PubMed

A phase I study of intravitreal vascular endothelial growth factor trap-eye in patients with neovascular age-related macular degeneration.

Nguyen QD, Shah SM, Browning DJ, Hudson H, Sonkin P, Hariprasad SM, Kaiser P, Slakter JS, Haller J, Do DV, Mieler WF, Chu K, Yang K, Ingerman A, Vitti RL, Berliner AJ, Cedarbaum JM, Campochiaro PA.

Ophthalmology. 2009 Nov;116(11):2141-8.e1. Epub 2009 Aug 22.PMID: 19700196 [PubMed - indexed for MEDLINE]Related articles

Monitoring ocular drug therapy by analysis of aqueous samples.

Campochiaro PA, Choy DF, Do DV, Hafiz G, Shah SM, Nguyen QD, Rubio R, Arron JR.

Ophthalmology. 2009 Nov;116(11):2158-64. Epub 2009 Aug 22.PMID: 19700195 [PubMed - indexed for MEDLINE]Related articles

Primary End Point (Six Months) Results of the Ranibizumab for Edema of the mAcula in diabetes (READ-2) study.

Nguyen QD, Shah SM, Heier JS, Do DV, Lim J, Boyer D, Abraham P, Campochiaro PA; READ-2 Study Group.

Ophthalmology. 2009 Nov;116(11):2175-81.e1. Epub 2009 Aug 22.PMID: 19700194 [PubMed - indexed for MEDLINE]Related articles

Effects of intraocular ranibizumab and bevacizumab in transgenic mice expressing human vascular endothelial growth factor.

Miki K, Miki A, Matsuoka M, Muramatsu D, Hackett SF, Campochiaro PA.

Ophthalmology. 2009 Sep;116(9):1748-54. Epub 2009 Jul 29.PMID: 19643496 [PubMed - indexed for MEDLINE]Related articles

NADPH oxidase plays a central role in cone cell death in retinitis pigmentosa.

Usui S, Oveson BC, Lee SY, Jo YJ, Yoshida T, Miki A, Miki K, Iwase T, Lu L, Campochiaro PA.

J Neurochem. 2009 Aug;110(3):1028-37. Epub 2009 May 30.PMID: 19493169 [PubMed - indexed for MEDLINE]Related articles

Suppression and regression of choroidal neovascularization by the multitargeted kinase inhibitor pazopanib.

Takahashi K, Saishin Y, Saishin Y, King AG, Levin R, Campochiaro PA.

Arch Ophthalmol. 2009 Apr;127(4):494-9.PMID: 19365030 [PubMed - indexed for MEDLINE]Related articles

Increased expression of catalase and superoxide dismutase 2 reduces cone cell death in retinitis pigmentosa.

Usui S, Komeima K, Lee SY, Jo YJ, Ueno S, Rogers BS, Wu Z, Shen J, Lu L, Oveson BC, Rabinovitch PS, Campochiaro PA.

Mol Ther. 2009 May;17(5):778-86. Epub 2009 Mar 17.PMID: 19293779 [PubMed - indexed for MEDLINE]Related articles

ADAM9 is involved in pathological retinal neovascularization.

Guaiquil V, Swendeman S, Yoshida T, Chavala S, Campochiaro PA, Blobel CP.

Mol Cell Biol. 2009 May;29(10):2694-703. Epub 2009 Mar 9.PMID: 19273593 [PubMed - indexed for MEDLINE]Related articlesFree article

An exploratory study of the safety, tolerability and bioactivity of a single intravitreal injection of vascular endothelial growth factor Trap-Eye in patients with diabetic macular oedema.

Do DV, Nguyen QD, Shah SM, Browning DJ, Haller JA, Chu K, Yang K, Cedarbaum JM, Vitti RL, Ingerman A, Campochiaro PA.

Br J Ophthalmol. 2009 Feb;93(2):144-9.PMID: 19174400 [PubMed - indexed for MEDLINE]Related articles

Oxidative stress promotes ocular neovascularization.

Dong A, Xie B, Shen J, Yoshida T, Yokoi K, Hackett SF, Campochiaro PA.

J Cell Physiol. 2009 Jun;219(3):544-52.PMID: 19142872 [PubMed - indexed for MEDLINE]Related articles

BEST1 expression in the retinal pigment epithelium is modulated by OTX family members.

Esumi N, Kachi S, Hackler L Jr, Masuda T, Yang Z, Campochiaro PA, Zack DJ.

Hum Mol Genet. 2009 Jan 1;18(1):128-41. Epub 2008 Oct 10.PMID: 18849347 [PubMed - indexed for MEDLINE]Related articles

EIAV vector-mediated co-delivery of Endostatin and Angiostatin driven by the RPE-specific VMD2 Promoter Inhibits Choroidal Neovascularization.

Kachi S, Binley K, Yokoi K, Umeda N, Akiyama H, Igball S, Kan O, Naylor S, Campochiaro PA.

Hum Gene Ther. 2008 Oct 7. [Epub ahead of print]PMID: 18840069 [PubMed - as supplied by publisher]Related articles

Increased expression of glutathione peroxidase 4 strongly protects retina from oxidative damage.

Lu L, Oveson BC, Jo YJ, Lauer TW, Usui S, Komeima K, Xie B, Campochiaro PA.

Antioxid Redox Signal. 2009 Apr;11(4):715-24.PMID: 18823256 [PubMed - in process]Related articles

Blockade of sphingosine-1-phosphate reduces macrophage influx and retinal and choroidal neovascularization.

Xie B, Shen J, Dong A, Rashid A, Stoller G, Campochiaro PA.

J Cell Physiol. 2009 Jan;218(1):192-8.PMID: 18781584 [PubMed - indexed for MEDLINE]Related articles

Blockade of neuronal nitric oxide synthase reduces cone cell death in a model of retinitis pigmentosa.

Komeima K, Usui S, Shen J, Rogers BS, Campochiaro PA.

Free Radic Biol Med. 2008 Sep 15;45(6):905-12. Epub 2008 Jun 28.PMID: 18634866 [PubMed - indexed for MEDLINE]Related articlesFree article

Prolonged blockade of VEGF family members does not cause identifiable damage to retinal neurons or vessels.

Ueno S, Pease ME, Wersinger DM, Masuda T, Vinores SA, Licht T, Zack DJ, Quigley H, Keshet E, Campochiaro PA.

J Cell Physiol. 2008 Oct;217(1):13-22.PMID: 18543272 [PubMed - indexed for MEDLINE]Related articles

MicroRNAs regulate ocular neovascularization.

Shen J, Yang X, Xie B, Chen Y, Swaim M, Hackett SF, Campochiaro PA.

Mol Ther. 2008 Jul;16(7):1208-16. Epub 2008 May 20.PMID: 18500251 [PubMed - indexed for MEDLINE]Related articles

Mecamylamine suppresses Basal and nicotine-stimulated choroidal neovascularization.

Kiuchi K, Matsuoka M, Wu JC, Lima e Silva R, Kengatharan M, Verghese M, Ueno S, Yokoi K, Khu NH, Cooke JP, Campochiaro PA.

Invest Ophthalmol Vis Sci. 2008 Apr;49(4):1705-11.PMID: 18385094 [PubMed - indexed for MEDLINE]Related articlesFree article

An Adam15 amplification loop promotes vascular endothelial growth factor-induced ocular neovascularization.

Xie B, Shen J, Dong A, Swaim M, Hackett SF, Wyder L, Worpenberg S, Barbieri S, Campochiaro PA.

FASEB J. 2008 Aug;22(8):2775-83. Epub 2008 Apr 1.PMID: 18381816 [PubMed - indexed for MEDLINE]Related articlesFree article

Trans-scleral delivery of antiangiogenic proteins.

Demetriades AM, Deering T, Liu H, Lu L, Gehlbach P, Packer JD, Mac Gabhann F, Popel AS, Wei LL, Campochiaro PA.

J Ocul Pharmacol Ther. 2008 Feb;24(1):70-9.PMID: 18370877 [PubMed - indexed for MEDLINE]Related articles

Ranibizumab for macular edema due to retinal vein occlusions: implication of VEGF as a critical stimulator.

Campochiaro PA, Hafiz G, Shah SM, Nguyen QD, Ying H, Do DV, Quinlan E, Zimmer-Galler I, Haller JA, Solomon SD, Sung JU, Hadi Y, Janjua KA, Jawed N, Choy DF, Arron JR.

Mol Ther. 2008 Apr;16(4):791-9. Epub 2008 Feb 5.PMID: 18362932 [PubMed - indexed for MEDLINE]Related articles

Topical administration of a multi-targeted kinase inhibitor suppresses choroidal neovascularization and retinal edema.

Doukas J, Mahesh S, Umeda N, Kachi S, Akiyama H, Yokoi K, Cao J, Chen Z, Dellamary L, Tam B, Racanelli-Layton A, Hood J, Martin M, Noronha G, Soll R, Campochiaro PA.

J Cell Physiol. 2008 Jul;216(1):29-37.PMID: 18330892 [PubMed - indexed for MEDLINE]Related articles

Intravenous bevacizumab causes regression of choroidal neovascularization secondary to diseases other than age-related macular degeneration.

Nguyen QD, Shah SM, Hafiz G, Do DV, Haller JA, Pili R, Zimmer-Galler IE, Janjua K, Symons RC, Campochiaro PA.

Am J Ophthalmol. 2008 Feb;145(2):257-266. Epub 2007 Dec 11.PMID: 18054887 [PubMed - indexed for MEDLINE]Related articles

Increased expression of glial cell line-derived neurotrophic factor protects against oxidative damage-induced retinal degeneration.

Dong A, Shen J, Krause M, Hackett SF, Campochiaro PA.

J Neurochem. 2007 Nov;103(3):1041-52.PMID: 17935603 [PubMed - indexed for MEDLINE]Related articles

Targeted pharmacotherapy of retinal diseases with ranibizumab.

Campochiaro PA.

Drugs Today (Barc). 2007 Aug;43(8):529-37. Review.PMID: 17925884 [PubMed - indexed for MEDLINE]Related articles

Optical coherence tomography findings in persistent diabetic macular edema: the vitreomacular interface.

Ghazi NG, Ciralsky JB, Shah SM, Campochiaro PA, Haller JA.

Am J Ophthalmol. 2007 Nov;144(5):747-754. Epub 2007 Sep 17.PMID: 17869207 [PubMed - indexed for MEDLINE]Related articles

In vivo immunostaining demonstrates macrophages associate with growing and regressing vessels.

Shen J, Xie B, Dong A, Swaim M, Hackett SF, Campochiaro PA.

Invest Ophthalmol Vis Sci. 2007 Sep;48(9):4335-41.PMID: 17724225 [PubMed - indexed for MEDLINE]Related articlesFree article

Oxidative damage in age-related macular degeneration.

Shen JK, Dong A, Hackett SF, Bell WR, Green WR, Campochiaro PA.

Histol Histopathol. 2007 Dec;22(12):1301-8.PMID: 17701910 [PubMed - indexed for MEDLINE]Related articles

Gene transfer of an engineered zinc finger protein enhances the anti-angiogenic defense system.

Yokoi K, Zhang HS, Kachi S, Balaggan KS, Yu Q, Guschin D, Kunis M, Surosky R, Africa LM, Bainbridge JW, Spratt SK, Gregory PD, Ali RR, Campochiaro PA.

Mol Ther. 2007 Nov;15(11):1917-23. Epub 2007 Aug 14.PMID: 17700545 [PubMed - indexed for MEDLINE]Related articles

Vegf or EphA2 antisense polyamide-nucleic acids; vascular localization and suppression of retinal neovascularization.

Shen J, Xie B, Hatara CM, Hackett SF, Campochiaro PA.

Mol Ther. 2007 Nov;15(11):1924-30. Epub 2007 Aug 7.PMID: 17680030 [PubMed - indexed for MEDLINE]Related articles

Seeing the light: new insights into the molecular pathogenesis of retinal diseases.

Campochiaro PA.

J Cell Physiol. 2007 Nov;213(2):348-54. Review.PMID: 17654481 [PubMed - indexed for MEDLINE]Related articles

Ocular gene transfer with self-complementary AAV vectors.

Yokoi K, Kachi S, Zhang HS, Gregory PD, Spratt SK, Samulski RJ, Campochiaro PA.

Invest Ophthalmol Vis Sci. 2007 Jul;48(7):3324-8.PMID: 17591905 [PubMed - indexed for MEDLINE]Related articlesFree article

Intraobserver repeatability of automated versus adjusted optical coherence tomography measurements in patients with neovascular age-related macular degeneration.

Tatlipinar S, Shah SM, Campochiaro PA, Nguyen QD.

Ophthalmologica. 2007;221(4):227-32.PMID: 17579287 [PubMed - indexed for MEDLINE]Related articles

Impact of optical coherence tomography on surgical decision making for epiretinal membranes and vitreomacular traction.

Do DV, Cho M, Nguyen QD, Shah SM, Handa JT, Campochiaro PA, Zimmer-Galler I, Sung JU, Haller JA.

Retina. 2007 Jun;27(5):552-6.PMID: 17558315 [PubMed - indexed for MEDLINE]Related articles

Oxidative stress modulates complement factor H expression in retinal pigmented epithelial cells by acetylation of FOXO3.

Wu Z, Lauer TW, Sick A, Hackett SF, Campochiaro PA.

J Biol Chem. 2007 Aug 3;282(31):22414-25. Epub 2007 Jun 8.PMID: 17558024 [PubMed - indexed for MEDLINE]Related articlesFree article

The SDF-1/CXCR4 ligand/receptor pair is an important contributor to several types of ocular neovascularization.

Lima e Silva R, Shen J, Hackett SF, Kachi S, Akiyama H, Kiuchi K, Yokoi K, Hatara MC, Lauer T, Aslam S, Gong YY, Xiao WH, Khu NH, Thut C, Campochiaro PA.

FASEB J. 2007 Oct;21(12):3219-30. Epub 2007 May 23.PMID: 17522382 [PubMed - indexed for MEDLINE]Related articlesFree article

Antioxidants slow photoreceptor cell death in mouse models of retinitis pigmentosa.

Komeima K, Rogers BS, Campochiaro PA.

J Cell Physiol. 2007 Dec;213(3):809-15.PMID: 17520694 [PubMed - indexed for MEDLINE]Related articles

The impact of optical coherence tomography on surgical decision making in epiretinal membrane and vitreomacular traction.

Do DV, Cho M, Nguyen QD, Shah SM, Handa JT, Campochiaro PA, Zimmer-Galler I, Sung JU, Haller JA.

Trans Am Ophthalmol Soc. 2006;104:161-6.PMID: 17471336 [PubMed - indexed for MEDLINE]Related articlesFree article

Gene therapy for ocular neovascularization.

Campochiaro PA.

Curr Gene Ther. 2007 Feb;7(1):25-33. Review.PMID: 17305526 [PubMed - indexed for MEDLINE]Related articles

Protein transport to choroid and retina following periocular injection: theoretical and experimental study.

Mac Gabhann F, Demetriades AM, Deering T, Packer JD, Shah SM, Duh E, Campochiaro PA, Popel AS.

Ann Biomed Eng. 2007 Apr;35(4):615-30. Epub 2007 Feb 3.PMID: 17277991 [PubMed - indexed for MEDLINE]Related articles

Differential sensitivity of cones to iron-mediated oxidative damage.

Rogers BS, Symons RC, Komeima K, Shen J, Xiao W, Swaim ME, Gong YY, Kachi S, Campochiaro PA.

Invest Ophthalmol Vis Sci. 2007 Jan;48(1):438-45.PMID: 17197565 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular targets for retinal vascular diseases.

Campochiaro PA.

J Cell Physiol. 2007 Mar;210(3):575-81. Review.PMID: 17133346 [PubMed - indexed for MEDLINE]Related articles

Dynamic and quantitative analysis of choroidal neovascularization by fluorescein angiography.

Shah SM, Tatlipinar S, Quinlan E, Sung JU, Tabandeh H, Nguyen QD, Fahmy AS, Zimmer-Galler I, Symons RC, Cedarbaum JM, Campochiaro PA.

Invest Ophthalmol Vis Sci. 2006 Dec;47(12):5460-8.PMID: 17122137 [PubMed - indexed for MEDLINE]Related articlesFree article

TNF-alpha is critical for ischemia-induced leukostasis, but not retinal neovascularization nor VEGF-induced leakage.

Vinores SA, Xiao WH, Shen J, Campochiaro PA.

J Neuroimmunol. 2007 Jan;182(1-2):73-9. Epub 2006 Nov 14.PMID: 17107717 [PubMed - indexed for MEDLINE]Related articlesFree article

VMD2 promoter requires two proximal E-box sites for its activity in vivo and is regulated by the MITF-TFE family.

Esumi N, Kachi S, Campochiaro PA, Zack DJ.

J Biol Chem. 2007 Jan 19;282(3):1838-50. Epub 2006 Nov 3.PMID: 17085443 [PubMed - indexed for MEDLINE]Related articlesFree article

Vascular endothelial growth factor is a critical stimulus for diabetic macular edema.

Nguyen QD, Tatlipinar S, Shah SM, Haller JA, Quinlan E, Sung J, Zimmer-Galler I, Do DV, Campochiaro PA.

Am J Ophthalmol. 2006 Dec;142(6):961-9. Epub 2006 Aug 2.PMID: 17046701 [PubMed - indexed for MEDLINE]Related articles

Delivery from episcleral exoplants.

Pontes de Carvalho RA, Krausse ML, Murphree AL, Schmitt EE, Campochiaro PA, Maumenee IH.

Invest Ophthalmol Vis Sci. 2006 Oct;47(10):4532-9.PMID: 17003449 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduction of p66Shc suppresses oxidative damage in retinal pigmented epithelial cells and retina.

Wu Z, Rogers B, Kachi S, Hackett SF, Sick A, Campochiaro PA.

J Cell Physiol. 2006 Dec;209(3):996-1005.PMID: 16972253 [PubMed - indexed for MEDLINE]Related articles

Trans-scleral delivery of polyamine analogs for ocular neovascularization.

Lima e Silva R, Kachi S, Akiyama H, Shen J, Hatara MC, Aslam S, Gong YY, Khu NH, Lauer TW, Hackett SF, Marton LJ, Campochiaro PA.

Exp Eye Res. 2006 Nov;83(5):1260-7. Epub 2006 Sep 6.PMID: 16950258 [PubMed - indexed for MEDLINE]Related articles

A phase I trial of an IV-administered vascular endothelial growth factor trap for treatment in patients with choroidal neovascularization due to age-related macular degeneration.

Nguyen QD, Shah SM, Hafiz G, Quinlan E, Sung J, Chu K, Cedarbaum JM, Campochiaro PA; CLEAR-AMD 1 Study Group.

Ophthalmology. 2006 Sep;113(9):1522.e1-1522.e14. Epub 2006 Jul 28.PMID: 16876249 [PubMed - indexed for MEDLINE]Related articles