PubMed

Balancing needs and means: the dilemma of the beta-cell in the modern world.

Leibowitz G, Kaiser N, Cerasi E.

Diabetes Obes Metab. 2009 Nov;11 Suppl 4:1-9.PMID: 19817783 [PubMed - in process]Related articles

beta-Cell research - A decade of rapid growth.

Ahrén B, Accili D, Boitard C, Efendic S, Henquin JC, Seino S, Steiner DF, Cerasi E.

Diabetes Obes Metab. 2009 Nov;11 Suppl 4:iv-ix. No abstract available. PMID: 19817782 [PubMed - in process]Related articles

Glucose amplifies fatty acid-induced endoplasmic reticulum stress in pancreatic beta-cells via activation of mTORC1.

Bachar E, Ariav Y, Ketzinel-Gilad M, Cerasi E, Kaiser N, Leibowitz G.

PLoS One. 2009;4(3):e4954. Epub 2009 Mar 23.PMID: 19305497 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin counteracts glucotoxic effects by suppressing thioredoxin-interacting protein production in INS-1E beta cells and in Psammomys obesus pancreatic islets.

Shaked M, Ketzinel-Gilad M, Ariav Y, Cerasi E, Kaiser N, Leibowitz G.

Diabetologia. 2009 Apr;52(4):636-44. Epub 2009 Feb 13.PMID: 19214472 [PubMed - indexed for MEDLINE]Related articles

Novel D-xylose derivatives stimulate muscle glucose uptake by activating AMP-activated protein kinase alpha.

Gruzman A, Shamni O, Ben Yakir M, Sandovski D, Elgart A, Alpert E, Cohen G, Hoffman A, Katzhendler Y, Cerasi E, Sasson S.

J Med Chem. 2008 Dec 25;51(24):8096-108.PMID: 19049348 [PubMed - indexed for MEDLINE]Related articles

The role of mTOR in the adaptation and failure of beta-cells in type 2 diabetes.

Leibowitz G, Cerasi E, Ketzinel-Gilad M.

Diabetes Obes Metab. 2008 Nov;10 Suppl 4:157-69. Review.PMID: 18834443 [PubMed - indexed for MEDLINE]Related articles

Pancreatic beta-cell mass or beta-cell function? That is the question!

Henquin JC, Cerasi E, Efendic S, Steiner DF, Boitard C.

Diabetes Obes Metab. 2008 Nov;10 Suppl 4:1-4. No abstract available. PMID: 18834427 [PubMed - indexed for MEDLINE]Related articles

PKCepsilon mediates glucose-regulated insulin production in pancreatic beta-cells.

Warwar N, Dov A, Abramovitch E, Wu R, Jmoudiak M, Haber E, Cerasi E, Nesher R.

Biochim Biophys Acta. 2008 Oct;1783(10):1929-34. Epub 2008 Apr 29.PMID: 18486624 [PubMed - indexed for MEDLINE]Related articles

[And what about diabetes?]

Cerasi E.

Bull Acad Natl Med. 2007 Apr-May;191(4-5):941-3; discussion 943. French. PMID: 18225448 [PubMed - indexed for MEDLINE]Related articles

mTOR inhibition by rapamycin prevents beta-cell adaptation to hyperglycemia and exacerbates the metabolic state in type 2 diabetes.

Fraenkel M, Ketzinel-Gilad M, Ariav Y, Pappo O, Karaca M, Castel J, Berthault MF, Magnan C, Cerasi E, Kaiser N, Leibowitz G.

Diabetes. 2008 Apr;57(4):945-57. Epub 2008 Jan 3.PMID: 18174523 [PubMed - indexed for MEDLINE]Related articlesFree article

[Anatomical and functional plasticity of pancreatic beta-cells and type 2 diabetes]

Cerasi E, Ktorza A.

Med Sci (Paris). 2007 Oct;23(10):885-94. Review. French. PMID: 17937902 [PubMed - indexed for MEDLINE]Related articles

Of mighty mice and diabetic men: animal models of islet dysfunction.

Efendic S, Boitard C, Ferrannini E, Henquin JC, Steiner DF, Cerasi E.

Diabetes Obes Metab. 2007 Nov;9 Suppl 2:1-4. No abstract available. PMID: 17919172 [PubMed - indexed for MEDLINE]Related articles

Comment on: Nathan DM, Buse JB, Davidson MB et al (2006) Management of hyperglycaemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy. A consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetologia 49:1711-1721.

Cerasi E.

Diabetologia. 2007 Mar;50(3):693-4. Epub 2006 Dec 23. No abstract available. PMID: 17187245 [PubMed - indexed for MEDLINE]Related articles

Regulation of insulin secretion and proinsulin biosynthesis by succinate.

Attali V, Parnes M, Ariav Y, Cerasi E, Kaiser N, Leibowitz G.

Endocrinology. 2006 Nov;147(11):5110-8. Epub 2006 Aug 17.PMID: 16916949 [PubMed - indexed for MEDLINE]Related articlesFree article

Dynamics of glucose-induced localization of PKC isoenzymes in pancreatic beta-cells: diabetes-related changes in the GK rat.

Warwar N, Efendic S, Ostenson CG, Haber EP, Cerasi E, Nesher R.

Diabetes. 2006 Mar;55(3):590-9.PMID: 16505220 [PubMed - indexed for MEDLINE]Related articlesFree article

Psammomys obesus, a model for environment-gene interactions in type 2 diabetes.

Kaiser N, Nesher R, Donath MY, Fraenkel M, Behar V, Magnan C, Ktorza A, Cerasi E, Leibowitz G.

Diabetes. 2005 Dec;54 Suppl 2:S137-44. Review.PMID: 16306331 [PubMed - indexed for MEDLINE]Related articlesFree article

A tale of two cousins: type 1 and type 2 diabetes.

Boitard C, Efendic S, Ferrannini E, Henquin JC, Steiner DF, Cerasi E.

Diabetes. 2005 Dec;54 Suppl 2:S1-3. No abstract available. PMID: 16306326 [PubMed - indexed for MEDLINE]Related articlesFree article

K-value and low insulin secretion in a non-obese white population: predicted glucose tolerance after 25 years.

Alvarsson M, Wajngot A, Cerasi E, Efendic S.

Diabetologia. 2005 Nov;48(11):2262-8. Epub 2005 Sep 14.PMID: 16160865 [PubMed - indexed for MEDLINE]Related articles

Characterization of the action of S 21403 (mitiglinide) on insulin secretion and biosynthesis in normal and diabetic beta-cells.

Kaiser N, Nesher R, Oprescu A, Efendic S, Cerasi E.

Br J Pharmacol. 2005 Nov;146(6):872-81.PMID: 16158072 [PubMed - indexed for MEDLINE]Related articlesFree article

Mitochondrial regulation of insulin production in rat pancreatic islets.

Leibowitz G, Khaldi MZ, Shauer A, Parnes M, Oprescu AI, Cerasi E, Jonas JC, Kaiser N.

Diabetologia. 2005 Aug;48(8):1549-59. Epub 2005 Jun 29.PMID: 15986240 [PubMed - indexed for MEDLINE]Related articles

Improvement of metabolic state in an animal model of nutrition-dependent type 2 diabetes following treatment with S 23521, a new glucagon-like peptide 1 (GLP-1) analogue.

Uçkaya G, Delagrange P, Chavanieu A, Grassy G, Berthault MF, Ktorza A, Cerasi E, Leibowitz G, Kaiser N.

J Endocrinol. 2005 Mar;184(3):505-13.PMID: 15749809 [PubMed - indexed for MEDLINE]Related articlesFree article

Dynamic changes in {beta}-cell mass and pancreatic insulin during the evolution of nutrition-dependent diabetes in psammomys obesus: impact of glycemic control.

Kaiser N, Yuli M, Uçkaya G, Oprescu AI, Berthault MF, Kargar C, Donath MY, Cerasi E, Ktorza A.

Diabetes. 2005 Jan;54(1):138-45.PMID: 15616021 [PubMed - indexed for MEDLINE]Related articlesFree article

Impact of treatment on islet function in type 2 diabetes.

Henquin JC, Boitard C, Cerasi E, Ferrannini E, Steiner DF, Efendic S.

Diabetes. 2004 Dec;53 Suppl 3:S1-5. No abstract available. PMID: 15561896 [PubMed - indexed for MEDLINE]Related articlesFree article

Novel factors in the regulation of beta-cell function.

Boitard C, Cerasi E, Efendic S, Henquin JC, Steiner DF, Ferrannini E.

Diabetes. 2004 Feb;53 Suppl 1:S1-3. No abstract available. PMID: 14749258 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin does not mediate glucose stimulation of proinsulin biosynthesis.

Leibowitz G, Oprescu AI, Uçkaya G, Gross DJ, Cerasi E, Kaiser N.

Diabetes. 2003 Apr;52(4):998-1003.PMID: 12663472 [PubMed - indexed for MEDLINE]Related articlesFree article

Gliclazide directly inhibits arginine-induced glucagon release.

Cejvan K, Coy DH, Holst JJ, Cerasi E, Efendic S.

Diabetes. 2002 Dec;51 Suppl 3:S381-4.PMID: 12475779 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of pdx-1 gene expression.

Melloul D, Marshak S, Cerasi E.

Diabetes. 2002 Dec;51 Suppl 3:S320-5. Review.PMID: 12475770 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose-regulated proinsulin gene expression is required for adequate insulin production during chronic glucose exposure.

Leibowitz G, Uçkaya G, Oprescu AI, Cerasi E, Gross DJ, Kaiser N.

Endocrinology. 2002 Sep;143(9):3214-20.PMID: 12193532 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased glucose sensitivity of stimulus-secretion coupling in islets from Psammomys obesus after diet induction of diabetes.

Pertusa JA, Nesher R, Kaiser N, Cerasi E, Henquin JC, Jonas JC.

Diabetes. 2002 Aug;51(8):2552-60.PMID: 12145170 [PubMed - indexed for MEDLINE]Related articlesFree article

Does gliclazide stimulate first-phase, second-phase, or both phases of insulin release?

Cerasi E.

Horm Metab Res. 2002 Feb;34(2):107-8; author reply 109-10. No abstract available. PMID: 11972296 [PubMed - indexed for MEDLINE]Related articles

Regulation of insulin gene transcription.

Melloul D, Marshak S, Cerasi E.

Diabetologia. 2002 Mar;45(3):309-26. Review.PMID: 11914736 [PubMed - indexed for MEDLINE]Related articles

Insulin responses to sulfonylureas.

Cerasi E.

Diabetes Res Clin Pract. 2002 Apr;56(1):69-70; author reply 71. No abstract available. PMID: 11879723 [PubMed - indexed for MEDLINE]Related articles

Beta-cell protein kinases and the dynamics of the insulin response to glucose.

Nesher R, Anteby E, Yedovizky M, Warwar N, Kaiser N, Cerasi E.

Diabetes. 2002 Feb;51 Suppl 1:S68-73. Review.PMID: 11815461 [PubMed - indexed for MEDLINE]Related articlesFree article

Modeling phasic insulin release: immediate and time-dependent effects of glucose.

Nesher R, Cerasi E.

Diabetes. 2002 Feb;51 Suppl 1:S53-9. Review.PMID: 11815459 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin secretion: movement at all levels.

Henquin JC, Boitard C, Efendic S, Ferrannini E, Steiner DF, Cerasi E.

Diabetes. 2002 Feb;51 Suppl 1:S1-2. No abstract available. PMID: 11815449 [PubMed - indexed for MEDLINE]Related articlesFree article

IPF1/PDX1 deficiency and beta-cell dysfunction in Psammomys obesus, an animal With type 2 diabetes.

Leibowitz G, Ferber S, Apelqvist A, Edlund H, Gross DJ, Cerasi E, Melloul D, Kaiser N.

Diabetes. 2001 Aug;50(8):1799-806.PMID: 11473041 [PubMed - indexed for MEDLINE]Related articlesFree article

A pancreatic beta -cell-specific enhancer in the human PDX-1 gene is regulated by hepatocyte nuclear factor 3beta (HNF-3beta ), HNF-1alpha, and SPs transcription factors.

Ben-Shushan E, Marshak S, Shoshkes M, Cerasi E, Melloul D.

J Biol Chem. 2001 May 18;276(20):17533-40. Epub 2001 Feb 5.PMID: 11278466 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulatory elements involved in human pdx-1 gene expression.

Marshak S, Ben-Shushan E, Shoshkes M, Havin L, Cerasi E, Melloul D.

Diabetes. 2001 Feb;50 Suppl 1:S37-8.PMID: 11272196 [PubMed - indexed for MEDLINE]Related articles

Defective glucose-regulated insulin gene expression associated with PDX-1 deficiency in the Psammomys obesus model of type 2 diabetes.

Leibowitz G, Melloul D, Yuli M, Gross DJ, Apelqvist A, Edlund H, Cerasi E, Kaiser N.

Diabetes. 2001 Feb;50 Suppl 1:S138-9. No abstract available. PMID: 11272175 [PubMed - indexed for MEDLINE]Related articles

beta-cell-specific expression of insulin and PDX-1 genes.

Marshak S, Benshushan E, Shoshkes M, Leibovitz G, Kaiser N, Gross D, Bertuzzi F, Cerasi E, Melloul D.

Diabetes. 2001 Feb;50 Suppl 1:S131-2. No abstract available. PMID: 11272171 [PubMed - indexed for MEDLINE]Related articles

beta-cell glucotoxicity in the Psammomys obesus model of type 2 diabetes.

Leibowitz G, Yuli M, Donath MY, Nesher R, Melloul D, Cerasi E, Gross DJ, Kaiser N.

Diabetes. 2001 Feb;50 Suppl 1:S113-7.PMID: 11272167 [PubMed - indexed for MEDLINE]Related articles

The islet in type 2 diabetes: back to center stage.

Cerasi E, Boitard C, Efendic S, Ferrannini E, Henquin JC, Steiner DF.

Diabetes. 2001 Feb;50 Suppl 1:S1-3. No abstract available. PMID: 11272163 [PubMed - indexed for MEDLINE]Related articles

Defective stimulus-secretion coupling in islets of Psammomys obesus, an animal model for type 2 diabetes.

Nesher R, Warwar N, Khan A, Efendic S, Cerasi E, Kaiser N.

Diabetes. 2001 Feb;50(2):308-14.PMID: 11272141 [PubMed - indexed for MEDLINE]Related articlesFree article

Early intensive insulin treatment for induction of long-term glycaemic control in type 2 diabetes.

Glaser B, Cerasi E.

Diabetes Obes Metab. 1999 Mar;1(2):67-74. Review. No abstract available. PMID: 11220514 [PubMed - indexed for MEDLINE]Related articles

Type 2 diabetes: to stimulate or not to stimulate the beta cell.

Cerasi E.

Metabolism. 2000 Oct;49(10 Suppl 2):1-2. No abstract available. PMID: 11078467 [PubMed - indexed for MEDLINE]Related articles

Functional conservation of regulatory elements in the pdx-1 gene: PDX-1 and hepatocyte nuclear factor 3beta transcription factors mediate beta-cell-specific expression.

Marshak S, Benshushan E, Shoshkes M, Havin L, Cerasi E, Melloul D.

Mol Cell Biol. 2000 Oct;20(20):7583-90.PMID: 11003654 [PubMed - indexed for MEDLINE]Related articlesFree article

[Type 2 diabetes and beta cell apoptosis]

Cerasi E, Kaiser N, Leibowitz G.

Diabetes Metab. 2000 Jun;26 Suppl 3:13-6. Review. French. PMID: 10945145 [PubMed - indexed for MEDLINE]Related articlesFree article

[Non-insulin dependent diabetes and apoptosis of beta-cells]

Kaiser N, Donath MY, Gross DJ, Cerasi E.

Journ Annu Diabetol Hotel Dieu. 1999:13-23. French. No abstract available. PMID: 10732401 [PubMed - indexed for MEDLINE]Related articles

Regulation of the insulin gene by glucose: stimulation of trans-activation potency of human PDX-1 N-terminal domain.

Shushan EB, Cerasi E, Melloul D.

DNA Cell Biol. 1999 Jun;18(6):471-9.PMID: 10390156 [PubMed - indexed for MEDLINE]Related articles

Impaired beta-cell functions induced by chronic exposure of cultured human pancreatic islets to high glucose.

Marshak S, Leibowitz G, Bertuzzi F, Socci C, Kaiser N, Gross DJ, Cerasi E, Melloul D.

Diabetes. 1999 Jun;48(6):1230-6.PMID: 10342809 [PubMed - indexed for MEDLINE]Related articlesFree article