PubMed

Inhibition of neutral endopeptidase 24.11 does not potentiate the improvement in glycemic control obtained with dipeptidyl peptidase-4 inhibition in diabetic Goto-Kakizaki rats.

Simonsen L, Pilgaard S, Carr RD, Kanstrup AB, Holst JJ, Deacon CF.

Horm Metab Res. 2009 Nov;41(11):851-3. Epub 2009 Jul 3. No abstract available. PMID: 19579179 [PubMed - in process]Related articles

Differential islet and incretin hormone responses in morning versus afternoon after standardized meal in healthy men.

Lindgren O, Mari A, Deacon CF, Carr RD, Winzell MS, Vikman J, Ahrén B.

J Clin Endocrinol Metab. 2009 Aug;94(8):2887-92. Epub 2009 May 12.PMID: 19435824 [PubMed - indexed for MEDLINE]Related articles

Overnight hypoxic exposure and glucagon-like peptide-1 and leptin levels in humans.

Snyder EM, Carr RD, Deacon CF, Johnson BD.

Appl Physiol Nutr Metab. 2008 Oct;33(5):929-35.PMID: 18923568 [PubMed - indexed for MEDLINE]Related articlesFree article

Incretin and islet hormonal responses to fat and protein ingestion in healthy men.

Carr RD, Larsen MO, Winzell MS, Jelic K, Lindgren O, Deacon CF, Ahrén B.

Am J Physiol Endocrinol Metab. 2008 Oct;295(4):E779-84. Epub 2008 Jul 8.PMID: 18612044 [PubMed - indexed for MEDLINE]Related articlesFree article

The importance of empathic listening in alcohol screening.

Kennealley D, Carr RD.

S D Med. 2008 Mar;61(3):93. No abstract available. PMID: 18491459 [PubMed - indexed for MEDLINE]Related articles

Metformin protects the ischemic heart by the Akt-mediated inhibition of mitochondrial permeability transition pore opening.

Bhamra GS, Hausenloy DJ, Davidson SM, Carr RD, Paiva M, Wynne AM, Mocanu MM, Yellon DM.

Basic Res Cardiol. 2008 May;103(3):274-84. Epub 2007 Dec 13.PMID: 18080084 [PubMed - indexed for MEDLINE]Related articles

DPP-4 inhibitor therapy: new directions in the treatment of type 2 diabetes.

Deacon CF, Carr RD, Holst JJ.

Front Biosci. 2008 Jan 1;13:1780-94. Review.PMID: 17981667 [PubMed - indexed for MEDLINE]Related articles

Public health informatics training in New Mexico.

Eldredge JD, Carr RD.

J Med Libr Assoc. 2007 Jul;95(3):343-6. No abstract available. PMID: 17641772 [PubMed - indexed for MEDLINE]Related articlesFree article

Myocardial ischaemia-reperfusion injury is attenuated by intact glucagon like peptide-1 (GLP-1) in the in vitro rat heart and may involve the p70s6K pathway.

Bose AK, Mocanu MM, Carr RD, Yellon DM.

Cardiovasc Drugs Ther. 2007 Aug;21(4):253-6.PMID: 17541736 [PubMed - indexed for MEDLINE]Related articles

Capsaicin-sensitive sensory fibers in the islets of Langerhans contribute to defective insulin secretion in Zucker diabetic rat, an animal model for some aspects of human type 2 diabetes.

Gram DX, Ahrén B, Nagy I, Olsen UB, Brand CL, Sundler F, Tabanera R, Svendsen O, Carr RD, Santha P, Wierup N, Hansen AJ.

Eur J Neurosci. 2007 Jan;25(1):213-23.PMID: 17241282 [PubMed - indexed for MEDLINE]Related articles

Plasma dipeptidyl peptidase-IV activity in patients with type-2 diabetes mellitus correlates positively with HbAlc levels, but is not acutely affected by food intake.

Ryskjaer J, Deacon CF, Carr RD, Krarup T, Madsbad S, Holst J, Vilsbøll T.

Eur J Endocrinol. 2006 Sep;155(3):485-93.PMID: 16914604 [PubMed - indexed for MEDLINE]Related articlesFree article

Cholinergic regulation of fuel-induced hormone secretion and respiration of SUR1-/- mouse islets.

Doliba NM, Qin W, Vatamaniuk MZ, Buettger CW, Collins HW, Magnuson MA, Kaestner KH, Wilson DF, Carr RD, Matschinsky FM.

Am J Physiol Endocrinol Metab. 2006 Sep;291(3):E525-35. Epub 2006 Apr 25.PMID: 16638820 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose-induced incretin hormone release and inactivation are differently modulated by oral fat and protein in mice.

Gunnarsson PT, Winzell MS, Deacon CF, Larsen MO, Jelic K, Carr RD, Ahrén B.

Endocrinology. 2006 Jul;147(7):3173-80. Epub 2006 Apr 20.PMID: 16627575 [PubMed - indexed for MEDLINE]Related articlesFree article

Plasma calcitonin gene-related peptide is increased prior to obesity, and sensory nerve desensitization by capsaicin improves oral glucose tolerance in obese Zucker rats.

Gram DX, Hansen AJ, Wilken M, Elm T, Svendsen O, Carr RD, Ahrén B, Brand CL.

Eur J Endocrinol. 2005 Dec;153(6):963-9.PMID: 16322403 [PubMed - indexed for MEDLINE]Related articlesFree article

Measurements of insulin responses as predictive markers of pancreatic beta-cell mass in normal and beta-cell-reduced lean and obese Göttingen minipigs in vivo.

Larsen MO, Rolin B, Sturis J, Wilken M, Carr RD, Pørksen N, Gotfredsen CF.

Am J Physiol Endocrinol Metab. 2006 Apr;290(4):E670-7. Epub 2005 Nov 8.PMID: 16278249 [PubMed - indexed for MEDLINE]Related articlesFree article

Preconditioning the diabetic heart: the importance of Akt phosphorylation.

Tsang A, Hausenloy DJ, Mocanu MM, Carr RD, Yellon DM.

Diabetes. 2005 Aug;54(8):2360-4.PMID: 16046302 [PubMed - indexed for MEDLINE]Related articlesFree article

Neutral endopeptidase 24.11 and dipeptidyl peptidase IV are both mediators of the degradation of glucagon-like peptide 1 in the anaesthetised pig.

Plamboeck A, Holst JJ, Carr RD, Deacon CF.

Diabetologia. 2005 Sep;48(9):1882-90. Epub 2005 Jul 16.PMID: 16025254 [PubMed - indexed for MEDLINE]Related articles

Subdiaphragmatic vagal deafferentation affects body weight gain and glucose metabolism in obese male Zucker (fa/fa) rats.

Ferrari B, Arnold M, Carr RD, Langhans W, Pacini G, Bodvarsdóttir TB, Gram DX.

Am J Physiol Regul Integr Comp Physiol. 2005 Oct;289(4):R1027-34. Epub 2005 May 26.PMID: 15919730 [PubMed - indexed for MEDLINE]Related articles

Glucagon like peptide-1 is protective against myocardial ischemia/reperfusion injury when given either as a preconditioning mimetic or at reperfusion in an isolated rat heart model.

Bose AK, Mocanu MM, Carr RD, Yellon DM.

Cardiovasc Drugs Ther. 2005 Jan;19(1):9-11. No abstract available. PMID: 15883751 [PubMed - indexed for MEDLINE]Related articles

Sensory nerve inactivation by resiniferatoxin improves insulin sensitivity in male obese Zucker rats.

Moesgaard SG, Brand CL, Sturis J, Ahrén B, Wilken M, Fleckner J, Carr RD, Svendsen O, Hansen AJ, Gram DX.

Am J Physiol Endocrinol Metab. 2005 Jun;288(6):E1137-45.PMID: 15883192 [PubMed - indexed for MEDLINE]Related articlesFree article

Novel and established potassium channel openers stimulate hair growth in vitro: implications for their modes of action in hair follicles.

Davies GC, Thornton MJ, Jenner TJ, Chen YJ, Hansen JB, Carr RD, Randall VA.

J Invest Dermatol. 2005 Apr;124(4):686-94.PMID: 15816824 [PubMed - indexed for MEDLINE]Related articlesFree article

Sensory nerve desensitization by resiniferatoxin improves glucose tolerance and increases insulin secretion in Zucker Diabetic Fatty rats and is associated with reduced plasma activity of dipeptidyl peptidase IV.

Gram DX, Hansen AJ, Deacon CF, Brand CL, Ribel U, Wilken M, Carr RD, Svendsen O, Ahrén B.

Eur J Pharmacol. 2005 Feb 21;509(2-3):211-7.PMID: 15733558 [PubMed - indexed for MEDLINE]Related articles

Kir6.2-dependent high-affinity repaglinide binding to beta-cell K(ATP) channels.

Hansen AM, Hansen JB, Carr RD, Ashcroft FM, Wahl P.

Br J Pharmacol. 2005 Feb;144(4):551-7.PMID: 15678092 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucagon-like peptide 1 can directly protect the heart against ischemia/reperfusion injury.

Bose AK, Mocanu MM, Carr RD, Brand CL, Yellon DM.

Diabetes. 2005 Jan;54(1):146-51.PMID: 15616022 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduction of beta cell mass: partial insulin secretory compensation from the residual beta cell population in the nicotinamide-streptozotocin Göttingen minipig after oral glucose in vivo and in the perfused pancreas.

Larsen MO, Rolin B, Gotfredsen CF, Carr RD, Holst JJ.

Diabetologia. 2004 Nov;47(11):1873-8. Epub 2004 Nov 24.PMID: 15565374 [PubMed - indexed for MEDLINE]Related articles

Sulfonylurea induced beta-cell apoptosis in cultured human islets.

Maedler K, Carr RD, Bosco D, Zuellig RA, Berney T, Donath MY.

J Clin Endocrinol Metab. 2005 Jan;90(1):501-6. Epub 2004 Oct 13.PMID: 15483097 [PubMed - indexed for MEDLINE]Related articlesFree article

Beta-cell function and islet morphology in normal, obese, and obese beta-cell mass-reduced Göttingen minipigs.

Larsen MO, Juhl CB, Pørksen N, Gotfredsen CF, Carr RD, Ribel U, Wilken M, Rolin B.

Am J Physiol Endocrinol Metab. 2005 Feb;288(2):E412-21. Epub 2004 Oct 12.PMID: 15479954 [PubMed - indexed for MEDLINE]Related articlesFree article

Beta-cell insulin secretory response to oral hypoglycemic agents is blunted in humans in vivo during moderate hypoglycemia.

Aldhahi W, Armstrong J, Bouche C, Carr RD, Moses A, Goldfine AB.

J Clin Endocrinol Metab. 2004 Sep;89(9):4553-7.PMID: 15356061 [PubMed - indexed for MEDLINE]Related articlesFree article

The major glucagon-like peptide-1 metabolite, GLP-1-(9-36)-amide, does not affect glucose or insulin levels in mice.

Rolin B, Deacon CF, Carr RD, Ahrén B.

Eur J Pharmacol. 2004 Jun 28;494(2-3):283-8.PMID: 15212985 [PubMed - indexed for MEDLINE]Related articles

Effects of high-fat feeding and fasting on ghrelin expression in the mouse stomach.

Moesgaard SG, Ahrén B, Carr RD, Gram DX, Brand CL, Sundler F.

Regul Pept. 2004 Aug 15;120(1-3):261-7.PMID: 15177945 [PubMed - indexed for MEDLINE]Related articles

Neutral endopeptidase 24.11 is important for the degradation of both endogenous and exogenous glucagon in anesthetized pigs.

Trebbien R, Klarskov L, Olesen M, Holst JJ, Carr RD, Deacon CF.

Am J Physiol Endocrinol Metab. 2004 Sep;287(3):E431-8. Epub 2004 May 4.PMID: 15126240 [PubMed - indexed for MEDLINE]Related articlesFree article

The signature molecular descriptor. 4. Canonizing molecules using extended valence sequences.

Faulon JL, Collins MJ, Carr RD.

J Chem Inf Comput Sci. 2004 Mar-Apr;44(2):427-36.PMID: 15032522 [PubMed]Related articles

Restitution of defective glucose-stimulated insulin release of sulfonylurea type 1 receptor knockout mice by acetylcholine.

Doliba NM, Qin W, Vatamaniuk MZ, Li C, Zelent D, Najafi H, Buettger CW, Collins HW, Carr RD, Magnuson MA, Matschinsky FM.

Am J Physiol Endocrinol Metab. 2004 May;286(5):E834-43. Epub 2004 Jan 21.PMID: 14736703 [PubMed - indexed for MEDLINE]Related articlesFree article

The insulin secretagogues glibenclamide and repaglinide do not influence growth hormone secretion in humans but stimulate glucagon secretion during profound insulin deficiency.

Østergård T, Degn KB, Gall MA, Carr RD, Veldhuis JD, Thomsen MK, Rizza RA, Schmitz O.

J Clin Endocrinol Metab. 2004 Jan;89(1):297-302.PMID: 14715864 [PubMed - indexed for MEDLINE]Related articlesFree article

Valine pyrrolidide preserves intact glucose-dependent insulinotropic peptide and improves abnormal glucose tolerance in minipigs with reduced beta-cell mass.

Larsen MO, Rolin B, Ribel U, Wilken M, Deacon CF, Svendsen O, Gotfredsen CF, Carr RD.

Exp Diabesity Res. 2003 Apr-Jun;4(2):93-105.PMID: 14630571 [PubMed - indexed for MEDLINE]Related articlesFree article

NN414, a SUR1/Kir6.2-selective potassium channel opener, reduces blood glucose and improves glucose tolerance in the VDF Zucker rat.

Carr RD, Brand CL, Bodvarsdottir TB, Hansen JB, Sturis J.

Diabetes. 2003 Oct;52(10):2513-8.PMID: 14514634 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucagon-like peptide-1: a basis for new approaches to the management of diabetes.

Deacon CF, Holst JJ, Carr RD.

Drugs Today (Barc). 1999 Mar;35(3):159-70.PMID: 12973381 [PubMed]Related articles

GLP-1 derivative liraglutide in rats with beta-cell deficiencies: influence of metabolic state on beta-cell mass dynamics.

Sturis J, Gotfredsen CF, Rømer J, Rolin B, Ribel U, Brand CL, Wilken M, Wassermann K, Deacon CF, Carr RD, Knudsen LB.

Br J Pharmacol. 2003 Sep;140(1):123-32. Epub 2003 Jul 29.PMID: 12967942 [PubMed - indexed for MEDLINE]Related articlesFree article

Neutral endopeptidase 24.11 and dipeptidyl peptidase IV are both involved in regulating the metabolic stability of glucagon-like peptide-1 in vivo.

Plamboeck A, Holst JJ, Carr RD, Deacon CF.

Adv Exp Med Biol. 2003;524:303-12. Review. No abstract available. PMID: 12675252 [PubMed - indexed for MEDLINE]Related articles

Loss of beta-cell mass leads to a reduction of pulse mass with normal periodicity, regularity and entrainment of pulsatile insulin secretion in Göttingen minipigs.

Larsen MO, Gotfredsen CF, Wilken M, Carr RD, Pørksen N, Rolin B.

Diabetologia. 2003 Feb;46(2):195-202. Epub 2003 Jan 11. Erratum in: Diabetologia. 2004 Jan;47(1):155. PMID: 12627318 [PubMed - indexed for MEDLINE]Related articles

Differential effects of glucose and glyburide on energetics and Na+ levels of betaHC9 cells: nuclear magnetic resonance spectroscopy and respirometry studies.

Doliba NM, Vatamaniuk MZ, Buettger CW, Qin W, Collins HW, Wehrli SL, Carr RD, Matschinsky FM.

Diabetes. 2003 Feb;52(2):394-402.PMID: 12540613 [PubMed - indexed for MEDLINE]Related articlesFree article

Measurements of insulin secretory capacity and glucose tolerance to predict pancreatic beta-cell mass in vivo in the nicotinamide/streptozotocin Göttingen minipig, a model of moderate insulin deficiency and diabetes.

Larsen MO, Rolin B, Wilken M, Carr RD, Gotfredsen CF.

Diabetes. 2003 Jan;52(1):118-23.PMID: 12502501 [PubMed - indexed for MEDLINE]Related articlesFree article

The conscious Göttingen minipig as a model for studying rapid pulsatile insulin secretion in vivo.

Larsen MO, Elander M, Sturis J, Wilken M, Carr RD, Rolin B, Pørksen N.

Diabetologia. 2002 Oct;45(10):1389-96. Epub 2002 Sep 5.PMID: 12378379 [PubMed - indexed for MEDLINE]Related articles

NN2211: a long-acting glucagon-like peptide-1 derivative with anti-diabetic effects in glucose-intolerant pigs.

Ribel U, Larsen MO, Rolin B, Carr RD, Wilken M, Sturis J, Westergaard L, Deacon CF, Knudsen LB.

Eur J Pharmacol. 2002 Sep 13;451(2):217-25.PMID: 12231394 [PubMed - indexed for MEDLINE]Related articles

The long-acting GLP-1 derivative NN2211 ameliorates glycemia and increases beta-cell mass in diabetic mice.

Rolin B, Larsen MO, Gotfredsen CF, Deacon CF, Carr RD, Wilken M, Knudsen LB.

Am J Physiol Endocrinol Metab. 2002 Oct;283(4):E745-52.PMID: 12217892 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential interactions of nateglinide and repaglinide on the human beta-cell sulphonylurea receptor 1.

Hansen AM, Christensen IT, Hansen JB, Carr RD, Ashcroft FM, Wahl P.

Diabetes. 2002 Sep;51(9):2789-95.PMID: 12196472 [PubMed - indexed for MEDLINE]Related articlesFree article

High-fat high-energy feeding impairs fasting glucose and increases fasting insulin levels in the Göttingen minipig: results from a pilot study.

Larsen MO, Rolin B, Wilken M, Carr RD, Svendsen O.

Ann N Y Acad Sci. 2002 Jun;967:414-23.PMID: 12079869 [PubMed - indexed for MEDLINE]Related articles

Mild streptozotocin diabetes in the Göttingen minipig. A novel model of moderate insulin deficiency and diabetes.

Larsen MO, Wilken M, Gotfredsen CF, Carr RD, Svendsen O, Rolin B.

Am J Physiol Endocrinol Metab. 2002 Jun;282(6):E1342-51.PMID: 12006365 [PubMed - indexed for MEDLINE]Related articlesFree article

Parameters of glucose and lipid metabolism in the male Göttingen minipig: influence of age, body weight, and breeding family.

Larsen MO, Rolin B, Wilken M, Carr RD, Svendsen O, Bollen P.

Comp Med. 2001 Oct;51(5):436-42.PMID: 11924804 [PubMed - indexed for MEDLINE]Related articles

Peroxyvanadium compounds inhibit glucose-6-phosphatase activity and glucagon-stimulated hepatic glucose output in the rat in vivo.

Westergaard N, Brand CL, Lewinsky RH, Andersen HS, Carr RD, Burchell A, Lundgren K.

Arch Biochem Biophys. 1999 Jun 1;366(1):55-60.PMID: 10334863 [PubMed - indexed for MEDLINE]Related articles