PubMed

Mouse Models of Diabetic Nephropathy.

Brosius FC 3rd, Alpers CE, Bottinger EP, Breyer MD, Coffman TM, Gurley SB, Harris RC, Kakoki M, Kretzler M, Leiter EH, Levi M, McIndoe RA, Sharma K, Smithies O, Susztak K, Takahashi N, Takahashi T; for the Animal Models of Diabetic Complications Consortium.

J Am Soc Nephrol. 2009 Sep 3. [Epub ahead of print]PMID: 19729434 [PubMed - as supplied by publisher]Related articles

Reduction of renal superoxide dismutase in progressive diabetic nephropathy.

Fujita H, Fujishima H, Chida S, Takahashi K, Qi Z, Kanetsuna Y, Breyer MD, Harris RC, Yamada Y, Takahashi T.

J Am Soc Nephrol. 2009 Jun;20(6):1303-13. Epub 2009 May 21.PMID: 19470681 [PubMed - indexed for MEDLINE]Related articles

Effects of global or targeted deletion of the EP4 receptor on the response of osteoblasts to prostaglandin in vitro and on bone histomorphometry in aged mice.

Gao Q, Zhan P, Alander CB, Kream BE, Hao C, Breyer MD, Pilbeam CC, Raisz LG.

Bone. 2009 Jul;45(1):98-103. Epub 2009 Apr 1.PMID: 19344793 [PubMed - indexed for MEDLINE]Related articles

Measurement of glomerular filtration rate in conscious mice.

Qi Z, Breyer MD.

Methods Mol Biol. 2009;466:61-72.PMID: 19148601 [PubMed - indexed for MEDLINE]Related articles

Macrophage EP4 deficiency increases apoptosis and suppresses early atherosclerosis.

Babaev VR, Chew JD, Ding L, Davis S, Breyer MD, Breyer RM, Oates JA, Fazio S, Linton MF.

Cell Metab. 2008 Dec;8(6):492-501.PMID: 19041765 [PubMed - indexed for MEDLINE]Related articles

Single amino acid substitution in aquaporin 11 causes renal failure.

Tchekneva EE, Khuchua Z, Davis LS, Kadkina V, Dunn SR, Bachman S, Ishibashi K, Rinchik EM, Harris RC, Dikov MM, Breyer MD.

J Am Soc Nephrol. 2008 Oct;19(10):1955-64. Epub 2008 Aug 13.PMID: 18701606 [PubMed - indexed for MEDLINE]Related articlesFree article

Stacking the deck for drug discovery in diabetic nephropathy: in search of an animal model.

Breyer MD.

J Am Soc Nephrol. 2008 Sep;19(9):1623-4. Epub 2008 Aug 6. No abstract available. PMID: 18684892 [PubMed - indexed for MEDLINE]Related articlesFree article

Markers of glycemic control in the mouse: comparisons of 6-h- and overnight-fasted blood glucoses to Hb A1c.

Han BG, Hao CM, Tchekneva EE, Wang YY, Lee CA, Ebrahim B, Harris RC, Kern TS, Wasserman DH, Breyer MD, Qi Z.

Am J Physiol Endocrinol Metab. 2008 Oct;295(4):E981-6. Epub 2008 Jul 29.PMID: 18664598 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression profiling of hepatic genes associated with lipid metabolism in nephrotic rats.

Zhou Y, Zhang X, Chen L, Wu J, Dang H, Wei M, Fan Y, Zhang Y, Zhu Y, Wang N, Breyer MD, Guan Y.

Am J Physiol Renal Physiol. 2008 Sep;295(3):F662-71. Epub 2008 Jul 9.PMID: 18614621 [PubMed - indexed for MEDLINE]Related articlesFree article

Apoptosis of the thick ascending limb results in acute kidney injury.

Srichai MB, Hao C, Davis L, Golovin A, Zhao M, Moeckel G, Dunn S, Bulus N, Harris RC, Zent R, Breyer MD.

J Am Soc Nephrol. 2008 Aug;19(8):1538-46. Epub 2008 May 21.PMID: 18495962 [PubMed - indexed for MEDLINE]Related articlesFree article

Examining diabetic nephropathy through the lens of mouse genetics.

Breyer MD, Tchekneva E, Qi Z, Takahashi T, Fogo AB, Harris RC.

Curr Diab Rep. 2007 Dec;7(6):459-66. Review.PMID: 18255011 [PubMed - indexed for MEDLINE]Related articles

Mouse EP3 alpha, beta, and gamma receptor variants reduce tumor cell proliferation and tumorigenesis in vivo.

Macias-Perez IM, Zent R, Carmosino M, Breyer MD, Breyer RM, Pozzi A.

J Biol Chem. 2008 May 2;283(18):12538-45. Epub 2008 Jan 29.PMID: 18230618 [PubMed - indexed for MEDLINE]Related articlesFree article

Insight into the genetics of diabetic nephropathy through the study of mice.

Breyer MD, Qi Z, Tchekneva EE, Harris RC.

Curr Opin Nephrol Hypertens. 2008 Jan;17(1):82-6. Review.PMID: 18090675 [PubMed - indexed for MEDLINE]Related articles

Physiological regulation of prostaglandins in the kidney.

Hao CM, Breyer MD.

Annu Rev Physiol. 2008;70:357-77. Review.PMID: 17988207 [PubMed - indexed for MEDLINE]Related articles

Effect of selective cyclooxygenase-2 (COX-2) inhibitor treatment on glucose-stimulated insulin secretion in C57BL/6 mice.

Fujita H, Kakei M, Fujishima H, Morii T, Yamada Y, Qi Z, Breyer MD.

Biochem Biophys Res Commun. 2007 Nov 9;363(1):37-43. Epub 2007 Aug 27.PMID: 17825788 [PubMed - indexed for MEDLINE]Related articlesFree article

Antihypertensive effects of selective prostaglandin E2 receptor subtype 1 targeting.

Guan Y, Zhang Y, Wu J, Qi Z, Yang G, Dou D, Gao Y, Chen L, Zhang X, Davis LS, Wei M, Fan X, Carmosino M, Hao C, Imig JD, Breyer RM, Breyer MD.

J Clin Invest. 2007 Sep;117(9):2496-505.PMID: 17710229 [PubMed - indexed for MEDLINE]Related articlesFree article

Update on cyclooxygenase-2 inhibitors.

Harris RC, Breyer MD.

Clin J Am Soc Nephrol. 2006 Mar;1(2):236-45. Epub 2006 Feb 1. Review.PMID: 17699212 [PubMed - indexed for MEDLINE]Related articlesFree article

Peroxisome proliferator-activated receptor-alpha deficiency protects aged mice from insulin resistance induced by high-fat diet.

Cha DR, Han JY, Su DM, Zhang Y, Fan X, Breyer MD, Guan Y.

Am J Nephrol. 2007;27(5):479-82. Epub 2007 Jul 25.PMID: 17652964 [PubMed - indexed for MEDLINE]Related articles

Peroxisome proliferator activated receptor alpha/gamma dual agonist tesaglitazar attenuates diabetic nephropathy in db/db mice.

Cha DR, Zhang X, Zhang Y, Wu J, Su D, Han JY, Fang X, Yu B, Breyer MD, Guan Y.

Diabetes. 2007 Aug;56(8):2036-45. Epub 2007 May 29.PMID: 17536062 [PubMed - indexed for MEDLINE]Related articlesFree article

Roles of lipid mediators in kidney injury.

Hao CM, Breyer MD.

Semin Nephrol. 2007 May;27(3):338-51. Review.PMID: 17533010 [PubMed - indexed for MEDLINE]Related articles

Deficiency of endothelial nitric-oxide synthase confers susceptibility to diabetic nephropathy in nephropathy-resistant inbred mice.

Kanetsuna Y, Takahashi K, Nagata M, Gannon MA, Breyer MD, Harris RC, Takahashi T.

Am J Pathol. 2007 May;170(5):1473-84.PMID: 17456755 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetics of diabetic nephropathy: lessons from mice.

Breyer MD, Tchekneva E, Qi Z, Takahashi T, Fogo AB, Zhao HJ, Harris RC.

Semin Nephrol. 2007 Mar;27(2):237-47.PMID: 17418691 [PubMed - indexed for MEDLINE]Related articles

Diabetic nephropathy: introduction.

Breyer MD.

Semin Nephrol. 2007 Mar;27(2):129. No abstract available. PMID: 17418681 [PubMed - indexed for MEDLINE]Related articles

Prostaglandin E2-EP4 receptor promotes endothelial cell migration via ERK activation and angiogenesis in vivo.

Rao R, Redha R, Macias-Perez I, Su Y, Hao C, Zent R, Breyer MD, Pozzi A.

J Biol Chem. 2007 Jun 8;282(23):16959-68. Epub 2007 Mar 31.PMID: 17401137 [PubMed - indexed for MEDLINE]Related articlesFree article

Physiologic and pathophysiologic roles of lipid mediators in the kidney.

Hao CM, Breyer MD.

Kidney Int. 2007 Jun;71(11):1105-15. Epub 2007 Mar 14. Review.PMID: 17361113 [PubMed - indexed for MEDLINE]Related articles

Long-term treatment of glucagon-like peptide-1 analog exendin-4 ameliorates diabetic nephropathy through improving metabolic anomalies in db/db mice.

Park CW, Kim HW, Ko SH, Lim JH, Ryu GR, Chung HW, Han SW, Shin SJ, Bang BK, Breyer MD, Chang YS.

J Am Soc Nephrol. 2007 Apr;18(4):1227-38. Epub 2007 Mar 14.PMID: 17360951 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of nestin in the podocytes of normal and diseased human kidneys.

Su W, Chen J, Yang H, You L, Xu L, Wang X, Li R, Gao L, Gu Y, Lin S, Xu H, Breyer MD, Hao CM.

Am J Physiol Regul Integr Comp Physiol. 2007 May;292(5):R1761-7. Epub 2007 Jan 25.PMID: 17255215 [PubMed - indexed for MEDLINE]Related articles

Overexpression of cyclooxygenase-2 predisposes to podocyte injury.

Cheng H, Wang S, Jo YI, Hao CM, Zhang M, Fan X, Kennedy C, Breyer MD, Moeckel GW, Harris RC.

J Am Soc Nephrol. 2007 Feb;18(2):551-9. Epub 2007 Jan 3.PMID: 17202413 [PubMed - indexed for MEDLINE]Related articlesFree article

Glycogen synthase kinase 3 inhibition improves insulin-stimulated glucose metabolism but not hypertension in high-fat-fed C57BL/6J mice.

Rao R, Hao CM, Redha R, Wasserman DH, McGuinness OP, Breyer MD.

Diabetologia. 2007 Feb;50(2):452-60. Epub 2006 Dec 7.PMID: 17151860 [PubMed - indexed for MEDLINE]Related articles

A sensitized screen of N-ethyl-N-nitrosourea-mutagenized mice identifies dominant mutants predisposed to diabetic nephropathy.

Tchekneva EE, Rinchik EM, Polosukhina D, Davis LS, Kadkina V, Mohamed Y, Dunn SR, Sharma K, Qi Z, Fogo AB, Breyer MD.

J Am Soc Nephrol. 2007 Jan;18(1):103-12. Epub 2006 Dec 6.PMID: 17151334 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased severity of renal impairment in nephritic mice lacking the EP1 receptor.

Rahal S, McVeigh LI, Zhang Y, Guan Y, Breyer MD, Kennedy CR.

Can J Physiol Pharmacol. 2006 Aug-Sep;84(8-9):877-85.PMID: 17111032 [PubMed - indexed for MEDLINE]Related articles

Expression of mouse membrane-associated prostaglandin E2 synthase-2 (mPGES-2) along the urogenital tract.

Yang G, Chen L, Zhang Y, Zhang X, Wu J, Li S, Wei M, Zhang Z, Breyer MD, Guan Y.

Biochim Biophys Acta. 2006 Dec;1761(12):1459-68. Epub 2006 Sep 8.PMID: 17064959 [PubMed - indexed for MEDLINE]Related articles

Endothelial nitric oxide synthase deficiency produces accelerated nephropathy in diabetic mice.

Zhao HJ, Wang S, Cheng H, Zhang MZ, Takahashi T, Fogo AB, Breyer MD, Harris RC.

J Am Soc Nephrol. 2006 Oct;17(10):2664-9. Epub 2006 Sep 13.PMID: 16971655 [PubMed - indexed for MEDLINE]Related articlesFree article

Urine concentrating defect in prostaglandin EP1-deficient mice.

Kennedy CR, Xiong H, Rahal S, Vanderluit J, Slack RS, Zhang Y, Guan Y, Breyer MD, Hébert RL.

Am J Physiol Renal Physiol. 2007 Feb;292(2):F868-75. Epub 2006 Aug 1.PMID: 16885154 [PubMed - indexed for MEDLINE]Related articlesFree article

Axial heterogeneity of vasopressin-receptor subtypes along the human and mouse collecting duct.

Carmosino M, Brooks HL, Cai Q, Davis LS, Opalenik S, Hao C, Breyer MD.

Am J Physiol Renal Physiol. 2007 Jan;292(1):F351-60. Epub 2006 Jul 11.PMID: 16835408 [PubMed - indexed for MEDLINE]Related articlesFree article

Differentiation of cyclooxygenase 1- and 2-derived prostanoids in mouse kidney and aorta.

Qi Z, Cai H, Morrow JD, Breyer MD.

Hypertension. 2006 Aug;48(2):323-8. Epub 2006 Jun 26.PMID: 16801485 [PubMed - indexed for MEDLINE]Related articlesFree article

Glomerular injury is exacerbated in diabetic integrin alpha1-null mice.

Zent R, Yan X, Su Y, Hudson BG, Borza DB, Moeckel GW, Qi Z, Sado Y, Breyer MD, Voziyan P, Pozzi A.

Kidney Int. 2006 Aug;70(3):460-70. Epub 2006 Jun 14.PMID: 16775606 [PubMed - indexed for MEDLINE]Related articles

Cardiovascular effects of selective COX-2 inhibition: is there a class effect? The International COX-2 Study Group.

Crofford LJ, Breyer MD, Strand CV, Rushitzka F, Brune K, Farkouh ME, Simon LS.

J Rheumatol. 2006 Jul;33(7):1403-8. Epub 2006 May 15.PMID: 16724374 [PubMed - indexed for MEDLINE]Related articles

Characterization of diabetic nephropathy in a transgenic model of hypoinsulinemic diabetes.

Kanetsuna Y, Hirano K, Nagata M, Gannon MA, Takahashi K, Harris RC, Breyer MD, Takahashi T.

Am J Physiol Renal Physiol. 2006 Dec;291(6):F1315-22. Epub 2006 May 16.PMID: 16705146 [PubMed - indexed for MEDLINE]Related articlesFree article

Salt-sensitive hypertension is associated with dysfunctional Cyp4a10 gene and kidney epithelial sodium channel.

Nakagawa K, Holla VR, Wei Y, Wang WH, Gatica A, Wei S, Mei S, Miller CM, Cha DR, Price E Jr, Zent R, Pozzi A, Breyer MD, Guan Y, Falck JR, Waterman MR, Capdevila JH.

J Clin Invest. 2006 Jun;116(6):1696-702. Epub 2006 May 11.PMID: 16691295 [PubMed - indexed for MEDLINE]Related articlesFree article

Diabetic nephropathy: leveraging mouse genetics.

Breyer MD, Qi Z, Tchekneva E.

Curr Opin Nephrol Hypertens. 2006 May;15(3):227-32. Review.PMID: 16609287 [PubMed - indexed for MEDLINE]Related articles

Differential expression of the intermediate filament protein nestin during renal development and its localization in adult podocytes.

Chen J, Boyle S, Zhao M, Su W, Takahashi K, Davis L, Decaestecker M, Takahashi T, Breyer MD, Hao CM.

J Am Soc Nephrol. 2006 May;17(5):1283-91. Epub 2006 Mar 29.PMID: 16571784 [PubMed - indexed for MEDLINE]Related articlesFree article

Accelerated diabetic nephropathy in mice lacking the peroxisome proliferator-activated receptor alpha.

Park CW, Kim HW, Ko SH, Chung HW, Lim SW, Yang CW, Chang YS, Sugawara A, Guan Y, Breyer MD.

Diabetes. 2006 Apr;55(4):885-93.PMID: 16567507 [PubMed - indexed for MEDLINE]Related articlesFree article

Cyclooxygenase-1 deficiency in bone marrow cells increases early atherosclerosis in apolipoprotein E- and low-density lipoprotein receptor-null mice.

Babaev VR, Ding L, Reese J, Morrow JD, Breyer MD, Dey SK, Fazio S, Linton MF.

Circulation. 2006 Jan 3;113(1):108-17. Epub 2005 Dec 27.PMID: 16380543 [PubMed - indexed for MEDLINE]Related articlesFree article

Liver X receptor agonist TO-901317 upregulates SCD1 expression in renal proximal straight tubule.

Zhang Y, Zhang X, Chen L, Wu J, Su D, Lu WJ, Hwang MT, Yang G, Li S, Wei M, Davis L, Breyer MD, Guan Y.

Am J Physiol Renal Physiol. 2006 May;290(5):F1065-73. Epub 2005 Dec 20.PMID: 16368743 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of deletion of the prostaglandin EP4 receptor on stimulation of calcium release from cultured mouse calvariae: impaired responsiveness in heterozygotes.

Zhan P, Alander C, Kaneko H, Pilbeam CC, Guan Y, Zhang Y, Breyer MD, Raisz LG.

Prostaglandins Other Lipid Mediat. 2005 Dec;78(1-4):19-26. Epub 2005 Sep 12.PMID: 16303601 [PubMed - indexed for MEDLINE]Related articles

Diabetic nephropathy: big and bad.

Qi Z, Breyer MD.

Kidney Int. 2005 Oct;68(4):1896-7. No abstract available. PMID: 16164670 [PubMed - indexed for MEDLINE]Related articles

Getting to the heart of COX-2 inhibition.

Breyer MD.

Cell Metab. 2005 Sep;2(3):149-50.PMID: 16154096 [PubMed - indexed for MEDLINE]Related articles

Characterization of susceptibility of inbred mouse strains to diabetic nephropathy.

Qi Z, Fujita H, Jin J, Davis LS, Wang Y, Fogo AB, Breyer MD.

Diabetes. 2005 Sep;54(9):2628-37.PMID: 16123351 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of a rabbit kidney prostaglandin F(2{alpha}) receptor exhibiting G(i)-restricted signaling that inhibits water absorption in the collecting duct.

Hébert RL, Carmosino M, Saito O, Yang G, Jackson CA, Qi Z, Breyer RM, Natarajan C, Hata AN, Zhang Y, Guan Y, Breyer MD.

J Biol Chem. 2005 Oct 14;280(41):35028-37. Epub 2005 Aug 10.PMID: 16096282 [PubMed - indexed for MEDLINE]Related articlesFree article