PubMed

A new glucagon and GLP-1 co-agonist eliminates obesity in rodents.

Day JW, Ottaway N, Patterson JT, Gelfanov V, Smiley D, Gidda J, Findeisen H, Bruemmer D, Drucker DJ, Chaudhary N, Holland J, Hembree J, Abplanalp W, Grant E, Ruehl J, Wilson H, Kirchner H, Lockie SH, Hofmann S, Woods SC, Nogueiras R, Pfluger PT, Perez-Tilve D, DiMarchi R, Tschöp MH.

Nat Chem Biol. 2009 Oct;5(10):749-57. Epub 2009 Jul 13.PMID: 19597507 [PubMed - indexed for MEDLINE]Related articles

Deficiency of the NR4A neuron-derived orphan receptor-1 attenuates neointima formation after vascular injury.

Nomiyama T, Zhao Y, Gizard F, Findeisen HM, Heywood EB, Jones KL, Conneely OM, Bruemmer D.

Circulation. 2009 Feb 3;119(4):577-86. Epub 2009 Jan 19.PMID: 19153266 [PubMed - indexed for MEDLINE]Related articlesFree article

The PPARalpha/p16INK4a pathway inhibits vascular smooth muscle cell proliferation by repressing cell cycle-dependent telomerase activation.

Gizard F, Nomiyama T, Zhao Y, Findeisen HM, Heywood EB, Jones KL, Staels B, Bruemmer D.

Circ Res. 2008 Nov 7;103(10):1155-63. Epub 2008 Sep 25.PMID: 18818403 [PubMed - indexed for MEDLINE]Related articlesFree article

Liver X receptors as therapeutic targets in metabolism and atherosclerosis.

Nomiyama T, Bruemmer D.

Curr Atheroscler Rep. 2008 Feb;10(1):88-95. Review.PMID: 18366990 [PubMed - indexed for MEDLINE]Related articles

Phosphorylated troglitazone activates PPARgamma and inhibits vascular smooth muscle cell proliferation and proteoglycan synthesis.

Little PJ, Ballinger ML, Survase S, Osman N, Ogru E, Geytenbeek S, Bruemmer D, Nigro J.

J Cardiovasc Pharmacol. 2008 Mar;51(3):274-9.PMID: 18356692 [PubMed - indexed for MEDLINE]Related articles

Transcriptional Control of Vascular Smooth Muscle Cell Proliferation by Peroxisome Proliferator-Activated Receptor-gamma: Therapeutic Implications for Cardiovascular Diseases.

Gizard F, Bruemmer D.

PPAR Res. 2008;2008:429123.PMID: 18288288 [PubMed - in process]Related articlesFree article

Zinc deficiency alters lipid metabolism in LDL receptor deficient mice treated with rosiglitazone.

Shen H, MacDonald R, Bruemmer D, Stromberg A, Daugherty A, Li XA, Toborek M, Hennig B.

J Nutr. 2007 Nov;137(11):2339-45.PMID: 17951467 [PubMed - indexed for MEDLINE]Related articlesFree article

Osteopontin mediates obesity-induced adipose tissue macrophage infiltration and insulin resistance in mice.

Nomiyama T, Perez-Tilve D, Ogawa D, Gizard F, Zhao Y, Heywood EB, Jones KL, Kawamori R, Cassis LA, Tschöp MH, Bruemmer D.

J Clin Invest. 2007 Oct;117(10):2877-88.PMID: 17823662 [PubMed - indexed for MEDLINE]Related articlesFree article

PPARalpha agonists suppress osteopontin expression in macrophages and decrease plasma levels in patients with type 2 diabetes.

Nakamachi T, Nomiyama T, Gizard F, Heywood EB, Jones KL, Zhao Y, Fuentes L, Takebayashi K, Aso Y, Staels B, Inukai T, Bruemmer D.

Diabetes. 2007 Jun;56(6):1662-70. Epub 2007 Mar 14.PMID: 17360982 [PubMed - indexed for MEDLINE]Related articlesFree article

C-Peptide in insulin resistance and vascular complications: teaching an old dog new tricks.

Bruemmer D.

Circ Res. 2006 Nov 24;99(11):1149-51. Review. No abstract available. PMID: 17122442 [PubMed - indexed for MEDLINE]Related articlesFree article

The NR4A orphan nuclear receptor NOR1 is induced by platelet-derived growth factor and mediates vascular smooth muscle cell proliferation.

Nomiyama T, Nakamachi T, Gizard F, Heywood EB, Jones KL, Ohkura N, Kawamori R, Conneely OM, Bruemmer D.

J Biol Chem. 2006 Nov 3;281(44):33467-76. Epub 2006 Aug 31.PMID: 16945922 [PubMed - indexed for MEDLINE]Related articlesFree article

Osteopontin deficiency protects mice from Dextran sodium sulfate-induced colitis.

Zhong J, Eckhardt ER, Oz HS, Bruemmer D, de Villiers WJ.

Inflamm Bowel Dis. 2006 Aug;12(8):790-6.PMID: 16917234 [PubMed - indexed for MEDLINE]Related articles

Activation of peroxisome proliferator-activated receptor gamma suppresses telomerase activity in vascular smooth muscle cells.

Ogawa D, Nomiyama T, Nakamachi T, Heywood EB, Stone JF, Berger JP, Law RE, Bruemmer D.

Circ Res. 2006 Apr 14;98(7):e50-9. Epub 2006 Mar 23.PMID: 16556873 [PubMed - indexed for MEDLINE]Related articlesFree article

Liver x receptors: potential novel targets in cardiovascular diseases.

Bruemmer D, Law RE.

Curr Drug Targets Cardiovasc Haematol Disord. 2005 Dec;5(6):533-40. Review.PMID: 16503873 [PubMed - indexed for MEDLINE]Related articles

Transcriptional repression of ATP-binding cassette transporter A1 gene in macrophages: a novel atherosclerotic effect of angiotensin II.

Takata Y, Chu V, Collins AR, Lyon CJ, Wang W, Blaschke F, Bruemmer D, Caglayan E, Daley W, Higaki J, Fishbein MC, Tangirala RK, Law RE, Hsueh WA.

Circ Res. 2005 Oct 28;97(9):e88-96. Epub 2005 Oct 13.PMID: 16224068 [PubMed - indexed for MEDLINE]Related articlesFree article

Angiotensin II induces peroxisome proliferator-activated receptor gamma in PC12W cells via angiotensin type 2 receptor activation.

Zhao Y, Foryst-Ludwig A, Bruemmer D, Culman J, Bader M, Unger T, Kintscher U.

J Neurochem. 2005 Sep;94(5):1395-401. Epub 2005 Jun 30.PMID: 15992368 [PubMed - indexed for MEDLINE]Related articles

Liver x receptor agonists inhibit cytokine-induced osteopontin expression in macrophages through interference with activator protein-1 signaling pathways.

Ogawa D, Stone JF, Takata Y, Blaschke F, Chu VH, Towler DA, Law RE, Hsueh WA, Bruemmer D.

Circ Res. 2005 Apr 15;96(7):e59-67. Epub 2005 Mar 24.PMID: 15790955 [PubMed - indexed for MEDLINE]Related articlesFree article

New targets for PPARgamma in the vessel wall: implications for restenosis.

Bruemmer D, Blaschke F, Law RE.

Int J Obes (Lond). 2005 Mar;29 Suppl 1:S26-30. Review.PMID: 15711579 [PubMed - indexed for MEDLINE]Related articles

Liver X receptor agonists suppress vascular smooth muscle cell proliferation and inhibit neointima formation in balloon-injured rat carotid arteries.

Blaschke F, Leppanen O, Takata Y, Caglayan E, Liu J, Fishbein MC, Kappert K, Nakayama KI, Collins AR, Fleck E, Hsueh WA, Law RE, Bruemmer D.

Circ Res. 2004 Dec 10;95(12):e110-23. Epub 2004 Nov 11.PMID: 15539633 [PubMed - indexed for MEDLINE]Related articlesFree article

Will the potential of peroxisome proliferator-activated receptor agonists be realized in the clinical setting?

Blaschke F, Bruemmer D, Law RE.

Clin Cardiol. 2004 Jul;27(7 Suppl 4):IV3-10. Review.PMID: 15470905 [PubMed - indexed for MEDLINE]Related articles

C-reactive protein induces apoptosis in human coronary vascular smooth muscle cells.

Blaschke F, Bruemmer D, Yin F, Takata Y, Wang W, Fishbein MC, Okura T, Higaki J, Graf K, Fleck E, Hsueh WA, Law RE.

Circulation. 2004 Aug 3;110(5):579-87. Epub 2004 Jul 26.PMID: 15277326 [PubMed - indexed for MEDLINE]Related articlesFree article

Egr-1 is a major vascular pathogenic transcription factor in atherosclerosis and restenosis.

Blaschke F, Bruemmer D, Law RE.

Rev Endocr Metab Disord. 2004 Aug;5(3):249-54. Review. No abstract available. PMID: 15211096 [PubMed - indexed for MEDLINE]Related articles

Osteopontin modulates angiotensin II-induced fibrosis in the intact murine heart.

Collins AR, Schnee J, Wang W, Kim S, Fishbein MC, Bruemmer D, Law RE, Nicholas S, Ross RS, Hsueh WA.

J Am Coll Cardiol. 2004 May 5;43(9):1698-705.PMID: 15120833 [PubMed - indexed for MEDLINE]Related articles

Signaling pathways involved in induction of GADD45 gene expression and apoptosis by troglitazone in human MCF-7 breast carcinoma cells.

Yin F, Bruemmer D, Blaschke F, Hsueh WA, Law RE, Herle AJ.

Oncogene. 2004 Jun 3;23(26):4614-23.PMID: 15064713 [PubMed - indexed for MEDLINE]Related articles

Peroxisome proliferator-activated receptor gamma: implications for cardiovascular disease.

Hsueh WA, Bruemmer D.

Hypertension. 2004 Feb;43(2):297-305. Epub 2004 Jan 19. Review.PMID: 14732733 [PubMed - indexed for MEDLINE]Related articlesFree article

Thiazolidinedione regulation of smooth muscle cell proliferation.

Bruemmer D, Law RE.

Am J Med. 2003 Dec 8;115 Suppl 8A:87S-92S. Review.PMID: 14678872 [PubMed - indexed for MEDLINE]Related articles

Angiotensin II-accelerated atherosclerosis and aneurysm formation is attenuated in osteopontin-deficient mice.

Bruemmer D, Collins AR, Noh G, Wang W, Territo M, Arias-Magallona S, Fishbein MC, Blaschke F, Kintscher U, Graf K, Law RE, Hsueh WA.

J Clin Invest. 2003 Nov;112(9):1318-31.PMID: 14597759 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of minichromosome maintenance proteins in vascular smooth muscle cells is ERK/MAPK dependent.

Bruemmer D, Yin F, Liu J, Kiyono T, Fleck E, Van Herle AJ, Law RE.

Exp Cell Res. 2003 Oct 15;290(1):28-37.PMID: 14516785 [PubMed - indexed for MEDLINE]Related articles

Regulation of the growth arrest and DNA damage-inducible gene 45 (GADD45) by peroxisome proliferator-activated receptor gamma in vascular smooth muscle cells.

Bruemmer D, Yin F, Liu J, Berger JP, Sakai T, Blaschke F, Fleck E, Van Herle AJ, Forman BM, Law RE.

Circ Res. 2003 Aug 22;93(4):e38-47. Epub 2003 Jul 24.PMID: 12881480 [PubMed - indexed for MEDLINE]Related articlesFree article

PGE(2) is generated by specific COX-2 activity and increases VEGF production in COX-2-expressing human pancreatic cancer cells.

Eibl G, Bruemmer D, Okada Y, Duffy JP, Law RE, Reber HA, Hines OJ.

Biochem Biophys Res Commun. 2003 Jul 11;306(4):887-97.PMID: 12821125 [PubMed - indexed for MEDLINE]Related articles

p38 MAP kinase negatively regulates angiotensin II-mediated effects on cell cycle molecules in human coronary smooth muscle cells.

Kintscher U, Bruemmer D, Blaschke F, Unger T, Law RE.

Biochem Biophys Res Commun. 2003 Jun 6;305(3):552-6.PMID: 12763029 [PubMed - indexed for MEDLINE]Related articles

Inhibitory activity of clinical thiazolidinedione peroxisome proliferator activating receptor-gamma ligands toward internal mammary artery, radial artery, and saphenous vein smooth muscle cell proliferation.

de Dios ST, Bruemmer D, Dilley RJ, Ivey ME, Jennings GL, Law RE, Little PJ.

Circulation. 2003 May 27;107(20):2548-50. Epub 2003 May 12.PMID: 12742988 [PubMed - indexed for MEDLINE]Related articlesFree article

A non-thiazolidinedione partial peroxisome proliferator-activated receptor gamma ligand inhibits vascular smooth muscle cell growth.

Bruemmer D, Berger JP, Liu J, Kintscher U, Wakino S, Fleck E, Moller DE, Law RE.

Eur J Pharmacol. 2003 Apr 18;466(3):225-34.PMID: 12694805 [PubMed - indexed for MEDLINE]Related articles

Peroxisome proliferator-activated receptor gamma inhibits expression of minichromosome maintenance proteins in vascular smooth muscle cells.

Bruemmer D, Yin F, Liu J, Berger JP, Kiyono T, Chen J, Fleck E, Van Herle AJ, Forman BM, Law RE.

Mol Endocrinol. 2003 Jun;17(6):1005-18. Epub 2003 Apr 3.PMID: 12677008 [PubMed - indexed for MEDLINE]Related articlesFree article

Rapamycin inhibits E2F-dependent expression of minichromosome maintenance proteins in vascular smooth muscle cells.

Bruemmer D, Yin F, Liu J, Kiyono T, Fleck E, Van Herle AJ, Law RE.

Biochem Biophys Res Commun. 2003 Mar 28;303(1):251-8.PMID: 12646195 [PubMed - indexed for MEDLINE]Related articles

Atorvastatin inhibits expression of minichromosome maintenance proteins in vascular smooth muscle cells.

Bruemmer D, Yin F, Liu J, Kiyono T, Fleck E, Van Herle A, Graf K, Law RE.

Eur J Pharmacol. 2003 Feb 21;462(1-3):15-23.PMID: 12591091 [PubMed - indexed for MEDLINE]Related articles

PPARalpha inhibits TGF-beta-induced beta5 integrin transcription in vascular smooth muscle cells by interacting with Smad4.

Kintscher U, Lyon C, Wakino S, Bruemmer D, Feng X, Goetze S, Graf K, Moustakas A, Staels B, Fleck E, Hsueh WA, Law RE.

Circ Res. 2002 Nov 29;91(11):e35-44.PMID: 12456495 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased expression of renal neutral endopeptidase in severe heart failure.

Knecht M, Pagel I, Langenickel T, Philipp S, Scheuermann-Freestone M, Willnow T, Bruemmer D, Graf K, Dietz R, Willenbrock R.

Life Sci. 2002 Oct 25;71(23):2701-12.PMID: 12383878 [PubMed - indexed for MEDLINE]Related articles

TGF-beta(1) induces peroxisome proliferator-activated receptor gamma1 and gamma2 expression in human THP-1 monocytes.

Kintscher U, Wakino S, Bruemmer D, Goetze S, Graf K, Hsueh WA, Law RE.

Biochem Biophys Res Commun. 2002 Oct 4;297(4):794-9.PMID: 12359222 [PubMed - indexed for MEDLINE]Related articles

TNFalpha inhibits insulin's antiapoptotic signaling in vascular smooth muscle cells.

Goetze S, Blaschke F, Stawowy P, Bruemmer D, Spencer C, Graf K, Gräfe M, Law RE, Fleck E.

Biochem Biophys Res Commun. 2001 Sep 28;287(3):662-70.PMID: 11563846 [PubMed - indexed for MEDLINE]Related articles

Expression of CD40 in vascular smooth muscle cells and macrophages is associated with early development of human atherosclerotic lesions.

Bruemmer D, Riggers U, Holzmeister J, Grill M, Lippek F, Settmacher U, Regitz-Zagrosek V, Fleck E, Graf K.

Am J Cardiol. 2001 Jan 1;87(1):21-7.PMID: 11137828 [PubMed - indexed for MEDLINE]Related articles