]Related articlesFree article

Novel benzophenones as non-nucleoside reverse transcriptase inhibitors of HIV-1.

Chan JH, Freeman GA, Tidwell JH, Romines KR, Schaller LT, Cowan JR, Gonzales SS, Lowell GS, Andrews CW 3rd, Reynolds DJ, St Clair M, Hazen RJ, Ferris RG, Creech KL, Roberts GB, Short SA, Weaver K, Koszalka GW, Boone LR.

J Med Chem. 2004 Feb 26;47(5):1175-82.PMID: 14971897 [PubMed - indexed for MEDLINE]Related articles

Phase II study of alpha-tocopherol in improving the cognitive function of patients with temporal lobe radionecrosis.

Chan AS, Cheung MC, Law SC, Chan JH.

Cancer. 2004 Jan 15;100(2):398-404.PMID: 14716777 [PubMed - indexed for MEDLINE]Related articlesFree article

Replacement of the alpha5 helix of Galpha16 with Galphas-specific sequences enhances promiscuity of Galpha16 toward Gs-coupled receptors.

Hazari A, Lowes V, Chan JH, Wong CS, Ho MK, Wong YH.

Cell Signal. 2004 Jan;16(1):51-62.PMID: 14607275 [PubMed - indexed for MEDLINE]Related articles

IL-10 regulates plasmacytoid dendritic cell response to CpG-containing immunostimulatory sequences.

Duramad O, Fearon KL, Chan JH, Kanzler H, Marshall JD, Coffman RL, Barrat FJ.

Blood. 2003 Dec 15;102(13):4487-92. Epub 2003 Aug 28.PMID: 12946990 [PubMed - indexed for MEDLINE]Related articlesFree article

Galpha(16/z) chimeras efficiently link a wide range of G protein-coupled receptors to calcium mobilization.

Liu AM, Ho MK, Wong CS, Chan JH, Pau AH, Wong YH.

J Biomol Screen. 2003 Feb;8(1):39-49.PMID: 12854997 [PubMed - indexed for MEDLINE]Related articles

Three-dimensional time-of-flight subtraction angiography of subacute cerebral hemorrhage.

Chan JH, Peh WC, Tsui EY, Wong KP, Yuen MK.

AJR Am J Roentgenol. 2003 Jul;181(1):242-4. No abstract available. PMID: 12818867 [PubMed - indexed for MEDLINE]Related articlesFree article

IL-10 synergistically enhances GM-CSF-induced CCR1 expression in myelomonocytic cells.

Li H, Cheung W, Choo HH, Chan JH, Lai PS, Fred Wong WS.

Biochem Biophys Res Commun. 2003 May 2;304(2):417-24.PMID: 12711332 [PubMed - indexed for MEDLINE]Related articles

Impact of radionecrosis on cognitive dysfunction in patients after radiotherapy for nasopharyngeal carcinoma.

Cheung MC, Chan AS, Law SC, Chan JH, Tse VK.

Cancer. 2003 Apr 15;97(8):2019-26.PMID: 12673733 [PubMed - indexed for MEDLINE]Related articlesFree article

3D time of flight MR angiography: acquisition with small field of view and low phase encodes.

Chan JH, Tsui EY, Kwong KL, Poon WL, Yuen MK, Leung JO, Lai WT, Yu CW, Wong KP.

Comput Med Imaging Graph. 2003 Jul-Aug;27(4):283-7.PMID: 12631512 [PubMed - indexed for MEDLINE]Related articles

Diffuse axonal injury: detection of changes in anisotropy of water diffusion by diffusion-weighted imaging.

Chan JH, Tsui EY, Peh WC, Fong D, Fok KF, Leung KM, Yuen MK, Fung KK.

Neuroradiology. 2003 Jan;45(1):34-8. Epub 2002 Dec 10.PMID: 12525952 [PubMed - indexed for MEDLINE]Related articles

Excitability of human muscle afferents studied using threshold tracking of the H reflex.

Lin CS, Chan JH, Pierrot-Deseilligny E, Burke D.

J Physiol. 2002 Dec 1;545(Pt 2):661-9.PMID: 12456841 [PubMed - indexed for MEDLINE]Related articlesFree article

Syphilitic myelitis with diffuse spinal cord abnormality on MR imaging.

Tsui EY, Ng SH, Chow L, Lai KF, Fong D, Chan JH.

Eur Radiol. 2002 Dec;12(12):2973-6. Epub 2001 Dec 21.PMID: 12439578 [PubMed - indexed for MEDLINE]Related articles

Evaluation of cerebral abscesses by diffusion-weighted MR imaging and MR spectroscopy.

Tsui EY, Chan JH, Cheung YK, Lai KF, Fong D, Ng SH.

Comput Med Imaging Graph. 2002 Sep-Oct;26(5):347-51.PMID: 12204241 [PubMed - indexed for MEDLINE]Related articles

Tumefactive demyelinating lesions by combined perfusion-weighted and diffusion weighted imaging.

Tsui EY, Leung WH, Chan JH, Cheung YK, Ng SH.

Comput Med Imaging Graph. 2002 Sep-Oct;26(5):343-6.PMID: 12204240 [PubMed - indexed for MEDLINE]Related articles

Digital subtraction in gadolinium-enhanced MR imaging of the brain: a method to reduce contrast dosage.

Chan JH, Tsui EY, Chan CY, Lai KF, Chau LF, Fong D, Mok CK, Cheung YK, Wong KP, Yuen MK.

Eur Radiol. 2002 Sep;12(9):2317-21. Epub 2002 Feb 14.PMID: 12195488 [PubMed - indexed for MEDLINE]Related articles

Excitability changes in human peripheral nerve axons in a paradigm mimicking paired-pulse transcranial magnetic stimulation.

Chan JH, Lin CS, Pierrot-Deseilligny E, Burke D.

J Physiol. 2002 Aug 1;542(Pt 3):951-61.PMID: 12154192 [PubMed - indexed for MEDLINE]Related articlesFree article

"Order effect" in the provision of medication information.

de Almeida Neto AC, Chen TF, Chan JH.

Med J Aust. 2002 Apr 15;176(8):401-2. No abstract available. PMID: 12041642 [PubMed - indexed for MEDLINE]Related articlesFree article

Acute vertebral body compression fractures: discrimination between benign and malignant causes using apparent diffusion coefficients.

Chan JH, Peh WC, Tsui EY, Chau LF, Cheung KK, Chan KB, Yuen MK, Wong ET, Wong KP.

Br J Radiol. 2002 Mar;75(891):207-14.PMID: 11932212 [PubMed - indexed for MEDLINE]Related articlesFree article

Creutzfeldt-Jakob disease in Hong Kong.

Ng KK, Li PC, Wong CK, Chan JH, Yeung JH, Loo KT.

Hong Kong Med J. 1997 Dec;3(4):439-443.PMID: 11847399 [PubMed - as supplied by publisher]Related articlesFree article

Discrimination of an infected brain tumor from a cerebral abscess by combined MR perfusion and diffusion imaging.

Chan JH, Tsui EY, Chau LF, Chow KY, Chan MS, Yuen MK, Chan TL, Cheng WK, Wong KP.

Comput Med Imaging Graph. 2002 Jan-Feb;26(1):19-23.PMID: 11734370 [PubMed - indexed for MEDLINE]Related articles

Idiopathic pulmonary artery aneurysm: digital subtraction pulmonary angiography grossly underestimates the size of the aneurysm.

Tsui EY, Cheung YK, Chow L, Chau LF, Yu SK, Chan JH.

Clin Imaging. 2001 May-Jun;25(3):178-80.PMID: 11679224 [PubMed - indexed for MEDLINE]Related articles