PubMed

On the reversibility of glutamate dehydrogenase and the source of hyperammonemia in the hyperinsulinism/hyperammonemia syndrome.

Treberg JR, Brosnan ME, Watford M, Brosnan JT.

Adv Enzyme Regul. 2009 Nov 4. [Epub ahead of print] No abstract available. PMID: 19895831 [PubMed - as supplied by publisher]Related articles

Hepatic glutamate metabolism: a tale of 2 hepatocytes.

Brosnan ME, Brosnan JT.

Am J Clin Nutr. 2009 Sep;90(3):857S-861S. Epub 2009 Jul 22. Review.PMID: 19625684 [PubMed - indexed for MEDLINE]Related articles

Lack of phosphatidylethanolamine N-methyltransferase alters plasma VLDL phospholipids and attenuates atherosclerosis in mice.

Zhao Y, Su B, Jacobs RL, Kennedy B, Francis GA, Waddington E, Brosnan JT, Vance JE, Vance DE.

Arterioscler Thromb Vasc Biol. 2009 Sep;29(9):1349-55. Epub 2009 Jun 11.PMID: 19520976 [PubMed - indexed for MEDLINE]Related articles

Creatine synthesis is a major metabolic process in neonatal piglets and has important implications for amino acid metabolism and methyl balance.

Brosnan JT, Wijekoon EP, Warford-Woolgar L, Trottier NL, Brosnan ME, Brunton JA, Bertolo RF.

J Nutr. 2009 Jul;139(7):1292-7. Epub 2009 May 27.PMID: 19474158 [PubMed - indexed for MEDLINE]Related articles

Creatine synthesis: hepatic metabolism of guanidinoacetate and creatine in the rat in vitro and in vivo.

da Silva RP, Nissim I, Brosnan ME, Brosnan JT.

Am J Physiol Endocrinol Metab. 2009 Feb;296(2):E256-61. Epub 2008 Nov 18.PMID: 19017728 [PubMed - indexed for MEDLINE]Related articles

Elevated tissue betaine contents in developing rats are due to dietary betaine, not to synthesis.

Clow KA, Treberg JR, Brosnan ME, Brosnan JT.

J Nutr. 2008 Sep;138(9):1641-6.PMID: 18716163 [PubMed - indexed for MEDLINE]Related articlesFree article

Homocysteine metabolism in diabetes.

Wijekoon EP, Brosnan ME, Brosnan JT.

Biochem Soc Trans. 2007 Nov;35(Pt 5):1175-9. Review.PMID: 17956306 [PubMed - indexed for MEDLINE]Related articles

Creatine synthesis: production of guanidinoacetate by the rat and human kidney in vivo.

Edison EE, Brosnan ME, Meyer C, Brosnan JT.

Am J Physiol Renal Physiol. 2007 Dec;293(6):F1799-804. Epub 2007 Oct 10.PMID: 17928413 [PubMed - indexed for MEDLINE]Related articlesFree article

Orotic acid excretion and arginine metabolism.

Brosnan ME, Brosnan JT.

J Nutr. 2007 Jun;137(6 Suppl 2):1656S-1661S. Review.PMID: 17513443 [PubMed - indexed for MEDLINE]Related articlesFree article

Creatine: endogenous metabolite, dietary, and therapeutic supplement.

Brosnan JT, Brosnan ME.

Annu Rev Nutr. 2007;27:241-61. Review.PMID: 17430086 [PubMed - indexed for MEDLINE]Related articles

New insights into creatine function and synthesis.

Brosnan ME, Edison EE, da Silva R, Brosnan JT.

Adv Enzyme Regul. 2007;47:252-60. Epub 2007 Mar 1. Review. No abstract available. PMID: 17335874 [PubMed - indexed for MEDLINE]Related articles

Methyl balance and transmethylation fluxes in humans.

Mudd SH, Brosnan JT, Brosnan ME, Jacobs RL, Stabler SP, Allen RH, Vance DE, Wagner C.

Am J Clin Nutr. 2007 Jan;85(1):19-25.PMID: 17209172 [PubMed - indexed for MEDLINE]Related articlesFree article

Amino acids and the regulation of methyl balance in humans.

Brosnan JT, da Silva R, Brosnan ME.

Curr Opin Clin Nutr Metab Care. 2007 Jan;10(1):52-7. Review.PMID: 17143055 [PubMed - indexed for MEDLINE]Related articles

The sulfur-containing amino acids: an overview.

Brosnan JT, Brosnan ME.

J Nutr. 2006 Jun;136(6 Suppl):1636S-1640S. Review.PMID: 16702333 [PubMed - indexed for MEDLINE]Related articlesFree article

Is it time to reevaluate methyl balance in humans?

Stead LM, Brosnan JT, Brosnan ME, Vance DE, Jacobs RL.

Am J Clin Nutr. 2006 Jan;83(1):5-10.PMID: 16400042 [PubMed - indexed for MEDLINE]Related articlesFree article

Branched-chain amino acids: enzyme and substrate regulation.

Brosnan JT, Brosnan ME.

J Nutr. 2006 Jan;136(1 Suppl):207S-11S. Review.PMID: 16365084 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of diabetes and insulin on betaine-homocysteine S-methyltransferase expression in rat liver.

Ratnam S, Wijekoon EP, Hall B, Garrow TA, Brosnan ME, Brosnan JT.

Am J Physiol Endocrinol Metab. 2006 May;290(5):E933-9. Epub 2005 Dec 13.PMID: 16352668 [PubMed - indexed for MEDLINE]Related articlesFree article

Homocysteine metabolism in ZDF (type 2) diabetic rats.

Wijekoon EP, Hall B, Ratnam S, Brosnan ME, Zeisel SH, Brosnan JT.

Diabetes. 2005 Nov;54(11):3245-51.PMID: 16249451 [PubMed - indexed for MEDLINE]Related articlesFree article

Metabolic design principles: chemical and physical determinants of cell chemistry.

Brosnan JT.

Adv Enzyme Regul. 2005;45:27-36. Epub 2005 Aug 26. No abstract available. PMID: 16126257 [PubMed - indexed for MEDLINE]Related articles

Hyperglycinemia due to folate deficiency in rats: evidence for the lack of involvement of the hepatic glycine cleavage system.

Dickson TM, Edison E, Brosnan JT, House JD.

J Nutr Biochem. 2005 Dec;16(12):736-42. Epub 2005 Aug 2.PMID: 16081265 [PubMed - indexed for MEDLINE]Related articles

Physiological regulation of phospholipid methylation alters plasma homocysteine in mice.

Jacobs RL, Stead LM, Devlin C, Tabas I, Brosnan ME, Brosnan JT, Vance DE.

J Biol Chem. 2005 Aug 5;280(31):28299-305. Epub 2005 Jun 15.PMID: 15958390 [PubMed - indexed for MEDLINE]Related articlesFree article

The Fourth Workshop on the Assessment of Adequate intake of Dietary Amino Acids: general discussion of sessions 1 and 2.

Brosnan JT.

J Nutr. 2005 Jun;135(6 Suppl):1576S-9S. No abstract available. PMID: 15930472 [PubMed - indexed for MEDLINE]Related articlesFree article

Localization-independent regulation of homocysteine secretion by phosphatidylethanolamine N-methyltransferase.

Shields DJ, Lingrell S, Agellon LB, Brosnan JT, Vance DE.

J Biol Chem. 2005 Jul 22;280(29):27339-44. Epub 2005 May 31.PMID: 15927961 [PubMed - indexed for MEDLINE]Related articlesFree article

Homocysteine and cardiovascular disease: interactions between nutrition, genetics and lifestyle.

Brosnan JT.

Can J Appl Physiol. 2004 Dec;29(6):773-80. Review.PMID: 15630149 [PubMed - indexed for MEDLINE]Related articles

Methylation demand and homocysteine metabolism.

Stead LM, Jacobs RL, Brosnan ME, Brosnan JT.

Adv Enzyme Regul. 2004;44:321-33. Review. No abstract available. PMID: 15581499 [PubMed - indexed for MEDLINE]Related articles

Renal arginine metabolism.

Brosnan ME, Brosnan JT.

J Nutr. 2004 Oct;134(10 Suppl):2791S-2795S; discussion 2796S-2797S. Review.PMID: 15465786 [PubMed - indexed for MEDLINE]Related articlesFree article

Amino acid metabolism in the Zucker diabetic fatty rat: effects of insulin resistance and of type 2 diabetes.

Wijekoon EP, Skinner C, Brosnan ME, Brosnan JT.

Can J Physiol Pharmacol. 2004 Jul;82(7):506-14.PMID: 15389298 [PubMed - indexed for MEDLINE]Related articles

Methylation demand: a key determinant of homocysteine metabolism.

Brosnan JT, Jacobs RL, Stead LM, Brosnan ME.

Acta Biochim Pol. 2004;51(2):405-13. Review.PMID: 15218538 [PubMed - indexed for MEDLINE]Related articlesFree article

A window into cellular metabolism: hepatic metabolism of (15)N-labelled substrates.

Brosnan JT, Brosnan ME, Nissim I.

Metab Eng. 2004 Jan;6(1):6-11.PMID: 14734251 [PubMed - indexed for MEDLINE]Related articles

Interorgan amino acid transport and its regulation.

Brosnan JT.

J Nutr. 2003 Jun;133(6 Suppl 1):2068S-2072S. Review.PMID: 12771367 [PubMed - indexed for MEDLINE]Related articlesFree article

Plasma homocysteine is regulated by phospholipid methylation.

Noga AA, Stead LM, Zhao Y, Brosnan ME, Brosnan JT, Vance DE.

J Biol Chem. 2003 Feb 21;278(8):5952-5. Epub 2002 Dec 12. Erratum in: J Biol Chem. 2003 Apr 18;278(16):14586. PMID: 12482759 [PubMed - indexed for MEDLINE]Related articlesFree article

Hormonal regulation of cystathionine beta-synthase expression in liver.

Ratnam S, Maclean KN, Jacobs RL, Brosnan ME, Kraus JP, Brosnan JT.

J Biol Chem. 2002 Nov 8;277(45):42912-8. Epub 2002 Aug 26.PMID: 12198128 [PubMed - indexed for MEDLINE]Related articlesFree article

Application of 15N to the study of hepatic nitrogen metabolism.

Brosnan JT, Brosnan ME, Nissim I.

Adv Enzyme Regul. 2002;42:305-15. No abstract available. PMID: 12123722 [PubMed - indexed for MEDLINE]Related articles

Hepatic glutaminase--a special role in urea synthesis?

Brosnan JT, Brosnan ME.

Nutrition. 2002 Jun;18(6):455-7.PMID: 12044815 [PubMed - indexed for MEDLINE]Related articles

Amino acids, then and now--a reflection on Sir Hans Krebs' contribution to nitrogen metabolism.

Brosnan JT.

IUBMB Life. 2001 Dec;52(6):265-70.PMID: 11895074 [PubMed - indexed for MEDLINE]Related articles

Threonine metabolism in isolated rat hepatocytes.

House JD, Hall BN, Brosnan JT.

Am J Physiol Endocrinol Metab. 2001 Dec;281(6):E1300-7.PMID: 11701446 [PubMed - indexed for MEDLINE]Related articlesFree article

Methylation demand and homocysteine metabolism: effects of dietary provision of creatine and guanidinoacetate.

Stead LM, Au KP, Jacobs RL, Brosnan ME, Brosnan JT.

Am J Physiol Endocrinol Metab. 2001 Nov;281(5):E1095-100.PMID: 11595668 [PubMed - indexed for MEDLINE]Related articlesFree article

Hyperglucagonemia in rats results in decreased plasma homocysteine and increased flux through the transsulfuration pathway in liver.

Jacobs RL, Stead LM, Brosnan ME, Brosnan JT.

J Biol Chem. 2001 Nov 23;276(47):43740-7. Epub 2001 Sep 14.PMID: 11559709 [PubMed - indexed for MEDLINE]Related articlesFree article

Alanine metabolism in the perfused rat liver. Studies with (15)N.

Brosnan JT, Brosnan ME, Yudkoff M, Nissim I, Daikhin Y, Lazarow A, Horyn O, Nissim I.

J Biol Chem. 2001 Aug 24;276(34):31876-82. Epub 2001 Jun 21.PMID: 11423541 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of homocysteine metabolism in the rat liver.

Stead LM, Brosnan ME, Brosnan JT.

Biochem J. 2000 Sep 15;350 Pt 3:685-92.PMID: 10970780 [PubMed - indexed for MEDLINE]Related articlesFree article

Plasma homocysteine is decreased in the hypothyroid rat.

Jacobs RL, Stead LM, Brosnan ME, Brosnan JT.

Can J Physiol Pharmacol. 2000 Jul;78(7):565-70.PMID: 10926163 [PubMed - indexed for MEDLINE]Related articles

Folate and vitamin B12 status of women in Newfoundland at their first prenatal visit.

House JD, March SB, Ratnam S, Ives E, Brosnan JT, Friel JK.

CMAJ. 2000 May 30;162(11):1557-9.PMID: 10862228 [PubMed - indexed for MEDLINE]Related articlesFree article

Glutamate, at the interface between amino acid and carbohydrate metabolism.

Brosnan JT.

J Nutr. 2000 Apr;130(4S Suppl):988S-90S. Review.PMID: 10736367 [PubMed - indexed for MEDLINE]Related articlesFree article

Catabolism of arginine and ornithine in the perfused rat liver: effect of dietary protein and of glucagon.

O'Sullivan D, Brosnan JT, Brosnan ME.

Am J Physiol Endocrinol Metab. 2000 Mar;278(3):E516-21.PMID: 10710507 [PubMed - indexed for MEDLINE]Related articlesFree article

Studies of hepatic glutamine metabolism in the perfused rat liver with (15)N-labeled glutamine.

Nissim I, Brosnan ME, Yudkoff M, Brosnan JT.

J Biol Chem. 1999 Oct 8;274(41):28958-65.PMID: 10506142 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of homocysteine metabolism.

House JD, Jacobs RL, Stead LM, Brosnan ME, Brosnan JT.

Adv Enzyme Regul. 1999;39:69-91.PMID: 10470367 [PubMed - indexed for MEDLINE]Related articles

Report of the IDECG Working Group on lower and upper limits of carbohydrate and fat intake. International Dietary Energy Consultative Group.

Bier DM, Brosnan JT, Flatt JP, Hanson RW, Heird W, Hellerstein MK, Jéquier E, Kalhan S, Koletzko B, Macdonald I, Owen O, Uauy R.

Eur J Clin Nutr. 1999 Apr;53 Suppl 1:S177-8. No abstract available. PMID: 10365996 [PubMed - indexed for MEDLINE]Related articles

Comments on metabolic needs for glucose and the role of gluconeogenesis.

Brosnan JT.

Eur J Clin Nutr. 1999 Apr;53 Suppl 1:S107-11. Review.PMID: 10365987 [PubMed - indexed for MEDLINE]Related articles

Renal uptake and excretion of homocysteine in rats with acute hyperhomocysteinemia.

House JD, Brosnan ME, Brosnan JT.

Kidney Int. 1998 Nov;54(5):1601-7.PMID: 9844136 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of streptozotocin-induced diabetes and of insulin treatment on homocysteine metabolism in the rat.

Jacobs RL, House JD, Brosnan ME, Brosnan JT.

Diabetes. 1998 Dec;47(12):1967-70.PMID: 9836532 [PubMed - indexed for MEDLINE]Related articlesFree article