PubMed

CCR5 ligands modulate CXCL12-induced chemotaxis, adhesion, and Akt phosphorylation of human cord blood CD34+ cells.

Basu S, Broxmeyer HE.

J Immunol. 2009 Dec 1;183(11):7478-88. Epub 2009 Nov 16.PMID: 19917679 [PubMed - in process]Related articles

Experimental basis of cord blood transplantation.

Broxmeyer HE, Cooper S, Hass DM, Hathaway JK, Stehman FB, Hangoc G.

Bone Marrow Transplant. 2009 Nov;44(10):627-33. Epub 2009 Oct 5.PMID: 19802026 [PubMed - in process]Related articles

Overexpression of Rheb2 enhances mouse hematopoietic progenitor cell growth while impairing stem cell repopulation.

Campbell TB, Basu S, Hangoc G, Tao W, Broxmeyer HE.

Blood. 2009 Oct 15;114(16):3392-401. Epub 2009 Aug 18.PMID: 19690340 [PubMed - indexed for MEDLINE]Related articles

Targeted disruption of Zfp36l2, encoding a CCCH tandem zinc finger RNA-binding protein, results in defective hematopoiesis.

Stumpo DJ, Broxmeyer HE, Ward T, Cooper S, Hangoc G, Chung YJ, Shelley WC, Richfield EK, Ray MK, Yoder MC, Aplan PD, Blackshear PJ.

Blood. 2009 Sep 17;114(12):2401-10. Epub 2009 Jul 24.PMID: 19633199 [PubMed - indexed for MEDLINE]Related articles

A noncytotoxic DsRed variant for whole-cell labeling.

Strack RL, Strongin DE, Bhattacharyya D, Tao W, Berman A, Broxmeyer HE, Keenan RJ, Glick BS.

Nat Methods. 2008 Nov;5(11):955-7. Epub 2008 Oct 26.PMID: 18953349 [PubMed - indexed for MEDLINE]Related articles

Sirt1, notch and stem cell "age asymmetry".

Mantel CR, Wang RH, Deng C, Broxmeyer HE.

Cell Cycle. 2008 Sep 15;7(18):2821-5. Epub 2008 Sep 26.PMID: 18797187 [PubMed - indexed for MEDLINE]Related articles

Mouse hematopoietic stem cells, unlike human and mouse embryonic stem cells, exhibit checkpoint-apoptosis coupling.

Rohrabaugh S, Mantel C, Broxmeyer HE.

Stem Cells Dev. 2008 Oct;17(5):1017-20.PMID: 18788999 [PubMed - indexed for MEDLINE]Related articles

Identification of parameters required for efficient lentiviral vector transduction and engraftment of human cord blood CD34(+) NOD/SCID-repopulating cells.

Liu Y, Hangoc G, Campbell TB, Goodman M, Tao W, Pollok K, Srour EF, Broxmeyer HE.

Exp Hematol. 2008 Aug;36(8):947-56.PMID: 18640494 [PubMed - indexed for MEDLINE]Related articlesFree article

Leukocytosis and Mobilization of CD34+ Hematopoietic Progenitor Cells by AMD3100, a CXCR4 Antagonist.

Hübel K, Liles WC, Broxmeyer HE, Rodger E, Wood B, Cooper S, Hangoc G, Macfarland R, Bridger GJ, Henson GW, Calandra G, Dale DC.

Support Cancer Ther. 2004 Apr 1;1(3):165-72.PMID: 18628138 [PubMed - in process]Related articlesFree article

Sirtuin 1, stem cells, aging, and stem cell aging.

Mantel C, Broxmeyer HE.

Curr Opin Hematol. 2008 Jul;15(4):326-31. Review.PMID: 18536570 [PubMed - indexed for MEDLINE]Related articlesFree article

AMD3100 synergizes with G-CSF to mobilize repopulating stem cells in Fanconi anemia knockout mice.

Pulliam AC, Hobson MJ, Ciccone SL, Li Y, Chen S, Srour EF, Yang FC, Broxmeyer HE, Clapp DW.

Exp Hematol. 2008 Sep;36(9):1084-90. Epub 2008 May 20.PMID: 18495331 [PubMed - indexed for MEDLINE]Related articles

Measurement of interleukin 3 and other hematopoietic cytokines, such as GM-CSF, G-CSF, M-CSF, erythropoietin, steel factor, and Flt-3 ligand.

Cooper SH, Broxmeyer HE.

Curr Protoc Immunol. 2001 May;Chapter 6:Unit 6.4.PMID: 18432817 [PubMed - indexed for MEDLINE]Related articles

SIRT1 regulates apoptosis and Nanog expression in mouse embryonic stem cells by controlling p53 subcellular localization.

Han MK, Song EK, Guo Y, Ou X, Mantel C, Broxmeyer HE.

Cell Stem Cell. 2008 Mar 6;2(3):241-51.PMID: 18371449 [PubMed - indexed for MEDLINE]Related articles

Mechanism unknown: prostaglandin E2 may improve HSC therapies.

Broxmeyer HE.

Cell Stem Cell. 2007 Aug 16;1(2):135-6.PMID: 18371345 [PubMed - indexed for MEDLINE]Related articles

Vaccinia virus infection modulates the hematopoietic cell compartments in the bone marrow.

Singh P, Yao Y, Weliver A, Broxmeyer HE, Hong SC, Chang CH.

Stem Cells. 2008 Apr;26(4):1009-16. Epub 2008 Feb 7.PMID: 18258722 [PubMed - indexed for MEDLINE]Related articlesFree article

Cells enter a unique intermediate 4N stage, not 4N-G1, after aborted mitosis.

Mantel C, Guo Y, Lee MR, Han MK, Rhorabough S, Kim KS, Broxmeyer HE.

Cell Cycle. 2008 Feb 15;7(4):484-92. Epub 2007 Nov 16.PMID: 18235235 [PubMed - indexed for MEDLINE]Related articles

Chemokines in hematopoiesis.

Broxmeyer HE.

Curr Opin Hematol. 2008 Jan;15(1):49-58. Review.PMID: 18043246 [PubMed - indexed for MEDLINE]Related articles

4-1BB regulates NKG2D costimulation in human cord blood CD8+ T cells.

Kim YJ, Han MK, Broxmeyer HE.

Blood. 2008 Feb 1;111(3):1378-86. Epub 2007 Nov 16.PMID: 18024793 [PubMed - indexed for MEDLINE]Related articlesFree article

CD26 inhibition and hematopoiesis: a novel approach to enhance transplantation.

Campbell TB, Broxmeyer HE.

Front Biosci. 2008 Jan 1;13:1795-805. Review.PMID: 17981668 [PubMed - indexed for MEDLINE]Related articles

Oct-4 is critical for survival/antiapoptosis of murine embryonic stem cells subjected to stress: effects associated with Stat3/survivin.

Guo Y, Mantel C, Hromas RA, Broxmeyer HE.

Stem Cells. 2008 Jan;26(1):30-4. Epub 2007 Oct 11.PMID: 17932422 [PubMed - indexed for MEDLINE]Related articlesFree article

Vitamin A metabolites induce gut-homing FoxP3+ regulatory T cells.

Kang SG, Lim HW, Andrisani OM, Broxmeyer HE, Kim CH.

J Immunol. 2007 Sep 15;179(6):3724-33.PMID: 17785809 [PubMed - indexed for MEDLINE]Related articlesFree article

SDF-1/CXCL12 enhances in vitro replating capacity of murine and human multipotential and macrophage progenitor cells.

Broxmeyer HE, Mejia JA, Hangoc G, Barese C, Dinauer M, Cooper S.

Stem Cells Dev. 2007 Aug;16(4):589-96.PMID: 17784832 [PubMed - indexed for MEDLINE]Related articles

Protein phosphatase 2A plays an important role in stromal cell-derived factor-1/CXC chemokine ligand 12-mediated migration and adhesion of CD34+ cells.

Basu S, Ray NT, Atkinson SJ, Broxmeyer HE.

J Immunol. 2007 Sep 1;179(5):3075-85.PMID: 17709522 [PubMed - indexed for MEDLINE]Related articlesFree article

Depsipeptide (FK228) preferentially induces apoptosis in BCR/ABL-expressing cell lines and cells from patients with chronic myelogenous leukemia in blast crisis.

Okabe S, Tauchi T, Nakajima A, Sashida G, Gotoh A, Broxmeyer HE, Ohyashiki JH, Ohyashiki K.

Stem Cells Dev. 2007 Jun;16(3):503-14.PMID: 17610380 [PubMed - indexed for MEDLINE]Related articles

Inhibition of CD26 in human cord blood CD34+ cells enhances their engraftment of nonobese diabetic/severe combined immunodeficiency mice.

Campbell TB, Hangoc G, Liu Y, Pollok K, Broxmeyer HE.

Stem Cells Dev. 2007 Jun;16(3):347-54.PMID: 17610364 [PubMed - indexed for MEDLINE]Related articles

TGF-beta combined with M-CSF and IL-4 induces generation of immune inhibitory cord blood dendritic cells capable of enhancing cytokine-induced ex vivo expansion of myeloid progenitors.

Li G, Abediankenari S, Kim YJ, Campbell TB, Ito S, Graham-Evans B, Cooper S, Broxmeyer HE.

Blood. 2007 Oct 15;110(8):2872-9. Epub 2007 Jun 21.PMID: 17585053 [PubMed - indexed for MEDLINE]Related articlesFree article

Aberrant regulation of hematopoiesis by T cells in BAZF-deficient mice.

Broxmeyer HE, Sehra S, Cooper S, Toney LM, Kusam S, Aloor JJ, Marchal CC, Dinauer MC, Dent AL.

Mol Cell Biol. 2007 Aug;27(15):5275-85. Epub 2007 May 25.PMID: 17526724 [PubMed - indexed for MEDLINE]Related articlesFree article

A naturally occurring splice variant of CXCL12/stromal cell-derived factor 1 is a potent human immunodeficiency virus type 1 inhibitor with weak chemotaxis and cell survival activities.

Altenburg JD, Broxmeyer HE, Jin Q, Cooper S, Basu S, Alkhatib G.

J Virol. 2007 Aug;81(15):8140-8. Epub 2007 May 16.PMID: 17507482 [PubMed - indexed for MEDLINE]Related articlesFree article

A role for natural killer T cells and CD1d molecules in counteracting suppression of hematopoiesis in mice induced by infection with murine cytomegalovirus.

Broxmeyer HE, Dent A, Cooper S, Hangoc G, Wang ZY, Du W, Gervay-Haque J, Sriram V, Renukaradhya GJ, Brutkiewicz RR.

Exp Hematol. 2007 Apr;35(4 Suppl 1):87-93.PMID: 17379092 [PubMed - indexed for MEDLINE]Related articles

Regulation of myeloid progenitor cell proliferation/survival by IL-31 receptor and IL-31.

Broxmeyer HE, Li J, Hangoc G, Cooper S, Tao W, Mantel C, Graham-Evans B, Ghilardi N, de Sauvage FJ.

Exp Hematol. 2007 Apr;35(4 Suppl 1):78-86.PMID: 17379091 [PubMed - indexed for MEDLINE]Related articlesFree article

AMD3100 and CD26 modulate mobilization, engraftment, and survival of hematopoietic stem and progenitor cells mediated by the SDF-1/CXCL12-CXCR4 axis.

Broxmeyer HE, Hangoc G, Cooper S, Campbell T, Ito S, Mantel C.

Ann N Y Acad Sci. 2007 Jun;1106:1-19. Epub 2007 Mar 14.PMID: 17360804 [PubMed - indexed for MEDLINE]Related articles

A new connection between the spindle checkpoint, asymmetric cell division and cytokine signaling.

Mantel C, Broxmeyer HE.

Cell Cycle. 2007 Jan 15;6(2):144-6. Epub 2007 Jan 3. Review.PMID: 17314513 [PubMed - indexed for MEDLINE]Related articles

Checkpoint-apoptosis uncoupling in human and mouse embryonic stem cells: a source of karyotpic instability.

Mantel C, Guo Y, Lee MR, Kim MK, Han MK, Shibayama H, Fukuda S, Yoder MC, Pelus LM, Kim KS, Broxmeyer HE.

Blood. 2007 May 15;109(10):4518-27. Epub 2007 Feb 8.PMID: 17289813 [PubMed - indexed for MEDLINE]Related articlesFree article

Influence of ERK activation on decreased chemotaxis of mature human cord blood monocyte-derived dendritic cells to CCL19 and CXCL12.

Li G, Basu S, Han MK, Kim YJ, Broxmeyer HE.

Blood. 2007 Apr 15;109(8):3173-6. Epub 2006 Dec 19.PMID: 17179222 [PubMed - indexed for MEDLINE]Related articlesFree article

Cord blood stem and progenitor cells.

Broxmeyer HE, Srour E, Orschell C, Ingram DA, Cooper S, Plett PA, Mead LE, Yoder MC.

Methods Enzymol. 2006;419:439-73. Review.PMID: 17141066 [PubMed - indexed for MEDLINE]Related articles

Enhanced green fluorescent protein is a nearly ideal long-term expression tracer for hematopoietic stem cells, whereas DsRed-express fluorescent protein is not.

Tao W, Evans BG, Yao J, Cooper S, Cornetta K, Ballas CB, Hangoc G, Broxmeyer HE.

Stem Cells. 2007 Mar;25(3):670-8. Epub 2006 Nov 30.PMID: 17138958 [PubMed - indexed for MEDLINE]Related articlesFree article

Negative regulation of chemokine receptor CXCR4 by tumor suppressor p53 in breast cancer cells: implications of p53 mutation or isoform expression on breast cancer cell invasion.

Mehta SA, Christopherson KW, Bhat-Nakshatri P, Goulet RJ Jr, Broxmeyer HE, Kopelovich L, Nakshatri H.

Oncogene. 2007 May 17;26(23):3329-37. Epub 2006 Nov 27.PMID: 17130833 [PubMed - indexed for MEDLINE]Related articles

Mad2 is required for optimal hematopoiesis: Mad2 associates with c-Kit in MO7e cells.

Ito S, Mantel CR, Han MK, Basu S, Fukuda S, Cooper S, Broxmeyer HE.

Blood. 2007 Mar 1;109(5):1923-30. Epub 2006 Oct 12.PMID: 17038523 [PubMed - indexed for MEDLINE]Related articlesFree article

SHP-2 phosphatase is required for hematopoietic cell transformation by Bcr-Abl.

Chen J, Yu WM, Daino H, Broxmeyer HE, Druker BJ, Qu CK.

Blood. 2007 Jan 15;109(2):778-85. Epub 2006 Sep 26.PMID: 17003374 [PubMed - indexed for MEDLINE]Related articlesFree article

Class II transactivator-mediated regulation of major histocompatibility complex class II antigen expression is important for hematopoietic progenitor cell suppression by chemokines and iron-binding proteins.

Broxmeyer HE, Cooper S, Hangoc G, Chang CH.

Exp Hematol. 2006 Aug;34(8):1078-84.PMID: 16863914 [PubMed - indexed for MEDLINE]Related articles

Synergistic inhibition in vivo of bone marrow myeloid progenitors by myelosuppressive chemokines and chemokine-accelerated recovery of progenitors after treatment of mice with Ara-C.

Broxmeyer HE, Pelus LM, Kim CH, Hangoc G, Cooper S, Hromas R.

Exp Hematol. 2006 Aug;34(8):1069-77.PMID: 16863913 [PubMed - indexed for MEDLINE]Related articles

Chemokines and chemokine receptors in hematopoiesis and immunology.

Broxmeyer HE.

Exp Hematol. 2006 Aug;34(8):965-6. No abstract available. PMID: 16863902 [PubMed - indexed for MEDLINE]Related articles

Enhanced functional response to CXCL12/SDF-1 through retroviral overexpression of CXCR4 on M07e cells: implications for hematopoietic stem cell transplantation.

Porecha NK, English K, Hangoc G, Broxmeyer HE, Christopherson KW 2nd.

Stem Cells Dev. 2006 Jun;15(3):325-33.PMID: 16846371 [PubMed - indexed for MEDLINE]Related articles

The IL-17 cytokine family members are inhibitors of human hematopoietic progenitor proliferation.

Broxmeyer HE, Starnes T, Ramsey H, Cooper S, Dahl R, Williamson E, Hromas R.

Blood. 2006 Jul 15;108(2):770. No abstract available. PMID: 16822904 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of trafficking receptor expression in human forkhead box P3+ regulatory T cells.

Lim HW, Broxmeyer HE, Kim CH.

J Immunol. 2006 Jul 15;177(2):840-51.PMID: 16818738 [PubMed - indexed for MEDLINE]Related articlesFree article

Retraction. Macrophage inflammatory protein-1alpha and interferon-inducible protein 10 inhibit synergistically induced growth factor stimulation of MAP kinase activity and suppress phosphorylation of eukaryotic initiation factor 4E and 4E binding protein 1.

Broxmeyer HE, Ginras AC, Sonenberg N, Cooper S.

Blood. 2006 Jun 15;107(12):4713. No abstract available. PMID: 16754774 [PubMed - indexed for MEDLINE]Related articlesFree article

Stromal-cell-derived factor-1/CXCL12-induced chemotaxis of a T cell line involves intracellular signaling through Cbl and Cbl-b and their regulation by Src kinases and CD45.

Okabe S, Tauchi T, Ohyashiki K, Broxmeyer HE.

Blood Cells Mol Dis. 2006 Mar-Apr;36(2):308-14. Epub 2006 Feb 28.PMID: 16503409 [PubMed - indexed for MEDLINE]Related articles

Murine embryonic stem cells secrete cytokines/growth modulators that enhance cell survival/anti-apoptosis and stimulate colony formation of murine hematopoietic progenitor cells.

Guo Y, Graham-Evans B, Broxmeyer HE.

Stem Cells. 2006 Apr;24(4):850-6. Epub 2005 Dec 8.PMID: 16339641 [PubMed - indexed for MEDLINE]Related articlesFree article

SDF-1/CXCL12 enhances survival and chemotaxis of murine embryonic stem cells and production of primitive and definitive hematopoietic progenitor cells.

Guo Y, Hangoc G, Bian H, Pelus LM, Broxmeyer HE.

Stem Cells. 2005 Oct;23(9):1324-32. Erratum in: Stem Cells. 2006 Jan;24(1):211. PMID: 16210409 [PubMed - indexed for MEDLINE]Related articlesFree article

Biology of cord blood cells and future prospects for enhanced clinical benefit.

Broxmeyer HE.

Cytotherapy. 2005;7(3):209-18. Review.PMID: 16081347 [PubMed - indexed for MEDLINE]Related articles