PubMed

Chylomicronemia Elicits Atherosclerosis in Mice.

Weinstein MM, Yin L, Tu Y, Wang X, Wu X, Castellani LW, Walzem RL, Lusis AJ, Fong LG, Beigneux AP, Young SG.

Arterioscler Thromb Vasc Biol. 2009 Oct 8. [Epub ahead of print]PMID: 19815815 [PubMed - as supplied by publisher]Related articles

Genetic disruption of myostatin reduces the development of proatherogenic dyslipidemia and atherogenic lesions in Ldlr null mice.

Tu P, Bhasin S, Hruz PW, Herbst KL, Castellani LW, Hua N, Hamilton JA, Guo W.

Diabetes. 2009 Aug;58(8):1739-48. Epub 2009 Jun 9.PMID: 19509018 [PubMed - indexed for MEDLINE]Related articlesFree article

Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks.

Yang X, Deignan JL, Qi H, Zhu J, Qian S, Zhong J, Torosyan G, Majid S, Falkard B, Kleinhanz RR, Karlsson J, Castellani LW, Mumick S, Wang K, Xie T, Coon M, Zhang C, Estrada-Smith D, Farber CR, Wang SS, van Nas A, Ghazalpour A, Zhang B, Macneil DJ, Lamb JR, Dipple KM, Reitman ML, Mehrabian M, Lum PY, Schadt EE, Lusis AJ, Drake TA.

Nat Genet. 2009 Apr;41(4):415-23. Epub 2009 Mar 8.PMID: 19270708 [PubMed - indexed for MEDLINE]Related articles

Plasma apolipoprotein AV levels in mice are positively associated with plasma triglyceride levels.

Vaessen SF, Dallinga-Thie GM, Ross CJ, Splint LJ, Castellani LW, Rensen PC, Hayden MR, Schaap FG, Kuivenhoven JA.

J Lipid Res. 2009 May;50(5):880-4. Epub 2009 Jan 13.PMID: 19141870 [PubMed - indexed for MEDLINE]Related articles

Identification of ALOX5 as a gene regulating adiposity and pancreatic function.

Mehrabian M, Schulthess FT, Nebohacova M, Castellani LW, Zhou Z, Hartiala J, Oberholzer J, Lusis AJ, Maedler K, Allayee H.

Diabetologia. 2008 Jun;51(6):978-88. Epub 2008 Apr 18.PMID: 18421434 [PubMed - indexed for MEDLINE]Related articles

The antiinflammatory cytokine interleukin-1 receptor antagonist protects from high-fat diet-induced hyperglycemia.

Sauter NS, Schulthess FT, Galasso R, Castellani LW, Maedler K.

Endocrinology. 2008 May;149(5):2208-18. Epub 2008 Jan 31.PMID: 18239070 [PubMed - indexed for MEDLINE]Related articlesFree article

Apolipoprotein AII is a regulator of very low density lipoprotein metabolism and insulin resistance.

Castellani LW, Nguyen CN, Charugundla S, Weinstein MM, Doan CX, Blaner WS, Wongsiriroj N, Lusis AJ.

J Biol Chem. 2008 Apr 25;283(17):11633-44. Epub 2007 Dec 26.PMID: 18160395 [PubMed - indexed for MEDLINE]Related articlesFree article

ApoE-/-Fas-/- C57BL/6 mice: a novel murine model simultaneously exhibits lupus nephritis, atherosclerosis, and osteopenia.

Feng X, Li H, Rumbin AA, Wang X, La Cava A, Brechtelsbauer K, Castellani LW, Witztum JL, Lusis AJ, Tsao BP.

J Lipid Res. 2007 Apr;48(4):794-805. Epub 2007 Jan 26.PMID: 17259598 [PubMed - indexed for MEDLINE]Related articlesFree article

Mass spectral analysis of the apolipoproteins on mouse high density lipoproteins. Detection of post-translational modifications.

Puppione DL, Yam LM, Bassilian S, Souda P, Castellani LW, Schumaker VN, Whitelegge JP.

Biochim Biophys Acta. 2006 Aug;1764(8):1363-71. Epub 2006 Jun 18.PMID: 16876491 [PubMed - indexed for MEDLINE]Related articles

Transgenic mice express human MPO -463G/A alleles at atherosclerotic lesions, developing hyperlipidemia and obesity in -463G males.

Castellani LW, Chang JJ, Wang X, Lusis AJ, Reynolds WF.

J Lipid Res. 2006 Jul;47(7):1366-77. Epub 2006 Apr 25.PMID: 16639078 [PubMed - indexed for MEDLINE]Related articlesFree article

Integrating genotypic and expression data in a segregating mouse population to identify 5-lipoxygenase as a susceptibility gene for obesity and bone traits.

Mehrabian M, Allayee H, Stockton J, Lum PY, Drake TA, Castellani LW, Suh M, Armour C, Edwards S, Lamb J, Lusis AJ, Schadt EE.

Nat Genet. 2005 Nov;37(11):1224-33. Epub 2005 Oct 2. Erratum in: Nat Genet. 2005 Dec;37(12):1381. PMID: 16200066 [PubMed - indexed for MEDLINE]Related articles

Integrating QTL and high-density SNP analyses in mice to identify Insig2 as a susceptibility gene for plasma cholesterol levels.

Cervino AC, Li G, Edwards S, Zhu J, Laurie C, Tokiwa G, Lum PY, Wang S, Castellani LW, Lusis AJ, Carlson S, Sachs AB, Schadt EE.

Genomics. 2005 Nov;86(5):505-17. Epub 2005 Aug 29. Erratum in: Genomics. 2009 Apr;93(4):399. Castellini, Lawrence W [corrected to Castellani, Lawrence W]. PMID: 16126366 [PubMed - indexed for MEDLINE]Related articles

The 3' untranslated region of the lipoprotein lipase gene: haplotype structure and association with post-heparin plasma lipase activity.

Goodarzi MO, Wong H, Quiñones MJ, Taylor KD, Guo X, Castellani LW, Antoine HJ, Yang H, Hsueh WA, Rotter JI.

J Clin Endocrinol Metab. 2005 Aug;90(8):4816-23. Epub 2005 May 31.PMID: 15928243 [PubMed - indexed for MEDLINE]Related articlesFree article

Thioredoxin-interacting protein deficiency disrupts the fasting-feeding metabolic transition.

Sheth SS, Castellani LW, Chari S, Wagg C, Thipphavong CK, Bodnar JS, Tontonoz P, Attie AD, Lopaschuk GD, Lusis AJ.

J Lipid Res. 2005 Jan;46(1):123-34. Epub 2004 Nov 1.PMID: 15520447 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanisms mediating insulin resistance in transgenic mice overexpressing mouse apolipoprotein A-II.

Castellani LW, Gargalovic P, Febbraio M, Charugundla S, Jien ML, Lusis AJ.

J Lipid Res. 2004 Dec;45(12):2377-87. Epub 2004 Oct 1.PMID: 15466364 [PubMed - indexed for MEDLINE]Related articlesFree article

Hyplip2, a new gene for combined hyperlipidemia and increased atherosclerosis.

Wang X, Gargalovic P, Wong J, Gu JL, Wu X, Qi H, Wen P, Xi L, Tan B, Gogliotti R, Castellani LW, Chatterjee A, Lusis AJ.

Arterioscler Thromb Vasc Biol. 2004 Oct;24(10):1928-34. Epub 2004 Aug 26.PMID: 15331434 [PubMed - indexed for MEDLINE]Related articlesFree article

Coronary vasomotor abnormalities in insulin-resistant individuals.

Quiñones MJ, Hernandez-Pampaloni M, Schelbert H, Bulnes-Enriquez I, Jimenez X, Hernandez G, De La Rosa R, Chon Y, Yang H, Nicholas SB, Modilevsky T, Yu K, Van Herle K, Castellani LW, Elashoff R, Hsueh WA.

Ann Intern Med. 2004 May 4;140(9):700-8.PMID: 15126253 [PubMed - indexed for MEDLINE]Related articlesFree article

Mice heterozygous for Atp10c, a putative amphipath, represent a novel model of obesity and type 2 diabetes.

Dhar MS, Sommardahl CS, Kirkland T, Nelson S, Donnell R, Johnson DK, Castellani LW.

J Nutr. 2004 Apr;134(4):799-805.PMID: 15051828 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of macrophage-derived apolipoprotein E on hyperlipidemia and atherosclerosis of LDLR-deficient mice.

Shi W, Wang X, Wong J, Hedrick CC, Wong H, Castellani LW, Lusis AJ.

Biochem Biophys Res Commun. 2004 Apr 23;317(1):223-9.PMID: 15047172 [PubMed - indexed for MEDLINE]Related articles

ApoA-II modulates the association of HDL with class B scavenger receptors SR-BI and CD36.

de Beer MC, Castellani LW, Cai L, Stromberg AJ, de Beer FC, van der Westhuyzen DR.

J Lipid Res. 2004 Apr;45(4):706-15. Epub 2004 Jan 16.PMID: 14729860 [PubMed - indexed for MEDLINE]Related articlesFree article

Peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha) regulates triglyceride metabolism by activation of the nuclear receptor FXR.

Zhang Y, Castellani LW, Sinal CJ, Gonzalez FJ, Edwards PA.

Genes Dev. 2004 Jan 15;18(2):157-69. Epub 2004 Jan 16.PMID: 14729567 [PubMed - indexed for MEDLINE]Related articlesFree article

Dissection of multigenic obesity traits in congenic mouse strains.

Estrada-Smith D, Castellani LW, Wong H, Wen PZ, Chui A, Lusis AJ, Davis RC.

Mamm Genome. 2004 Jan;15(1):14-22.PMID: 14727138 [PubMed - indexed for MEDLINE]Related articles

Biochemical and genetic association of plasma apolipoprotein A-II levels with familial combined hyperlipidemia.

Allayee H, Castellani LW, Cantor RM, de Bruin TW, Lusis AJ.

Circ Res. 2003 Jun 13;92(11):1262-7. Epub 2003 May 8.PMID: 12738753 [PubMed - indexed for MEDLINE]Related articlesFree article

Decreased atherosclerotic lesion formation in human serum paraoxonase transgenic mice.

Tward A, Xia YR, Wang XP, Shi YS, Park C, Castellani LW, Lusis AJ, Shih DM.

Circulation. 2002 Jul 23;106(4):484-90.PMID: 12135950 [PubMed - indexed for MEDLINE]Related articlesFree article

Heritability of subclinical atherosclerosis in Latino families ascertained through a hypertensive parent.

Xiang AH, Azen SP, Buchanan TA, Raffel LJ, Tan S, Cheng LS, Diaz J, Toscano E, Quinonnes M, Liu CR, Liu CH, Castellani LW, Hsueh WA, Rotter JI, Hodis HN.

Arterioscler Thromb Vasc Biol. 2002 May 1;22(5):843-8.PMID: 12006400 [PubMed - indexed for MEDLINE]Related articlesFree article

Transgenic expression of cholesterol-7-alpha-hydroxylase prevents atherosclerosis in C57BL/6J mice.

Miyake JH, Duong-Polk XT, Taylor JM, Du EZ, Castellani LW, Lusis AJ, Davis RA.

Arterioscler Thromb Vasc Biol. 2002 Jan;22(1):121-6.PMID: 11788471 [PubMed - indexed for MEDLINE]Related articlesFree article

Positional cloning of the combined hyperlipidemia gene Hyplip1.

Bodnar JS, Chatterjee A, Castellani LW, Ross DA, Ohmen J, Cavalcoli J, Wu C, Dains KM, Catanese J, Chu M, Sheth SS, Charugundla K, Demant P, West DB, de Jong P, Lusis AJ.

Nat Genet. 2002 Jan;30(1):110-6. Epub 2001 Dec 20.PMID: 11753387 [PubMed - indexed for MEDLINE]Related articles

ApoA-II versus ApoA-I: two for one is not always a good deal.

Castellani LW, Lusis AJ.

Arterioscler Thromb Vasc Biol. 2001 Dec;21(12):1870-2. No abstract available. PMID: 11742857 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased production of apolipoprotein B-containing lipoproteins in the absence of hyperlipidemia in transgenic mice expressing cholesterol 7alpha-hydroxylase.

Miyake JH, Doung XD, Strauss W, Moore GL, Castellani LW, Curtiss LK, Taylor JM, Davis RA.

J Biol Chem. 2001 Jun 29;276(26):23304-11. Epub 2001 Apr 25. Erratum in: J Biol Chem 2001 Nov 2;276(44):41526. PMID: 11323427 [PubMed - indexed for MEDLINE]Related articlesFree article

HDL and the inflammatory response induced by LDL-derived oxidized phospholipids.

Navab M, Berliner JA, Subbanagounder G, Hama S, Lusis AJ, Castellani LW, Reddy S, Shih D, Shi W, Watson AD, Van Lenten BJ, Vora D, Fogelman AM.

Arterioscler Thromb Vasc Biol. 2001 Apr;21(4):481-8. Review. Erratum in: Arterioscler Thromb Vasc Biol 2001 May;21(5):880. PMID: 11304461 [PubMed - indexed for MEDLINE]Related articlesFree article

In vivo interactions of apoA-II, apoA-I, and hepatic lipase contributing to HDL structure and antiatherogenic functions.

Hedrick CC, Castellani LW, Wong H, Lusis AJ.

J Lipid Res. 2001 Apr;42(4):563-70.PMID: 11290828 [PubMed - indexed for MEDLINE]Related articlesFree article

Fine mapping of Hyplip1 and the human homolog, a potential locus for FCHL.

Pajukanta P, Bodnar JS, Sallinen R, Chu M, Airaksinen T, Xiao Q, Castellani LW, Sheth SS, Wessman M, Palotie A, Sinsheimer JS, Demant P, Lusis AJ, Peltonen L.

Mamm Genome. 2001 Mar;12(3):238-45.PMID: 11252174 [PubMed - indexed for MEDLINE]Related articles

Studies with apolipoprotein A-II transgenic mice indicate a role for HDLs in adiposity and insulin resistance.

Castellani LW, Goto AM, Lusis AJ.

Diabetes. 2001 Mar;50(3):643-51.PMID: 11246886 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic control of HDL levels and composition in an interspecific mouse cross (CAST/Ei x C57BL/6J).

Mehrabian M, Castellani LW, Wen PZ, Wong J, Rithaporn T, Hama SY, Hough GP, Johnson D, Albers JJ, Mottino GA, Frank JS, Navab M, Fogelman AM, Lusis AJ.

J Lipid Res. 2000 Dec;41(12):1936-46.PMID: 11108726 [PubMed - indexed for MEDLINE]Related articlesFree article

Combined serum paraoxonase knockout/apolipoprotein E knockout mice exhibit increased lipoprotein oxidation and atherosclerosis.

Shih DM, Xia YR, Wang XP, Miller E, Castellani LW, Subbanagounder G, Cheroutre H, Faull KF, Berliner JA, Witztum JL, Lusis AJ.

J Biol Chem. 2000 Jun 9;275(23):17527-35.PMID: 10748217 [PubMed - indexed for MEDLINE]Related articlesFree article

A locus conferring resistance to diet-induced hypercholesterolemia and atherosclerosis on mouse chromosome 2.

Mouzeyan A, Choi J, Allayee H, Wang X, Sinsheimer J, Phan J, Castellani LW, Reue K, Lusis AJ, Davis RC.

J Lipid Res. 2000 Apr;41(4):573-82.PMID: 10744778 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of group II secretory phospholipase A2 in atherosclerosis: 1. Increased atherogenesis and altered lipoproteins in transgenic mice expressing group IIa phospholipase A2.

Ivandic B, Castellani LW, Wang XP, Qiao JH, Mehrabian M, Navab M, Fogelman AM, Grass DS, Swanson ME, de Beer MC, de Beer F, Lusis AJ.

Arterioscler Thromb Vasc Biol. 1999 May;19(5):1284-90.PMID: 10323781 [PubMed - indexed for MEDLINE]Related articlesFree article

Paradoxical effect on atherosclerosis of hormone-sensitive lipase overexpression in macrophages.

Escary JL, Choy HA, Reue K, Wang XP, Castellani LW, Glass CK, Lusis AJ, Schotz MC.

J Lipid Res. 1999 Mar;40(3):397-404.PMID: 10064727 [PubMed - indexed for MEDLINE]Related articlesFree article

Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis.

Shih DM, Gu L, Xia YR, Navab M, Li WF, Hama S, Castellani LW, Furlong CE, Costa LG, Fogelman AM, Lusis AJ.

Nature. 1998 Jul 16;394(6690):284-7.PMID: 9685159 [PubMed - indexed for MEDLINE]Related articles

Mapping a gene for combined hyperlipidaemia in a mutant mouse strain.

Castellani LW, Weinreb A, Bodnar J, Goto AM, Doolittle M, Mehrabian M, Demant P, Lusis AJ.

Nat Genet. 1998 Apr;18(4):374-7.PMID: 9537422 [PubMed - indexed for MEDLINE]Related articles

Secretory non-pancreatic phospholipase A2: influence on lipoprotein metabolism.

de Beer FC, de Beer MC, van der Westhuyzen DR, Castellani LW, Lusis AJ, Swanson ME, Grass DS.

J Lipid Res. 1997 Nov;38(11):2232-9.PMID: 9392421 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of apolipoprotein AII in transgenic mice converts high density lipoproteins to proinflammatory particles.

Castellani LW, Navab M, Van Lenten BJ, Hedrick CC, Hama SY, Goto AM, Fogelman AM, Lusis AJ.

J Clin Invest. 1997 Jul 15;100(2):464-74.PMID: 9218525 [PubMed - indexed for MEDLINE]Related articlesFree article

Mildly oxidized LDL induces an increased apolipoprotein J/paraoxonase ratio.

Navab M, Hama-Levy S, Van Lenten BJ, Fonarow GC, Cardinez CJ, Castellani LW, Brennan ML, Lusis AJ, Fogelman AM, La Du BN.

J Clin Invest. 1997 Apr 15;99(8):2005-19. Erratum in: J Clin Invest 1997 Jun 15;99(12):3043. PMID: 9109446 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduced aortic lesions and elevated high density lipoprotein levels in transgenic mice overexpressing mouse apolipoprotein A-IV.

Cohen RD, Castellani LW, Qiao JH, Van Lenten BJ, Lusis AJ, Reue K.

J Clin Invest. 1997 Apr 15;99(8):1906-16.PMID: 9109435 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic factors in lipoprotein metabolism. Analysis of a genetic cross between inbred mouse strains NZB/BINJ and SM/J using a complete linkage map approach.

Purcell-Huynh DA, Weinreb A, Castellani LW, Mehrabian M, Doolittle MH, Lusis AJ.

J Clin Invest. 1995 Oct;96(4):1845-58.PMID: 7560076 [PubMed - indexed for MEDLINE]Related articlesFree article

Alteration of lipid profiles in plasma of transgenic mice expressing human lipoprotein lipase.

Liu MS, Jirik FR, LeBoeuf RC, Henderson H, Castellani LW, Lusis AJ, Ma Y, Forsythe IJ, Zhang H, Kirk E, et al.

J Biol Chem. 1994 Apr 15;269(15):11417-24.PMID: 8157673 [PubMed - indexed for MEDLINE]Related articlesFree article

Influence of mouse apolipoprotein A-II on plasma lipoproteins in transgenic mice.

Hedrick CC, Castellani LW, Warden CH, Puppione DL, Lusis AJ.

J Biol Chem. 1993 Sep 25;268(27):20676-82.PMID: 8376417 [PubMed - indexed for MEDLINE]Related articlesFree article

Atherosclerosis in transgenic mice overexpressing apolipoprotein A-II.

Warden CH, Hedrick CC, Qiao JH, Castellani LW, Lusis AJ.

Science. 1993 Jul 23;261(5120):469-72. Erratum in: Science 1993 Oct 8;262(5131):164. PMID: 8332912 [PubMed - indexed for MEDLINE]Related articles

Immune-complex-mediated vasculitis increases coronary artery lipid accumulation in autoimmune-prone MRL mice.

Qiao JH, Castellani LW, Fishbein MC, Lusis AJ.

Arterioscler Thromb. 1993 Jun;13(6):932-43.PMID: 8499414 [PubMed - indexed for MEDLINE]Related articlesFree article

Relationships between fatty acid synthesis and lipid secretion in the isolated perfused rat liver: effects of hyperthyroidism, glucose and oleate.

Castellani LW, Wilcox HC, Heimberg M.

Biochim Biophys Acta. 1991 Nov 5;1086(2):197-208.PMID: 1932102 [PubMed - indexed for MEDLINE]Related articles