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Sustained antiretroviral effect of raltegravir after 96 weeks of combination therapy in treatment-naive patients with HIV-1 infection.

Markowitz M, Nguyen BY, Gotuzzo E, Mendo F, Ratanasuwan W, Kovacs C, Prada G, Morales-Ramirez JO, Crumpacker CS, Isaacs RD, Campbell H, Strohmaier KM, Wan H, Danovich RM, Teppler H; Protocol 004 Part II Study Team.

J Acquir Immune Defic Syndr. 2009 Nov 1;52(3):350-6.PMID: 19648823 [PubMed - indexed for MEDLINE]Related articles

Low rate of CMV end-organ disease in HIV-infected patients despite low CD4+ cell counts and CMV viremia: results of ACTG protocol A5030.

Wohl DA, Kendall MA, Andersen J, Crumpacker C, Spector SA, Feinberg J, Alston-Smith B, Owens S, Chafey S, Marco M, Maxwell S, Lurain N, Jabs D, Benson C, Keiser P, Jacobson MA; A5030 Study Team.

HIV Clin Trials. 2009 May-Jun;10(3):143-52.PMID: 19632953 [PubMed - indexed for MEDLINE]Related articlesFree article

Cytomegalovirus infection causes an increase of arterial blood pressure.

Cheng J, Ke Q, Jin Z, Wang H, Kocher O, Morgan JP, Zhang J, Crumpacker CS.

PLoS Pathog. 2009 May;5(5):e1000427. Epub 2009 May 15.PMID: 19436702 [PubMed - indexed for MEDLINE]Related articlesFree article

Valganciclovir and human herpesvirus-8.

Crumpacker CS.

J Infect Dis. 2008 Jul 1;198(1):6-7. No abstract available. PMID: 18491975 [PubMed - indexed for MEDLINE]Related articles

Rapid and durable antiretroviral effect of the HIV-1 Integrase inhibitor raltegravir as part of combination therapy in treatment-naive patients with HIV-1 infection: results of a 48-week controlled study.

Markowitz M, Nguyen BY, Gotuzzo E, Mendo F, Ratanasuwan W, Kovacs C, Prada G, Morales-Ramirez JO, Crumpacker CS, Isaacs RD, Gilde LR, Wan H, Miller MD, Wenning LA, Teppler H; Protocol 004 Part II Study Team.

J Acquir Immune Defic Syndr. 2007 Oct 1;46(2):125-33.PMID: 17721395 [PubMed - indexed for MEDLINE]Related articles

Primitive hematopoietic cells resist HIV-1 infection via p21.

Zhang J, Scadden DT, Crumpacker CS.

J Clin Invest. 2007 Feb;117(2):473-81.PMID: 17273559 [PubMed - indexed for MEDLINE]Related articlesFree article

Propranolol ameliorates and epinephrine exacerbates progression of acute and chronic viral myocarditis.

Wang JF, Meissner A, Malek S, Chen Y, Ke Q, Zhang J, Chu V, Hampton TG, Crumpacker CS, Abelmann WH, Amende I, Morgan JP.

Am J Physiol Heart Circ Physiol. 2005 Oct;289(4):H1577-83. Epub 2005 May 27.PMID: 15923319 [PubMed - indexed for MEDLINE]Related articlesFree article

Silencing p21(Waf1/Cip1/Sdi1) expression increases gene transduction efficiency in primitive human hematopoietic cells.

Zhang J, Attar E, Cohen K, Crumpacker C, Scadden D.

Gene Ther. 2005 Oct;12(19):1444-52.PMID: 15877047 [PubMed - indexed for MEDLINE]Related articles

Mixed glycoprotein B genotypes of cytomegalovirus and immunosuppression.

Crumpacker CS.

Clin Infect Dis. 2004 Jul 15;39(2):162-4. Epub 2004 Jun 23. No abstract available. PMID: 15307022 [PubMed - indexed for MEDLINE]Related articles

Current topics in herpes research.

Crumpacker C.

Herpes. 2003 Dec;10(3):59. No abstract available. PMID: 14759336 [PubMed - indexed for MEDLINE]Related articlesFree article

Use of antiviral drugs to prevent herpesvirus transmission.

Crumpacker CS.

N Engl J Med. 2004 Jan 1;350(1):67-8. No abstract available. PMID: 14702430 [PubMed - indexed for MEDLINE]Related articles

Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 26-2003. A 50-year-old Colombian man with fever and seizures.

Crumpacker CS, Gonzalez RG, Makar RS.

N Engl J Med. 2003 Aug 21;349(8):789-96. No abstract available. PMID: 12930932 [PubMed - indexed for MEDLINE]Related articles

Comparison of molecular tests for detection and quantification of cell-associated cytomegalovirus DNA.

Caliendo AM, Yen-Lieberman B, Baptista J, Andersen J, Crumpacker C, Schuurman R, Spector SA, Bremer J, Lurain NS.

J Clin Microbiol. 2003 Aug;41(8):3509-13.PMID: 12904347 [PubMed - indexed for MEDLINE]Related articlesFree article

Mutations conferring foscarnet resistance in a cohort of patients with acquired immunodeficiency syndrome and cytomegalovirus retinitis.

Weinberg A, Jabs DA, Chou S, Martin BK, Lurain NS, Forman MS, Crumpacker C; Cytomegalovirus Retinitis and Viral Resistance Study Group; Adult AIDS Clinical Trials Group Cytomegalovirus Laboratories.

J Infect Dis. 2003 Mar 1;187(5):777-84. Epub 2003 Feb 24.PMID: 12599051 [PubMed - indexed for MEDLINE]Related articles

A passive immunotherapy, (PE)HRG214, in patients infected with human immunodeficiency virus: a phase I study.

Dezube BJ, Proper J, Zhang J, Choy VJ, Weeden W, Morrissey J, Burns EM, Dixon JD, O'Loughlin C, Williams LA, Pickering PJ, Crumpacker CS, Gelder FB.

J Infect Dis. 2003 Feb 1;187(3):500-3. Epub 2003 Jan 8.PMID: 12552435 [PubMed - indexed for MEDLINE]Related articles

Human immunodeficiency virus type 1 nucleocapsid protein nuclear localization mediates early viral mRNA expression.

Zhang J, Crumpacker CS.

J Virol. 2002 Oct;76(20):10444-54.PMID: 12239321 [PubMed - indexed for MEDLINE]Related articlesFree article

New anti-HSV therapeutics target the helicase-primase complex.

Crumpacker CS, Schaffer PA.

Nat Med. 2002 Apr;8(4):327-8. No abstract available. PMID: 11927930 [PubMed - indexed for MEDLINE]Related articles

Cocaine enhances myocarditis induced by encephalomyocarditis virus in murine model.

Wang JF, Zhang J, Min JY, Sullivan MF, Crumpacker CS, Abelmann WH, Morgan JP.

Am J Physiol Heart Circ Physiol. 2002 Mar;282(3):H956-63.PMID: 11834492 [PubMed - indexed for MEDLINE]Related articlesFree article

Human immunodeficiency virus type 1 RNA in peripheral blood mononuclear cells of patients receiving prolonged highly active antiretroviral therapy.

Zhang J, Crumpacker CS.

J Infect Dis. 2001 Nov 15;184(10):1341-4. Epub 2001 Oct 2.PMID: 11679927 [PubMed - indexed for MEDLINE]Related articles

Sequencing of cytomegalovirus UL97 gene for genotypic antiviral resistance testing.

Lurain NS, Weinberg A, Crumpacker CS, Chou S; Adult AIDS Clinical Trials Group-CMV Laboratories.

Antimicrob Agents Chemother. 2001 Oct;45(10):2775-80.PMID: 11557468 [PubMed - indexed for MEDLINE]Related articlesFree article

Comparison of quantitative and qualitative PCR assays for cytomegalovirus DNA in plasma.

Caliendo AM, Schuurman R, Yen-Lieberman B, Spector SA, Andersen J, Manjiry R, Crumpacker C, Lurain NS, Erice A; CMV Working Group of the Complications of HIV Disease RAC, AIDS Clinical Trials Group.

J Clin Microbiol. 2001 Apr;39(4):1334-8.PMID: 11283052 [PubMed - indexed for MEDLINE]Related articlesFree article

A fusion inhibitor (FP-21399) for the treatment of human immunodeficiency virus infection: a phase I study.

Dezube BJ, Dahl TA, Wong TK, Chapman B, Ono M, Yamaguchi N, Gillies SD, Chen LB, Crumpacker CS.

J Infect Dis. 2000 Aug;182(2):607-10. Epub 2000 Jul 28.PMID: 10915097 [PubMed - indexed for MEDLINE]Related articles

Characterization of an acyclovir-resistant herpes simplex virus type 2 strain isolated from a premature neonate.

Oram RJ, Marcellino D, Strauss D, Gustafson E, Talarico CL, Root AK, Sharma PL, Thompson K, Fingeroth JD, Crumpacker C, Herold BC.

J Infect Dis. 2000 Apr;181(4):1458-61. Epub 2000 Apr 13.PMID: 10762577 [PubMed - indexed for MEDLINE]Related articles

Enhancement of the basal-level activity of HIV-1 long terminal repeat by HIV-1 nucleocapsid protein.

Zhang JL, Sharma PL, Crumpacker CS.

Virology. 2000 Mar 15;268(2):251-63.PMID: 10704334 [PubMed - indexed for MEDLINE]Related articles

A standardized plaque reduction assay for determination of drug susceptibilities of cytomegalovirus clinical isolates.

Landry ML, Stanat S, Biron K, Brambilla D, Britt W, Jokela J, Chou S, Drew WL, Erice A, Gilliam B, Lurain N, Manischewitz J, Miner R, Nokta M, Reichelderfer P, Spector S, Weinberg A, Yen-Lieberman B, Crumpacker C.

Antimicrob Agents Chemother. 2000 Mar;44(3):688-92.PMID: 10681339 [PubMed - indexed for MEDLINE]Related articlesFree article

Decreased processivity of human immunodeficiency virus type 1 reverse transcriptase (RT) containing didanosine-selected mutation Leu74Val: a comparative analysis of RT variants Leu74Val and lamivudine-selected Met184Val.

Sharma PL, Crumpacker CS.

J Virol. 1999 Oct;73(10):8448-56.PMID: 10482597 [PubMed - indexed for MEDLINE]Related articlesFree article

Interstrain variation in the human cytomegalovirus DNA polymerase sequence and its effect on genotypic diagnosis of antiviral drug resistance. Adult AIDS Clinical Trials Group CMV Laboratories.

Chou S, Lurain NS, Weinberg A, Cai GY, Sharma PL, Crumpacker CS.

Antimicrob Agents Chemother. 1999 Jun;43(6):1500-2.PMID: 10348781 [PubMed - indexed for MEDLINE]Related articlesFree article

Phase I studies of hypericin, the active compound in St. John's Wort, as an antiretroviral agent in HIV-infected adults. AIDS Clinical Trials Group Protocols 150 and 258.

Gulick RM, McAuliffe V, Holden-Wiltse J, Crumpacker C, Liebes L, Stein DS, Meehan P, Hussey S, Forcht J, Valentine FT.

Ann Intern Med. 1999 Mar 16;130(6):510-4.PMID: 10075619 [PubMed - indexed for MEDLINE]Related articlesFree article

Rapid ganciclovir susceptibility assay using flow cytometry for human cytomegalovirus clinical isolates.

McSharry JJ, Lurain NS, Drusano GL, Landay AL, Notka M, O'Gorman MR, Weinberg A, Shapiro HM, Reichelderfer PS, Crumpacker CS.

Antimicrob Agents Chemother. 1998 Sep;42(9):2326-31.PMID: 9736557 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of the CD8alpha beta-heterodimer on CD8(+) T lymphocytes in peripheral blood lymphocytes of human immunodeficiency virus- and human immunodeficiency virus+ individuals.

Schmitz JE, Forman MA, Lifton MA, Concepción O, Reimann KA Jr, Crumpacker CS, Daley JF, Gelman RS, Letvin NL.

Blood. 1998 Jul 1;92(1):198-206.PMID: 9639517 [PubMed - indexed for MEDLINE]Related articlesFree article

The bis-azo compound FP-21399 inhibits HIV-1 replication by preventing viral entry.

Zhang JL, Choe H, Dezube BJ, Farzan M, Sharma PL, Zhou XC, Chen LB, Ono M, Gillies S, Wu Y, Sodroski JG, Crumpacker CS.

Virology. 1998 May 10;244(2):530-41.PMID: 9601521 [PubMed - indexed for MEDLINE]Related articles

Flow cytometric determination of ganciclovir susceptibilities of human cytomegalovirus clinical isolates.

McSharry JM, Lurain NS, Drusano GL, Landay A, Manischewitz J, Nokta M, O'Gorman M, Shapiro HM, Weinberg A, Reichelderfer P, Crumpacker C.

J Clin Microbiol. 1998 Apr;36(4):958-64.PMID: 9542916 [PubMed - indexed for MEDLINE]Related articlesFree article

Sorivudine versus acyclovir for treatment of dermatomal herpes zoster in human immunodeficiency virus-infected patients: results from a randomized, controlled clinical trial. Collaborative Antiviral Study Group/AIDS Clinical Trials Group, Herpes Zoster Study Group.

Gnann JW Jr, Crumpacker CS, Lalezari JP, Smith JA, Tyring SK, Baum KF, Borucki MJ, Joseph WP, Mertz GJ, Steigbigel RT, Cloud GA, Soong SJ, Sherrill LC, DeHertogh DA, Whitley RJ.

Antimicrob Agents Chemother. 1998 May;42(5):1139-45.PMID: 9593141 [PubMed - indexed for MEDLINE]Related articlesFree article

Attenuated replication of human immunodeficiency virus type 1 with a didanosine-selected reverse transcriptase mutation.

Sharma PL, Crumpacker CS.

J Virol. 1997 Nov;71(11):8846-51. Erratum in: J Virol 1998 Apr;72(4):3504. PMID: 9343245 [PubMed - indexed for MEDLINE]Related articlesFree article

The effect of tenidap on cytokines, acute-phase proteins, and virus load in human immunodeficiency virus (HIV)-infected patients: correlation between plasma HIV-1 RNA and proinflammatory cytokine levels.

Dezube BJ, Lederman MM, Chapman B, Georges DL, Dogon AL, Mudido P, Reis-Lishing J, Cheng SL, Silberman SL, Crumpacker CS.

J Infect Dis. 1997 Sep;176(3):807-10.PMID: 9291340 [PubMed - indexed for MEDLINE]Related articles

Topotecan inhibits human immunodeficiency virus type 1 infection through a topoisomerase-independent mechanism in a cell line with altered topoisomerase I.

Zhang JL, Sharma PL, Li CJ, Dezube BJ, Pardee AB, Crumpacker CS.

Antimicrob Agents Chemother. 1997 May;41(5):977-81.PMID: 9145855 [PubMed - indexed for MEDLINE]Related articlesFree article

The interleukin-2 fusion protein, DAB389IL-2, inhibits the development of infectious virus in human immunodeficiency virus type 1-infected human peripheral blood mononuclear cells.

Zhang LJ, Waters CA, Poisson LR, Estis LF, Crumpacker CS.

J Infect Dis. 1997 Apr;175(4):790-4.PMID: 9086131 [PubMed - indexed for MEDLINE]Related articles

Effect of foscarnet on quantities of cytomegalovirus and human immunodeficiency virus in blood of persons with AIDS.

Balfour HH Jr, Fletcher CV, Erice A, Henry WK, Acosta EP, Smith SA, Holm MA, Boivin G, Shepp DH, Crumpacker CS, Eaton CA, Martin-Munley SS.

Antimicrob Agents Chemother. 1996 Dec;40(12):2721-6.PMID: 9124829 [PubMed - indexed for MEDLINE]Related articlesFree article

A phase-I study of the safety, pharmacokinetics, and antiviral activity of combination didanosine and ribavirin in patients with HIV-1 disease. AIDS Clinical Trials Group 231 Protocol Team.

Japour AJ, Lertora JJ, Meehan PM, Erice A, Connor JD, Griffith BP, Clax PA, Holden-Wiltse J, Hussey S, Walesky M, Cooney E, Pollard R, Timpone J, McLaren C, Johanneson N, Wood K, Booth D, Bassiakos Y, Crumpacker CS.

J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Nov 1;13(3):235-46.PMID: 8898668 [PubMed - indexed for MEDLINE]Related articles

Association of plasma human immunodeficiency virus type 1 RNA level with risk of clinical progression in patients with advanced infection. AIDS Clinical Trials Group (ACTG) 116B/117 Study Team. ACTG Virology Committee Resistance and HIV-1 RNA Working Groups.

Coombs RW, Welles SL, Hooper C, Reichelderfer PS, D'Aquila RT, Japour AJ, Johnson VA, Kuritzkes DR, Richman DD, Kwok S, Todd J, Jackson JB, DeGruttola V, Crumpacker CS, Kahn J.

J Infect Dis. 1996 Oct;174(4):704-12.PMID: 8843206 [PubMed - indexed for MEDLINE]Related articles

Prognostic value of plasma human immunodeficiency virus type 1 (HIV-1) RNA levels in patients with advanced HIV-1 disease and with little or no prior zidovudine therapy. AIDS Clinical Trials Group Protocol 116A/116B/117 Team.

Welles SL, Jackson JB, Yen-Lieberman B, Demeter L, Japour AJ, Smeaton LM, Johnson VA, Kuritzkes DR, D'Aquila RT, Reichelderfer PA, Richman DD, Reichman R, Fischl M, Dolin R, Coombs RW, Kahn JO, McLaren C, Todd J, Kwok S, Crumpacker CS.

J Infect Dis. 1996 Oct;174(4):696-703.PMID: 8843205 [PubMed - indexed for MEDLINE]Related articles

AZT-related mutation Lys70Arg in reverse transcriptase of human immunodeficiency virus type 1 confers decrease in susceptibility to ddATP in in vitro RT inhibition assay.

Sharma PL, Chatis PA, Dogon AL, Mayers DL, McCutchan FE, Page C, Crumpacker CS.

Virology. 1996 Sep 15;223(2):365-9. Erratum in: Virology 1996 Nov 15;225(2):428. PMID: 8806572 [PubMed - indexed for MEDLINE]Related articles

Ganciclovir.

Crumpacker CS.

N Engl J Med. 1996 Sep 5;335(10):721-9. Review. No abstract available. PMID: 8786764 [PubMed - indexed for MEDLINE]Related articles

The pharmacological profile of famciclovir.

Crumpacker C.

Semin Dermatol. 1996 Jun;15(2 Suppl 1):14-26. Review.PMID: 8840412 [PubMed - indexed for MEDLINE]Related articles

Oral ganciclovir as maintenance treatment for cytomegalovirus retinitis in patients with AIDS. Syntex Cooperative Oral Ganciclovir Study Group.

Drew WL, Ives D, Lalezari JP, Crumpacker C, Follansbee SE, Spector SA, Benson CA, Friedberg DN, Hubbard L, Stempien MJ, et al.

N Engl J Med. 1995 Sep 7;333(10):615-20.PMID: 7637721 [PubMed - indexed for MEDLINE]Related articlesFree article

Prevalence and clinical significance of zidovudine resistance mutations in human immunodeficiency virus isolated from patients after long-term zidovudine treatment. AIDS Clinical Trials Group 116B/117 Study Team and the Virology Committee Resistance Working Group.

Japour AJ, Welles S, D'Aquila RT, Johnson VA, Richman DD, Coombs RW, Reichelderfer PS, Kahn JO, Crumpacker CS, Kuritzkes DR.

J Infect Dis. 1995 May;171(5):1172-9.PMID: 7538548 [PubMed - indexed for MEDLINE]Related articles

Detection of human cytomegalovirus DNA, RNA, and antibody in normal donor blood.

Zhang LJ, Hanff P, Rutherford C, Churchill WH, Crumpacker CS.

J Infect Dis. 1995 Apr;171(4):1002-6.PMID: 7706776 [PubMed - indexed for MEDLINE]Related articles

Antiviral resistance in clinical practice.

Kimberlin DW, Crumpacker CS, Straus SE, Biron KK, Drew WL, Hayden FG, McKinlay M, Richman DD, Whitley RJ.

Antiviral Res. 1995 Apr;26(4):423-38. Review. No abstract available. PMID: 7574544 [PubMed - indexed for MEDLINE]Related articles

Zidovudine resistance and HIV-1 disease progression during antiretroviral therapy. AIDS Clinical Trials Group Protocol 116B/117 Team and the Virology Committee Resistance Working Group.

D'Aquila RT, Johnson VA, Welles SL, Japour AJ, Kuritzkes DR, DeGruttola V, Reichelderfer PS, Coombs RW, Crumpacker CS, Kahn JO, Richman DD.

Ann Intern Med. 1995 Mar 15;122(6):401-8.PMID: 7856987 [PubMed - indexed for MEDLINE]Related articlesFree article

A rapid, direct test for zidovudine susceptibility in clinical isolates of human immunodeficiency virus type 1 (HIV-1) from infected children.

Lan Y, Japour AJ, Kim S, Welles SL, Crumpacker CS, Cooper E, Al-Attar I, McIntosh K.

Clin Diagn Virol. 1995 Mar;3(3):259-71.PMID: 15566807 [PubMed]Related articles