PubMed

Kupffer cell activation is a causal factor for hepatic insulin resistance.

Lanthier N, Molendi-Coste O, Horsmans Y, van Rooijen N, Cani PD, Leclercq IA.

Am J Physiol Gastrointest Liver Physiol. 2009 Oct 29. [Epub ahead of print]PMID: 19875703 [PubMed - as supplied by publisher]Related articles

Gut microbiota fermentation of prebiotics increases satietogenic and incretin gut peptide production with consequences for appetite sensation and glucose response after a meal.

Cani PD, Lecourt E, Dewulf EM, Sohet FM, Pachikian BD, Naslain D, De Backer F, Neyrinck AM, Delzenne NM.

Am J Clin Nutr. 2009 Nov;90(5):1236-43. Epub 2009 Sep 23.PMID: 19776140 [PubMed - in process]Related articles

Coenzyme Q10 supplementation lowers hepatic oxidative stress and inflammation associated with diet-induced obesity in mice.

Sohet FM, Neyrinck AM, Pachikian BD, de Backer FC, Bindels LB, Niklowitz P, Menke T, Cani PD, Delzenne NM.

Biochem Pharmacol. 2009 Dec 1;78(11):1391-400. Epub 2009 Jul 23.PMID: 19632207 [PubMed - indexed for MEDLINE]Related articles

Interplay between obesity and associated metabolic disorders: new insights into the gut microbiota.

Cani PD, Delzenne NM.

Curr Opin Pharmacol. 2009 Dec;9(6):737-43. Epub 2009 Jul 21.PMID: 19628432 [PubMed - in process]Related articles

An adiponectin-like molecule with antidiabetic properties.

Sulpice T, Prunet-Marcassus B, Molveaux C, Cani PD, Vitte PA, Graber P, Dreano M, Burcelin R.

Endocrinology. 2009 Oct;150(10):4493-501. Epub 2009 Jul 16.PMID: 19608652 [PubMed - indexed for MEDLINE]Related articles

Cannabinoid CB2 receptor potentiates obesity-associated inflammation, insulin resistance and hepatic steatosis.

Deveaux V, Cadoudal T, Ichigotani Y, Teixeira-Clerc F, Louvet A, Manin S, Nhieu JT, Belot MP, Zimmer A, Even P, Cani PD, Knauf C, Burcelin R, Bertola A, Le Marchand-Brustel Y, Gual P, Mallat A, Lotersztajn S.

PLoS One. 2009 Jun 9;4(6):e5844.PMID: 19513120 [PubMed - indexed for MEDLINE]Related articlesFree article

Critical role of Kupffer cells in the management of diet-induced diabetes and obesity.

Neyrinck AM, Cani PD, Dewulf EM, De Backer F, Bindels LB, Delzenne NM.

Biochem Biophys Res Commun. 2009 Jul 31;385(3):351-6. Epub 2009 May 20.PMID: 19463788 [PubMed - indexed for MEDLINE]Related articles

The role of the gut microbiota in energy metabolism and metabolic disease.

Cani PD, Delzenne NM.

Curr Pharm Des. 2009;15(13):1546-58. Review.PMID: 19442172 [PubMed - indexed for MEDLINE]Related articles

Dietary supplementation with chitosan derived from mushrooms changes adipocytokine profile in diet-induced obese mice, a phenomenon linked to its lipid-lowering action.

Neyrinck AM, Bindels LB, De Backer F, Pachikian BD, Cani PD, Delzenne NM.

Int Immunopharmacol. 2009 Jun;9(6):767-73. Epub 2009 Mar 13.PMID: 19286482 [PubMed - indexed for MEDLINE]Related articles

Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability.

Cani PD, Possemiers S, Van de Wiele T, Guiot Y, Everard A, Rottier O, Geurts L, Naslain D, Neyrinck A, Lambert DM, Muccioli GG, Delzenne NM.

Gut. 2009 Aug;58(8):1091-103. Epub 2009 Feb 24.PMID: 19240062 [PubMed - indexed for MEDLINE]Related articlesFree article

Lipid peroxidation is not a prerequisite for the development of obesity and diabetes in high-fat-fed mice.

Sohet FM, Neyrinck AM, Dewulf EM, Bindels LB, Portois L, Malaisse WJ, Carpentier YA, Cani PD, Delzenne NM.

Br J Nutr. 2009 Aug;102(3):462-9. Epub 2009 Jan 23.PMID: 19161640 [PubMed - indexed for MEDLINE]Related articles

Gut microbiota and pregnancy, a matter of inner life.

Cani PD.

Br J Nutr. 2009 Jun;101(11):1579-80. Epub 2008 Dec 15. No abstract available. PMID: 19079837 [PubMed - indexed for MEDLINE]Related articles

Apelin stimulates glucose utilization in normal and obese insulin-resistant mice.

Dray C, Knauf C, Daviaud D, Waget A, Boucher J, Buléon M, Cani PD, Attané C, Guigné C, Carpéné C, Burcelin R, Castan-Laurell I, Valet P.

Cell Metab. 2008 Nov;8(5):437-45.PMID: 19046574 [PubMed - indexed for MEDLINE]Related articles

Hepatic steatosis in n-3 fatty acid depleted mice: focus on metabolic alterations related to tissue fatty acid composition.

Pachikian BD, Neyrinck AM, Cani PD, Portois L, Deldicque L, De Backer FC, Bindels LB, Sohet FM, Malaisse WJ, Francaux M, Carpentier YA, Delzenne NM.

BMC Physiol. 2008 Dec 1;8:21.PMID: 19046413 [PubMed - indexed for MEDLINE]Related articlesFree article

Immunomodulatory properties of two wheat bran fractions - aleurone-enriched and crude fractions - in obese mice fed a high fat diet.

Neyrinck AM, De Backer F, Cani PD, Bindels LB, Stroobants A, Portetelle D, Delzenne NM.

Int Immunopharmacol. 2008 Oct;8(10):1423-32. Epub 2008 Jun 20.PMID: 18687304 [PubMed - indexed for MEDLINE]Related articles

Pancreatic alpha-cell dysfunction in diabetes.

Burcelin R, Knauf C, Cani PD.

Diabetes Metab. 2008 Feb;34 Suppl 2:S49-55. Review.PMID: 18640586 [PubMed - indexed for MEDLINE]Related articlesFree article

Brain glucagon-like peptide 1 signaling controls the onset of high-fat diet-induced insulin resistance and reduces energy expenditure.

Knauf C, Cani PD, Ait-Belgnaoui A, Benani A, Dray C, Cabou C, Colom A, Uldry M, Rastrelli S, Sabatier E, Godet N, Waget A, Pénicaud L, Valet P, Burcelin R.

Endocrinology. 2008 Oct;149(10):4768-77. Epub 2008 Jun 12.PMID: 18556349 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of central nervous system glucagon-like Peptide-1 receptors in enteric glucose sensing.

Knauf C, Cani PD, Kim DH, Iglesias MA, Chabo C, Waget A, Colom A, Rastrelli S, Delzenne NM, Drucker DJ, Seeley RJ, Burcelin R.

Diabetes. 2008 Oct;57(10):2603-12. Epub 2008 Jun 2.PMID: 18519802 [PubMed - indexed for MEDLINE]Related articlesFree article

Energy intake is associated with endotoxemia in apparently healthy men.

Amar J, Burcelin R, Ruidavets JB, Cani PD, Fauvel J, Alessi MC, Chamontin B, Ferriéres J.

Am J Clin Nutr. 2008 May;87(5):1219-23.PMID: 18469242 [PubMed - indexed for MEDLINE]Related articlesFree article

[Gut microflora is a key player in host energy homeostasis]

Delzenne NM, Cani PD.

Med Sci (Paris). 2008 May;24(5):505-10. Review. French. PMID: 18466728 [PubMed - indexed for MEDLINE]Related articles

Gut microbiota modulation with norfloxacin and ampicillin enhances glucose tolerance in mice.

Membrez M, Blancher F, Jaquet M, Bibiloni R, Cani PD, Burcelin RG, Corthesy I, Macé K, Chou CJ.

FASEB J. 2008 Jul;22(7):2416-26. Epub 2008 Mar 7.PMID: 18326786 [PubMed - indexed for MEDLINE]Related articlesFree article

Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice.

Cani PD, Bibiloni R, Knauf C, Waget A, Neyrinck AM, Delzenne NM, Burcelin R.

Diabetes. 2008 Jun;57(6):1470-81. Epub 2008 Feb 27.PMID: 18305141 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of gut microflora in the development of obesity and insulin resistance following high-fat diet feeding.

Cani PD, Delzenne NM, Amar J, Burcelin R.

Pathol Biol (Paris). 2008 Jul;56(5):305-9. Epub 2008 Jan 30. Review.PMID: 18178333 [PubMed - indexed for MEDLINE]Related articles

Gut microflora as a target for energy and metabolic homeostasis.

Cani PD, Delzenne NM.

Curr Opin Clin Nutr Metab Care. 2007 Nov;10(6):729-34. Review.PMID: 18089955 [PubMed - indexed for MEDLINE]Related articles

Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes.

Pospisilik JA, Knauf C, Joza N, Benit P, Orthofer M, Cani PD, Ebersberger I, Nakashima T, Sarao R, Neely G, Esterbauer H, Kozlov A, Kahn CR, Kroemer G, Rustin P, Burcelin R, Penninger JM.

Cell. 2007 Nov 2;131(3):476-91.PMID: 17981116 [PubMed - indexed for MEDLINE]Related articles

Modulation of glucagon-like peptide 1 and energy metabolism by inulin and oligofructose: experimental data.

Delzenne NM, Cani PD, Neyrinck AM.

J Nutr. 2007 Nov;137(11 Suppl):2547S-2551S. Review.PMID: 17951500 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucagon-like peptide-1 and energy homeostasis.

Burcelin R, Cani PD, Knauf C.

J Nutr. 2007 Nov;137(11 Suppl):2534S-2538S. Review.PMID: 17951498 [PubMed - indexed for MEDLINE]Related articlesFree article

Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia.

Cani PD, Neyrinck AM, Fava F, Knauf C, Burcelin RG, Tuohy KM, Gibson GR, Delzenne NM.

Diabetologia. 2007 Nov;50(11):2374-83. Epub 2007 Sep 6.PMID: 17823788 [PubMed - indexed for MEDLINE]Related articles

Lower insulin secretory response to glucose induced by artificial nutrition in children: prolonged and total parenteral nutrition.

Beltrand J, Colomb V, Marinier E, Daubrosse C, Alison M, Burcelin R, Cani PD, Chevenne D, Marchal CL.

Pediatr Res. 2007 Nov;62(5):624-9.PMID: 17805200 [PubMed - indexed for MEDLINE]Related articles

Central insulin regulates heart rate and arterial blood flow: an endothelial nitric oxide synthase-dependent mechanism altered during diabetes.

Cabou C, Cani PD, Campistron G, Knauf C, Mathieu C, Sartori C, Amar J, Scherrer U, Burcelin R.

Diabetes. 2007 Dec;56(12):2872-7. Epub 2007 Sep 5.PMID: 17804761 [PubMed - indexed for MEDLINE]Related articlesFree article

Physiological effects of dietary fructans extracted from Agave tequilana Gto. and Dasylirion spp.

Urías-Silvas JE, Cani PD, Delmée E, Neyrinck A, López MG, Delzenne NM.

Br J Nutr. 2008 Feb;99(2):254-61. Epub 2007 Aug 22.PMID: 17711612 [PubMed - indexed for MEDLINE]Related articles

GLUT2 and the incretin receptors are involved in glucose-induced incretin secretion.

Cani PD, Holst JJ, Drucker DJ, Delzenne NM, Thorens B, Burcelin R, Knauf C.

Mol Cell Endocrinol. 2007 Sep 30;276(1-2):18-23. Epub 2007 Jun 29.PMID: 17681422 [PubMed - indexed for MEDLINE]Related articles

Metabolic endotoxemia initiates obesity and insulin resistance.

Cani PD, Amar J, Iglesias MA, Poggi M, Knauf C, Bastelica D, Neyrinck AM, Fava F, Tuohy KM, Chabo C, Waget A, Delmée E, Cousin B, Sulpice T, Chamontin B, Ferrières J, Tanti JF, Gibson GR, Casteilla L, Delzenne NM, Alessi MC, Burcelin R.

Diabetes. 2007 Jul;56(7):1761-72. Epub 2007 Apr 24.PMID: 17456850 [PubMed - indexed for MEDLINE]Related articlesFree article

SREBP-1 regulates the expression of heme oxygenase 1 and the phosphatidylinositol-3 kinase regulatory subunit p55 gamma.

Kallin A, Johannessen LE, Cani PD, Marbehant CY, Essaghir A, Foufelle F, Ferré P, Heldin CH, Delzenne NM, Demoulin JB.

J Lipid Res. 2007 Jul;48(7):1628-36. Epub 2007 Apr 23.PMID: 17452746 [PubMed - indexed for MEDLINE]Related articlesFree article

Dietary non-digestible carbohydrates promote L-cell differentiation in the proximal colon of rats.

Cani PD, Hoste S, Guiot Y, Delzenne NM.

Br J Nutr. 2007 Jul;98(1):32-7. Epub 2007 Mar 19.PMID: 17367575 [PubMed - indexed for MEDLINE]Related articles

Effect on components of the intestinal microflora and plasma neuropeptide levels of feeding Lactobacillus delbrueckii, Bifidobacterium lactis, and inulin to adult and elderly rats.

Lesniewska V, Rowland I, Cani PD, Neyrinck AM, Delzenne NM, Naughton PJ.

Appl Environ Microbiol. 2006 Oct;72(10):6533-8.PMID: 17021202 [PubMed - indexed for MEDLINE]Related articlesFree article

Peroxisome proliferator-activated receptor-alpha-null mice have increased white adipose tissue glucose utilization, GLUT4, and fat mass: Role in liver and brain.

Knauf C, Rieusset J, Foretz M, Cani PD, Uldry M, Hosokawa M, Martinez E, Bringart M, Waget A, Kersten S, Desvergne B, Gremlich S, Wahli W, Seydoux J, Delzenne NM, Thorens B, Burcelin R.

Endocrinology. 2006 Sep;147(9):4067-78. Epub 2006 Jun 15.PMID: 16777972 [PubMed - indexed for MEDLINE]Related articlesFree article

Relation between colonic proglucagon expression and metabolic response to oligofructose in high fat diet-fed mice.

Delmée E, Cani PD, Gual G, Knauf C, Burcelin R, Maton N, Delzenne NM.

Life Sci. 2006 Aug 1;79(10):1007-13. Epub 2006 May 20.PMID: 16757002 [PubMed - indexed for MEDLINE]Related articles

Improvement of glucose tolerance and hepatic insulin sensitivity by oligofructose requires a functional glucagon-like peptide 1 receptor.

Cani PD, Knauf C, Iglesias MA, Drucker DJ, Delzenne NM, Burcelin R.

Diabetes. 2006 May;55(5):1484-90.PMID: 16644709 [PubMed - indexed for MEDLINE]Related articlesFree article

[GLP-1 and cerebral detection of glucose, a key mechanism for the regulation of glucose homeostasis]

Burcelin R, Cani PD, Knauf C.

Med Sci (Paris). 2006 Mar;22(3):237-9. French. No abstract available. PMID: 16527198 [PubMed - indexed for MEDLINE]Related articles

Liver adenosine monophosphate-activated kinase-alpha2 catalytic subunit is a key target for the control of hepatic glucose production by adiponectin and leptin but not insulin.

Andreelli F, Foretz M, Knauf C, Cani PD, Perrin C, Iglesias MA, Pillot B, Bado A, Tronche F, Mithieux G, Vaulont S, Burcelin R, Viollet B.

Endocrinology. 2006 May;147(5):2432-41. Epub 2006 Feb 2.PMID: 16455782 [PubMed - indexed for MEDLINE]Related articlesFree article

Liver-specific deletion of insulin receptor substrate 2 does not impair hepatic glucose and lipid metabolism in mice.

Simmgen M, Knauf C, Lopez M, Choudhury AI, Charalambous M, Cantley J, Bedford DC, Claret M, Iglesias MA, Heffron H, Cani PD, Vidal-Puig A, Burcelin R, Withers DJ.

Diabetologia. 2006 Mar;49(3):552-61. Epub 2006 Jan 11.PMID: 16404553 [PubMed - indexed for MEDLINE]Related articles

Oligofructose promotes satiety in healthy human: a pilot study.

Cani PD, Joly E, Horsmans Y, Delzenne NM.

Eur J Clin Nutr. 2006 May;60(5):567-72.PMID: 16340949 [PubMed - indexed for MEDLINE]Related articles

Brain glucagon-like peptide-1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage.

Knauf C, Cani PD, Perrin C, Iglesias MA, Maury JF, Bernard E, Benhamed F, Grémeaux T, Drucker DJ, Kahn CR, Girard J, Tanti JF, Delzenne NM, Postic C, Burcelin R.

J Clin Invest. 2005 Dec;115(12):3554-63.PMID: 16322793 [PubMed - indexed for MEDLINE]Related articlesFree article

A place for dietary fibre in the management of the metabolic syndrome.

Delzenne NM, Cani PD.

Curr Opin Clin Nutr Metab Care. 2005 Nov;8(6):636-40. Review.PMID: 16205465 [PubMed - indexed for MEDLINE]Related articles

Oligofructose promotes satiety in rats fed a high-fat diet: involvement of glucagon-like Peptide-1.

Cani PD, Neyrinck AM, Maton N, Delzenne NM.

Obes Res. 2005 Jun;13(6):1000-7.PMID: 15976142 [PubMed - indexed for MEDLINE]Related articles

Involvement of endogenous glucagon-like peptide-1(7-36) amide on glycaemia-lowering effect of oligofructose in streptozotocin-treated rats.

Cani PD, Daubioul CA, Reusens B, Remacle C, Catillon G, Delzenne NM.

J Endocrinol. 2005 Jun;185(3):457-65.PMID: 15930172 [PubMed - indexed for MEDLINE]Related articlesFree article

Impact of inulin and oligofructose on gastrointestinal peptides.

Delzenne NM, Cani PD, Daubioul C, Neyrinck AM.

Br J Nutr. 2005 Apr;93 Suppl 1:S157-61.PMID: 15877889 [PubMed - indexed for MEDLINE]Related articles

Potential modulation of plasma ghrelin and glucagon-like peptide-1 by anorexigenic cannabinoid compounds, SR141716A (rimonabant) and oleoylethanolamide.

Cani PD, Montoya ML, Neyrinck AM, Delzenne NM, Lambert DM.

Br J Nutr. 2004 Nov;92(5):757-61.PMID: 15533263 [PubMed - indexed for MEDLINE]Related articles

Inulin-type fructans modulate gastrointestinal peptides involved in appetite regulation (glucagon-like peptide-1 and ghrelin) in rats.

Cani PD, Dewever C, Delzenne NM.

Br J Nutr. 2004 Sep;92(3):521-6.PMID: 15469657 [PubMed - indexed for MEDLINE]Related articles