PubMed

Fyn mediates leptin actions in the thymus of rodents.

Girasol A, Albuquerque GG, Mansour E, Araújo EP, Degasperi G, Denis RG, Carvalheira JB, Saad MJ, Velloso LA.

PLoS One. 2009 Nov 3;4(11):e7707.PMID: 19888448 [PubMed - in process]Related articlesFree article

The Incapacity of the Surgeon to Identify NASH in Bariatric Surgery Makes Biopsy Mandatory.

Teixeira AR, Bellodi-Privato M, Carvalheira JB, Pilla VF, Pareja JC, D Albuquerque LA.

Obes Surg. 2009 Sep 30. [Epub ahead of print]PMID: 19789933 [PubMed - as supplied by publisher]Related articles

Aspirin attenuates insulin resistance in muscle of diet-induced obese rats by inhibiting inducible nitric oxide synthase production and S-nitrosylation of IRbeta/IRS-1 and Akt.

Carvalho-Filho MA, Ropelle ER, Pauli RJ, Cintra DE, Tsukumo DM, Silveira LR, Curi R, Carvalheira JB, Velloso LA, Saad MJ.

Diabetologia. 2009 Sep 3. [Epub ahead of print]PMID: 19730809 [PubMed - as supplied by publisher]Related articles

An EGFR Tyrosine-Kinase Inhibitor (PD153035) Improves Glucose Tolerance and Insulin Action in High-Fat Diet-Fed Mice.

Prada PO, Ropelle ER, Mourão RH, de Souza CT, Pauli JR, Cintra DE, Schenka A, Rocco SA, Rittner R, Franchini KG, Vassalo J, Velloso LA, Carvalheira JB, Saad MJ.

Diabetes. 2009 Aug 20. [Epub ahead of print]PMID: 19696185 [PubMed - as supplied by publisher]Related articles

Epidemiological and molecular mechanisms aspects linking obesity and cancer.

Osório-Costa F, Rocha GZ, Dias MM, Carvalheira JB.

Arq Bras Endocrinol Metabol. 2009 Mar;53(2):213-26.PMID: 19466214 [PubMed - in process]Related articlesFree article

Birth weight and type 2 diabetes in adults.

Saad MJ, Carvalheira JB, Velloso LA.

JAMA. 2009 Apr 15;301(15):1539; author reply 1540-1. No abstract available. PMID: 19366768 [PubMed - indexed for MEDLINE]Related articles

High-fat diet induces apoptosis of hypothalamic neurons.

Moraes JC, Coope A, Morari J, Cintra DE, Roman EA, Pauli JR, Romanatto T, Carvalheira JB, Oliveira AL, Saad MJ, Velloso LA.

PLoS One. 2009;4(4):e5045. Epub 2009 Apr 2.PMID: 19340313 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of hypothalamic Foxo1 expression reduced food intake in diet-induced obesity rats.

Ropelle ER, Pauli JR, Prada P, Cintra DE, Rocha GZ, Moraes JC, Frederico MJ, da Luz G, Pinho RA, Carvalheira JB, Velloso LA, Saad MA, De Souza CT.

J Physiol. 2009 May 15;587(Pt 10):2341-51. Epub 2009 Mar 30.PMID: 19332486 [PubMed - indexed for MEDLINE]Related articles

Tear film and ocular surface changes in diabetes mellitus.

Alves Mde C, Carvalheira JB, Módulo CM, Rocha EM.

Arq Bras Oftalmol. 2008 Nov-Dec;71(6 Suppl):96-103. Review.PMID: 19274419 [PubMed - indexed for MEDLINE]Related articlesFree article

Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity.

Milanski M, Degasperi G, Coope A, Morari J, Denis R, Cintra DE, Tsukumo DM, Anhe G, Amaral ME, Takahashi HK, Curi R, Oliveira HC, Carvalheira JB, Bordin S, Saad MJ, Velloso LA.

J Neurosci. 2009 Jan 14;29(2):359-70.PMID: 19144836 [PubMed - indexed for MEDLINE]Related articlesFree article

Central exercise action increases the AMPK and mTOR response to leptin.

Ropelle ER, Fernandes MF, Flores MB, Ueno M, Rocco S, Marin R, Cintra DE, Velloso LA, Franchini KG, Saad MJ, Carvalheira JB.

PLoS One. 2008;3(12):e3856. Epub 2008 Dec 4.PMID: 19052642 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of toll-like receptor 2 expression improves insulin sensitivity and signaling in muscle and white adipose tissue of mice fed a high-fat diet.

Caricilli AM, Nascimento PH, Pauli JR, Tsukumo DM, Velloso LA, Carvalheira JB, Saad MJ.

J Endocrinol. 2008 Dec;199(3):399-406. Epub 2008 Sep 11.PMID: 18787058 [PubMed - indexed for MEDLINE]Related articles

Reduction of hypothalamic protein tyrosine phosphatase improves insulin and leptin resistance in diet-induced obese rats.

Picardi PK, Calegari VC, Prada Pde O, Moraes JC, Araújo E, Marcondes MC, Ueno M, Carvalheira JB, Velloso LA, Saad MJ.

Endocrinology. 2008 Aug;149(8):3870-80. Epub 2008 May 8.PMID: 18467448 [PubMed - indexed for MEDLINE]Related articlesFree article

Distinct subsets of hypothalamic genes are modulated by two different thermogenesis-inducing stimuli.

De Souza CT, Pereira-da-Silva M, Araujo EP, Morari J, Alvarez-Rojas F, Bordin S, Moreira-Filho DC, Carvalheira JB, Saad MJ, Velloso LA.

Obesity (Silver Spring). 2008 Jun;16(6):1239-47. Epub 2008 Mar 20.PMID: 18356833 [PubMed - indexed for MEDLINE]Related articles

[Sympathetic system hyperactivity in obesity]

Carvalheira JB.

Arq Bras Endocrinol Metabol. 2008 Feb;52(1):6-7. Portuguese. No abstract available. PMID: 18345391 [PubMed - indexed for MEDLINE]Related articlesFree article

Antineoplastic effect of rapamycin is potentiated by inhibition of IRS-1 signaling in prostate cancer cells xenografts.

Oliveira JC, Souza KK, Dias MM, Faria MC, Ropelle ER, Flores MB, Ueno M, Velloso LA, Saad ST, Saad MJ, Carvalheira JB.

J Cancer Res Clin Oncol. 2008 Aug;134(8):833-9. Epub 2008 Feb 9.PMID: 18264722 [PubMed - indexed for MEDLINE]Related articles

A central role for neuronal AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) in high-protein diet-induced weight loss.

Ropelle ER, Pauli JR, Fernandes MF, Rocco SA, Marin RM, Morari J, Souza KK, Dias MM, Gomes-Marcondes MC, Gontijo JA, Franchini KG, Velloso LA, Saad MJ, Carvalheira JB.

Diabetes. 2008 Mar;57(3):594-605. Epub 2007 Dec 5.PMID: 18057094 [PubMed - indexed for MEDLINE]Related articlesFree article

Acute physical exercise reverses S-nitrosation of the insulin receptor, insulin receptor substrate 1 and protein kinase B/Akt in diet-induced obese Wistar rats.

Pauli JR, Ropelle ER, Cintra DE, Carvalho-Filho MA, Moraes JC, De Souza CT, Velloso LA, Carvalheira JB, Saad MJ.

J Physiol. 2008 Jan 15;586(2):659-71. Epub 2007 Nov 1.PMID: 17974582 [PubMed - indexed for MEDLINE]Related articlesFree article

Infliximab restores glucose homeostasis in an animal model of diet-induced obesity and diabetes.

Araújo EP, De Souza CT, Ueno M, Cintra DE, Bertolo MB, Carvalheira JB, Saad MJ, Velloso LA.

Endocrinology. 2007 Dec;148(12):5991-7. Epub 2007 Aug 30.PMID: 17761768 [PubMed - indexed for MEDLINE]Related articlesFree article

A central role for neuronal adenosine 5'-monophosphate-activated protein kinase in cancer-induced anorexia.

Ropelle ER, Pauli JR, Zecchin KG, Ueno M, de Souza CT, Morari J, Faria MC, Velloso LA, Saad MJ, Carvalheira JB.

Endocrinology. 2007 Nov;148(11):5220-9. Epub 2007 Aug 23.PMID: 17717055 [PubMed - indexed for MEDLINE]Related articlesFree article

L-glutamine supplementation induces insulin resistance in adipose tissue and improves insulin signalling in liver and muscle of rats with diet-induced obesity.

Prada PO, Hirabara SM, de Souza CT, Schenka AA, Zecchin HG, Vassallo J, Velloso LA, Carneiro E, Carvalheira JB, Curi R, Saad MJ.

Diabetologia. 2007 Sep;50(9):1949-59. Epub 2007 Jun 29.PMID: 17604977 [PubMed - indexed for MEDLINE]Related articles

Acanthosis nigricans, tripe palms and the sign of Leser-Trelat in a patient with a benign hepatic neoplasia.

da Costa França AF, Siqueira NS, Carvalheira JB, Saad MJ, Souza EM.

J Eur Acad Dermatol Venereol. 2007 Jul;21(6):846-8. No abstract available. PMID: 17567332 [PubMed - indexed for MEDLINE]Related articles

Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance.

Tsukumo DM, Carvalho-Filho MA, Carvalheira JB, Prada PO, Hirabara SM, Schenka AA, Araújo EP, Vassallo J, Curi R, Velloso LA, Saad MJ.

Diabetes. 2007 Aug;56(8):1986-98. Epub 2007 May 22.PMID: 17519423 [PubMed - indexed for MEDLINE]Related articlesFree article

[Insulin and angiotensin II signaling pathways cross-talk: implications with the association between diabetes mellitus, arterial hypertension and cardiovascular disease]

Carvalho-Filho MA, Carvalheira JB, Velloso LA, Saad MJ.

Arq Bras Endocrinol Metabol. 2007 Mar;51(2):195-203. Review. Portuguese. PMID: 17505626 [PubMed - indexed for MEDLINE]Related articlesFree article

Defective insulin and acetylcholine induction of endothelial cell-nitric oxide synthase through insulin receptor substrate/Akt signaling pathway in aorta of obese rats.

Zecchin HG, Priviero FB, Souza CT, Zecchin KG, Prada PO, Carvalheira JB, Velloso LA, Antunes E, Saad MJ.

Diabetes. 2007 Apr;56(4):1014-24. Epub 2007 Jan 17.PMID: 17229938 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of UCP2 expression reverses diet-induced diabetes mellitus by effects on both insulin secretion and action.

De Souza CT, Araújo EP, Stoppiglia LF, Pauli JR, Ropelle E, Rocco SA, Marin RM, Franchini KG, Carvalheira JB, Saad MJ, Boschero AC, Carneiro EM, Velloso LA.

FASEB J. 2007 Apr;21(4):1153-63. Epub 2007 Jan 5.PMID: 17209127 [PubMed - indexed for MEDLINE]Related articlesFree article

Reversal of diet-induced insulin resistance with a single bout of exercise in the rat: the role of PTP1B and IRS-1 serine phosphorylation.

Ropelle ER, Pauli JR, Prada PO, de Souza CT, Picardi PK, Faria MC, Cintra DE, Fernandes MF, Flores MB, Velloso LA, Saad MJ, Carvalheira JB.

J Physiol. 2006 Dec 15;577(Pt 3):997-1007. Epub 2006 Sep 28.PMID: 17008371 [PubMed - indexed for MEDLINE]Related articlesFree article

Circulating ghrelin concentrations are lowered by intracerebroventricular insulin.

Ueno M, Carvalheira JB, Oliveira RL, Velloso LA, Saad MJ.

Diabetologia. 2006 Oct;49(10):2449-52. Epub 2006 Aug 29.PMID: 16955211 [PubMed - indexed for MEDLINE]Related articles

Exercise improves insulin and leptin sensitivity in hypothalamus of Wistar rats.

Flores MB, Fernandes MF, Ropelle ER, Faria MC, Ueno M, Velloso LA, Saad MJ, Carvalheira JB.

Diabetes. 2006 Sep;55(9):2554-61.PMID: 16936204 [PubMed - indexed for MEDLINE]Related articlesFree article

Selective modulation of the CAP/Cbl pathway in the adipose tissue of high fat diet treated rats.

Prada PO, Pauli JR, Ropelle ER, Zecchin HG, Carvalheira JB, Velloso LA, Saad MJ.

FEBS Lett. 2006 Sep 4;580(20):4889-94. Epub 2006 Aug 10.PMID: 16919274 [PubMed - indexed for MEDLINE]Related articles

Phosphoinositide-specific inositol polyphosphate 5-phosphatase IV inhibits inositide trisphosphate accumulation in hypothalamus and regulates food intake and body weight.

Bertelli DF, Araújo EP, Cesquini M, Stoppa GR, Gasparotto-Contessotto M, Toyama MH, Felix JV, Carvalheira JB, Michelini LC, Chiavegatto S, Boschero AC, Saad MJ, Lopes-Cendes I, Velloso LA.

Endocrinology. 2006 Nov;147(11):5385-99. Epub 2006 Aug 17.PMID: 16916951 [PubMed - indexed for MEDLINE]Related articlesFree article

Use of traditional medicine and globalized complementary and alternative medicine among low-income cancer service users in Brazil.

Tovey P, de Barros NF, Hoehne EL, Carvalheira JB.

Integr Cancer Ther. 2006 Sep;5(3):232-5.PMID: 16880428 [PubMed - indexed for MEDLINE]Related articles

[Insulin resistance/hyperinsulinemia associated diseases not included in the metabolic syndrome]

Carvalheira JB, Saad MJ.

Arq Bras Endocrinol Metabol. 2006 Apr;50(2):360-7. Epub 2006 May 23. Review. Portuguese. PMID: 16767302 [PubMed - indexed for MEDLINE]Related articlesFree article

Targeted disruption of iNOS prevents LPS-induced S-nitrosation of IRbeta/IRS-1 and Akt and insulin resistance in muscle of mice.

Carvalho-Filho MA, Ueno M, Carvalheira JB, Velloso LA, Saad MJ.

Am J Physiol Endocrinol Metab. 2006 Sep;291(3):E476-82. Epub 2006 Apr 25.PMID: 16638822 [PubMed - indexed for MEDLINE]Related articlesFree article

Disruption of metabolic pathways--perspectives for the treatment of cancer.

Araujo EP, Carvalheira JB, Velloso LA.

Curr Cancer Drug Targets. 2006 Feb;6(1):77-87. Review.PMID: 16475977 [PubMed - indexed for MEDLINE]Related articles

Effects of NH4Cl intake on renal growth in rats: role of MAPK signalling pathway.

Bento LM, Carvalheira JB, Menegon LF, Saad MJ, Gontijo JA.

Nephrol Dial Transplant. 2005 Dec;20(12):2654-60. Epub 2005 Sep 16.PMID: 16169866 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of AMPK in rat hypothalamus participates in cold-induced resistance to nutrient-dependent anorexigenic signals.

Roman EA, Cesquini M, Stoppa GR, Carvalheira JB, Torsoni MA, Velloso LA.

J Physiol. 2005 Nov 1;568(Pt 3):993-1001. Epub 2005 Sep 1.PMID: 16141267 [PubMed - indexed for MEDLINE]Related articlesFree article

Aspirin inhibits serine phosphorylation of insulin receptor substrate 1 in growth hormone treated animals.

Prattali RR, Barreiro GC, Caliseo CT, Fugiwara FY, Ueno M, Prada PO, Velloso LA, Saad MJ, Carvalheira JB.

FEBS Lett. 2005 Jun 6;579(14):3152-8.PMID: 15922338 [PubMed - indexed for MEDLINE]Related articles

S-nitrosation of the insulin receptor, insulin receptor substrate 1, and protein kinase B/Akt: a novel mechanism of insulin resistance.

Carvalho-Filho MA, Ueno M, Hirabara SM, Seabra AB, Carvalheira JB, de Oliveira MG, Velloso LA, Curi R, Saad MJ.

Diabetes. 2005 Apr;54(4):959-67.PMID: 15793233 [PubMed - indexed for MEDLINE]Related articlesFree article

Cross-talk between the insulin and leptin signaling systems in rat hypothalamus.

Carvalheira JB, Torsoni MA, Ueno M, Amaral ME, Araújo EP, Velloso LA, Gontijo JA, Saad MJ.

Obes Res. 2005 Jan;13(1):48-57.PMID: 15761162 [PubMed - indexed for MEDLINE]Related articles

Effect of thiopental, pentobarbital and diethyl ether on early steps of insulin action in liver and muscle of the intact rat.

Cardoso AR, Carvalho CR, Velloso LA, Brenelli SL, Saad MJ, Carvalheira JB.

Life Sci. 2005 Apr 1;76(20):2287-97.PMID: 15748623 [PubMed - indexed for MEDLINE]Related articles

Regulation of insulin signalling by hyperinsulinaemia: role of IRS-1/2 serine phosphorylation and the mTOR/p70 S6K pathway.

Ueno M, Carvalheira JB, Tambascia RC, Bezerra RM, Amaral ME, Carneiro EM, Folli F, Franchini KG, Saad MJ.

Diabetologia. 2005 Mar;48(3):506-18. Epub 2005 Feb 4.PMID: 15692808 [PubMed - indexed for MEDLINE]Related articles

Aspirin inhibits serine phosphorylation of IRS-1 in muscle and adipose tissue of septic rats.

Barreiro GC, Prattali RR, Caliseo CT, Fugiwara FY, Ueno M, Prada PO, Velloso LA, Saad MJ, Carvalheira JB.

Biochem Biophys Res Commun. 2004 Jul 30;320(3):992-7.PMID: 15240146 [PubMed - indexed for MEDLINE]Related articles

Angiotensin II (AngII) induces the expression of suppressor of cytokine signaling (SOCS)-3 in rat hypothalamus - a mechanism for desensitization of AngII signaling.

Torsoni MA, Carvalheira JB, Calegari VC, Bezerra RM, Saad MJ, Gontijo JA, Velloso LA.

J Endocrinol. 2004 Apr;181(1):117-28.PMID: 15072572 [PubMed - indexed for MEDLINE]Related articlesFree article

Selective impairment of insulin signalling in the hypothalamus of obese Zucker rats.

Carvalheira JB, Ribeiro EB, Araújo EP, Guimarães RB, Telles MM, Torsoni M, Gontijo JA, Velloso LA, Saad MJ.

Diabetologia. 2003 Dec;46(12):1629-40. Epub 2003 Nov 5.PMID: 14600817 [PubMed - indexed for MEDLINE]Related articles

Peroxisome proliferator-activated receptor gamma coactivator-1-dependent uncoupling protein-2 expression in pancreatic islets of rats: a novel pathway for neural control of insulin secretion.

De Souza CT, Gasparetti AL, Pereira-da-Silva M, Araújo EP, Carvalheira JB, Saad MJ, Boschero AC, Carneiro EM, Velloso LA.

Diabetologia. 2003 Nov;46(11):1522-31. Epub 2003 Oct 24.PMID: 14576981 [PubMed - indexed for MEDLINE]Related articles

Regulation of Cbl-associated protein/Cbl pathway in muscle and adipose tissues of two animal models of insulin resistance.

Thirone AC, Carvalheira JB, Hirata AE, Velloso LA, Saad MJ.

Endocrinology. 2004 Jan;145(1):281-93. Epub 2003 Oct 2.PMID: 14525909 [PubMed - indexed for MEDLINE]Related articlesFree article

Hypothalamic melanin-concentrating hormone is induced by cold exposure and participates in the control of energy expenditure in rats.

Pereira-da-Silva M, Torsoni MA, Nourani HV, Augusto VD, Souza CT, Gasparetti AL, Carvalheira JB, Ventrucci G, Marcondes MC, Cruz-Neto AP, Saad MJ, Boschero AC, Carneiro EM, Velloso LA.

Endocrinology. 2003 Nov;144(11):4831-40. Epub 2003 Jul 24.PMID: 12960043 [PubMed - indexed for MEDLINE]Related articlesFree article

The cross-talk between angiotensin and insulin differentially affects phosphatidylinositol 3-kinase- and mitogen-activated protein kinase-mediated signaling in rat heart: implications for insulin resistance.

Carvalheira JB, Calegari VC, Zecchin HG, Nadruz W Jr, Guimarães RB, Ribeiro EB, Franchini KG, Velloso LA, Saad MJ.

Endocrinology. 2003 Dec;144(12):5604-14. Epub 2003 Sep 4.PMID: 12960006 [PubMed - indexed for MEDLINE]Related articlesFree article

Prolactin-signal transduction in neonatal rat pancreatic islets and interaction with the insulin-signaling pathway.

Amaral ME, Ueno M, Carvalheira JB, Carneiro EM, Velloso LA, Saad MJ, Boschero AC.

Horm Metab Res. 2003 May;35(5):282-9.PMID: 12915997 [PubMed - indexed for MEDLINE]Related articles