PubMed

"Actin"g on GLUT4: membrane & cytoskeletal components of insulin action.

Brozinick JT Jr, Berkemeier BA, Elmendorf JS.

Curr Diabetes Rev. 2007 May;3(2):111-22. Review.PMID: 18220662 [PubMed - indexed for MEDLINE]Related articlesFree article

Antidiabetogenic effects of chromium mitigate hyperinsulinemia-induced cellular insulin resistance via correction of plasma membrane cholesterol imbalance.

Horvath EM, Tackett L, McCarthy AM, Raman P, Brozinick JT, Elmendorf JS.

Mol Endocrinol. 2008 Apr;22(4):937-50. Epub 2007 Dec 28.PMID: 18165437 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance.

Holland WL, Brozinick JT, Wang LP, Hawkins ED, Sargent KM, Liu Y, Narra K, Hoehn KL, Knotts TA, Siesky A, Nelson DH, Karathanasis SK, Fontenot GK, Birnbaum MJ, Summers SA.

Cell Metab. 2007 Mar;5(3):167-79.PMID: 17339025 [PubMed - indexed for MEDLINE]Related articles

Synthesis and evaluation of aminomethyl dihydrocinnamates as a new class of PPAR ligands.

Warshawsky AM, Alt CA, Brozinick JT, Harkness AR, Hawkins ED, Henry JR, Matthews DP, Miller AR, Misener EA, Montrose-Rafizadeh C, Rhodes GA, Shen Q, Vance JA, Udodong UE, Wang M, Zhang TY, Zink RW.

Bioorg Med Chem Lett. 2006 Dec 15;16(24):6328-33. Epub 2006 Sep 26.PMID: 17005394 [PubMed - indexed for MEDLINE]Related articles

Tetrahydroisoquinoline PPARgamma agonists: design of novel, highly selective non-TZD antihyperglycemic agents.

Henry JR, Li Y, Warshawsky AM, Brozinick JT, Hawkins ED, Misener EA, Briere DA, Montrose-Rafizadeh C, Zink RW, Yumibe NP, Ajamie RT, Wilken B, Devanarayan V.

Bioorg Med Chem Lett. 2006 Dec 15;16(24):6293-7. Epub 2006 Sep 26.PMID: 17005393 [PubMed - indexed for MEDLINE]Related articles

Loss of cortical actin filaments in insulin-resistant skeletal muscle cells impairs GLUT4 vesicle trafficking and glucose transport.

McCarthy AM, Spisak KO, Brozinick JT, Elmendorf JS.

Am J Physiol Cell Physiol. 2006 Nov;291(5):C860-8. Epub 2006 Jun 14.PMID: 16774991 [PubMed - indexed for MEDLINE]Related articlesFree article

FGF-21 as a novel metabolic regulator.

Kharitonenkov A, Shiyanova TL, Koester A, Ford AM, Micanovic R, Galbreath EJ, Sandusky GE, Hammond LJ, Moyers JS, Owens RA, Gromada J, Brozinick JT, Hawkins ED, Wroblewski VJ, Li DS, Mehrbod F, Jaskunas SR, Shanafelt AB.

J Clin Invest. 2005 Jun;115(6):1627-35. Epub 2005 May 2.PMID: 15902306 [PubMed - indexed for MEDLINE]Related articlesFree article

A peroxisome proliferator-activated receptor alpha/gamma dual agonist with a unique in vitro profile and potent glucose and lipid effects in rodent models of type 2 diabetes and dyslipidemia.

Reifel-Miller A, Otto K, Hawkins E, Barr R, Bensch WR, Bull C, Dana S, Klausing K, Martin JA, Rafaeloff-Phail R, Rafizadeh-Montrose C, Rhodes G, Robey R, Rojo I, Rungta D, Snyder D, Wilbur K, Zhang T, Zink R, Warshawsky A, Brozinick JT.

Mol Endocrinol. 2005 Jun;19(6):1593-605. Epub 2005 Apr 14.PMID: 15831517 [PubMed - indexed for MEDLINE]Related articlesFree article

2-Alkoxydihydrocinnamates as PPAR agonists. Activity modulation by the incorporation of phenoxy substituents.

Martín JA, Brooks DA, Prieto L, González R, Torrado A, Rojo I, López de Uralde B, Lamas C, Ferritto R, Dolores Martín-Ortega M, Agejas J, Parra F, Rizzo JR, Rhodes GA, Robey RL, Alt CA, Wendel SR, Zhang TY, Reifel-Miller A, Montrose-Rafizadeh C, Brozinick JT, Hawkins E, Misener EA, Briere DA, Ardecky R, Fraser JD, Warshawsky AM.

Bioorg Med Chem Lett. 2005 Jan 3;15(1):51-5.PMID: 15582409 [PubMed - indexed for MEDLINE]Related articles

Disruption of cortical actin in skeletal muscle demonstrates an essential role of the cytoskeleton in glucose transporter 4 translocation in insulin-sensitive tissues.

Brozinick JT Jr, Hawkins ED, Strawbridge AB, Elmendorf JS.

J Biol Chem. 2004 Sep 24;279(39):40699-706. Epub 2004 Jul 6.PMID: 15247264 [PubMed - indexed for MEDLINE]Related articlesFree article

Defective signaling through Akt-2 and -3 but not Akt-1 in insulin-resistant human skeletal muscle: potential role in insulin resistance.

Brozinick JT Jr, Roberts BR, Dohm GL.

Diabetes. 2003 Apr;52(4):935-41.PMID: 12663464 [PubMed - indexed for MEDLINE]Related articlesFree article

Measurement of contraction-stimulated GLUT-4 translocation in isolated skeletal muscle.

Brozinick JT Jr.

Methods Mol Med. 2003;83:163-9. No abstract available. PMID: 12619728 [PubMed - indexed for MEDLINE]Related articles

Metabolic and anthropometric factors related to skeletal muscle UCP3 gene expression in healthy human adults.

Calsbeek DJ, Thompson TL, Dahl JA, Stob NR, Brozinick JT Jr, Hill JO, Hickey MS.

Am J Physiol Endocrinol Metab. 2002 Oct;283(4):E631-7.PMID: 12217879 [PubMed - indexed for MEDLINE]Related articlesFree article

A tailored therapy for the metabolic syndrome: the dual peroxisome proliferator-activated receptor-alpha/gamma agonist LY465608 ameliorates insulin resistance and diabetic hyperglycemia while improving cardiovascular risk factors in preclinical models.

Etgen GJ, Oldham BA, Johnson WT, Broderick CL, Montrose CR, Brozinick JT, Misener EA, Bean JS, Bensch WR, Brooks DA, Shuker AJ, Rito CJ, McCarthy JR, Ardecky RJ, Tyhonas JS, Dana SL, Bilakovics JM, Paterniti JR Jr, Ogilvie KM, Liu S, Kauffman RF.

Diabetes. 2002 Apr;51(4):1083-7.PMID: 11916929 [PubMed - indexed for MEDLINE]Related articlesFree article

A role for AMP-activated protein kinase in contraction- and hypoxia-regulated glucose transport in skeletal muscle.

Mu J, Brozinick JT Jr, Valladares O, Bucan M, Birnbaum MJ.

Mol Cell. 2001 May;7(5):1085-94.PMID: 11389854 [PubMed - indexed for MEDLINE]Related articles

GLUT4 overexpression in db/db mice dose-dependently ameliorates diabetes but is not a lifelong cure.

Brozinick JT Jr, McCoid SC, Reynolds TH, Nardone NA, Hargrove DM, Stevenson RW, Cushman SW, Gibbs EM.

Diabetes. 2001 Mar;50(3):593-600.PMID: 11246879 [PubMed - indexed for MEDLINE]Related articlesFree article

Transient enhancement of GLUT-4 levels in rat epitrochlearis muscle after exercise training.

Reynolds TH 4th, Brozinick JT Jr, Larkin LM, Cushman SW.

J Appl Physiol. 2000 Jun;88(6):2240-5.PMID: 10846041 [PubMed - indexed for MEDLINE]Related articlesFree article

1-[N, O-bis-(5-isoquinolinesulphonyl)-N-methyl-L-tyrosyl]-4- phenylpiperazine (KN-62), an inhibitor of calcium-dependent camodulin protein kinase II, inhibits both insulin- and hypoxia-stimulated glucose transport in skeletal muscle.

Brozinick JT Jr, Reynolds TH, Dean D, Cartee G, Cushman SW.

Biochem J. 1999 May 1;339 ( Pt 3):533-40.PMID: 10215590 [PubMed - indexed for MEDLINE]Related articlesFree article

Calorie restriction increases cell surface GLUT-4 in insulin-stimulated skeletal muscle.

Dean DJ, Brozinick JT Jr, Cushman SW, Cartee GD.

Am J Physiol. 1998 Dec;275(6 Pt 1):E957-64.PMID: 9843737 [PubMed - indexed for MEDLINE]Related articlesFree article

Short-term exercise enhances insulin-stimulated GLUT-4 translocation and glucose transport in adipose cells.

Ferrara CM, Reynolds TH, Zarnowski MJ, Brozinick JT Jr, Cushman SW.

J Appl Physiol. 1998 Dec;85(6):2106-11.PMID: 9843532 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin, but not contraction, activates Akt/PKB in isolated rat skeletal muscle.

Brozinick JT Jr, Birnbaum MJ.

J Biol Chem. 1998 Jun 12;273(24):14679-82.PMID: 9614064 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanism of hypoxia-stimulated glucose transport in rat skeletal muscle: potential role of glycogen.

Reynolds TH 4th, Brozinick JT Jr, Rogers MA, Cushman SW.

Am J Physiol. 1998 May;274(5 Pt 1):E773-8.PMID: 9612232 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of exercise training on glucose transport and cell surface GLUT-4 in isolated rat epitrochlearis muscle.

Reynolds TH 4th, Brozinick JT Jr, Rogers MA, Cushman SW.

Am J Physiol. 1997 Feb;272(2 Pt 1):E320-5.PMID: 9124341 [PubMed - indexed for MEDLINE]Related articles

Regulation of cell surface GLUT4 in skeletal muscle of transgenic mice.

Brozinick JT Jr, McCoid SC, Reynolds TH, Wilson CM, Stevenson RW, Cushman SW, Gibbs EM.

Biochem J. 1997 Jan 1;321 ( Pt 1):75-81.PMID: 9003403 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose transport and GLUT4 protein distribution in skeletal muscle of GLUT4 transgenic mice.

Brozinick JT Jr, Yaspelkis BB 3rd, Wilson CM, Grant KE, Gibbs EM, Cushman SW, Ivy JL.

Biochem J. 1996 Jan 1;313 ( Pt 1):133-40.PMID: 8546674 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose uptake and GLUT-4 protein distribution in skeletal muscle of the obese Zucker rat.

Brozinick JT Jr, Etgen GJ Jr, Yaspelkis BB 3rd, Ivy JL.

Am J Physiol. 1994 Jul;267(1 Pt 2):R236-43.PMID: 8048627 [PubMed - indexed for MEDLINE]Related articles

The effects of muscle contraction and insulin on glucose-transporter translocation in rat skeletal muscle.

Brozinick JT Jr, Etgen GJ Jr, Yaspelkis BB 3rd, Ivy JL.

Biochem J. 1994 Feb 1;297 ( Pt 3):539-45.PMID: 8110191 [PubMed - indexed for MEDLINE]Related articlesFree article

Interaction of aerobic exercise training and clenbuterol: effects on insulin-resistant muscle.

Torgan CE, Etgen GJ Jr, Brozinick JT Jr, Wilcox RE, Ivy JL.

J Appl Physiol. 1993 Oct;75(4):1471-6.PMID: 8282592 [PubMed - indexed for MEDLINE]Related articles

Effects of exercise training on muscle GLUT-4 protein content and translocation in obese Zucker rats.

Brozinick JT Jr, Etgen GJ Jr, Yaspelkis BB 3rd, Kang HY, Ivy JL.

Am J Physiol. 1993 Sep;265(3 Pt 1):E419-27.PMID: 8214051 [PubMed - indexed for MEDLINE]Related articles

Effects of exercise training on skeletal muscle glucose uptake and transport.

Etgen GJ Jr, Brozinick JT Jr, Kang HY, Ivy JL.

Am J Physiol. 1993 Mar;264(3 Pt 1):C727-33.PMID: 8460676 [PubMed - indexed for MEDLINE]Related articles

Exercise training and clenbuterol reduce insulin resistance of obese Zucker rats.

Torgan CE, Brozinick JT Jr, Banks EA, Cortez MY, Wilcox RE, Ivy JL.

Am J Physiol. 1993 Mar;264(3 Pt 1):E373-9.PMID: 8384791 [PubMed - indexed for MEDLINE]Related articles

Muscle glucose transport, GLUT-4 content, and degree of exercise training in obese Zucker rats.

Banks EA, Brozinick JT Jr, Yaspelkis BB 3rd, Kang HY, Ivy JL.

Am J Physiol. 1992 Nov;263(5 Pt 1):E1010-5.PMID: 1443111 [PubMed - indexed for MEDLINE]Related articles

Contraction-activated glucose uptake is normal in insulin-resistant muscle of the obese Zucker rat.

Brozinick JT Jr, Etgen GJ Jr, Yaspelkis BB 3rd, Ivy JL.

J Appl Physiol. 1992 Jul;73(1):382-7.PMID: 1506395 [PubMed - indexed for MEDLINE]Related articles

Insulin resistance of obese Zucker rats exercise trained at two different intensities.

Cortez MY, Torgan CE, Brozinick JT Jr, Ivy JL.

Am J Physiol. 1991 Nov;261(5 Pt 1):E613-9.PMID: 1951686 [PubMed - indexed for MEDLINE]Related articles

Effects of pyruvate and dihydroxyacetone consumption on the growth and metabolic state of obese Zucker rats.

Cortez MY, Torgan CE, Brozinick JT Jr, Miller RH, Ivy JL.

Am J Clin Nutr. 1991 Apr;53(4):847-53.PMID: 2008862 [PubMed - indexed for MEDLINE]Related articlesFree article

Muscle glucose uptake of obese Zucker rats trained at two different intensities.

Willems ME, Brozinick JT Jr, Torgan CE, Cortez MY, Ivy JL.

J Appl Physiol. 1991 Jan;70(1):36-42.PMID: 2010393 [PubMed - indexed for MEDLINE]Related articles

Substrate utilization during acute exercise in obese Zucker rats.

Torgan CE, Brozinick JT Jr, Willems ME, Ivy JL.

J Appl Physiol. 1990 Dec;69(6):1987-91.PMID: 2076991 [PubMed - indexed for MEDLINE]Related articles

Muscle morphological and biochemical adaptations to training in obese Zucker rats.

Torgan CE, Brozinick JT Jr, Kastello GM, Ivy JL.

J Appl Physiol. 1989 Nov;67(5):1807-13.PMID: 2557320 [PubMed - indexed for MEDLINE]Related articles

Skeletal muscle glucose transport in obese Zucker rats after exercise training.

Ivy JL, Brozinick JT Jr, Torgan CE, Kastello GM.

J Appl Physiol. 1989 Jun;66(6):2635-41.PMID: 2745325 [PubMed - indexed for MEDLINE]Related articles

Muscle glycogen storage postexercise: effect of mode of carbohydrate administration.

Reed MJ, Brozinick JT Jr, Lee MC, Ivy JL.

J Appl Physiol. 1989 Feb;66(2):720-6.PMID: 2651386 [PubMed - indexed for MEDLINE]Related articles

Muscle glycogen storage after different amounts of carbohydrate ingestion.

Ivy JL, Lee MC, Brozinick JT Jr, Reed MJ.

J Appl Physiol. 1988 Nov;65(5):2018-23.PMID: 3145274 [PubMed - indexed for MEDLINE]Related articles

Effects of fasting and training on pyruvate dehydrogenase activation during exercise.

Brozinick JT Jr, Patel VK, Dohm GL.

Int J Biochem. 1988;20(3):297-301.PMID: 3356292 [PubMed - indexed for MEDLINE]Related articles