PubMed

The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901.

Barrett SD, Bridges AJ, Dudley DT, Saltiel AR, Fergus JH, Flamme CM, Delaney AM, Kaufman M, LePage S, Leopold WR, Przybranowski SA, Sebolt-Leopold J, Van Becelaere K, Doherty AM, Kennedy RM, Marston D, Howard WA Jr, Smith Y, Warmus JS, Tecle H.

Bioorg Med Chem Lett. 2008 Dec 15;18(24):6501-4. Epub 2008 Oct 15.PMID: 18952427 [PubMed - indexed for MEDLINE]Related articles

Antitumor activity and pharmacokinetic properties of PF-00299804, a second-generation irreversible pan-erbB receptor tyrosine kinase inhibitor.

Gonzales AJ, Hook KE, Althaus IW, Ellis PA, Trachet E, Delaney AM, Harvey PJ, Ellis TA, Amato DM, Nelson JM, Fry DW, Zhu T, Loi CM, Fakhoury SA, Schlosser KM, Sexton KE, Winters RT, Reed JE, Bridges AJ, Lettiere DJ, Baker DA, Yang J, Lee HT, Tecle H, Vincent PW.

Mol Cancer Ther. 2008 Jul;7(7):1880-9. Epub 2008 Jul 7.PMID: 18606718 [PubMed - indexed for MEDLINE]Related articlesFree article

Synthesis and structure-activity relationships of N-6 substituted analogues of 9-hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of Wee1 and Chk1 checkpoint kinases.

Smaill JB, Baker EN, Booth RJ, Bridges AJ, Dickson JM, Dobrusin EM, Ivanovic I, Kraker AJ, Lee HH, Lunney EA, Ortwine DF, Palmer BD, Quin J 3rd, Squire CJ, Thompson AM, Denny WA.

Eur J Med Chem. 2008 Jun;43(6):1276-96. Epub 2007 Aug 6.PMID: 17869387 [PubMed - indexed for MEDLINE]Related articles

How many is enough? Determining optimal sample sizes for normative studies in pediatric neuropsychology.

Bridges AJ, Holler KA.

Child Neuropsychol. 2007 Nov;13(6):528-38.PMID: 17852130 [PubMed - indexed for MEDLINE]Related articles

A phase I study of immunization using particle-mediated epidermal delivery of genes for gp100 and GM-CSF into uninvolved skin of melanoma patients.

Cassaday RD, Sondel PM, King DM, Macklin MD, Gan J, Warner TF, Zuleger CL, Bridges AJ, Schalch HG, Kim KM, Hank JA, Mahvi DM, Albertini MR.

Clin Cancer Res. 2007 Jan 15;13(2 Pt 1):540-9.PMID: 17255276 [PubMed - indexed for MEDLINE]Related articlesFree article

Standards for autoantibody testing; addressing future needs for autoimmune disease and cancer diagnosis.

Amos MD, Bridges AJ.

Cancer Biomark. 2005;1(4-5):221-7. Review.PMID: 17192045 [PubMed - indexed for MEDLINE]Related articles

Tyrosine kinase inhibitors. 19. 6-Alkynamides of 4-anilinoquinazolines and 4-anilinopyrido[3,4-d]pyrimidines as irreversible inhibitors of the erbB family of tyrosine kinase receptors.

Klutchko SR, Zhou H, Winters RT, Tran TP, Bridges AJ, Althaus IW, Amato DM, Elliott WL, Ellis PA, Meade MA, Roberts BJ, Fry DW, Gonzales AJ, Harvey PJ, Nelson JM, Sherwood V, Han HK, Pace G, Smaill JB, Denny WA, Showalter HD.

J Med Chem. 2006 Feb 23;49(4):1475-85.PMID: 16480284 [PubMed - indexed for MEDLINE]Related articles

Therapeutic challenges of kinase and phosphatase inhibition and use in anti-diabetic strategy.

Bridges AJ.

Biochem Soc Trans. 2005 Apr;33(Pt 2):343-5. Review.PMID: 15787602 [PubMed - indexed for MEDLINE]Related articles

Metabolic activation of troglitazone: identification of a reactive metabolite and mechanisms involved.

He K, Talaat RE, Pool WF, Reily MD, Reed JE, Bridges AJ, Woolf TF.

Drug Metab Dispos. 2004 Jun;32(6):639-46.PMID: 15155556 [PubMed - indexed for MEDLINE]Related articlesFree article

Romantic partners' use of pornography: its significance for women.

Bridges AJ, Bergner RM, Hesson-McInnis M.

J Sex Marital Ther. 2003 Jan-Feb;29(1):1-14.PMID: 12519658 [PubMed - indexed for MEDLINE]Related articles

The significance of heavy pornography involvement for romantic partners: research and clinical implications.

Bergner RM, Bridges AJ.

J Sex Marital Ther. 2002 May-Jun;28(3):193-206.PMID: 11995598 [PubMed - indexed for MEDLINE]Related articles

Chemical inhibitors of protein kinases.

Bridges AJ.

Chem Rev. 2001 Aug;101(8):2541-72. Review. No abstract available. PMID: 11749388 [PubMed - indexed for MEDLINE]Related articles

Tyrosine kinase inhibitors. 18. 6-Substituted 4-anilinoquinazolines and 4-anilinopyrido[3,4-d]pyrimidines as soluble, irreversible inhibitors of the epidermal growth factor receptor.

Smaill JB, Showalter HD, Zhou H, Bridges AJ, McNamara DJ, Fry DW, Nelson JM, Sherwood V, Vincent PW, Roberts BJ, Elliott WL, Denny WA.

J Med Chem. 2001 Feb 1;44(3):429-40.PMID: 11462982 [PubMed - indexed for MEDLINE]Related articles

Inhibition of epidermal growth factor receptor tyrosine kinase fails to suppress adenoma formation in ApcMin mice but induces duodenal injury.

Ritland SR, Gendler SJ, Burgart LJ, Fry DW, Nelson JM, Bridges AJ, Andress L, Karnes WE Jr.

Cancer Res. 2000 Sep 1;60(17):4678-81.PMID: 10987266 [PubMed - indexed for MEDLINE]Related articlesFree article

Dermatomyositis after interferon alpha treatment.

Dietrich LL, Bridges AJ, Albertini MR.

Med Oncol. 2000 Feb;17(1):64-9. Review.PMID: 10713663 [PubMed - indexed for MEDLINE]Related articles

Anticancer efficacy of the irreversible EGFr tyrosine kinase inhibitor PD 0169414 against human tumor xenografts.

Vincent PW, Bridges AJ, Dykes DJ, Fry DW, Leopold WR, Patmore SJ, Roberts BJ, Rose S, Sherwood V, Zhou H, Elliott WL.

Cancer Chemother Pharmacol. 2000;45(3):231-8.PMID: 10663641 [PubMed - indexed for MEDLINE]Related articles

Tyrosine kinase inhibitors. 16. 6,5,6-tricyclic benzothieno[3, 2-d]pyrimidines and pyrimido[5,4-b-] and -[4,5-b]ĭndoles as potent inhibitors of the epidermal growth factor receptor tyrosine kinase.

Showalter HD, Bridges AJ, Zhou H, Sercel AD, McMichael A, Fry DW.

J Med Chem. 1999 Dec 30;42(26):5464-74.PMID: 10639288 [PubMed - indexed for MEDLINE]Related articles

The rationale and strategy used to develop a series of highly potent, irreversible, inhibitors of the epidermal growth factor receptor family of tyrosine kinases.

Bridges AJ.

Curr Med Chem. 1999 Sep;6(9):825-43. Review.PMID: 10495354 [PubMed - indexed for MEDLINE]Related articles

Tyrosine kinase inhibitors. 15. 4-(Phenylamino)quinazoline and 4-(phenylamino)pyrido[d]pyrimidine acrylamides as irreversible inhibitors of the ATP binding site of the epidermal growth factor receptor.

Smaill JB, Palmer BD, Rewcastle GW, Denny WA, McNamara DJ, Dobrusin EM, Bridges AJ, Zhou H, Showalter HD, Winters RT, Leopold WR, Fry DW, Nelson JM, Slintak V, Elliot WL, Roberts BJ, Vincent PW, Patmore SJ.

J Med Chem. 1999 May 20;42(10):1803-15.PMID: 10346932 [PubMed - indexed for MEDLINE]Related articles

Antipolymer antibody reactivity in a subset of patients with fibromyalgia correlates with severity.

Wilson RB, Gluck OS, Tesser JR, Rice JC, Meyer A, Bridges AJ.

J Rheumatol. 1999 Feb;26(2):402-7.PMID: 9972976 [PubMed - indexed for MEDLINE]Related articles

Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor.

Fry DW, Bridges AJ, Denny WA, Doherty A, Greis KD, Hicks JL, Hook KE, Keller PR, Leopold WR, Loo JA, McNamara DJ, Nelson JM, Sherwood V, Smaill JB, Trumpp-Kallmeyer S, Dobrusin EM.

Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):12022-7.PMID: 9751783 [PubMed - indexed for MEDLINE]Related articlesFree article

Autoantibodies and common viral illnesses.

Hansen KE, Arnason J, Bridges AJ.

Semin Arthritis Rheum. 1998 Apr;27(5):263-71. Review.PMID: 9572708 [PubMed - indexed for MEDLINE]Related articles

Biochemical and antiproliferative properties of 4-[ar(alk)ylamino]pyridopyrimidines, a new chemical class of potent and specific epidermal growth factor receptor tyrosine kinase inhibitor.

Fry DW, Nelson JM, Slintak V, Keller PR, Rewcastle GW, Denny WA, Zhou H, Bridges AJ.

Biochem Pharmacol. 1997 Oct 15;54(8):877-87.PMID: 9354588 [PubMed - indexed for MEDLINE]Related articles

Autoantibody testing for connective tissue diseases. Comparison of immunodiffusion, immunoblot, and enzyme immunoassay.

Bridges AJ, Lorden TE, Havighurst TC.

Am J Clin Pathol. 1997 Oct;108(4):406-10.PMID: 9322593 [PubMed - indexed for MEDLINE]Related articles

Tyrosine kinase inhibitors. 12. Synthesis and structure-activity relationships for 6-substituted 4-(phenylamino)pyrimido[5,4-d]pyrimidines designed as inhibitors of the epidermal growth factor receptor.

Rewcastle GW, Bridges AJ, Fry DW, Rubin JR, Denny WA.

J Med Chem. 1997 Jun 6;40(12):1820-6.PMID: 9191958 [PubMed - indexed for MEDLINE]Related articles

Structure-activity relationships for 4-anilinoquinazolines as potent inhibitors at the ATP binding site of the epidermal growth factor receptor in vitro.

Denny WA, Rewcastle GW, Bridges AJ, Fry DW, Kraker AJ.

Clin Exp Pharmacol Physiol. 1996 May;23(5):424-7.PMID: 8713682 [PubMed - indexed for MEDLINE]Related articles

Tyrosine kinase inhibitors. 10. Isomeric 4-[(3-bromophenyl)amino]pyrido[d]-pyrimidines are potent ATP binding site inhibitors of the tyrosine kinase function of the epidermal growth factor receptor.

Rewcastle GW, Palmer BD, Thompson AM, Bridges AJ, Cody DR, Zhou H, Fry DW, McMichael A, Denny WA.

J Med Chem. 1996 Apr 26;39(9):1823-35.PMID: 8627606 [PubMed - indexed for MEDLINE]Related articles

Systemic pseudovasculitis from scurvy in anorexia nervosa.

Mehta CL, Cripps D, Bridges AJ.

Arthritis Rheum. 1996 Mar;39(3):532-3. No abstract available. PMID: 8607903 [PubMed - indexed for MEDLINE]Related articles

Tyrosine kinase inhibitors. 9. Synthesis and evaluation of fused tricyclic quinazoline analogues as ATP site inhibitors of the tyrosine kinase activity of the epidermal growth factor receptor.

Rewcastle GW, Palmer BD, Bridges AJ, Showalter HD, Sun L, Nelson J, McMichael A, Kraker AJ, Fry DW, Denny WA.

J Med Chem. 1996 Feb 16;39(4):918-28.PMID: 8632415 [PubMed - indexed for MEDLINE]Related articles

Tyrosine kinase inhibitors. 8. An unusually steep structure-activity relationship for analogues of 4-(3-bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a potent inhibitor of the epidermal growth factor receptor.

Bridges AJ, Zhou H, Cody DR, Rewcastle GW, McMichael A, Showalter HD, Fry DW, Kraker AJ, Denny WA.

J Med Chem. 1996 Jan 5;39(1):267-76.PMID: 8568816 [PubMed - indexed for MEDLINE]Related articles

Effectiveness of computer-assisted interactive videodisc instruction in teaching rheumatology to physical and occupational therapy students.

Sanford MK, Hazelwood SE, Bridges AJ, Cutts JH 3rd, Mitchell JA, Reid JC, Sharp G.

J Allied Health. 1996 Spring;25(2):141-8.PMID: 8827427 [PubMed - indexed for MEDLINE]Related articles

Clinical and laboratory features of patients with scleroderma and silicone implants.

Field T, Bridges AJ.

Curr Top Microbiol Immunol. 1996;210:283-90.PMID: 8565568 [PubMed - indexed for MEDLINE]Related articles

Autoantibodies in patients with silicone implants.

Bridges AJ, Anderson JD, Burns DE, Kemple K, Kaplan JD, Lorden T.

Curr Top Microbiol Immunol. 1996;210:277-82.PMID: 8565567 [PubMed - indexed for MEDLINE]Related articles

Enantioselective inhibition of the epidermal growth factor receptor tyrosine kinase by 4-(alpha-phenethylamino)quinazolines.

Bridges AJ, Cody DR, Zhou H, McMichael A, Fry DW.

Bioorg Med Chem. 1995 Dec;3(12):1651-6.PMID: 8770389 [PubMed - indexed for MEDLINE]Related articles

Inhibitors of protein tyrosine kinases.

Fry DW, Bridges AJ.

Curr Opin Biotechnol. 1995 Dec;6(6):662-7. Review.PMID: 8527837 [PubMed - indexed for MEDLINE]Related articles

Tyrosine kinase inhibitors. 7. 7-Amino-4-(phenylamino)- and 7-amino-4-[(phenylmethyl)amino]pyrido[4,3-d]pyrimidines: a new class of inhibitors of the tyrosine kinase activity of the epidermal growth factor receptor.

Thompson AM, Bridges AJ, Fry DW, Kraker AJ, Denny WA.

J Med Chem. 1995 Sep 15;38(19):3780-8.PMID: 7562908 [PubMed - indexed for MEDLINE]Related articles

Tyrosine kinase inhibitors. 5. Synthesis and structure-activity relationships for 4-[(phenylmethyl)amino]- and 4-(phenylamino)quinazolines as potent adenosine 5'-triphosphate binding site inhibitors of the tyrosine kinase domain of the epidermal growth factor receptor.

Rewcastle GW, Denny WA, Bridges AJ, Zhou H, Cody DR, McMichael A, Fry DW.

J Med Chem. 1995 Sep 1;38(18):3482-7.PMID: 7658435 [PubMed - indexed for MEDLINE]Related articles

A synthetic inhibitor of the mitogen-activated protein kinase cascade.

Dudley DT, Pang L, Decker SJ, Bridges AJ, Saltiel AR.

Proc Natl Acad Sci U S A. 1995 Aug 15;92(17):7686-9.PMID: 7644477 [PubMed - indexed for MEDLINE]Related articlesFree article

Bullous rash and brown urine in a systemic lupus erythematosus patient treated with hydroxychloroquine.

Kutz DC, Bridges AJ.

Arthritis Rheum. 1995 Mar;38(3):440-3. No abstract available. PMID: 7880200 [PubMed - indexed for MEDLINE]Related articles

Rheumatic disorders in patients with silicone implants: a critical review.

Bridges AJ.

J Biomater Sci Polym Ed. 1995;7(2):147-57. Review.PMID: 7654629 [PubMed - indexed for MEDLINE]Related articles

Fibrodysplasia (myositis) ossificans progressiva.

Bridges AJ, Hsu KC, Singh A, Churchill R, Miles J.

Semin Arthritis Rheum. 1994 Dec;24(3):155-64. Review.PMID: 7899873 [PubMed - indexed for MEDLINE]Related articles

Subcutaneous cholesterol nodules.

Szachnowski P, Bridges AJ.

J Rheumatol. 1994 Dec;21(12):2391-2. No abstract available. PMID: 7699652 [PubMed - indexed for MEDLINE]Related articles

Silicone implant controversy continues.

Bridges AJ.

Lancet. 1994 Nov 26;344(8935):1451-2. No abstract available. PMID: 7968116 [PubMed - indexed for MEDLINE]Related articles

A specific inhibitor of the epidermal growth factor receptor tyrosine kinase.

Fry DW, Kraker AJ, McMichael A, Ambroso LA, Nelson JM, Leopold WR, Connors RW, Bridges AJ.

Science. 1994 Aug 19;265(5175):1093-5.PMID: 8066447 [PubMed - indexed for MEDLINE]Related articles

Autoantibodies in patients with silicone implants.

Bridges AJ.

Semin Arthritis Rheum. 1994 Aug;24(1 Suppl 1):54-60. Review.PMID: 7801140 [PubMed - indexed for MEDLINE]Related articles

Silicone breast implants. History, safety, and potential complications.

Bridges AJ, Vasey FB.

Arch Intern Med. 1993 Dec 13;153(23):2638-44. Review.PMID: 8250660 [PubMed - indexed for MEDLINE]Related articles

The synthesis of three 4-substituted benzo[b]thiophene-2-carboxamidines as potent and selective inhibitors of urokinase.

Bridges AJ, Lee A, Schwartz CE, Towle MJ, Littlefield BA.

Bioorg Med Chem. 1993 Dec;1(6):403-10.PMID: 8087561 [PubMed - indexed for MEDLINE]Related articles

Fibromyalgia, antinuclear antibodies and clinical features of connective tissue disease.

Bridges AJ.

Clin Exp Rheumatol. 1993 Nov-Dec;11(6):696-7. No abstract available. PMID: 8299270 [PubMed - indexed for MEDLINE]Related articles

Tissue plasminogen activator treatment of digital thrombosis in severe Raynaud's phenomenon--a case report.

Bridges AJ, Spadone DP.

Angiology. 1993 Jul;44(7):566-9.PMID: 8328685 [PubMed - indexed for MEDLINE]Related articles

A clinical and immunologic evaluation of women with silicone breast implants and symptoms of rheumatic disease.

Bridges AJ, Conley C, Wang G, Burns DE, Vasey FB.

Ann Intern Med. 1993 Jun 15;118(12):929-36.PMID: 8489106 [PubMed - indexed for MEDLINE]Related articlesFree article