PubMed

EGFR testing in lung cancer is ready for prime time.

Hirsch FR, Bunn PA Jr.

Lancet Oncol. 2009 May;10(5):432-3. No abstract available. PMID: 19410185 [PubMed - indexed for MEDLINE]Related articles

A randomized phase II chemoprevention trial of 13-CIS retinoic acid with or without alpha tocopherol or observation in subjects at high risk for lung cancer.

Kelly K, Kittelson J, Franklin WA, Kennedy TC, Klein CE, Keith RL, Dempsey EC, Lewis M, Jackson MK, Hirsch FR, Bunn PA, Miller YE.

Cancer Prev Res (Phila Pa). 2009 May;2(5):440-9. Epub 2009 Apr 28.PMID: 19401528 [PubMed - indexed for MEDLINE]Related articles

N-(Fluorenyl-9-methoxycarbonyl)amino acid amide derivatives as a new class of anti-cancer agents.

Gera L, Chan DC, Simkeviciene V, Bunn PA Jr, Stewart JM.

Adv Exp Med Biol. 2009;611:465-6. No abstract available. PMID: 19400267 [PubMed - indexed for MEDLINE]Related articles

Novel therapies for non-small-cell lung cancer: a 2008 update.

Bunn PA Jr.

Clin Lung Cancer. 2009 Mar;10 Suppl 1:S6. No abstract available. PMID: 19362947 [PubMed - indexed for MEDLINE]Related articlesFree article

EGFR and HER2 genomic gain in recurrent non-small cell lung cancer after surgery: impact on outcome to treatment with gefitinib and association with EGFR and KRAS mutations in a Japanese cohort.

Varella-Garcia M, Mitsudomi T, Yatabe Y, Kosaka T, Nakajima E, Xavier AC, Skokan M, Zeng C, Franklin WA, Bunn PA Jr, Hirsch FR.

J Thorac Oncol. 2009 Mar;4(3):318-25.PMID: 19247083 [PubMed - indexed for MEDLINE]Related articles

ErbB-3 expression is associated with E-cadherin and their coexpression restores response to gefitinib in non-small-cell lung cancer (NSCLC).

Witta SE, Dziadziuszko R, Yoshida K, Hedman K, Varella-Garcia M, Bunn PA Jr, Hirsch FR.

Ann Oncol. 2009 Apr;20(4):689-95. Epub 2009 Jan 15.PMID: 19150934 [PubMed - indexed for MEDLINE]Related articles

Fibroblast growth factor (FGF) and FGF receptor-mediated autocrine signaling in non-small-cell lung cancer cells.

Marek L, Ware KE, Fritzsche A, Hercule P, Helton WR, Smith JE, McDermott LA, Coldren CD, Nemenoff RA, Merrick DT, Helfrich BA, Bunn PA Jr, Heasley LE.

Mol Pharmacol. 2009 Jan;75(1):196-207. Epub 2008 Oct 10.PMID: 18849352 [PubMed - indexed for MEDLINE]Related articlesFree article

Fluorescence in situ hybridization subgroup analysis of TRIBUTE, a phase III trial of erlotinib plus carboplatin and paclitaxel in non-small cell lung cancer.

Hirsch FR, Varella-Garcia M, Dziadziuszko R, Xiao Y, Gajapathy S, Skokan M, Lin M, O'Neill V, Bunn PA Jr.

Clin Cancer Res. 2008 Oct 1;14(19):6317-23.PMID: 18829515 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased EGFR gene copy number detected by fluorescent in situ hybridization predicts outcome in non-small-cell lung cancer patients treated with cetuximab and chemotherapy.

Hirsch FR, Herbst RS, Olsen C, Chansky K, Crowley J, Kelly K, Franklin WA, Bunn PA Jr, Varella-Garcia M, Gandara DR.

J Clin Oncol. 2008 Jul 10;26(20):3351-7.PMID: 18612151 [PubMed - indexed for MEDLINE]Related articles

First-generation epidermal growth factor receptor inhibitors in non-small cell lung cancer: clinical impact of the epidermal growth factor receptor fluorescence in situ hybridization assay.

Hirsch FR, Dziadziuszko R, Varella-Garcia M, Franklin WA, Gandara DR, Bunn PA Jr.

J Thorac Oncol. 2008 Jun;3(6 Suppl 2):S138-42. Review.PMID: 18520298 [PubMed - indexed for MEDLINE]Related articles

Summary report 7th Annual Targeted Therapies of the Treatment of Lung Cancer.

Einhorn LH, Bonomi P, Bunn PA Jr, Camidge DR, Carbone DP, Choy H, Dubinett SM, Gandara DR, Gaspar LE, Govindan R, Johnson DH, Minna JD, Scagliotti G, West HJ, Herbst RS.

J Thorac Oncol. 2008 May;3(5):545-55. No abstract available. PMID: 18449013 [PubMed - indexed for MEDLINE]Related articles

Diseases desperate grown.

Bunn PA Jr.

J Natl Cancer Inst. 2008 Apr 16;100(8):520-1. Epub 2008 Apr 8. No abstract available. PMID: 18398099 [PubMed - indexed for MEDLINE]Related articlesFree article

Systemic treatment for advanced (stage IIIb/IV) non-small cell lung cancer: more treatment options; more things to consider. Conclusion.

Bunn PA Jr, Thatcher N.

Oncologist. 2008;13 Suppl 1:37-46. Review.PMID: 18263773 [PubMed - indexed for MEDLINE]Related articlesFree article

Systemic treatment for advanced (stage IIIb/IV) non-small cell lung cancer: more treatment options; more things to consider. Introduction.

Bunn PA Jr, Thatcher N.

Oncologist. 2008;13 Suppl 1:1-4.PMID: 18263768 [PubMed - indexed for MEDLINE]Related articlesFree article

EGFR regulation by microRNA in lung cancer: correlation with clinical response and survival to gefitinib and EGFR expression in cell lines.

Weiss GJ, Bemis LT, Nakajima E, Sugita M, Birks DK, Robinson WA, Varella-Garcia M, Bunn PA Jr, Haney J, Helfrich BA, Kato H, Hirsch FR, Franklin WA.

Ann Oncol. 2008 Jun;19(6):1053-9. Epub 2008 Feb 27.PMID: 18304967 [PubMed - indexed for MEDLINE]Related articlesFree article

Epidermal growth factor receptor immunohistochemistry: comparison of antibodies and cutoff points to predict benefit from gefitinib in a phase 3 placebo-controlled study in advanced nonsmall-cell lung cancer.

Hirsch FR, Dziadziuszko R, Thatcher N, Mann H, Watkins C, Parums DV, Speake G, Holloway B, Bunn PA Jr, Franklin WA.

Cancer. 2008 Mar 1;112(5):1114-21.PMID: 18219661 [PubMed - indexed for MEDLINE]Related articlesFree article

Sputum cytologic atypia predicts incident lung cancer: defining latency and histologic specificity.

Byers T, Wolf HJ, Franklin WA, Braudrick S, Merrick DT, Shroyer KR, Hirsch FR, Zeng C, Barón AE, Bunn PA, Miller YE, Kennedy TC.

Cancer Epidemiol Biomarkers Prev. 2008 Jan;17(1):158-62.PMID: 18199720 [PubMed - indexed for MEDLINE]Related articlesFree article

Bronchial epithelial Ki-67 index is related to histology, smoking, and gender, but not lung cancer or chronic obstructive pulmonary disease.

Miller YE, Blatchford P, Hyun DS, Keith RL, Kennedy TC, Wolf H, Byers T, Bunn PA Jr, Lewis MT, Franklin WA, Hirsch FR, Kittelson J.

Cancer Epidemiol Biomarkers Prev. 2007 Nov;16(11):2425-31.PMID: 18006932 [PubMed - indexed for MEDLINE]Related articlesFree article

Docetaxel and exisulind in previously treated non-small cell lung cancer (NSCLC) patients: a multicenter, phase II clinical trial.

Weiss GJ, Vokes EE, Bunn PA Jr, Magree L, Rusk J, Albert D, Kelly K.

J Thorac Oncol. 2007 Oct;2(10):933-8.PMID: 17909356 [PubMed - indexed for MEDLINE]Related articles

Adjuvant chemotherapy for non-small cell lung cancer.

Solomon B, Bunn PA Jr.

Cancer Invest. 2007 Jun;25(4):217-25. Review.PMID: 17612931 [PubMed - indexed for MEDLINE]Related articles

Can acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors be overcome by different small-molecule tyrosine kinase inhibitors?

Bunn PA Jr.

J Clin Oncol. 2007 Jun 20;25(18):2504-5. No abstract available. PMID: 17577025 [PubMed - indexed for MEDLINE]Related articles

Single-institution experience with pemetrexed and bevacizumab as salvage therapy in advanced non-small-cell lung cancer.

Weiss GJ, Zeng C, Kelly K, Tran ZV, Bunn PA Jr.

Clin Lung Cancer. 2007 Mar;8(5):335-8.PMID: 17562234 [PubMed - indexed for MEDLINE]Related articles

Mass spectrometry to classify non-small-cell lung cancer patients for clinical outcome after treatment with epidermal growth factor receptor tyrosine kinase inhibitors: a multicohort cross-institutional study.

Taguchi F, Solomon B, Gregorc V, Roder H, Gray R, Kasahara K, Nishio M, Brahmer J, Spreafico A, Ludovini V, Massion PP, Dziadziuszko R, Schiller J, Grigorieva J, Tsypin M, Hunsucker SW, Caprioli R, Duncan MW, Hirsch FR, Bunn PA Jr, Carbone DP.

J Natl Cancer Inst. 2007 Jun 6;99(11):838-46.PMID: 17551144 [PubMed - indexed for MEDLINE]Related articlesFree article

Epithelial to mesenchymal transition predicts gefitinib resistance in cell lines of head and neck squamous cell carcinoma and non-small cell lung carcinoma.

Frederick BA, Helfrich BA, Coldren CD, Zheng D, Chan D, Bunn PA Jr, Raben D.

Mol Cancer Ther. 2007 Jun;6(6):1683-91. Epub 2007 May 31.PMID: 17541031 [PubMed - indexed for MEDLINE]Related articlesFree article

Unusual chemosensitivity of advanced bronchioalveolar carcinoma after gefitinib response and progression: a case report.

Dziadziuszko R, Siemiatkowska A, Limon J, Rzyman W, Jassem J, Bunn PA Jr, Varella-Garcia M, Hirsch FR.

J Thorac Oncol. 2007 Jan;2(1):91-2.PMID: 17410018 [PubMed - indexed for MEDLINE]Related articles

Lack of association between sputum atypia and chronic obstructive pulmonary disease mortality.

Miller YE, Vu KO, Kennedy TC, Hirsch FR, Petty TL, Bunn PA Jr, Keith RL, Franklin WA, Wolf HJ, Prindiville S, Byers T.

J Thorac Oncol. 2006 May;1(4):302-7.PMID: 17409874 [PubMed - indexed for MEDLINE]Related articles

The impact of induction chemotherapy on the outcome of second-line therapy with pemetrexed or docetaxel in patients with advanced non-small-cell lung cancer.

Weiss GJ, Rosell R, Fossella F, Perry M, Stahel R, Barata F, Nguyen B, Paul S, McAndrews P, Hanna N, Kelly K, Bunn PA Jr.

Ann Oncol. 2007 Mar;18(3):453-60.PMID: 17322539 [PubMed - indexed for MEDLINE]Related articlesFree article

Combination of EGFR gene copy number and protein expression predicts outcome for advanced non-small-cell lung cancer patients treated with gefitinib.

Hirsch FR, Varella-Garcia M, Cappuzzo F, McCoy J, Bemis L, Xavier AC, Dziadziuszko R, Gumerlock P, Chansky K, West H, Gazdar AF, Crino L, Gandara DR, Franklin WA, Bunn PA Jr.

Ann Oncol. 2007 Apr;18(4):752-60. Epub 2007 Feb 22.PMID: 17317677 [PubMed - indexed for MEDLINE]Related articlesFree article

From radiotherapy to Targeted therapy: 20 years in the management of non-small-cell lung cancer.

Weiss GJ, Bunn PA Jr, Camidge DR.

Oncology (Williston Park). 2006 Nov;20(12):1515-24; discussion 1524-5, 1530, 1535. Review.PMID: 17153906 [PubMed - indexed for MEDLINE]Related articles

Antitumor activity of the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor gefitinib (ZD1839, Iressa) in non-small cell lung cancer cell lines correlates with gene copy number and EGFR mutations but not EGFR protein levels.

Helfrich BA, Raben D, Varella-Garcia M, Gustafson D, Chan DC, Bemis L, Coldren C, Barón A, Zeng C, Franklin WA, Hirsch FR, Gazdar A, Minna J, Bunn PA Jr.

Clin Cancer Res. 2006 Dec 1;12(23):7117-25.PMID: 17145836 [PubMed - indexed for MEDLINE]Related articlesFree article

Anti-growth factor therapy for lung cancer.

Chan DC, Geraci M, Bunn PA Jr.

Drug Resist Updat. 1998;1(6):377-88.PMID: 17092819 [PubMed]Related articles

Epidermal growth factor receptor gene copy number and protein level are not associated with outcome of non-small-cell lung cancer patients treated with chemotherapy.

Dziadziuszko R, Holm B, Skov BG, Osterlind K, Sellers MV, Franklin WA, Bunn PA Jr, Varella-Garcia M, Hirsch FR.

Ann Oncol. 2007 Mar;18(3):447-52. Epub 2006 Nov 2.PMID: 17082511 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular predictors of outcome with gefitinib in a phase III placebo-controlled study in advanced non-small-cell lung cancer.

Hirsch FR, Varella-Garcia M, Bunn PA Jr, Franklin WA, Dziadziuszko R, Thatcher N, Chang A, Parikh P, Pereira JR, Ciuleanu T, von Pawel J, Watkins C, Flannery A, Ellison G, Donald E, Knight L, Parums D, Botwood N, Holloway B.

J Clin Oncol. 2006 Nov 1;24(31):5034-42.PMID: 17075123 [PubMed - indexed for MEDLINE]Related articles

Can a single pill replace doublet chemotherapy in first-line therapy of advanced non-small cell lung cancer?

Bunn PA Jr.

Clin Cancer Res. 2006 Oct 15;12(20 Pt 1):5919-20. No abstract available. PMID: 17062660 [PubMed - indexed for MEDLINE]Related articlesFree article

Elderly patients benefit from second-line cytotoxic chemotherapy: a subset analysis of a randomized phase III trial of pemetrexed compared with docetaxel in patients with previously treated advanced non-small-cell lung cancer.

Weiss GJ, Langer C, Rosell R, Hanna N, Shepherd F, Einhorn LH, Nguyen B, Paul S, McAndrews P, Bunn PA Jr, Kelly K.

J Clin Oncol. 2006 Sep 20;24(27):4405-11. Erratum in: J Clin Oncol. 2006 Dec 1;24(34):5477. PMID: 16983108 [PubMed - indexed for MEDLINE]Related articles

Baseline gene expression predicts sensitivity to gefitinib in non-small cell lung cancer cell lines.

Coldren CD, Helfrich BA, Witta SE, Sugita M, Lapadat R, Zeng C, Barón A, Franklin WA, Hirsch FR, Geraci MW, Bunn PA Jr.

Mol Cancer Res. 2006 Aug;4(8):521-8.PMID: 16877703 [PubMed - indexed for MEDLINE]Related articlesFree article

Selecting lung cancer patients for treatment with epidermal growth factor receptor tyrosine kinase inhibitors by immunohistochemistry and fluorescence in situ hybridization--why, when, and how?

Dziadziuszko R, Hirsch FR, Varella-Garcia M, Bunn PA Jr.

Clin Cancer Res. 2006 Jul 15;12(14 Pt 2):4409s-4415s. Review.PMID: 16857819 [PubMed - indexed for MEDLINE]Related articlesFree article

Summary statement: novel agents in the treatment of lung cancer: advances in epidermal growth factor receptor-targeted agents.

Lynch TJ, Adjei AA, Bunn PA Jr, Eisen TG, Engelman J, Goss GD, Haber DA, Heymach JV, Jänne PA, Johnson BE, Johnson DH, Lilenbaum RC, Meyerson M, Sandler AB, Sequist LV, Settleman J, Wong KK, Hart CS.

Clin Cancer Res. 2006 Jul 15;12(14 Pt 2):4365s-4371s. No abstract available. PMID: 16857812 [PubMed - indexed for MEDLINE]Related articlesFree article

Biological markers for non-small cell lung cancer patient selection for epidermal growth factor receptor tyrosine kinase inhibitor therapy.

Bunn PA Jr, Dziadziuszko R, Varella-Garcia M, Franklin WA, Witta SE, Kelly K, Hirsch FR.

Clin Cancer Res. 2006 Jun 15;12(12):3652-6. Review. No abstract available. PMID: 16778092 [PubMed - indexed for MEDLINE]Related articlesFree article

Epidermal growth factor receptor messenger RNA expression, gene dosage, and gefitinib sensitivity in non-small cell lung cancer.

Dziadziuszko R, Witta SE, Cappuzzo F, Park S, Tanaka K, Danenberg PV, Barón AE, Crino L, Franklin WA, Bunn PA Jr, Varella-Garcia M, Danenberg KD, Hirsch FR.

Clin Cancer Res. 2006 May 15;12(10):3078-84.PMID: 16707605 [PubMed - indexed for MEDLINE]Related articlesFree article

Randomized phase III trial comparing irinotecan/cisplatin with etoposide/cisplatin in patients with previously untreated extensive-stage disease small-cell lung cancer.

Hanna N, Bunn PA Jr, Langer C, Einhorn L, Guthrie T Jr, Beck T, Ansari R, Ellis P, Byrne M, Morrison M, Hariharan S, Wang B, Sandler A.

J Clin Oncol. 2006 May 1;24(13):2038-43.PMID: 16648503 [PubMed - indexed for MEDLINE]Related articles

Insulin-like growth factor receptor 1 (IGFR-1) is significantly associated with longer survival in non-small-cell lung cancer patients treated with gefitinib.

Cappuzzo F, Toschi L, Tallini G, Ceresoli GL, Domenichini I, Bartolini S, Finocchiaro G, Magrini E, Metro G, Cancellieri A, Trisolini R, Crino L, Bunn PA Jr, Santoro A, Franklin WA, Varella-Garcia M, Hirsch FR.

Ann Oncol. 2006 Jul;17(7):1120-7. Epub 2006 Apr 6.PMID: 16600976 [PubMed - indexed for MEDLINE]Related articlesFree article

Clinical activity of pemetrexed: a multitargeted antifolate anticancer agent.

Solomon B, Bunn PA Jr.

Future Oncol. 2005 Dec;1(6):733-46. Review.PMID: 16556051 [PubMed - indexed for MEDLINE]Related articles

Promoter hypermethylation of multiple genes in sputum precedes lung cancer incidence in a high-risk cohort.

Belinsky SA, Liechty KC, Gentry FD, Wolf HJ, Rogers J, Vu K, Haney J, Kennedy TC, Hirsch FR, Miller Y, Franklin WA, Herman JG, Baylin SB, Bunn PA, Byers T.

Cancer Res. 2006 Mar 15;66(6):3338-44.PMID: 16540689 [PubMed - indexed for MEDLINE]Related articlesFree article

Adjuvant chemotherapy for resected non-small-cell lung cancer.

Solomon B, Mitchell JD, Bunn PA Jr.

Oncology (Williston Park). 2005 Nov;19(13):1685-97; discussion 1698-700, 1705. Review.PMID: 16425522 [PubMed - indexed for MEDLINE]Related articles

Restoring E-cadherin expression increases sensitivity to epidermal growth factor receptor inhibitors in lung cancer cell lines.

Witta SE, Gemmill RM, Hirsch FR, Coldren CD, Hedman K, Ravdel L, Helfrich B, Dziadziuszko R, Chan DC, Sugita M, Chan Z, Baron A, Franklin W, Drabkin HA, Girard L, Gazdar AF, Minna JD, Bunn PA Jr.

Cancer Res. 2006 Jan 15;66(2):944-50.PMID: 16424029 [PubMed - indexed for MEDLINE]Related articlesFree article

Analysis of orthologous gene expression between human pulmonary adenocarcinoma and a carcinogen-induced murine model.

Stearman RS, Dwyer-Nield L, Zerbe L, Blaine SA, Chan Z, Bunn PA Jr, Johnson GL, Hirsch FR, Merrick DT, Franklin WA, Baron AE, Keith RL, Nemenoff RA, Malkinson AM, Geraci MW.

Am J Pathol. 2005 Dec;167(6):1763-75.PMID: 16314486 [PubMed - indexed for MEDLINE]Related articlesFree article

Epidermal growth factor receptor inhibitors in lung cancer: smaller or larger molecules, selected or unselected populations?

Hirsch FR, Bunn PA Jr.

J Clin Oncol. 2005 Dec 20;23(36):9044-7. Epub 2005 Nov 21. No abstract available. PMID: 16301593 [PubMed - indexed for MEDLINE]Related articles

HER3 genomic gain and sensitivity to gefitinib in advanced non-small-cell lung cancer patients.

Cappuzzo F, Toschi L, Domenichini I, Bartolini S, Ceresoli GL, Rossi E, Ludovini V, Cancellieri A, Magrini E, Bemis L, Franklin WA, Crino L, Bunn PA Jr, Hirsch FR, Varella-Garcia M.

Br J Cancer. 2005 Dec 12;93(12):1334-40.PMID: 16288303 [PubMed - indexed for MEDLINE]Related articlesFree article

Multicenter phase I/II study of cetuximab with paclitaxel and carboplatin in untreated patients with stage IV non-small-cell lung cancer.

Thienelt CD, Bunn PA Jr, Hanna N, Rosenberg A, Needle MN, Long ME, Gustafson DL, Kelly K.

J Clin Oncol. 2005 Dec 1;23(34):8786-93. Epub 2005 Oct 24.PMID: 16246975 [PubMed - indexed for MEDLINE]Related articles