PubMed

No need to sweat: is dieting enough to alleviate insulin resistance in obesity?

Watt MJ, Bruce CR.

J Physiol. 2009 Nov 1;587(Pt 21):5001-2. No abstract available. PMID: 19880871 [PubMed - in process]Related articles

The Trypanosoma brucei sphingolipid synthase, an essential enzyme and drug target.

Mina JG, Pan SY, Wansadhipathi NK, Bruce CR, Shams-Eldin H, Schwarz RT, Steel PG, Denny PW.

Mol Biochem Parasitol. 2009 Nov;168(1):16-23. Epub 2009 Jun 21.PMID: 19545591 [PubMed - indexed for MEDLINE]Related articles

Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase.

Matthews VB, Aström MB, Chan MH, Bruce CR, Krabbe KS, Prelovsek O, Akerström T, Yfanti C, Broholm C, Mortensen OH, Penkowa M, Hojman P, Zankari A, Watt MJ, Bruunsgaard H, Pedersen BK, Febbraio MA.

Diabetologia. 2009 Jul;52(7):1409-18. Epub 2009 Apr 22.PMID: 19387610 [PubMed - indexed for MEDLINE]Related articles

Lipid and insulin infusion-induced skeletal muscle insulin resistance is likely due to metabolic feedback and not changes in IRS-1, Akt, or AS160 phosphorylation.

Hoy AJ, Brandon AE, Turner N, Watt MJ, Bruce CR, Cooney GJ, Kraegen EW.

Am J Physiol Endocrinol Metab. 2009 Jul;297(1):E67-75. Epub 2009 Apr 14.PMID: 19366875 [PubMed - indexed for MEDLINE]Related articles

Please don't call my mom: pediatric consent and confidentiality.

Bruce CR, Berg SL, McGuire AL.

Clin Pediatr (Phila). 2009 Apr;48(3):243-6. Epub 2008 Dec 11. No abstract available. PMID: 19074356 [PubMed - indexed for MEDLINE]Related articles

Overexpression of carnitine palmitoyltransferase-1 in skeletal muscle is sufficient to enhance fatty acid oxidation and improve high-fat diet-induced insulin resistance.

Bruce CR, Hoy AJ, Turner N, Watt MJ, Allen TL, Carpenter K, Cooney GJ, Febbraio MA, Kraegen EW.

Diabetes. 2009 Mar;58(3):550-8. Epub 2008 Dec 10.PMID: 19073774 [PubMed - indexed for MEDLINE]Related articlesFree article

Lethal injections: legal extensions and implications of "do no harm".

Bruce CR.

Am J Bioeth. 2008 Oct;8(10):58-9. No abstract available. PMID: 19003714 [PubMed - indexed for MEDLINE]Related articles

Alpha2-AMPK activity is not essential for an increase in fatty acid oxidation during low-intensity exercise.

Miura S, Kai Y, Kamei Y, Bruce CR, Kubota N, Febbraio MA, Kadowaki T, Ezaki O.

Am J Physiol Endocrinol Metab. 2009 Jan;296(1):E47-55. Epub 2008 Oct 21.PMID: 18940938 [PubMed - indexed for MEDLINE]Related articles

Prolonged interleukin-6 administration enhances glucose tolerance and increases skeletal muscle PPARalpha and UCP2 expression in rats.

Holmes AG, Mesa JL, Neill BA, Chung J, Carey AL, Steinberg GR, Kemp BE, Southgate RJ, Lancaster GI, Bruce CR, Watt MJ, Febbraio MA.

J Endocrinol. 2008 Aug;198(2):367-74. Epub 2008 Jun 3. Erratum in: J Endocrinol. 2008 Oct;199(1):147. PMID: 18523033 [PubMed - indexed for MEDLINE]Related articlesFree article

HSP72 protects against obesity-induced insulin resistance.

Chung J, Nguyen AK, Henstridge DC, Holmes AG, Chan MH, Mesa JL, Lancaster GI, Southgate RJ, Bruce CR, Duffy SJ, Horvath I, Mestril R, Watt MJ, Hooper PL, Kingwell BA, Vigh L, Hevener A, Febbraio MA.

Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1739-44. Epub 2008 Jan 25.PMID: 18223156 [PubMed - indexed for MEDLINE]Related articlesFree article

Adipose triglyceride lipase regulation of skeletal muscle lipid metabolism and insulin responsiveness.

Watt MJ, van Denderen BJ, Castelli LA, Bruce CR, Hoy AJ, Kraegen EW, Macaulay L, Kemp BE.

Mol Endocrinol. 2008 May;22(5):1200-12. Epub 2008 Jan 17.PMID: 18202145 [PubMed - indexed for MEDLINE]Related articlesFree article

It's what you do with the fat that matters!

Bruce CR, Febbraio MA.

Nat Med. 2007 Oct;13(10):1137-8. No abstract available. PMID: 17917654 [PubMed - indexed for MEDLINE]Related articles

A single MAPKKK regulates the Hog1 MAPK pathway in the pathogenic fungus Candida albicans.

Cheetham J, Smith DA, da Silva Dantas A, Doris KS, Patterson MJ, Bruce CR, Quinn J.

Mol Biol Cell. 2007 Nov;18(11):4603-14. Epub 2007 Sep 5.PMID: 17804815 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose infusion causes insulin resistance in skeletal muscle of rats without changes in Akt and AS160 phosphorylation.

Hoy AJ, Bruce CR, Cederberg A, Turner N, James DE, Cooney GJ, Kraegen EW.

Am J Physiol Endocrinol Metab. 2007 Nov;293(5):E1358-64. Epub 2007 Sep 4.PMID: 17785505 [PubMed - indexed for MEDLINE]Related articlesFree article

Excess lipid availability increases mitochondrial fatty acid oxidative capacity in muscle: evidence against a role for reduced fatty acid oxidation in lipid-induced insulin resistance in rodents.

Turner N, Bruce CR, Beale SM, Hoehn KL, So T, Rolph MS, Cooney GJ.

Diabetes. 2007 Aug;56(8):2085-92. Epub 2007 May 22.PMID: 17519422 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of carnitine palmitoyltransferase I in skeletal muscle in vivo increases fatty acid oxidation and reduces triacylglycerol esterification.

Bruce CR, Brolin C, Turner N, Cleasby ME, van der Leij FR, Cooney GJ, Kraegen EW.

Am J Physiol Endocrinol Metab. 2007 Apr;292(4):E1231-7. Epub 2006 Dec 19.PMID: 17179390 [PubMed - indexed for MEDLINE]Related articlesFree article

Proteomic studies of plant-pathogenic oomycetes and fungi.

Bruce CR, Van West P, Grenville-Briggs LJ.

Methods Biochem Anal. 2006;49:271-83. Review. No abstract available. PMID: 16929684 [PubMed - indexed for MEDLINE]Related articles

Discordant gene expression in skeletal muscle and adipose tissue of patients with type 2 diabetes: effect of interleukin-6 infusion.

Carey AL, Petersen EW, Bruce CR, Southgate RJ, Pilegaard H, Hawley JA, Pedersen BK, Febbraio MA.

Diabetologia. 2006 May;49(5):1000-7. Epub 2006 Mar 15.PMID: 16538490 [PubMed - indexed for MEDLINE]Related articles

The role of adipokines as regulators of skeletal muscle fatty acid metabolism and insulin sensitivity.

Dyck DJ, Heigenhauser GJ, Bruce CR.

Acta Physiol (Oxf). 2006 Jan;186(1):5-16. Review.PMID: 16497175 [PubMed - indexed for MEDLINE]Related articles

Metformin counters the insulin-induced suppression of fatty acid oxidation and stimulation of triacylglycerol storage in rodent skeletal muscle.

Collier CA, Bruce CR, Smith AC, Lopaschuk G, Dyck DJ.

Am J Physiol Endocrinol Metab. 2006 Jul;291(1):E182-9. Epub 2006 Feb 14.PMID: 16478780 [PubMed - indexed for MEDLINE]Related articlesFree article

Endurance training in obese humans improves glucose tolerance and mitochondrial fatty acid oxidation and alters muscle lipid content.

Bruce CR, Thrush AB, Mertz VA, Bezaire V, Chabowski A, Heigenhauser GJ, Dyck DJ.

Am J Physiol Endocrinol Metab. 2006 Jul;291(1):E99-E107. Epub 2006 Feb 7.PMID: 16464906 [PubMed - indexed for MEDLINE]Related articlesFree article

The stimulatory effect of globular adiponectin on insulin-stimulated glucose uptake and fatty acid oxidation is impaired in skeletal muscle from obese subjects.

Bruce CR, Mertz VA, Heigenhauser GJ, Dyck DJ.

Diabetes. 2005 Nov;54(11):3154-60.PMID: 16249439 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of fatty acid translocase on human skeletal muscle mitochondrial membranes: essential role in fatty acid oxidation.

Bezaire V, Bruce CR, Heigenhauser GJ, Tandon NN, Glatz JF, Luiken JJ, Bonen A, Spriet LL.

Am J Physiol Endocrinol Metab. 2006 Mar;290(3):E509-15. Epub 2005 Oct 11.PMID: 16219667 [PubMed - indexed for MEDLINE]Related articlesFree article

PGC-1alpha gene expression is down-regulated by Akt- mediated phosphorylation and nuclear exclusion of FoxO1 in insulin-stimulated skeletal muscle.

Southgate RJ, Bruce CR, Carey AL, Steinberg GR, Walder K, Monks R, Watt MJ, Hawley JA, Birnbaum MJ, Febbraio MA.

FASEB J. 2005 Dec;19(14):2072-4. Epub 2005 Oct 3. Retraction in: FASEB J. 2009 Aug;23(8):2790. PMID: 16203862 [PubMed - indexed for MEDLINE]Related articlesFree article

AMP kinase activation with AICAR simultaneously increases fatty acid and glucose oxidation in resting rat soleus muscle.

Smith AC, Bruce CR, Dyck DJ.

J Physiol. 2005 Jun 1;565(Pt 2):537-46. Epub 2005 Mar 17.PMID: 15774530 [PubMed - indexed for MEDLINE]Related articlesFree article

AMP kinase activation with AICAR further increases fatty acid oxidation and blunts triacylglycerol hydrolysis in contracting rat soleus muscle.

Smith AC, Bruce CR, Dyck DJ.

J Physiol. 2005 Jun 1;565(Pt 2):547-53. Epub 2005 Mar 17.PMID: 15774529 [PubMed - indexed for MEDLINE]Related articlesFree article

Elevated amino acid biosynthesis in Phytophthora infestans during appressorium formation and potato infection.

Grenville-Briggs LJ, Avrova AO, Bruce CR, Williams A, Whisson SC, Birch PR, van West P.

Fungal Genet Biol. 2005 Mar;42(3):244-56. Epub 2005 Jan 11.PMID: 15707845 [PubMed - indexed for MEDLINE]Related articles

Postexercise muscle triacylglycerol and glycogen metabolism in obese insulin-resistant zucker rats.

Bruce CR, Lee JS, Kiens B, Hawley JA.

Obes Res. 2004 Jul;12(7):1158-65.PMID: 15292481 [PubMed - indexed for MEDLINE]Related articles

Regulation of fuel metabolism by preexercise muscle glycogen content and exercise intensity.

Arkinstall MJ, Bruce CR, Clark SA, Rickards CA, Burke LM, Hawley JA.

J Appl Physiol. 2004 Dec;97(6):2275-83. Epub 2004 Jul 30.PMID: 15286047 [PubMed - indexed for MEDLINE]Related articlesFree article

Improvements in insulin resistance with aerobic exercise training: a lipocentric approach.

Bruce CR, Hawley JA.

Med Sci Sports Exerc. 2004 Jul;36(7):1196-201. Review.PMID: 15235325 [PubMed - indexed for MEDLINE]Related articles

Exercise alters the profile of phospholipid molecular species in rat skeletal muscle.

Mitchell TW, Turner N, Hulbert AJ, Else PL, Hawley JA, Lee JS, Bruce CR, Blanksby SJ.

J Appl Physiol. 2004 Nov;97(5):1823-9. Epub 2004 Jun 18.PMID: 15208292 [PubMed - indexed for MEDLINE]Related articlesFree article

Interleukin-6 and tumor necrosis factor-alpha are not increased in patients with Type 2 diabetes: evidence that plasma interleukin-6 is related to fat mass and not insulin responsiveness.

Carey AL, Bruce CR, Sacchetti M, Anderson MJ, Olsen DB, Saltin B, Hawley JA, Febbraio MA.

Diabetologia. 2004 Jun;47(6):1029-37. Epub 2004 May 28.PMID: 15168015 [PubMed - indexed for MEDLINE]Related articles

Cytokine regulation of skeletal muscle fatty acid metabolism: effect of interleukin-6 and tumor necrosis factor-alpha.

Bruce CR, Dyck DJ.

Am J Physiol Endocrinol Metab. 2004 Oct;287(4):E616-21. Epub 2004 May 18.PMID: 15149950 [PubMed - indexed for MEDLINE]Related articlesFree article

The effect of insulin and exercise on c-Cbl protein abundance and phosphorylation in insulin-resistant skeletal muscle in lean and obese Zucker rats.

Wadley GD, Bruce CR, Konstantopoulos N, Macaulay SL, Howlett KF, Hawley JA, Cameron-Smith D.

Diabetologia. 2004 Mar;47(3):412-9. Epub 2004 Jan 17.PMID: 14730380 [PubMed - indexed for MEDLINE]Related articles

Dietary regulation of fat oxidative gene expression in different skeletal muscle fiber types.

McAinch AJ, Lee JS, Bruce CR, Tunstall RJ, Hawley JA, Cameron-Smith D.

Obes Res. 2003 Dec;11(12):1471-9.PMID: 14694211 [PubMed - indexed for MEDLINE]Related articles

Disassociation of muscle triglyceride content and insulin sensitivity after exercise training in patients with Type 2 diabetes.

Bruce CR, Kriketos AD, Cooney GJ, Hawley JA.

Diabetologia. 2004 Jan;47(1):23-30. Epub 2003 Dec 12.PMID: 14673522 [PubMed - indexed for MEDLINE]Related articles

Greater effect of diet than exercise training on the fatty acid profile of rat skeletal muscle.

Turner N, Lee JS, Bruce CR, Mitchell TW, Else PL, Hulbert AJ, Hawley JA.

J Appl Physiol. 2004 Mar;96(3):974-80. Epub 2003 Nov 21.PMID: 14634030 [PubMed - indexed for MEDLINE]Related articlesFree article

Muscle oxidative capacity is a better predictor of insulin sensitivity than lipid status.

Bruce CR, Anderson MJ, Carey AL, Newman DG, Bonen A, Kriketos AD, Cooney GJ, Hawley JA.

J Clin Endocrinol Metab. 2003 Nov;88(11):5444-51.PMID: 14602787 [PubMed - indexed for MEDLINE]Related articlesFree article

Intramuscular heat shock protein 72 and heme oxygenase-1 mRNA are reduced in patients with type 2 diabetes: evidence that insulin resistance is associated with a disturbed antioxidant defense mechanism.

Bruce CR, Carey AL, Hawley JA, Febbraio MA.

Diabetes. 2003 Sep;52(9):2338-45.PMID: 12941774 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of different protocols of caffeine intake on metabolism and endurance performance.

Cox GR, Desbrow B, Montgomery PG, Anderson ME, Bruce CR, Macrides TA, Martin DT, Moquin A, Roberts A, Hawley JA, Burke LM.

J Appl Physiol. 2002 Sep;93(3):990-9.PMID: 12183495 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of training on activation of extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase pathways in rat soleus muscle.

Lee JS, Bruce CR, Spurrell BE, Hawley JA.

Clin Exp Pharmacol Physiol. 2002 Aug;29(8):655-60.PMID: 12099995 [PubMed - indexed for MEDLINE]Related articles

Interaction of exercise and diet on GLUT-4 protein and gene expression in Type I and Type II rat skeletal muscle.

Lee JS, Bruce CR, Tunstall RJ, Cameron-Smith D, Hugel H, Hawley JA.

Acta Physiol Scand. 2002 May;175(1):37-44.PMID: 11982503 [PubMed - indexed for MEDLINE]Related articles

Effect of carbohydrate ingestion on metabolism during running and cycling.

Arkinstall MJ, Bruce CR, Nikolopoulos V, Garnham AP, Hawley JA.

J Appl Physiol. 2001 Nov;91(5):2125-34.PMID: 11641353 [PubMed - indexed for MEDLINE]Related articlesFree article

Postexercise muscle glycogen resynthesis in obese insulin-resistant Zucker rats.

Bruce CR, Lee JS, Hawley JA.

J Appl Physiol. 2001 Oct;91(4):1512-9.PMID: 11568131 [PubMed - indexed for MEDLINE]Related articlesFree article

Interaction of diet and training on endurance performance in rats.

Lee JS, Bruce CR, Spriet LL, Hawley JA.

Exp Physiol. 2001 Jul;86(4):499-508.PMID: 11445829 [PubMed - indexed for MEDLINE]Related articlesFree article

Enhancement of 2000-m rowing performance after caffeine ingestion.

Bruce CR, Anderson ME, Fraser SF, Stepto NK, Klein R, Hopkins WG, Hawley JA.

Med Sci Sports Exerc. 2000 Nov;32(11):1958-63.PMID: 11079528 [PubMed - indexed for MEDLINE]Related articles

Improved 2000-meter rowing performance in competitive oarswomen after caffeine ingestion.

Anderson ME, Bruce CR, Fraser SF, Stepto NK, Klein R, Hopkins WG, Hawley JA.

Int J Sport Nutr Exerc Metab. 2000 Dec;10(4):464-75.PMID: 11099373 [PubMed - indexed for MEDLINE]Related articles