PubMed

Signaling by IL-1beta+IFN-gamma and ER stress converge on DP5/Hrk activation: a novel mechanism for pancreatic beta-cell apoptosis.

Gurzov EN, Ortis F, Cunha DA, Gosset G, Li M, Cardozo AK, Eizirik DL.

Cell Death Differ. 2009 Nov;16(11):1539-50. Epub 2009 Jul 24.PMID: 19629134 [PubMed - in process]Related articles

Inhibition of nuclear factor-kappaB or Bax prevents endoplasmic reticulum stress- but not nitric oxide-mediated apoptosis in INS-1E cells.

Tonnesen MF, Grunnet LG, Friberg J, Cardozo AK, Billestrup N, Eizirik DL, Størling J, Mandrup-Poulsen T.

Endocrinology. 2009 Sep;150(9):4094-103. Epub 2009 Jun 25.PMID: 19556421 [PubMed - indexed for MEDLINE]Related articles

PTPN2, a candidate gene for type 1 diabetes, modulates interferon-gamma-induced pancreatic beta-cell apoptosis.

Moore F, Colli ML, Cnop M, Esteve MI, Cardozo AK, Cunha DA, Bugliani M, Marchetti P, Eizirik DL.

Diabetes. 2009 Jun;58(6):1283-91. Epub 2009 Mar 31.PMID: 19336676 [PubMed - indexed for MEDLINE]Related articlesFree article

Initiation and execution of lipotoxic ER stress in pancreatic beta-cells.

Cunha DA, Hekerman P, Ladrière L, Bazarra-Castro A, Ortis F, Wakeham MC, Moore F, Rasschaert J, Cardozo AK, Bellomo E, Overbergh L, Mathieu C, Lupi R, Hai T, Herchuelz A, Marchetti P, Rutter GA, Eizirik DL, Cnop M.

J Cell Sci. 2008 Jul 15;121(Pt 14):2308-18. Epub 2008 Jun 17.PMID: 18559892 [PubMed - indexed for MEDLINE]Related articlesFree article

Mediators and mechanisms of pancreatic beta-cell death in type 1 diabetes.

Pirot P, Cardozo AK, Eizirik DL.

Arq Bras Endocrinol Metabol. 2008 Mar;52(2):156-65. Review.PMID: 18438526 [PubMed - indexed for MEDLINE]Related articlesFree article

The role for endoplasmic reticulum stress in diabetes mellitus.

Eizirik DL, Cardozo AK, Cnop M.

Endocr Rev. 2008 Feb;29(1):42-61. Epub 2007 Nov 29. Review.PMID: 18048764 [PubMed - indexed for MEDLINE]Related articlesFree article

Proteomics analysis of cytokine-induced dysfunction and death in insulin-producing INS-1E cells: new insights into the pathways involved.

D'Hertog W, Overbergh L, Lage K, Ferreira GB, Maris M, Gysemans C, Flamez D, Cardozo AK, Van den Bergh G, Schoofs L, Arckens L, Moreau Y, Hansen DA, Eizirik DL, Waelkens E, Mathieu C.

Mol Cell Proteomics. 2007 Dec;6(12):2180-99. Epub 2007 Oct 5.PMID: 17921177 [PubMed - indexed for MEDLINE]Related articlesFree article

Cell loss during pseudoislet formation hampers profound improvements in islet lentiviral transduction efficacy for transplantation purposes.

Callewaert H, Gysemans C, Cardozo AK, Elsner M, Tiedge M, Eizirik DL, Mathieu C.

Cell Transplant. 2007;16(5):527-37.PMID: 17708342 [PubMed - indexed for MEDLINE]Related articles

Cell-permeable peptides induce dose- and length-dependent cytotoxic effects.

Cardozo AK, Buchillier V, Mathieu M, Chen J, Ortis F, Ladrière L, Allaman-Pillet N, Poirot O, Kellenberger S, Beckmann JS, Eizirik DL, Bonny C, Maurer F.

Biochim Biophys Acta. 2007 Sep;1768(9):2222-34. Epub 2007 Jun 14.PMID: 17626783 [PubMed - indexed for MEDLINE]Related articles

Transcriptional regulation of the endoplasmic reticulum stress gene chop in pancreatic insulin-producing cells.

Pirot P, Ortis F, Cnop M, Ma Y, Hendershot LM, Eizirik DL, Cardozo AK.

Diabetes. 2007 Apr;56(4):1069-77.PMID: 17395747 [PubMed - indexed for MEDLINE]Related articlesFree article

Global profiling of genes modified by endoplasmic reticulum stress in pancreatic beta cells reveals the early degradation of insulin mRNAs.

Pirot P, Naamane N, Libert F, Magnusson NE, Ørntoft TF, Cardozo AK, Eizirik DL.

Diabetologia. 2007 May;50(5):1006-14. Epub 2007 Mar 1.PMID: 17333111 [PubMed - indexed for MEDLINE]Related articles

Scanning electron microscopic and profilometric study of different sharpening stones.

Andrade Acevedo RA, Cardozo AK, Sampaio JE.

Braz Dent J. 2006;17(3):237-42.PMID: 17262132 [PubMed - indexed for MEDLINE]Related articlesFree article

Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis.

Cnop M, Ladriere L, Hekerman P, Ortis F, Cardozo AK, Dogusan Z, Flamez D, Boyce M, Yuan J, Eizirik DL.

J Biol Chem. 2007 Feb 9;282(6):3989-97. Epub 2006 Dec 8.PMID: 17158450 [PubMed - indexed for MEDLINE]Related articlesFree article

Interferon-gamma potentiates endoplasmic reticulum stress-induced death by reducing pancreatic beta cell defence mechanisms.

Pirot P, Eizirik DL, Cardozo AK.

Diabetologia. 2006 Jun;49(6):1229-36. Epub 2006 Apr 8.PMID: 16604358 [PubMed - indexed for MEDLINE]Related articles

Cytokine-induced proapoptotic gene expression in insulin-producing cells is related to rapid, sustained, and nonoscillatory nuclear factor-kappaB activation.

Ortis F, Cardozo AK, Crispim D, Störling J, Mandrup-Poulsen T, Eizirik DL.

Mol Endocrinol. 2006 Aug;20(8):1867-79. Epub 2006 Mar 23.PMID: 16556731 [PubMed - indexed for MEDLINE]Related articlesFree article

Construction and validation of the APOCHIP, a spotted oligo-microarray for the study of beta-cell apoptosis.

Magnusson NE, Cardozo AK, Kruhøffer M, Eizirik DL, Ørntoft TF, Jensen JL.

BMC Bioinformatics. 2005 Dec 29;6:311.PMID: 16384535 [PubMed - indexed for MEDLINE]Related articlesFree article

High glucose and hydrogen peroxide increase c-Myc and haeme-oxygenase 1 mRNA levels in rat pancreatic islets without activating NFkappaB.

Elouil H, Cardozo AK, Eizirik DL, Henquin JC, Jonas JC.

Diabetologia. 2005 Mar;48(3):496-505. Epub 2005 Mar 1. Erratum in: Diabetologia. 2005 Dec;48(12):2693. PMID: 15739117 [PubMed - indexed for MEDLINE]Related articles

Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells.

Cardozo AK, Ortis F, Storling J, Feng YM, Rasschaert J, Tonnesen M, Van Eylen F, Mandrup-Poulsen T, Herchuelz A, Eizirik DL.

Diabetes. 2005 Feb;54(2):452-61.PMID: 15677503 [PubMed - indexed for MEDLINE]Related articlesFree article

1,25-Dihydroxyvitamin D3 modulates expression of chemokines and cytokines in pancreatic islets: implications for prevention of diabetes in nonobese diabetic mice.

Gysemans CA, Cardozo AK, Callewaert H, Giulietti A, Hulshagen L, Bouillon R, Eizirik DL, Mathieu C.

Endocrinology. 2005 Apr;146(4):1956-64. Epub 2005 Jan 6.PMID: 15637289 [PubMed - indexed for MEDLINE]Related articlesFree article

The cytokine interleukin-1beta reduces the docking and fusion of insulin granules in pancreatic beta-cells, preferentially decreasing the first phase of exocytosis.

Ohara-Imaizumi M, Cardozo AK, Kikuta T, Eizirik DL, Nagamatsu S.

J Biol Chem. 2004 Oct 1;279(40):41271-4. Epub 2004 Aug 18.PMID: 15319424 [PubMed - indexed for MEDLINE]Related articlesFree article

Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress.

Kharroubi I, Ladrière L, Cardozo AK, Dogusan Z, Cnop M, Eizirik DL.

Endocrinology. 2004 Nov;145(11):5087-96. Epub 2004 Aug 5.PMID: 15297438 [PubMed - indexed for MEDLINE]Related articlesFree article

Use of microarray analysis to unveil transcription factor and gene networks contributing to Beta cell dysfunction and apoptosis.

Eizirik DL, Kutlu B, Rasschaert J, Darville M, Cardozo AK.

Ann N Y Acad Sci. 2003 Nov;1005:55-74.PMID: 14679040 [PubMed - indexed for MEDLINE]Related articles

Global profiling of double stranded RNA- and IFN-gamma-induced genes in rat pancreatic beta cells.

Rasschaert J, Liu D, Kutlu B, Cardozo AK, Kruhøffer M, ØRntoft TF, Eizirik DL.

Diabetologia. 2003 Dec;46(12):1641-57. Epub 2003 Nov 5.PMID: 14600816 [PubMed - indexed for MEDLINE]Related articles

Gene microarray study corroborates proteomic findings in rodent islet cells.

Cardozo AK, Berthou L, Kruhøffer M, Orntoft T, Nicolls MR, Eizirik DL.

J Proteome Res. 2003 Sep-Oct;2(5):553-5.PMID: 14582652 [PubMed - indexed for MEDLINE]Related articles

Discovery of gene networks regulating cytokine-induced dysfunction and apoptosis in insulin-producing INS-1 cells.

Kutlu B, Cardozo AK, Darville MI, Kruhøffer M, Magnusson N, Ørntoft T, Eizirik DL.

Diabetes. 2003 Nov;52(11):2701-19.PMID: 14578289 [PubMed - indexed for MEDLINE]Related articlesFree article

IL-1beta and IFN-gamma induce the expression of diverse chemokines and IL-15 in human and rat pancreatic islet cells, and in islets from pre-diabetic NOD mice.

Cardozo AK, Proost P, Gysemans C, Chen MC, Mathieu C, Eizirik DL.

Diabetologia. 2003 Feb;46(2):255-66. Epub 2003 Feb 12.PMID: 12627325 [PubMed - indexed for MEDLINE]Related articles

Molecular regulation of monocyte chemoattractant protein-1 expression in pancreatic beta-cells.

Kutlu B, Darville MI, Cardozo AK, Eizirik DL.

Diabetes. 2003 Feb;52(2):348-55.PMID: 12540607 [PubMed - indexed for MEDLINE]Related articlesFree article

Double-stranded RNA cooperates with interferon-gamma and IL-1 beta to induce both chemokine expression and nuclear factor-kappa B-dependent apoptosis in pancreatic beta-cells: potential mechanisms for viral-induced insulitis and beta-cell death in type 1 diabetes mellitus.

Liu D, Cardozo AK, Darville MI, Eizirik DL.

Endocrinology. 2002 Apr;143(4):1225-34.PMID: 11897677 [PubMed - indexed for MEDLINE]Related articlesFree article

A comprehensive analysis of cytokine-induced and nuclear factor-kappa B-dependent genes in primary rat pancreatic beta-cells.

Cardozo AK, Heimberg H, Heremans Y, Leeman R, Kutlu B, Kruhøffer M, Ørntoft T, Eizirik DL.

J Biol Chem. 2001 Dec 28;276(52):48879-86. Epub 2001 Oct 30.PMID: 11687580 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of cytokine-induced NF-kappaB activation by adenovirus-mediated expression of a NF-kappaB super-repressor prevents beta-cell apoptosis.

Heimberg H, Heremans Y, Jobin C, Leemans R, Cardozo AK, Darville M, Eizirik DL.

Diabetes. 2001 Oct;50(10):2219-24.PMID: 11574401 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of novel cytokine-induced genes in pancreatic beta-cells by high-density oligonucleotide arrays.

Cardozo AK, Kruhøffer M, Leeman R, Orntoft T, Eizirik DL.

Diabetes. 2001 May;50(5):909-20.PMID: 11334433 [PubMed - indexed for MEDLINE]Related articlesFree article

Analysis of exonic mutations leading to exon skipping in patients with pyruvate dehydrogenase E1 alpha deficiency.

Cardozo AK, De Meirleir L, Liebaers I, Lissens W.

Pediatr Res. 2000 Dec;48(6):748-53.PMID: 11102541 [PubMed - indexed for MEDLINE]Related articles