PubMed

Nonerythropoietic tissue protective compounds are highly effective facilitators of wound healing.

Erbayraktar Z, Erbayraktar S, Yilmaz O, Cerami A, Coleman T, Brines M.

Mol Med. 2009 Jul-Aug;15(7-8):235-41. Epub 2009 Apr 16.PMID: 19593407 [PubMed - indexed for MEDLINE]Related articlesFree article

Erythropoietin modulation of astrocyte water permeability as a component of neuroprotection.

Gunnarson E, Song Y, Kowalewski JM, Brismar H, Brines M, Cerami A, Andersson U, Zelenina M, Aperia A.

Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1602-7. Epub 2009 Jan 21.PMID: 19164545 [PubMed - indexed for MEDLINE]Related articlesFree article

Erythropoietin-mediated tissue protection: reducing collateral damage from the primary injury response.

Brines M, Cerami A.

J Intern Med. 2008 Nov;264(5):405-32. Review.PMID: 19017170 [PubMed - indexed for MEDLINE]Related articles

Nonerythropoietic, tissue-protective peptides derived from the tertiary structure of erythropoietin.

Brines M, Patel NS, Villa P, Brines C, Mennini T, De Paola M, Erbayraktar Z, Erbayraktar S, Sepodes B, Thiemermann C, Ghezzi P, Yamin M, Hand CC, Xie QW, Coleman T, Cerami A.

Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10925-30. Epub 2008 Aug 1.PMID: 18676614 [PubMed - indexed for MEDLINE]Related articlesFree article

Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin. Science, 1985, 229(4716):869-871. Classical article.

Beutler B, Milsark IW, Cerami AC.

J Immunol. 2008 Jul 1;181(1):7-9. No abstract available. PMID: 18566363 [PubMed - indexed for MEDLINE]Related articlesFree article

TNF receptor I sensitizes neurons to erythropoietin- and VEGF-mediated neuroprotection after ischemic and excitotoxic injury.

Taoufik E, Petit E, Divoux D, Tseveleki V, Mengozzi M, Roberts ML, Valable S, Ghezzi P, Quackenbush J, Brines M, Cerami A, Probert L.

Proc Natl Acad Sci U S A. 2008 Apr 22;105(16):6185-90. Epub 2008 Apr 14.PMID: 18413601 [PubMed - indexed for MEDLINE]Related articlesFree article

Carbamylated erythropoietin ameliorates the metabolic stress induced in vivo by severe chronic hypoxia.

Fantacci M, Bianciardi P, Caretti A, Coleman TR, Cerami A, Brines M, Samaja M.

Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17531-6. Epub 2006 Nov 7.PMID: 17090665 [PubMed - indexed for MEDLINE]Related articlesFree article

Nonhematopoietic erythropoietin derivatives prevent motoneuron degeneration in vitro and in vivo.

Mennini T, De Paola M, Bigini P, Mastrotto C, Fumagalli E, Barbera S, Mengozzi M, Viviani B, Corsini E, Marinovich M, Torup L, Van Beek J, Leist M, Brines M, Cerami A, Ghezzi P.

Mol Med. 2006 Jul-Aug;12(7-8):153-60.PMID: 17088947 [PubMed - indexed for MEDLINE]Related articlesFree article

Carbamylated erythropoietin reduces radiosurgically-induced brain injury.

Erbayraktar S, de Lanerolle N, de Lotbinière A, Knisely JP, Erbayraktar Z, Yilmaz O, Cerami A, Coleman TR, Brines M.

Mol Med. 2006 Apr-Jun;12(4-6):74-80.PMID: 16953562 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduced functional deficits, neuroinflammation, and secondary tissue damage after treatment of stroke by nonerythropoietic erythropoietin derivatives.

Villa P, van Beek J, Larsen AK, Gerwien J, Christensen S, Cerami A, Brines M, Leist M, Ghezzi P, Torup L.

J Cereb Blood Flow Metab. 2007 Mar;27(3):552-63. Epub 2006 Jul 12.PMID: 16835629 [PubMed - indexed for MEDLINE]Related articles

Discovering erythropoietin's extra-hematopoietic functions: biology and clinical promise.

Brines M, Cerami A.

Kidney Int. 2006 Jul;70(2):246-50. Epub 2006 May 31. Review.PMID: 16738535 [PubMed - indexed for MEDLINE]Related articles

Protective effect of erythropoietin and its carbamylated derivative in experimental Cisplatin peripheral neurotoxicity.

Bianchi R, Brines M, Lauria G, Savino C, Gilardini A, Nicolini G, Rodriguez-Menendez V, Oggioni N, Canta A, Penza P, Lombardi R, Minoia C, Ronchi A, Cerami A, Ghezzi P, Cavaletti G.

Clin Cancer Res. 2006 Apr 15;12(8):2607-12.PMID: 16638873 [PubMed - indexed for MEDLINE]Related articlesFree article

Amelioration of spinal cord compressive injury by pharmacological preconditioning with erythropoietin and a nonerythropoietic erythropoietin derivative.

Grasso G, Sfacteria A, Erbayraktar S, Passalacqua M, Meli F, Gokmen N, Yilmaz O, La Torre D, Buemi M, Iacopino DG, Coleman T, Cerami A, Brines M, Tomasello F.

J Neurosurg Spine. 2006 Apr;4(4):310-8.PMID: 16619678 [PubMed - indexed for MEDLINE]Related articles

Cytoprotective doses of erythropoietin or carbamylated erythropoietin have markedly different procoagulant and vasoactive activities.

Coleman TR, Westenfelder C, Tögel FE, Yang Y, Hu Z, Swenson L, Leuvenink HG, Ploeg RJ, d'Uscio LV, Katusic ZS, Ghezzi P, Zanetti A, Kaushansky K, Fox NE, Cerami A, Brines M.

Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5965-70. Epub 2006 Apr 3.PMID: 16585502 [PubMed - indexed for MEDLINE]Related articlesFree article

Delayed administration of erythropoietin and its non-erythropoietic derivatives ameliorates chronic murine autoimmune encephalomyelitis.

Savino C, Pedotti R, Baggi F, Ubiali F, Gallo B, Nava S, Bigini P, Barbera S, Fumagalli E, Mennini T, Vezzani A, Rizzi M, Coleman T, Cerami A, Brines M, Ghezzi P, Bianchi R.

J Neuroimmunol. 2006 Mar;172(1-2):27-37. Epub 2005 Dec 7.PMID: 16337691 [PubMed - indexed for MEDLINE]Related articles

Methylprednisolone neutralizes the beneficial effects of erythropoietin in experimental spinal cord injury.

Gorio A, Madaschi L, Di Stefano B, Carelli S, Di Giulio AM, De Biasi S, Coleman T, Cerami A, Brines M.

Proc Natl Acad Sci U S A. 2005 Nov 8;102(45):16379-84. Epub 2005 Oct 31.PMID: 16260722 [PubMed - indexed for MEDLINE]Related articlesFree article

Tumor necrosis factor as a pharmacological target.

Ghezzi P, Cerami A.

Mol Biotechnol. 2005 Nov;31(3):239-44. Review.PMID: 16230774 [PubMed - indexed for MEDLINE]Related articles

Emerging biological roles for erythropoietin in the nervous system.

Brines M, Cerami A.

Nat Rev Neurosci. 2005 Jun;6(6):484-94. Review.PMID: 15928718 [PubMed - indexed for MEDLINE]Related articles

A nonerythropoietic derivative of erythropoietin protects the myocardium from ischemia-reperfusion injury.

Fiordaliso F, Chimenti S, Staszewsky L, Bai A, Carlo E, Cuccovillo I, Doni M, Mengozzi M, Tonelli R, Ghezzi P, Coleman T, Brines M, Cerami A, Latini R.

Proc Natl Acad Sci U S A. 2005 Feb 8;102(6):2046-51. Epub 2005 Jan 25.PMID: 15671158 [PubMed - indexed for MEDLINE]Related articlesFree article

Erythropoietin mediates tissue protection through an erythropoietin and common beta-subunit heteroreceptor.

Brines M, Grasso G, Fiordaliso F, Sfacteria A, Ghezzi P, Fratelli M, Latini R, Xie QW, Smart J, Su-Rick CJ, Pobre E, Diaz D, Gomez D, Hand C, Coleman T, Cerami A.

Proc Natl Acad Sci U S A. 2004 Oct 12;101(41):14907-12. Epub 2004 Sep 29.PMID: 15456912 [PubMed - indexed for MEDLINE]Related articlesFree article

Derivatives of erythropoietin that are tissue protective but not erythropoietic.

Leist M, Ghezzi P, Grasso G, Bianchi R, Villa P, Fratelli M, Savino C, Bianchi M, Nielsen J, Gerwien J, Kallunki P, Larsen AK, Helboe L, Christensen S, Pedersen LO, Nielsen M, Torup L, Sager T, Sfacteria A, Erbayraktar S, Erbayraktar Z, Gokmen N, Yilmaz O, Cerami-Hand C, Xie QW, Coleman T, Cerami A, Brines M.

Science. 2004 Jul 9;305(5681):239-42.PMID: 15247477 [PubMed - indexed for MEDLINE]Related articlesFree article

The aging factor in health and disease: the promise of basic research on aging.

Butler RN, Warner HR, Williams TF, Austad SN, Brody JA, Campisi J, Cerami A, Cohen G, Cristofalo VJ, Drachman DA, Finch CE, Fridovich I, Harley CB, Havlik RJ, Martin GM, Miller RA, Olshansky SJ, Pereira-Smith OM, Smith JR, Sprott RL, West MD, Wilmoth JR, Wright WE.

Aging Clin Exp Res. 2004 Apr;16(2):104-11; discussion 111-2. Review. No abstract available. PMID: 15195984 [PubMed - indexed for MEDLINE]Related articles

Erythropoietin as a tissue-protective cytokine in brain injury: what do we know and where do we go?

Grasso G, Sfacteria A, Cerami A, Brines M.

Neuroscientist. 2004 Apr;10(2):93-8. Review.PMID: 15070483 [PubMed - indexed for MEDLINE]Related articles

Tumor necrosis factor as a pharmacological target.

Ghezzi P, Cerami A.

Methods Mol Med. 2004;98:1-8. Review.PMID: 15064428 [PubMed - indexed for MEDLINE]Related articles

Increased expression of erythropoietin receptor on blood vessels in the human epileptogenic hippocampus with sclerosis.

Eid T, Brines ML, Cerami A, Spencer DD, Kim JH, Schweitzer JS, Ottersen OP, de Lanerolle NC.

J Neuropathol Exp Neurol. 2004 Jan;63(1):73-83.PMID: 14748563 [PubMed - indexed for MEDLINE]Related articles

Erythropoietin both protects from and reverses experimental diabetic neuropathy.

Bianchi R, Buyukakilli B, Brines M, Savino C, Cavaletti G, Oggioni N, Lauria G, Borgna M, Lombardi R, Cimen B, Comelekoglu U, Kanik A, Tataroglu C, Cerami A, Ghezzi P.

Proc Natl Acad Sci U S A. 2004 Jan 20;101(3):823-8. Epub 2004 Jan 12.PMID: 14718663 [PubMed - indexed for MEDLINE]Related articlesFree article

Erythropoietin: a candidate compound for neuroprotection in schizophrenia.

Ehrenreich H, Degner D, Meller J, Brines M, Béhé M, Hasselblatt M, Woldt H, Falkai P, Knerlich F, Jacob S, von Ahsen N, Maier W, Brück W, Rüther E, Cerami A, Becker W, Sirén AL.

Mol Psychiatry. 2004 Jan;9(1):42-54.PMID: 14581931 [PubMed - indexed for MEDLINE]Related articles

Erythropoietin selectively attenuates cytokine production and inflammation in cerebral ischemia by targeting neuronal apoptosis.

Villa P, Bigini P, Mennini T, Agnello D, Laragione T, Cagnotto A, Viviani B, Marinovich M, Cerami A, Coleman TR, Brines M, Ghezzi P.

J Exp Med. 2003 Sep 15;198(6):971-5.PMID: 12975460 [PubMed - indexed for MEDLINE]Related articlesFree article

Asialoerythropoietin is a nonerythropoietic cytokine with broad neuroprotective activity in vivo.

Erbayraktar S, Grasso G, Sfacteria A, Xie QW, Coleman T, Kreilgaard M, Torup L, Sager T, Erbayraktar Z, Gokmen N, Yilmaz O, Ghezzi P, Villa P, Fratelli M, Casagrande S, Leist M, Helboe L, Gerwein J, Christensen S, Geist MA, Pedersen LØ, Cerami-Hand C, Wuerth JP, Cerami A, Brines M.

Proc Natl Acad Sci U S A. 2003 May 27;100(11):6741-6. Epub 2003 May 13. Erratum in: Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):9102. PMID: 12746497 [PubMed - indexed for MEDLINE]Related articlesFree article

Recombinant human erythropoietin protects the myocardium from ischemia-reperfusion injury and promotes beneficial remodeling.

Calvillo L, Latini R, Kajstura J, Leri A, Anversa P, Ghezzi P, Salio M, Cerami A, Brines M.

Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4802-6. Epub 2003 Mar 27.PMID: 12663857 [PubMed - indexed for MEDLINE]Related articlesFree article

Erythropoietin therapy for acute stroke is both safe and beneficial.

Ehrenreich H, Hasselblatt M, Dembowski C, Cepek L, Lewczuk P, Stiefel M, Rustenbeck HH, Breiter N, Jacob S, Knerlich F, Bohn M, Poser W, Rüther E, Kochen M, Gefeller O, Gleiter C, Wessel TC, De Ryck M, Itri L, Prange H, Cerami A, Brines M, Sirén AL.

Mol Med. 2002 Aug;8(8):495-505.PMID: 12435860 [PubMed - indexed for MEDLINE]Related articlesFree article

Erythropoietin exerts an anti-inflammatory effect on the CNS in a model of experimental autoimmune encephalomyelitis.

Agnello D, Bigini P, Villa P, Mennini T, Cerami A, Brines ML, Ghezzi P.

Brain Res. 2002 Oct 11;952(1):128-34.PMID: 12363412 [PubMed - indexed for MEDLINE]Related articles

Erythropoietin administration protects retinal neurons from acute ischemia-reperfusion injury.

Junk AK, Mammis A, Savitz SI, Singh M, Roth S, Malhotra S, Rosenbaum PS, Cerami A, Brines M, Rosenbaum DM.

Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10659-64. Epub 2002 Jul 18.PMID: 12130665 [PubMed - indexed for MEDLINE]Related articlesFree article

Recombinant human erythropoietin counteracts secondary injury and markedly enhances neurological recovery from experimental spinal cord trauma.

Gorio A, Gokmen N, Erbayraktar S, Yilmaz O, Madaschi L, Cichetti C, Di Giulio AM, Vardar E, Cerami A, Brines M.

Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9450-5. Epub 2002 Jun 24.PMID: 12082184 [PubMed - indexed for MEDLINE]Related articlesFree article

Erythropoietin prevents motor neuron apoptosis and neurologic disability in experimental spinal cord ischemic injury.

Celik M, Gökmen N, Erbayraktar S, Akhisaroglu M, Konakc S, Ulukus C, Genc S, Genc K, Sagiroglu E, Cerami A, Brines M.

Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):2258-63.PMID: 11854521 [PubMed - indexed for MEDLINE]Related articlesFree article

Neuroprotective properties of epoetin alfa.

Cerami A, Brines M, Ghezzi P, Cerami C, Itri LM.

Nephrol Dial Transplant. 2002;17 Suppl 1:8-12. Review.PMID: 11812906 [PubMed - indexed for MEDLINE]Related articlesFree article

Beyond erythropoiesis: novel applications for recombinant human erythropoietin.

Cerami A.

Semin Hematol. 2001 Jul;38(3 Suppl 7):33-9. Review.PMID: 11523026 [PubMed - indexed for MEDLINE]Related articles

Effects of epoetin alfa on the central nervous system.

Cerami A, Brines ML, Ghezzi P, Cerami CJ.

Semin Oncol. 2001 Apr;28(2 Suppl 8):66-70. Review.PMID: 11395856 [PubMed - indexed for MEDLINE]Related articles

Pharmaceutical intervention of advanced glycation endproducts.

Cerami A, Ulrich P.

Novartis Found Symp. 2001;235:202-12; discussion 212-6, 217-20. Review.PMID: 11280026 [PubMed - indexed for MEDLINE]Related articles

Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress.

Sirén AL, Fratelli M, Brines M, Goemans C, Casagrande S, Lewczuk P, Keenan S, Gleiter C, Pasquali C, Capobianco A, Mennini T, Heumann R, Cerami A, Ehrenreich H, Ghezzi P.

Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):4044-9. Epub 2001 Mar 20.PMID: 11259643 [PubMed - indexed for MEDLINE]Related articlesFree article

Protein glycation, diabetes, and aging.

Ulrich P, Cerami A.

Recent Prog Horm Res. 2001;56:1-21. Review.PMID: 11237208 [PubMed - indexed for MEDLINE]Related articlesFree article

A cross-link breaker has sustained effects on arterial and ventricular properties in older rhesus monkeys.

Vaitkevicius PV, Lane M, Spurgeon H, Ingram DK, Roth GS, Egan JJ, Vasan S, Wagle DR, Ulrich P, Brines M, Wuerth JP, Cerami A, Lakatta EG.

Proc Natl Acad Sci U S A. 2001 Jan 30;98(3):1171-5.PMID: 11158613 [PubMed - indexed for MEDLINE]Related articlesFree article

Erythropoietin crosses the blood-brain barrier to protect against experimental brain injury.

Brines ML, Ghezzi P, Keenan S, Agnello D, de Lanerolle NC, Cerami C, Itri LM, Cerami A.

Proc Natl Acad Sci U S A. 2000 Sep 12;97(19):10526-31.PMID: 10984541 [PubMed - indexed for MEDLINE]Related articlesFree article

An advanced glycation endproduct cross-link breaker can reverse age-related increases in myocardial stiffness.

Asif M, Egan J, Vasan S, Jyothirmayi GN, Masurekar MR, Lopez S, Williams C, Torres RL, Wagle D, Ulrich P, Cerami A, Brines M, Regan TJ.

Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2809-13. Erratum in: Proc Natl Acad Sci U S A 2000 May 9;97(10):5679. PMID: 10706607 [PubMed - indexed for MEDLINE]Related articlesFree article

Chloroquine uptake, altered partitioning and the basis of drug resistance: evidence for chloride-dependent ionic regulation.

Martiney JA, Ferrer AS, Cerami A, Dzekunov S, Roepe P.

Novartis Found Symp. 1999;226:265-77; discussion 277-80. Review.PMID: 10645551 [PubMed - indexed for MEDLINE]Related articles

Inhibition of advanced glycation endproduct formation by acetaldehyde: role in the cardioprotective effect of ethanol.

Al-Abed Y, Mitsuhashi T, Li H, Lawson JA, FitzGerald GA, Founds H, Donnelly T, Cerami A, Ulrich P, Bucala R.

Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2385-90.PMID: 10051651 [PubMed - indexed for MEDLINE]Related articlesFree article

Induction of the chemokine beta peptides, MIP-1 alpha and MIP-1 beta, by lipopolysaccharide is differentially regulated by immunomodulatory cytokines gamma-IFN, IL-10, IL-4, and TGF-beta.

Sherry B, Espinoza M, Manogue KR, Cerami A.

Mol Med. 1998 Oct;4(10):648-57.PMID: 9848081 [PubMed - indexed for MEDLINE]Related articlesFree article

Prevention and treatment of experimental autoimmune encephalomyelitis by CNI-1493, a macrophage-deactivating agent.

Martiney JA, Rajan AJ, Charles PC, Cerami A, Ulrich PC, Macphail S, Tracey KJ, Brosnan CF.

J Immunol. 1998 Jun 1;160(11):5588-95.PMID: 9605164 [PubMed - indexed for MEDLINE]Related articlesFree article

CNI-H0294, a nuclear importation inhibitor of the human immunodeficiency virus type 1 genome, abrogates virus replication in infected activated peripheral blood mononuclear cells.

Haffar OK, Smithgall MD, Popov S, Ulrich P, Bruce AG, Nadler SG, Cerami A, Bukrinsky MI.

Antimicrob Agents Chemother. 1998 May;42(5):1133-8.PMID: 9593140 [PubMed - indexed for MEDLINE]Related articlesFree article

Breakers of advanced glycation end products restore large artery properties in experimental diabetes.

Wolffenbuttel BH, Boulanger CM, Crijns FR, Huijberts MS, Poitevin P, Swennen GN, Vasan S, Egan JJ, Ulrich P, Cerami A, Lévy BI.

Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4630-4.PMID: 9539789 [PubMed - indexed for MEDLINE]Related articlesFree article