PubMed

Role of seminiferous tubular development in determining the FSH versus LH responsiveness to GnRH in early sexual maturation.

Pitteloud N, Thambundit A, Dwyer AA, Falardeau JL, Plummer L, Caronia LM, Hayes FJ, Lee H, Boepple PA, Crowley WF Jr.

Neuroendocrinology. 2009;90(3):260-8. Epub 2009 Oct 15.PMID: 19829004 [PubMed - in process]Related articles

GNRH1 mutations in patients with idiopathic hypogonadotropic hypogonadism.

Chan YM, de Guillebon A, Lang-Muritano M, Plummer L, Cerrato F, Tsiaras S, Gaspert A, Lavoie HB, Wu CH, Crowley WF Jr, Amory JK, Pitteloud N, Seminara SB.

Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11703-8. Epub 2009 Jun 30.PMID: 19567835 [PubMed - indexed for MEDLINE]Related articles

Translational careers.

Andrews N, Burris JE, Cech TR, Coller BS, Crowley WF Jr, Gallin EK, Kelner KL, Kirch DG, Leshner AI, Morris CD, Nguyen FT, Oates J, Sung NS.

Science. 2009 May 15;324(5929):855. No abstract available. PMID: 19443750 [PubMed - indexed for MEDLINE]Related articlesFree article

Safety of frequent venous blood sampling in a pediatric research population.

Broder-Fingert S, Crowley WF Jr, Boepple PA.

J Pediatr. 2009 Apr;154(4):578-81. Epub 2008 Nov 20.PMID: 19026428 [PubMed - indexed for MEDLINE]Related articles

CHD7 mutations in patients initially diagnosed with Kallmann syndrome--the clinical overlap with CHARGE syndrome.

Jongmans MC, van Ravenswaaij-Arts CM, Pitteloud N, Ogata T, Sato N, Claahsen-van der Grinten HL, van der Donk K, Seminara S, Bergman JE, Brunner HG, Crowley WF Jr, Hoefsloot LH.

Clin Genet. 2009 Jan;75(1):65-71. Epub 2008 Nov 17.PMID: 19021638 [PubMed - indexed for MEDLINE]Related articles

Kisspeptin and GPR54: discovery of a novel pathway in reproduction.

Seminara SB, Crowley WF Jr.

J Neuroendocrinol. 2008 Jun;20(6):727-31. Review.PMID: 18601695 [PubMed - indexed for MEDLINE]Related articles

New genes controlling human reproduction and how you find them.

Crowley WF Jr, Pitteloud N, Seminara S.

Trans Am Clin Climatol Assoc. 2008;119:29-37; discussion 37-8. Review.PMID: 18596868 [PubMed - indexed for MEDLINE]Related articlesFree article

Mutations in prokineticin 2 and prokineticin receptor 2 genes in human gonadotrophin-releasing hormone deficiency: molecular genetics and clinical spectrum.

Cole LW, Sidis Y, Zhang C, Quinton R, Plummer L, Pignatelli D, Hughes VA, Dwyer AA, Raivio T, Hayes FJ, Seminara SB, Huot C, Alos N, Speiser P, Takeshita A, Van Vliet G, Pearce S, Crowley WF Jr, Zhou QY, Pitteloud N.

J Clin Endocrinol Metab. 2008 Sep;93(9):3551-9. Epub 2008 Jun 17.PMID: 18559922 [PubMed - indexed for MEDLINE]Related articlesFree article

Use of informatics and information technologies in the clinical research enterprise within US academic medical centers: progress and challenges from 2005 to 2007.

DiLaura R, Turisco F, McGrew C, Reel S, Glaser J, Crowley WF Jr.

J Investig Med. 2008 Jun;56(5):770-9.PMID: 18525452 [PubMed - indexed for MEDLINE]Related articles

The relative role of gonadal sex steroids and gonadotropin-releasing hormone pulse frequency in the regulation of follicle-stimulating hormone secretion in men.

Pitteloud N, Dwyer AA, DeCruz S, Lee H, Boepple PA, Crowley WF Jr, Hayes FJ.

J Clin Endocrinol Metab. 2008 Jul;93(7):2686-92. Epub 2008 Apr 29.PMID: 18445673 [PubMed - indexed for MEDLINE]Related articlesFree article

Relative roles of inhibin B and sex steroids in the negative feedback regulation of follicle-stimulating hormone in men across the full spectrum of seminiferous epithelium function.

Boepple PA, Hayes FJ, Dwyer AA, Raivio T, Lee H, Crowley WF Jr, Pitteloud N.

J Clin Endocrinol Metab. 2008 May;93(5):1809-14. Epub 2008 Feb 12.PMID: 18270253 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of luteinizing hormone secretion by testosterone in men requires aromatization for its pituitary but not its hypothalamic effects: evidence from the tandem study of normal and gonadotropin-releasing hormone-deficient men.

Pitteloud N, Dwyer AA, DeCruz S, Lee H, Boepple PA, Crowley WF Jr, Hayes FJ.

J Clin Endocrinol Metab. 2008 Mar;93(3):784-91. Epub 2007 Dec 11.PMID: 18073301 [PubMed - indexed for MEDLINE]Related articlesFree article

Interplay between dose and frequency of GnRH administration in determining pituitary gonadotropin responsiveness.

Hughes VA, Boepple PA, Crowley WF Jr, Seminara SB.

Neuroendocrinology. 2008;87(3):142-50. Epub 2007 Oct 26.PMID: 18063854 [PubMed - indexed for MEDLINE]Related articles

Mass spectrometric and physiological validation of a sensitive, automated, direct immunoassay for serum estradiol using the Architect.

Sluss PM, Hayes FJ, Adams JM, Barnes W, Williams G, Frost S, Ramp J, Pacenti D, Lehotay DC, George S, Ramsay C, Doss RC, Crowley WF Jr.

Clin Chim Acta. 2008 Feb;388(1-2):99-105. Epub 2007 Nov 26.PMID: 18023274 [PubMed - indexed for MEDLINE]Related articles

Loss-of-function mutation in the prokineticin 2 gene causes Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism.

Pitteloud N, Zhang C, Pignatelli D, Li JD, Raivio T, Cole LW, Plummer L, Jacobson-Dickman EE, Mellon PL, Zhou QY, Crowley WF Jr.

Proc Natl Acad Sci U S A. 2007 Oct 30;104(44):17447-52. Epub 2007 Oct 24.PMID: 17959774 [PubMed - indexed for MEDLINE]Related articlesFree article

Reversal of idiopathic hypogonadotropic hypogonadism.

Raivio T, Falardeau J, Dwyer A, Quinton R, Hayes FJ, Hughes VA, Cole LW, Pearce SH, Lee H, Boepple P, Crowley WF Jr, Pitteloud N.

N Engl J Med. 2007 Aug 30;357(9):863-73.PMID: 17761590 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of continuous intravenous administration of human metastin 45-54 on the neuroendocrine activity of the hypothalamic-pituitary-testicular axis in the adult male rhesus monkey (Macaca mulatta).

Ramaswamy S, Seminara SB, Pohl CR, DiPietro MJ, Crowley WF Jr, Plant TM.

Endocrinology. 2007 Jul;148(7):3364-70. Epub 2007 Apr 5.PMID: 17412800 [PubMed - indexed for MEDLINE]Related articlesFree article

Drug development and clinical research in the UK.

Crowley WF Jr.

Lancet. 2007 Jan 20;369(9557):174-5. No abstract available. PMID: 17240271 [PubMed - indexed for MEDLINE]Related articles

Characterizing discrete subsets of polycystic ovary syndrome as defined by the Rotterdam criteria: the impact of weight on phenotype and metabolic features.

Welt CK, Gudmundsson JA, Arason G, Adams J, Palsdottir H, Gudlaugsdottir G, Ingadottir G, Crowley WF.

J Clin Endocrinol Metab. 2006 Dec;91(12):4842-8. Epub 2006 Sep 26.PMID: 17003085 [PubMed - indexed for MEDLINE]Related articlesFree article

Defining constant versus variable phenotypic features of women with polycystic ovary syndrome using different ethnic groups and populations.

Welt CK, Arason G, Gudmundsson JA, Adams J, Palsdóttir H, Gudlaugsdóttir G, Ingadóttir G, Crowley WF.

J Clin Endocrinol Metab. 2006 Nov;91(11):4361-8. Epub 2006 Aug 29.PMID: 16940441 [PubMed - indexed for MEDLINE]Related articlesFree article

Mutations in fibroblast growth factor receptor 1 cause Kallmann syndrome with a wide spectrum of reproductive phenotypes.

Pitteloud N, Meysing A, Quinton R, Acierno JS Jr, Dwyer AA, Plummer L, Fliers E, Boepple P, Hayes F, Seminara S, Hughes VA, Ma J, Bouloux P, Mohammadi M, Crowley WF Jr.

Mol Cell Endocrinol. 2006 Jul 25;254-255:60-9. Epub 2006 Jun 9.PMID: 16764984 [PubMed - indexed for MEDLINE]Related articles

Neuroendocrine, gonadal, placental, and obstetric phenotypes in patients with IHH and mutations in the G-protein coupled receptor, GPR54.

Pallais JC, Bo-Abbas Y, Pitteloud N, Crowley WF Jr, Seminara SB.

Mol Cell Endocrinol. 2006 Jul 25;254-255:70-7. Epub 2006 Jun 6.PMID: 16757106 [PubMed - indexed for MEDLINE]Related articles

Mutations in fibroblast growth factor receptor 1 cause both Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism.

Pitteloud N, Acierno JS Jr, Meysing A, Eliseenkova AV, Ma J, Ibrahimi OA, Metzger DL, Hayes FJ, Dwyer AA, Hughes VA, Yialamas M, Hall JE, Grant E, Mohammadi M, Crowley WF Jr.

Proc Natl Acad Sci U S A. 2006 Apr 18;103(16):6281-6. Epub 2006 Apr 10.PMID: 16606836 [PubMed - indexed for MEDLINE]Related articlesFree article

Continuous human metastin 45-54 infusion desensitizes G protein-coupled receptor 54-induced gonadotropin-releasing hormone release monitored indirectly in the juvenile male Rhesus monkey (Macaca mulatta): a finding with therapeutic implications.

Seminara SB, Dipietro MJ, Ramaswamy S, Crowley WF Jr, Plant TM.

Endocrinology. 2006 May;147(5):2122-6. Epub 2006 Feb 9.PMID: 16469799 [PubMed - indexed for MEDLINE]Related articlesFree article

Testis morphology in patients with idiopathic hypogonadotropic hypogonadism.

Kumar PA, Pitteloud N, Andrews PA, Dwyer A, Hayes F, Crowley WF Jr, Dym M.

Hum Reprod. 2006 Apr;21(4):1033-40. Epub 2006 Jan 5.PMID: 16396935 [PubMed - indexed for MEDLINE]Related articlesFree article

Recombinant factor VIIa for the treatment of severe postoperative and traumatic hemorrhage.

Khan AZ, Parry JM, Crowley WF, McAllen K, Davis AT, Bonnell BW, Hoogeboom JE.

Am J Surg. 2005 Mar;189(3):331-4.PMID: 15792762 [PubMed - indexed for MEDLINE]Related articles

Increased hypothalamic GPR54 signaling: a potential mechanism for initiation of puberty in primates.

Shahab M, Mastronardi C, Seminara SB, Crowley WF, Ojeda SR, Plant TM.

Proc Natl Acad Sci U S A. 2005 Feb 8;102(6):2129-34. Epub 2005 Jan 31.PMID: 15684075 [PubMed - indexed for MEDLINE]Related articlesFree article

Reversible kallmann syndrome, delayed puberty, and isolated anosmia occurring in a single family with a mutation in the fibroblast growth factor receptor 1 gene.

Pitteloud N, Acierno JS Jr, Meysing AU, Dwyer AA, Hayes FJ, Crowley WF Jr.

J Clin Endocrinol Metab. 2005 Mar;90(3):1317-22. Epub 2004 Dec 21.PMID: 15613419 [PubMed - indexed for MEDLINE]Related articlesFree article

Polycystic ovarian morphology with regular ovulatory cycles: insights into the pathophysiology of polycystic ovarian syndrome.

Adams JM, Taylor AE, Crowley WF Jr, Hall JE.

J Clin Endocrinol Metab. 2004 Sep;89(9):4343-50.PMID: 15356031 [PubMed - indexed for MEDLINE]Related articlesFree article

GNRHR mutations in a woman with idiopathic hypogonadotropic hypogonadism highlight the differential sensitivity of luteinizing hormone and follicle-stimulating hormone to gonadotropin-releasing hormone.

Meysing AU, Kanasaki H, Bedecarrats GY, Acierno JS Jr, Conn PM, Martin KA, Seminara SB, Hall JE, Crowley WF Jr, Kaiser UB.

J Clin Endocrinol Metab. 2004 Jul;89(7):3189-98.PMID: 15240592 [PubMed - indexed for MEDLINE]Related articlesFree article

A role for kisspeptins in the regulation of gonadotropin secretion in the mouse.

Gottsch ML, Cunningham MJ, Smith JT, Popa SM, Acohido BV, Crowley WF, Seminara S, Clifton DK, Steiner RA.

Endocrinology. 2004 Sep;145(9):4073-7. Epub 2004 Jun 24.PMID: 15217982 [PubMed - indexed for MEDLINE]Related articlesFree article

Acute stress masking the biochemical phenotype of partial androgen insensitivity syndrome in a patient with a novel mutation in the androgen receptor.

Pitteloud N, Villegas J, Dwyer AA, Crowley WF Jr, McPhaul MJ, Hayes FJ.

J Clin Endocrinol Metab. 2004 Mar;89(3):1053-8.PMID: 15001585 [PubMed - indexed for MEDLINE]Related articlesFree article

Clinical research in the United States at a crossroads: proposal for a novel public-private partnership to establish a national clinical research enterprise.

Crowley WF Jr, Sherwood L, Salber P, Scheinberg D, Slavkin H, Tilson H, Reece EA, Catanese V, Johnson SB, Dobs A, Genel M, Korn A, Reame N, Bonow R, Grebb J, Rimoin D.

JAMA. 2004 Mar 3;291(9):1120-6.PMID: 14996782 [PubMed - indexed for MEDLINE]Related articles

The GPR54 gene as a regulator of puberty.

Seminara SB, Messager S, Chatzidaki EE, Thresher RR, Acierno JS Jr, Shagoury JK, Bo-Abbas Y, Kuohung W, Schwinof KM, Hendrick AG, Zahn D, Dixon J, Kaiser UB, Slaugenhaupt SA, Gusella JF, O'Rahilly S, Carlton MB, Crowley WF Jr, Aparicio SA, Colledge WH.

N Engl J Med. 2003 Oct 23;349(17):1614-27.PMID: 14573733 [PubMed - indexed for MEDLINE]Related articlesFree article

Heterogeneous expression of the potassium-chloride cotransporter KCC2 in gonadotropin-releasing hormone neurons of the adult mouse.

Leupen SM, Tobet SA, Crowley WF Jr, Kaila K.

Endocrinology. 2003 Jul;144(7):3031-6.PMID: 12810559 [PubMed - indexed for MEDLINE]Related articlesFree article

A locus for autosomal recessive idiopathic hypogonadotropic hypogonadism on chromosome 19p13.3.

Acierno JS Jr, Shagoury JK, Bo-Abbas Y, Crowley WF Jr, Seminara SB.

J Clin Endocrinol Metab. 2003 Jun;88(6):2947-50.PMID: 12788910 [PubMed - indexed for MEDLINE]Related articlesFree article

Autosomal recessive idiopathic hypogonadotropic hypogonadism: genetic analysis excludes mutations in the gonadotropin-releasing hormone (GnRH) and GnRH receptor genes.

Bo-Abbas Y, Acierno JS Jr, Shagoury JK, Crowley WF Jr, Seminara SB.

J Clin Endocrinol Metab. 2003 Jun;88(6):2730-7.PMID: 12788881 [PubMed - indexed for MEDLINE]Related articlesFree article

Translation of basic research into useful treatments: how often does it occur?

Crowley WF Jr.

Am J Med. 2003 Apr 15;114(6):503-5. No abstract available. PMID: 12727585 [PubMed - indexed for MEDLINE]Related articles

Central challenges facing the national clinical research enterprise.

Sung NS, Crowley WF Jr, Genel M, Salber P, Sandy L, Sherwood LM, Johnson SB, Catanese V, Tilson H, Getz K, Larson EL, Scheinberg D, Reece EA, Slavkin H, Dobs A, Grebb J, Martinez RA, Korn A, Rimoin D.

JAMA. 2003 Mar 12;289(10):1278-87.PMID: 12633190 [PubMed - indexed for MEDLINE]Related articles

Predictors of outcome of long-term GnRH therapy in men with idiopathic hypogonadotropic hypogonadism.

Pitteloud N, Hayes FJ, Dwyer A, Boepple PA, Lee H, Crowley WF Jr.

J Clin Endocrinol Metab. 2002 Sep;87(9):4128-36.PMID: 12213860 [PubMed - indexed for MEDLINE]Related articlesFree article

An instrument for determining the amount of NIH support for clinical investigations at one academic health center.

Taylor AE, Stubbs C, Singer DE, Curhan G, Crowley WF Jr.

Acad Med. 2002 Aug;77(8):824-30.PMID: 12176698 [PubMed - indexed for MEDLINE]Related articles

Genetic approaches to unraveling reproductive disorders: examples of bedside to bench research in the genomic era.

Seminara SB, Crowley WF Jr.

Endocr Rev. 2002 Jun;23(3):382-92. Review.PMID: 12050127 [PubMed - indexed for MEDLINE]Related articlesFree article

Hypogonadotropic hypogonadism and cerebellar ataxia: detailed phenotypic characterization of a large, extended kindred.

Seminara SB, Acierno JS Jr, Abdulwahid NA, Crowley WF Jr, Margolin DH.

J Clin Endocrinol Metab. 2002 Apr;87(4):1607-12.PMID: 11932290 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of prior pubertal development, biochemical markers of testicular maturation, and genetics in elucidating the phenotypic heterogeneity of idiopathic hypogonadotropic hypogonadism.

Pitteloud N, Hayes FJ, Boepple PA, DeCruz S, Seminara SB, MacLaughlin DT, Crowley WF Jr.

J Clin Endocrinol Metab. 2002 Jan;87(1):152-60.PMID: 11788640 [PubMed - indexed for MEDLINE]Related articlesFree article

Importance of inhibin B in the regulation of FSH secretion in the human male.

Hayes FJ, Pitteloud N, DeCruz S, Crowley WF Jr, Boepple PA.

J Clin Endocrinol Metab. 2001 Nov;86(11):5541-6.PMID: 11701733 [PubMed - indexed for MEDLINE]Related articlesFree article

The longitudinal study of adrenal maturation during gonadal suppression: evidence that adrenarche is a gradual process.

Palmert MR, Hayden DL, Mansfield MJ, Crigler JF Jr, Crowley WF Jr, Chandler DW, Boepple PA.

J Clin Endocrinol Metab. 2001 Sep;86(9):4536-42.PMID: 11549704 [PubMed - indexed for MEDLINE]Related articlesFree article

The genetics of IHH--a paradox.

Seminara S, Crowley WF Jr.

Clin Endocrinol (Oxf). 2001 Aug;55(2):159-60. No abstract available. PMID: 11531920 [PubMed - indexed for MEDLINE]Related articles

How do academic health centers value and encourage clinical research?

Oinonen MJ, Crowley WF Jr, Moskowitz J, Vlasses PH.

Acad Med. 2001 Jul;76(7):700-6.PMID: 11448823 [PubMed - indexed for MEDLINE]Related articles

The fertile eunuch variant of idiopathic hypogonadotropic hypogonadism: spontaneous reversal associated with a homozygous mutation in the gonadotropin-releasing hormone receptor.

Pitteloud N, Boepple PA, DeCruz S, Valkenburgh SB, Crowley WF Jr, Hayes FJ.

J Clin Endocrinol Metab. 2001 Jun;86(6):2470-5.PMID: 11397842 [PubMed - indexed for MEDLINE]Related articlesFree article

Perspective: the importance of genetic defects in humans in elucidating the complexities of the hypothalamic-pituitary-gonadal axis.

Seminara SB, Crowley WF Jr.

Endocrinology. 2001 Jun;142(6):2173-7. Review. No abstract available. PMID: 11356659 [PubMed - indexed for MEDLINE]Related articlesFree article