PubMed

Glucagon-like peptide-1 therapy and the exocrine pancreas: innocent bystander or friendly fire?

Butler PC, Matveyenko AV, Dry S, Bhushan A, Elashoff R.

Diabetologia. 2009 Nov 6. [Epub ahead of print] No abstract available. PMID: 19894028 [PubMed - as supplied by publisher]Related articles

Insulin glargine controversy: a tribute to the editorial team at Diabetologia.

Butler PC.

Diabetes. 2009 Nov;58(11):2427-8. No abstract available. PMID: 19875618 [PubMed - in process]Related articles

Calcium-activated calpain-2 is a mediator of beta cell dysfunction and apoptosis in type 2 diabetes.

Huang CJ, Gurlo T, Haataja L, Costes S, Daval M, Ryazantsev S, Wu X, Butler AE, Butler PC.

J Biol Chem. 2009 Oct 28. [Epub ahead of print]PMID: 19861418 [PubMed - as supplied by publisher]Related articlesFree article

Relationship between fractional pancreatic beta cell area and fasting plasma glucose concentration in monkeys.

Saisho Y, Butler AE, Manesso E, Galasso R, Zhang L, Gurlo T, Toffolo GM, Cobelli C, Kavanagh K, Wagner JD, Butler PC.

Diabetologia. 2009 Oct 22. [Epub ahead of print]PMID: 19847395 [PubMed - as supplied by publisher]Related articles

Pancreatic duct replication is increased with obesity and type 2 diabetes in humans.

Butler AE, Galasso R, Matveyenko A, Rizza RA, Dry S, Butler PC.

Diabetologia. 2009 Oct 21. [Epub ahead of print]PMID: 19844672 [PubMed - as supplied by publisher]Related articles

Annexin A5 directly interacts with amyloidogenic proteins and reduces their toxicity.

Bedrood S, Jayasinghe S, Sieburth D, Chen M, Erbel S, Butler PC, Langen R, Ritzel RA.

Biochemistry. 2009 Nov 10;48(44):10568-76.PMID: 19810772 [PubMed - indexed for MEDLINE]Related articles

Dynamics of beta-cell turnover: evidence for beta-cell turnover and regeneration from sources of beta-cells other than beta-cell replication in the HIP rat.

Manesso E, Toffolo GM, Saisho Y, Butler AE, Matveyenko AV, Cobelli C, Butler PC.

Am J Physiol Endocrinol Metab. 2009 Aug;297(2):E323-30. Epub 2009 May 26.PMID: 19470833 [PubMed - indexed for MEDLINE]Related articles

Beneficial endocrine but adverse exocrine effects of sitagliptin in the human islet amyloid polypeptide transgenic rat model of type 2 diabetes: interactions with metformin.

Matveyenko AV, Dry S, Cox HI, Moshtaghian A, Gurlo T, Galasso R, Butler AE, Butler PC.

Diabetes. 2009 Jul;58(7):1604-15. Epub 2009 Apr 29.PMID: 19403868 [PubMed - indexed for MEDLINE]Related articlesFree article

11C-dihydrotetrabenazine PET of the pancreas in subjects with long-standing type 1 diabetes and in healthy controls.

Goland R, Freeby M, Parsey R, Saisho Y, Kumar D, Simpson N, Hirsch J, Prince M, Maffei A, Mann JJ, Butler PC, Van Heertum R, Leibel RL, Ichise M, Harris PE.

J Nucl Med. 2009 Mar;50(3):382-9. Epub 2009 Feb 17. Erratum in: J Nucl Med. 2009 Oct;50(10):1578. PMID: 19223416 [PubMed - indexed for MEDLINE]Related articles

Successful versus failed adaptation to high-fat diet-induced insulin resistance: the role of IAPP-induced beta-cell endoplasmic reticulum stress.

Matveyenko AV, Gurlo T, Daval M, Butler AE, Butler PC.

Diabetes. 2009 Apr;58(4):906-16. Epub 2009 Jan 16.PMID: 19151199 [PubMed - indexed for MEDLINE]Related articlesFree article

Development of factors to convert frequency to rate for beta-cell replication and apoptosis quantified by time-lapse video microscopy and immunohistochemistry.

Saisho Y, Manesso E, Gurlo T, Huang CJ, Toffolo GM, Cobelli C, Butler PC.

Am J Physiol Endocrinol Metab. 2009 Jan;296(1):E89-96. Epub 2008 Oct 21.PMID: 18940937 [PubMed - indexed for MEDLINE]Related articles

Relationship between beta-cell mass and diabetes onset.

Matveyenko AV, Butler PC.

Diabetes Obes Metab. 2008 Nov;10 Suppl 4:23-31.PMID: 18834430 [PubMed - indexed for MEDLINE]Related articles

Relationship between pancreatic vesicular monoamine transporter 2 (VMAT2) and insulin expression in human pancreas.

Saisho Y, Harris PE, Butler AE, Galasso R, Gurlo T, Rizza RA, Butler PC.

J Mol Histol. 2008 Oct;39(5):543-51. Epub 2008 Sep 13.PMID: 18791800 [PubMed - indexed for MEDLINE]Related articlesFree article

Adaptations in pulsatile insulin secretion, hepatic insulin clearance, and beta-cell mass to age-related insulin resistance in rats.

Matveyenko AV, Veldhuis JD, Butler PC.

Am J Physiol Endocrinol Metab. 2008 Oct;295(4):E832-41. Epub 2008 Jul 29.PMID: 18664594 [PubMed - indexed for MEDLINE]Related articlesFree article

Many commercially available antibodies for detection of CHOP expression as a marker of endoplasmic reticulum stress fail specificity evaluation.

Haataja L, Gurlo T, Huang CJ, Butler PC.

Cell Biochem Biophys. 2008;51(2-3):105-7. Epub 2008 Jul 24.PMID: 18651105 [PubMed - indexed for MEDLINE]Related articlesFree article

Measurement of pulsatile insulin secretion in the rat: direct sampling from the hepatic portal vein.

Matveyenko AV, Veldhuis JD, Butler PC.

Am J Physiol Endocrinol Metab. 2008 Sep;295(3):E569-74. Epub 2008 Jun 24.PMID: 18577690 [PubMed - indexed for MEDLINE]Related articlesFree article

Pancreatic fat content and beta-cell function in men with and without type 2 diabetes: response to Tushuizen et al.

Saisho Y, Butler AE, Butler PC.

Diabetes Care. 2008 May;31(5):e38; author reply e39. No abstract available. PMID: 18445718 [PubMed - indexed for MEDLINE]Related articlesFree article

Beta-cell replication is the primary mechanism subserving the postnatal expansion of beta-cell mass in humans.

Meier JJ, Butler AE, Saisho Y, Monchamp T, Galasso R, Bhushan A, Rizza RA, Butler PC.

Diabetes. 2008 Jun;57(6):1584-94. Epub 2008 Mar 11.PMID: 18334605 [PubMed - indexed for MEDLINE]Related articlesFree article

Islet amyloid in type 2 diabetes, and the toxic oligomer hypothesis.

Haataja L, Gurlo T, Huang CJ, Butler PC.

Endocr Rev. 2008 May;29(3):303-16. Epub 2008 Feb 26. Review.PMID: 18314421 [PubMed - indexed for MEDLINE]Related articlesFree article

The replication of beta cells in normal physiology, in disease and for therapy.

Butler PC, Meier JJ, Butler AE, Bhushan A.

Nat Clin Pract Endocrinol Metab. 2007 Nov;3(11):758-68. Review.PMID: 17955017 [PubMed - indexed for MEDLINE]Related articles

Induction of endoplasmic reticulum stress-induced beta-cell apoptosis and accumulation of polyubiquitinated proteins by human islet amyloid polypeptide.

Huang CJ, Haataja L, Gurlo T, Butler AE, Wu X, Soeller WC, Butler PC.

Am J Physiol Endocrinol Metab. 2007 Dec;293(6):E1656-62. Epub 2007 Oct 2.PMID: 17911343 [PubMed - indexed for MEDLINE]Related articlesFree article

Pancreas volumes in humans from birth to age one hundred taking into account sex, obesity, and presence of type-2 diabetes.

Saisho Y, Butler AE, Meier JJ, Monchamp T, Allen-Auerbach M, Rizza RA, Butler PC.

Clin Anat. 2007 Nov;20(8):933-42.PMID: 17879305 [PubMed - indexed for MEDLINE]Related articlesFree article

Modestly increased beta cell apoptosis but no increased beta cell replication in recent-onset type 1 diabetic patients who died of diabetic ketoacidosis.

Butler AE, Galasso R, Meier JJ, Basu R, Rizza RA, Butler PC.

Diabetologia. 2007 Nov;50(11):2323-31. Epub 2007 Sep 6.PMID: 17805509 [PubMed - indexed for MEDLINE]Related articles

High expression rates of human islet amyloid polypeptide induce endoplasmic reticulum stress mediated beta-cell apoptosis, a characteristic of humans with type 2 but not type 1 diabetes.

Huang CJ, Lin CY, Haataja L, Gurlo T, Butler AE, Rizza RA, Butler PC.

Diabetes. 2007 Aug;56(8):2016-27. Epub 2007 May 2.PMID: 17475933 [PubMed - indexed for MEDLINE]Related articlesFree article

Hematopoietic stem cells derived from adult donors are not a source of pancreatic beta-cells in adult nondiabetic humans.

Butler AE, Huang A, Rao PN, Bhushan A, Hogan WJ, Rizza RA, Butler PC.

Diabetes. 2007 Jul;56(7):1810-6. Epub 2007 Apr 24.PMID: 17456852 [PubMed - indexed for MEDLINE]Related articlesFree article

Toxic human islet amyloid polypeptide (h-IAPP) oligomers are intracellular, and vaccination to induce anti-toxic oligomer antibodies does not prevent h-IAPP-induced beta-cell apoptosis in h-IAPP transgenic mice.

Lin CY, Gurlo T, Kayed R, Butler AE, Haataja L, Glabe CG, Butler PC.

Diabetes. 2007 May;56(5):1324-32. Epub 2007 Mar 12.PMID: 17353506 [PubMed - indexed for MEDLINE]Related articlesFree article

Human islet amyloid polypeptide oligomers disrupt cell coupling, induce apoptosis, and impair insulin secretion in isolated human islets.

Ritzel RA, Meier JJ, Lin CY, Veldhuis JD, Butler PC.

Diabetes. 2007 Jan;56(1):65-71.PMID: 17192466 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased islet beta cell replication adjacent to intrapancreatic gastrinomas in humans.

Meier JJ, Butler AE, Galasso R, Rizza RA, Butler PC.

Diabetologia. 2006 Nov;49(11):2689-96. Epub 2006 Sep 23.PMID: 17016695 [PubMed - indexed for MEDLINE]Related articles

Mechanisms of impaired fasting glucose and glucose intolerance induced by an approximate 50% pancreatectomy.

Matveyenko AV, Veldhuis JD, Butler PC.

Diabetes. 2006 Aug;55(8):2347-56.PMID: 16873700 [PubMed - indexed for MEDLINE]Related articlesFree article

Intrahepatic transplanted islets in humans secrete insulin in a coordinate pulsatile manner directly into the liver.

Meier JJ, Hong-McAtee I, Galasso R, Veldhuis JD, Moran A, Hering BJ, Butler PC.

Diabetes. 2006 Aug;55(8):2324-32.PMID: 16873697 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of human IAPP fibril formation does not prevent beta-cell death: evidence for distinct actions of oligomers and fibrils of human IAPP.

Meier JJ, Kayed R, Lin CY, Gurlo T, Haataja L, Jayasinghe S, Langen R, Glabe CG, Butler PC.

Am J Physiol Endocrinol Metab. 2006 Dec;291(6):E1317-24. Epub 2006 Jul 18.PMID: 16849627 [PubMed - indexed for MEDLINE]Related articlesFree article

Islet amyloid polypeptide (IAPP) transgenic rodents as models for type 2 diabetes.

Matveyenko AV, Butler PC.

ILAR J. 2006;47(3):225-33. Review.PMID: 16804197 [PubMed - indexed for MEDLINE]Related articlesFree article

Beta-cell deficit due to increased apoptosis in the human islet amyloid polypeptide transgenic (HIP) rat recapitulates the metabolic defects present in type 2 diabetes.

Matveyenko AV, Butler PC.

Diabetes. 2006 Jul;55(7):2106-14.PMID: 16804082 [PubMed - indexed for MEDLINE]Related articlesFree article

Direct evidence of attempted beta cell regeneration in an 89-year-old patient with recent-onset type 1 diabetes.

Meier JJ, Lin JC, Butler AE, Galasso R, Martinez DS, Butler PC.

Diabetologia. 2006 Aug;49(8):1838-44. Epub 2006 Jun 27.PMID: 16802132 [PubMed - indexed for MEDLINE]Related articles

Hyperinsulinemic hypoglycemia after gastric bypass surgery is not accompanied by islet hyperplasia or increased beta-cell turnover.

Meier JJ, Butler AE, Galasso R, Butler PC.

Diabetes Care. 2006 Jul;29(7):1554-9.PMID: 16801578 [PubMed - indexed for MEDLINE]Related articlesFree article

Postprandial suppression of glucagon secretion depends on intact pulsatile insulin secretion: further evidence for the intraislet insulin hypothesis.

Meier JJ, Kjems LL, Veldhuis JD, Lefèbvre P, Butler PC.

Diabetes. 2006 Apr;55(4):1051-6.PMID: 16567528 [PubMed - indexed for MEDLINE]Related articlesFree article

The potential for stem cell therapy in diabetes.

Meier JJ, Bhushan A, Butler PC.

Pediatr Res. 2006 Apr;59(4 Pt 2):65R-73R. Review.PMID: 16549551 [PubMed - indexed for MEDLINE]Related articles

Effects of the potential chemopreventive agent DMU-135 on adenoma development in the ApcMin+ mouse.

Sale S, Tunstall RG, Ruparelia KC, Butler PC, Potter GA, Steward WP, Gescher AJ.

Invest New Drugs. 2006 Nov;24(6):459-64.PMID: 16505954 [PubMed - indexed for MEDLINE]Related articles

Relationship between beta-cell mass and fasting blood glucose concentration in humans.

Ritzel RA, Butler AE, Rizza RA, Veldhuis JD, Butler PC.

Diabetes Care. 2006 Mar;29(3):717-8. No abstract available. PMID: 16505537 [PubMed - indexed for MEDLINE]Related articlesFree article

Comment to: Patti ME, McMahon G, Mun EC et al. (2005) Severe hypoglycaemia post-gastric bypass requiring partial pancreatectomy: evidence for inappropriate insulin secretion and pancreatic islet hyperplasia. Diabetologia 48:2236-2240.

Meier JJ, Nauck MA, Butler PC.

Diabetologia. 2006 Mar;49(3):607-8; author reply 609-10. Epub 2006 Jan 31. No abstract available. PMID: 16450091 [PubMed - indexed for MEDLINE]Related articles

Increased vulnerability of newly forming beta cells to cytokine-induced cell death.

Meier JJ, Ritzel RA, Maedler K, Gurlo T, Butler PC.

Diabetologia. 2006 Jan;49(1):83-9. Epub 2005 Dec 2.PMID: 16323002 [PubMed - indexed for MEDLINE]Related articles

The mass, but not the frequency, of insulin secretory bursts in isolated human islets is entrained by oscillatory glucose exposure.

Ritzel RA, Veldhuis JD, Butler PC.

Am J Physiol Endocrinol Metab. 2006 Apr;290(4):E750-6. Epub 2005 Nov 8.PMID: 16278244 [PubMed - indexed for MEDLINE]Related articlesFree article

Sustained beta cell apoptosis in patients with long-standing type 1 diabetes: indirect evidence for islet regeneration?

Meier JJ, Bhushan A, Butler AE, Rizza RA, Butler PC.

Diabetologia. 2005 Nov;48(11):2221-8. Epub 2005 Oct 5.PMID: 16205882 [PubMed - indexed for MEDLINE]Related articles

Activation of peroxisome proliferator-activated receptor-gamma by rosiglitazone protects human islet cells against human islet amyloid polypeptide toxicity by a phosphatidylinositol 3'-kinase-dependent pathway.

Lin CY, Gurlo T, Haataja L, Hsueh WA, Butler PC.

J Clin Endocrinol Metab. 2005 Dec;90(12):6678-86. Epub 2005 Oct 4.PMID: 16204373 [PubMed - indexed for MEDLINE]Related articlesFree article

Pulsatile insulin secretion dictates systemic insulin delivery by regulating hepatic insulin extraction in humans.

Meier JJ, Veldhuis JD, Butler PC.

Diabetes. 2005 Jun;54(6):1649-56.PMID: 15919785 [PubMed - indexed for MEDLINE]Related articlesFree article

Diabetes due to a progressive defect in beta-cell mass in rats transgenic for human islet amyloid polypeptide (HIP Rat): a new model for type 2 diabetes.

Butler AE, Jang J, Gurlo T, Carty MD, Soeller WC, Butler PC.

Diabetes. 2004 Jun;53(6):1509-16.PMID: 15161755 [PubMed - indexed for MEDLINE]Related articlesFree article

Induction of beta-cell rest by a Kir6.2/SUR1-selective K(ATP)-channel opener preserves beta-cell insulin stores and insulin secretion in human islets cultured at high (11 mM) glucose.

Ritzel RA, Hansen JB, Veldhuis JD, Butler PC.

J Clin Endocrinol Metab. 2004 Feb;89(2):795-805.PMID: 14764798 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased risk of type 2 diabetes in Alzheimer disease.

Janson J, Laedtke T, Parisi JE, O'Brien P, Petersen RC, Butler PC.

Diabetes. 2004 Feb;53(2):474-81.PMID: 14747300 [PubMed - indexed for MEDLINE]Related articlesFree article

Multiple corticosteroid receptors in a teleost fish: distinct sequences, expression patterns, and transcriptional activities.

Greenwood AK, Butler PC, White RB, DeMarco U, Pearce D, Fernald RD.

Endocrinology. 2003 Oct;144(10):4226-36. Epub 2003 Jul 3.PMID: 12959971 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased beta-cell apoptosis prevents adaptive increase in beta-cell mass in mouse model of type 2 diabetes: evidence for role of islet amyloid formation rather than direct action of amyloid.

Butler AE, Janson J, Soeller WC, Butler PC.

Diabetes. 2003 Sep;52(9):2304-14.PMID: 12941770 [PubMed - indexed for MEDLINE]Related articlesFree article