PubMed

The mammalian target of rapamycin as novel central regulator of puberty onset via modulation of hypothalamic Kiss1 system.

Roa J, Garcia-Galiano D, Varela L, Sánchez-Garrido MA, Pineda R, Castellano JM, Ruiz-Pino F, Romero M, Aguilar E, López M, Gaytan F, Diéguez C, Pinilla L, Tena-Sempere M.

Endocrinology. 2009 Nov;150(11):5016-26. Epub 2009 Sep 4.PMID: 19734277 [PubMed - indexed for MEDLINE]Related articles

Behavioral abnormalities in synapsin II knockout mice implicate a causal factor in schizophrenia.

Dyck BA, Skoblenick KJ, Castellano JM, Ki K, Thomas N, Mishra RK.

Synapse. 2009 Aug;63(8):662-72.PMID: 19360855 [PubMed - indexed for MEDLINE]Related articles

Dual-source CT coronary angiogram in heart transplant recipients in comparison with dobutamine stress echocardiography for detection of cardiac allograft vasculopathy.

Mastrobuoni S, Bastarrika G, Ubilla M, Castaño S, Azcarate P, Barrero EA, Castellano JM, Herreros J, Rabago G.

Transplantation. 2009 Feb 27;87(4):587-90.PMID: 19307798 [PubMed - indexed for MEDLINE]Related articles

Delayed puberty in spontaneously hypertensive rats involves a primary ovarian failure independent of the hypothalamic KiSS-1/GPR54/GnRH system.

Pinilla L, Castellano JM, Romero M, Tena-Sempere M, Gaytán F, Aguilar E.

Endocrinology. 2009 Jun;150(6):2889-97. Epub 2009 Feb 19.PMID: 19228890 [PubMed - indexed for MEDLINE]Related articles

KiSS-1 in the mammalian ovary: distribution of kisspeptin in human and marmoset and alterations in KiSS-1 mRNA levels in a rat model of ovulatory dysfunction.

Gaytán F, Gaytán M, Castellano JM, Romero M, Roa J, Aparicio B, Garrido N, Sánchez-Criado JE, Millar RP, Pellicer A, Fraser HM, Tena-Sempere M.

Am J Physiol Endocrinol Metab. 2009 Mar;296(3):E520-31. Epub 2009 Jan 13.PMID: 19141682 [PubMed - indexed for MEDLINE]Related articles

Persistent impairment of hypothalamic KiSS-1 system after exposures to estrogenic compounds at critical periods of brain sex differentiation.

Navarro VM, Sánchez-Garrido MA, Castellano JM, Roa J, García-Galiano D, Pineda R, Aguilar E, Pinilla L, Tena-Sempere M.

Endocrinology. 2009 May;150(5):2359-67. Epub 2008 Dec 23.PMID: 19106226 [PubMed - indexed for MEDLINE]Related articles

Alterations in hypothalamic KiSS-1 system in experimental diabetes: early changes and functional consequences.

Castellano JM, Navarro VM, Roa J, Pineda R, Sánchez-Garrido MA, García-Galiano D, Vigo E, Dieguez C, Aguilar E, Pinilla L, Tena-Sempere M.

Endocrinology. 2009 Feb;150(2):784-94. Epub 2008 Oct 9.PMID: 18845637 [PubMed - indexed for MEDLINE]Related articles

Kisspeptins and the control of gonadotropin secretion in male and female rodents.

Roa J, Castellano JM, Navarro VM, Handelsman DJ, Pinilla L, Tena-Sempere M.

Peptides. 2009 Jan;30(1):57-66. Epub 2008 Aug 22. Review.PMID: 18793689 [PubMed - indexed for MEDLINE]Related articles

Follicle-stimulating hormone responses to kisspeptin in the female rat at the preovulatory period: modulation by estrogen and progesterone receptors.

Roa J, Vigo E, Castellano JM, Gaytan F, García-Galiano D, Navarro VM, Aguilar E, Dijcks FA, Ederveen AG, Pinilla L, van Noort PI, Tena-Sempere M.

Endocrinology. 2008 Nov;149(11):5783-90. Epub 2008 Jul 17.PMID: 18635654 [PubMed - indexed for MEDLINE]Related articlesFree article

KiSS-1/kisspeptins and the metabolic control of reproduction: physiologic roles and putative physiopathological implications.

Castellano JM, Roa J, Luque RM, Dieguez C, Aguilar E, Pinilla L, Tena-Sempere M.

Peptides. 2009 Jan;30(1):139-45. Epub 2008 Jun 21. Review.PMID: 18634841 [PubMed - indexed for MEDLINE]Related articles

Desensitization of gonadotropin responses to kisspeptin in the female rat: analyses of LH and FSH secretion at different developmental and metabolic states.

Roa J, Vigo E, García-Galiano D, Castellano JM, Navarro VM, Pineda R, Diéguez C, Aguilar E, Pinilla L, Tena-Sempere M.

Am J Physiol Endocrinol Metab. 2008 Jun;294(6):E1088-96. Epub 2008 Apr 15.PMID: 18413669 [PubMed - indexed for MEDLINE]Related articlesFree article

Opposite roles of estrogen receptor (ER)-alpha and ERbeta in the modulation of luteinizing hormone responses to kisspeptin in the female rat: implications for the generation of the preovulatory surge.

Roa J, Vigo E, Castellano JM, Gaytan F, Navarro VM, Aguilar E, Dijcks FA, Ederveen AG, Pinilla L, van Noort PI, Tena-Sempere M.

Endocrinology. 2008 Apr;149(4):1627-37. Epub 2008 Jan 3.PMID: 18174277 [PubMed - indexed for MEDLINE]Related articlesFree article

Synapsin II knockout mice show sensorimotor gating and behavioural abnormalities similar to those in the phencyclidine-induced preclinical animal model of schizophrenia.

Dyck BA, Skoblenick KJ, Castellano JM, Ki K, Thomas N, Mishra RK.

Schizophr Res. 2007 Dec;97(1-3):292-3. Epub 2007 Sep 27. No abstract available. PMID: 17900867 [PubMed - indexed for MEDLINE]Related articles

Association of increased plasma cardiotrophin-1 with inappropriate left ventricular mass in essential hypertension.

López B, Castellano JM, González A, Barba J, Díez J.

Hypertension. 2007 Nov;50(5):977-83. Epub 2007 Sep 10.PMID: 17846346 [PubMed - indexed for MEDLINE]Related articlesFree article

Selective role of neuropeptide Y receptor subtype Y2 in the control of gonadotropin secretion in the rat.

Pinilla L, Fernández-Fernández R, Roa J, Castellano JM, Tena-Sempere M, Aguilar E.

Am J Physiol Endocrinol Metab. 2007 Nov;293(5):E1385-92. Epub 2007 Sep 4.PMID: 17785504 [PubMed - indexed for MEDLINE]Related articlesFree article

MIF-1 and its peptidomimetic analogs attenuate haloperidol-induced vacuous chewing movements and modulate apomorphine-induced rotational behavior in 6-hydroxydopamine-lesioned rats.

Castellano JM, Batrynchuk J, Dolbeare K, Verma V, Mann A, Skoblenick KJ, Johnson RL, Mishra RK.

Peptides. 2007 Oct;28(10):2009-15. Epub 2007 Aug 1.PMID: 17766011 [PubMed - indexed for MEDLINE]Related articles

Novel role of the anorexigenic peptide neuromedin U in the control of LH secretion and its regulation by gonadal hormones and photoperiod.

Vigo E, Roa J, Pineda R, Castellano JM, Navarro VM, Aguilar E, Pinilla L, Tena-Sempere M.

Am J Physiol Endocrinol Metab. 2007 Nov;293(5):E1265-73. Epub 2007 Aug 28.PMID: 17726140 [PubMed - indexed for MEDLINE]Related articlesFree article

Direct stimulatory effect of ghrelin on pituitary release of LH through a nitric oxide-dependent mechanism that is modulated by estrogen.

Fernández-Fernández R, Tena-Sempere M, Roa J, Castellano JM, Navarro VM, Aguilar E, Pinilla L.

Reproduction. 2007 Jun;133(6):1223-32.PMID: 17636176 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of KiSS-1 in rat oviduct: possible involvement in prevention of ectopic implantation?

Gaytán M, Castellano JM, Roa J, Sánchez-Criado JE, Tena-Sempere M, Gaytán F.

Cell Tissue Res. 2007 Sep;329(3):571-9. Epub 2007 May 15.PMID: 17503086 [PubMed - indexed for MEDLINE]Related articles

Neuroendocrine factors in the initiation of puberty: the emergent role of kisspeptin.

Navarro VM, Castellano JM, García-Galiano D, Tena-Sempere M.

Rev Endocr Metab Disord. 2007 Mar;8(1):11-20. Review.PMID: 17340172 [PubMed - indexed for MEDLINE]Related articles

Neuromedin s as novel putative regulator of luteinizing hormone secretion.

Vigo E, Roa J, López M, Castellano JM, Fernandez-Fernandez R, Navarro VM, Pineda R, Aguilar E, Diéguez C, Pinilla L, Tena-Sempere M.

Endocrinology. 2007 Feb;148(2):813-23. Epub 2006 Nov 16.PMID: 17110433 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of hypothalamic KiSS-1 system and rescue of defective gonadotropic responses by kisspeptin in streptozotocin-induced diabetic male rats.

Castellano JM, Navarro VM, Fernández-Fernández R, Roa J, Vigo E, Pineda R, Dieguez C, Aguilar E, Pinilla L, Tena-Sempere M.

Diabetes. 2006 Sep;55(9):2602-10.PMID: 16936210 [PubMed - indexed for MEDLINE]Related articlesFree article

Ontogeny and mechanisms of action for the stimulatory effect of kisspeptin on gonadotropin-releasing hormone system of the rat.

Castellano JM, Navarro VM, Fernández-Fernández R, Castaño JP, Malagón MM, Aguilar E, Dieguez C, Magni P, Pinilla L, Tena-Sempere M.

Mol Cell Endocrinol. 2006 Sep 26;257-258:75-83. Epub 2006 Aug 22.PMID: 16930819 [PubMed - indexed for MEDLINE]Related articles

Effects of galanin-like peptide on luteinizing hormone secretion in the rat: sexually dimorphic responses and enhanced sensitivity at male puberty.

Castellano JM, Navarro VM, Fernández-Fernández R, Roa J, Vigo E, Pineda R, Steiner RA, Aguilar E, Pinilla L, Tena-Sempere M.

Am J Physiol Endocrinol Metab. 2006 Dec;291(6):E1281-9. Epub 2006 Jul 18.PMID: 16849629 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of KiSS-1 in rat ovary: putative local regulator of ovulation?

Castellano JM, Gaytan M, Roa J, Vigo E, Navarro VM, Bellido C, Dieguez C, Aguilar E, Sánchez-Criado JE, Pellicer A, Pinilla L, Gaytan F, Tena-Sempere M.

Endocrinology. 2006 Oct;147(10):4852-62. Epub 2006 Jul 6.PMID: 16825322 [PubMed - indexed for MEDLINE]Related articlesFree article

Novel signals for the integration of energy balance and reproduction.

Fernandez-Fernandez R, Martini AC, Navarro VM, Castellano JM, Dieguez C, Aguilar E, Pinilla L, Tena-Sempere M.

Mol Cell Endocrinol. 2006 Jul 25;254-255:127-32. Epub 2006 Jun 8. Review.PMID: 16759792 [PubMed - indexed for MEDLINE]Related articles

Effects of ghrelin upon gonadotropin-releasing hormone and gonadotropin secretion in adult female rats: in vivo and in vitro studies.

Fernández-Fernández R, Tena-Sempere M, Navarro VM, Barreiro ML, Castellano JM, Aguilar E, Pinilla L.

Neuroendocrinology. 2005;82(5-6):245-55. Epub 2006 Apr 20.PMID: 16721030 [PubMed - indexed for MEDLINE]Related articles

Translocation of AIF in the human and rat striatum following protracted haloperidol, but not clozapine treatment.

Skoblenick KJ, Castellano JM, Rogoza RM, Dyck BA, Thomas N, Gabriele JP, Chong VZ, Mishra RK.

Apoptosis. 2006 May;11(5):663-72.PMID: 16528470 [PubMed - indexed for MEDLINE]Related articles

Hypothalamic expression of KiSS-1 system and gonadotropin-releasing effects of kisspeptin in different reproductive states of the female Rat.

Roa J, Vigo E, Castellano JM, Navarro VM, Fernández-Fernández R, Casanueva FF, Dieguez C, Aguilar E, Pinilla L, Tena-Sempere M.

Endocrinology. 2006 Jun;147(6):2864-78. Epub 2006 Mar 9.PMID: 16527840 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of single or repeated intravenous administration of kisspeptin upon dynamic LH secretion in conscious male rats.

Tovar S, Vázquez MJ, Navarro VM, Fernández-Fernández R, Castellano JM, Vigo E, Roa J, Casanueva FF, Aguilar E, Pinilla L, Dieguez C, Tena-Sempere M.

Endocrinology. 2006 Jun;147(6):2696-704. Epub 2006 Mar 2.PMID: 16513831 [PubMed - indexed for MEDLINE]Related articlesFree article

cDNA array reveals increased expression of glucose-dependent insulinotropic polypeptide following chronic clozapine treatment: role in atypical antipsychotic drug-induced adverse metabolic effects.

Sondhi S, Castellano JM, Chong VZ, Rogoza RM, Skoblenick KJ, Dyck BA, Gabriele J, Thomas N, Ki K, Pristupa ZB, Singh AN, MacCrimmon D, Voruganti P, Foster J, Mishra RK.

Pharmacogenomics J. 2006 Mar-Apr;6(2):131-40.PMID: 16402076 [PubMed - indexed for MEDLINE]Related articles

Stimulatory effect of PYY-(3-36) on gonadotropin secretion is potentiated in fasted rats.

Pinilla L, Fernández-Fernández R, Vigo E, Navarro VM, Roa J, Castellano JM, Pineda R, Tena-Sempere M, Aguilar E.

Am J Physiol Endocrinol Metab. 2006 Jun;290(6):E1162-71. Epub 2006 Jan 3.PMID: 16390861 [PubMed - indexed for MEDLINE]Related articlesFree article

Pattern of orexin expression and direct biological actions of orexin-a in rat testis.

Barreiro ML, Pineda R, Gaytan F, Archanco M, Burrell MA, Castellano JM, Hakovirta H, Nurmio M, Pinilla L, Aguilar E, Toppari J, Dieguez C, Tena-Sempere M.

Endocrinology. 2005 Dec;146(12):5164-75. Epub 2005 Sep 1.PMID: 16141395 [PubMed - indexed for MEDLINE]Related articlesFree article

Modulation of agonist binding to human dopamine receptor subtypes by L-prolyl-L-leucyl-glycinamide and a peptidomimetic analog.

Verma V, Mann A, Costain W, Pontoriero G, Castellano JM, Skoblenick K, Gupta SK, Pristupa Z, Niznik HB, Johnson RL, Nair VD, Mishra RK.

J Pharmacol Exp Ther. 2005 Dec;315(3):1228-36. Epub 2005 Aug 26.PMID: 16126839 [PubMed - indexed for MEDLINE]Related articlesFree article

Changes in hypothalamic KiSS-1 system and restoration of pubertal activation of the reproductive axis by kisspeptin in undernutrition.

Castellano JM, Navarro VM, Fernández-Fernández R, Nogueiras R, Tovar S, Roa J, Vazquez MJ, Vigo E, Casanueva FF, Aguilar E, Pinilla L, Dieguez C, Tena-Sempere M.

Endocrinology. 2005 Sep;146(9):3917-25. Epub 2005 Jun 2.PMID: 15932928 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of KiSS-1 peptide, the natural ligand of GPR54, on follicle-stimulating hormone secretion in the rat.

Navarro VM, Castellano JM, Fernández-Fernández R, Tovar S, Roa J, Mayen A, Barreiro ML, Casanueva FF, Aguilar E, Dieguez C, Pinilla L, Tena-Sempere M.

Endocrinology. 2005 Apr;146(4):1689-97. Epub 2005 Jan 6.PMID: 15637288 [PubMed - indexed for MEDLINE]Related articlesFree article

Advanced vaginal opening and precocious activation of the reproductive axis by KiSS-1 peptide, the endogenous ligand of GPR54.

Navarro VM, Fernández-Fernández R, Castellano JM, Roa J, Mayen A, Barreiro ML, Gaytan F, Aguilar E, Pinilla L, Dieguez C, Tena-Sempere M.

J Physiol. 2004 Dec 1;561(Pt 2):379-86. Epub 2004 Oct 14.PMID: 15486019 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of the potent luteinizing hormone-releasing activity of KiSS-1 peptide, the natural ligand of GPR54.

Navarro VM, Castellano JM, Fernández-Fernández R, Tovar S, Roa J, Mayen A, Nogueiras R, Vazquez MJ, Barreiro ML, Magni P, Aguilar E, Dieguez C, Pinilla L, Tena-Sempere M.

Endocrinology. 2005 Jan;146(1):156-63. Epub 2004 Sep 16.PMID: 15375028 [PubMed - indexed for MEDLINE]Related articlesFree article

Ghrelin inhibits the proliferative activity of immature Leydig cells in vivo and regulates stem cell factor messenger ribonucleic acid expression in rat testis.

Barreiro ML, Gaytan F, Castellano JM, Suominen JS, Roa J, Gaytan M, Aguilar E, Dieguez C, Toppari J, Tena-Sempere M.

Endocrinology. 2004 Nov;145(11):4825-34. Epub 2004 Jul 29.PMID: 15284210 [PubMed - indexed for MEDLINE]Related articlesFree article

Developmental and hormonally regulated messenger ribonucleic acid expression of KiSS-1 and its putative receptor, GPR54, in rat hypothalamus and potent luteinizing hormone-releasing activity of KiSS-1 peptide.

Navarro VM, Castellano JM, Fernández-Fernández R, Barreiro ML, Roa J, Sanchez-Criado JE, Aguilar E, Dieguez C, Pinilla L, Tena-Sempere M.

Endocrinology. 2004 Oct;145(10):4565-74. Epub 2004 Jul 8.PMID: 15242985 [PubMed - indexed for MEDLINE]Related articlesFree article

[(18)F]-FDG PET and localized fibrous mesothelioma.

Cortes J, Rodriguez J, Garcia-Velloso MJ, Rodriguez-Espiteri N, Boan JF, Castellano JM, Torre W.

Lung. 2003;181(1):49-54. Review.PMID: 12879339 [PubMed - indexed for MEDLINE]Related articles

Epidural analgesia and cardiac surgery: worth the risk?

Castellano JM, Durbin CG Jr.

Chest. 2000 Feb;117(2):305-7. No abstract available. PMID: 10669666 [PubMed - indexed for MEDLINE]Related articlesFree article

Chromophore-modified bis-naphthalimides: synthesis and antitumor activity of bis-dibenz[de,h]isoquinoline-1,3-diones.

Braña MF, Castellano JM, Perron D, Maher C, Conlon D, Bousquet PF, George J, Qian XD, Robinson SP.

J Med Chem. 1997 Feb 14;40(4):449-54.PMID: 9046334 [PubMed - indexed for MEDLINE]Related articles

Bis-naphthalimides 3: synthesis and antitumor activity of N,N'-bis[2-(1,8-naphthalimido)-ethyl] alkanediamines.

Braña MF, Castellano JM, Morán M, Pérez de Vega MJ, Perron D, Conlon D, Bousquet PF, Romerdahl CA, Robinson SP.

Anticancer Drug Des. 1996 Jun;11(4):297-309.PMID: 8679053 [PubMed - indexed for MEDLINE]Related articles

Synthesis, structure and antitumor activity of new benz[d,e]isoquinoline-1,3-diones.

Braña MF, Castellano JM, Morán M, Emling F, Kluge M, Schlick E, Klebe G, Walker N.

Arzneimittelforschung. 1995 Dec;45(12):1311-8.PMID: 8595091 [PubMed - indexed for MEDLINE]Related articles

Benzimidazo[1,2-c]quinazolines: a new class of antitumor compounds.

Braña MF, Castellano JM, Keilhauer G, Machuca A, Martín Y, Redondo C, Schlick E, Walker N.

Anticancer Drug Des. 1994 Dec;9(6):527-38.PMID: 7880377 [PubMed - indexed for MEDLINE]Related articles

Bis-naphthalimides: a new class of antitumor agents.

Braña MF, Castellano JM, Morán M, Pérez de Vega MJ, Romerdahl CR, Qian XD, Bousquet P, Emling F, Schlick E, Keilhauer G.

Anticancer Drug Des. 1993 Aug;8(4):257-68.PMID: 8240655 [PubMed - indexed for MEDLINE]Related articles

[Peroxidases and ethylene formation in olive tree leaves]

Vioque B, Fernández-Maculet JC, Albi MA, Castellano JM, Vioque A.

Rev Esp Fisiol. 1989 Mar;45(1):47-52. Spanish. PMID: 2748977 [PubMed - indexed for MEDLINE]Related articles

Synthesis and mode(s) of action of a new series of imide derivatives of 3-nitro-1,8 naphthalic acid.

Braña MF, Castellano JM, Roldán CM, Santos A, Vázquez D, Jiménez A.

Cancer Chemother Pharmacol. 1980;4(1):61-6.PMID: 6153938 [PubMed - indexed for MEDLINE]Related articles

Medicinal chemistry of 3.5-dimethylbenzoic acid, I: N-picolyl-amides.

Braña MF, Castellano JM, Roldán CM, Rabadán FP.

Arch Farmacol Toxicol. 1978 Aug;4(2):237-46. No abstract available. PMID: 727836 [PubMed - indexed for MEDLINE]Related articles