PubMed

Initiating insulin therapy in type 2 diabetic patients failing on oral hypoglycemic agents: basal or prandial insulin? The APOLLO trial and beyond.

Bretzel RG, Eckhard M, Landgraf W, Owens DR, Linn T.

Diabetes Care. 2009 Nov;32 Suppl 2:S260-5. No abstract available. PMID: 19875561 [PubMed - in process]Related articles

New-onset diabetes mellitus after renal transplantation.

Eckhard M, Schindler RA, Renner FC, Schief W, Padberg W, Weimer R, Bretzel RG, Brendel MD.

Transplant Proc. 2009 Jul-Aug;41(6):2544-5.PMID: 19715971 [PubMed - in process]Related articles

Anti-inflammatory thalidomide improves islet grafts survival and functions in a xenogenic environment.

Chen C, Kuehn C, Bretzel RG, Linn T.

PLoS One. 2009 Jul 20;4(7):e6312.PMID: 19617916 [PubMed - indexed for MEDLINE]Related articlesFree article

Food derived carbonyl compounds affect basal and stimulated secretion of interleukin-6 and -8 in Caco-2 cells.

Kuntz S, Rudloff S, Ehl J, Bretzel RG, Kunz C.

Eur J Nutr. 2009 Dec;48(8):499-503. Epub 2009 Jun 21.PMID: 19544037 [PubMed - in process]Related articles

Comparison of treatment costs in inadequately controlled type 2 diabetes in Germany based on the APOLLO trial with insulin glargine.

Bretzel RG, Dippel FW, Linn T, Neilson AR.

J Med Econ. 2009;12(2):87-97.PMID: 19473110 [PubMed - in process]Related articles

Determinants of Exocrine Pancreatic Function as Measured by Fecal Elastase-1 Concentrations (FEC) in Patients with Diabetes mellitus.

Ewald N, Raspe A, Kaufmann C, Bretzel RG, Kloer HU, Hardt PD.

Eur J Med Res. 2009 Mar 17;14(3):118-22.PMID: 19380282 [PubMed - indexed for MEDLINE]Related articles

Bone Mineral Density in Human Immunodeficiency Virus-1 Infected Men with Hypogonadism Prior to Highly-active-antiretroviral-therapy (HAART).

Teichmann J, Lange U, Discher T, Lohmeyer J, Stracke H, Bretzel RG.

Eur J Med Res. 2009 Feb 18;14(2):59-64.PMID: 19258214 [PubMed - in process]Related articles

Parathormone levels and Vitamin D metabolism in female patients with various grades of fecal elastase 1 deficiency.

Teichmann J, Mann ST, Stracke H, Lange U, Hardt PD, Bretzel RG, Klör HU.

Eur J Med Res. 2008 Dec 3;13(12):563-7.PMID: 19073396 [PubMed - indexed for MEDLINE]Related articles

Distinct autoantibodies against exocrine pancreatic antigens in European patients with type 1 diabetes mellitus and non-alcoholic chronic pancreatitis.

Hardt PD, Ewald N, Bröckling K, Tanaka S, Endo T, Kloer HU, Bretzel RG, Jaeger C, Shimura H, Kobayashi T.

JOP. 2008 Nov 3;9(6):683-9.PMID: 18981548 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of basswood honey, honey-comparable glucose-fructose solution, and oral glucose tolerance test solution on serum insulin, glucose, and C-peptide concentrations in healthy subjects.

Münstedt K, Sheybani B, Hauenschild A, Brüggmann D, Bretzel RG, Winter D.

J Med Food. 2008 Sep;11(3):424-8.PMID: 18800887 [PubMed - indexed for MEDLINE]Related articles

Nocturnal glucose metabolism after bedtime injection of insulin glargine or neutral protamine hagedorn insulin in patients with type 2 diabetes.

Linn T, Fischer B, Soydan N, Eckhard M, Ehl J, Kunz C, Bretzel RG.

J Clin Endocrinol Metab. 2008 Oct;93(10):3839-46. Epub 2008 Jul 8.PMID: 18611975 [PubMed - indexed for MEDLINE]Related articlesFree article

Scalable selection of hepatocyte- and hepatocyte precursor-like cells from culture of differentiating transgenically modified murine embryonic stem cells.

Drobinskaya I, Linn T, Saric T, Bretzel RG, Bohlen H, Hescheler J, Kolossov E.

Stem Cells. 2008 Sep;26(9):2245-56. Epub 2008 Jun 12.PMID: 18556507 [PubMed - indexed for MEDLINE]Related articlesFree article

Growth hormone and bone mineral densitiy in HIV-1-infected male subjects.

Teichmann J, Lange U, Discher T, Lohmeyer J, Stracke H, Bretzel RG.

Eur J Med Res. 2008 Apr 30;13(4):173-8.PMID: 18504173 [PubMed - indexed for MEDLINE]Related articles

Binding characteristics and crossreactivity of insulin autoantibodies and insulin antibodies directed to three different insulin molecules.

Jaeger C, Winter S, Eckhard M, Hardt P, Brendel MD, Bretzel RG.

Acta Diabetol. 2008 Sep;45(3):191-4. Epub 2008 May 21.PMID: 18493700 [PubMed - indexed for MEDLINE]Related articles

Insulin binding to antibodies is a risk factor for inexplicable severe hypoglycaemia in children with type-1 diabetes mellitus.

Seewi O, Jaeger C, Bretzel RG, Schönau E.

Exp Clin Endocrinol Diabetes. 2008 May;116(5):293-7.PMID: 18484562 [PubMed - indexed for MEDLINE]Related articles

Benfotiamine in diabetic polyneuropathy (BENDIP): results of a randomised, double blind, placebo-controlled clinical study.

Stracke H, Gaus W, Achenbach U, Federlin K, Bretzel RG.

Exp Clin Endocrinol Diabetes. 2008 Nov;116(10):600-5. Epub 2008 May 13.PMID: 18473286 [PubMed - indexed for MEDLINE]Related articles

Once-daily basal insulin glargine versus thrice-daily prandial insulin lispro in people with type 2 diabetes on oral hypoglycaemic agents (APOLLO): an open randomised controlled trial.

Bretzel RG, Nuber U, Landgraf W, Owens DR, Bradley C, Linn T.

Lancet. 2008 Mar 29;371(9618):1073-84. Erratum in: Lancet. 2008 Aug 30;372(9640):718. PMID: 18374840 [PubMed - indexed for MEDLINE]Related articles

Is pancreatic diabetes (type 3c diabetes) underdiagnosed and misdiagnosed?

Hardt PD, Brendel MD, Kloer HU, Bretzel RG.

Diabetes Care. 2008 Feb;31 Suppl 2:S165-9. Review.PMID: 18227480 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of liquid pancreatic enzymes on the assimilation of fat in different liquid formula diets.

Hauenschild A, Ewald N, Klauke T, Liebchen A, Bretzel RG, Kloer HU, Hardt PD.

JPEN J Parenter Enteral Nutr. 2008 Jan-Feb;32(1):98-100.PMID: 18165455 [PubMed - indexed for MEDLINE]Related articles

Alterations of vitamin D3 metabolism in young women with various grades of chronic pancreatitis.

Teichmann J, Mann ST, Stracke H, Lange U, Hardt PD, Klör HU, Bretzel RG.

Eur J Med Res. 2007 Aug 16;12(8):347-50.PMID: 17933711 [PubMed - indexed for MEDLINE]Related articles

Fungal foot infections in patients with diabetes mellitus--results of two independent investigations.

Eckhard M, Lengler A, Liersch J, Bretzel RG, Mayser P.

Mycoses. 2007;50 Suppl 2:14-9.PMID: 17681049 [PubMed - indexed for MEDLINE]Related articles

Fecal pyruvate kinase-M2 (tumor M2-PK) measurement: a new screening concept for colorectal cancer.

Ewald N, Schaller M, Bayer M, Akinci A, Bretzel RG, Kloer HU, Hardt PD.

Anticancer Res. 2007 Jul-Aug;27(4A):1949-52.PMID: 17649802 [PubMed - indexed for MEDLINE]Related articles

Human Krüppel-like factor 11 inhibits human proinsulin promoter activity in pancreatic beta cells.

Niu X, Perakakis N, Laubner K, Limbert C, Stahl T, Brendel MD, Bretzel RG, Seufert J, Päth G.

Diabetologia. 2007 Jul;50(7):1433-41. Epub 2007 May 4. Erratum in: Diabetologia. 2007 Sep;50(9):2031. PMID: 17479246 [PubMed - indexed for MEDLINE]Related articles

Islet cell transplantation today.

Bretzel RG, Jahr H, Eckhard M, Martin I, Winter D, Brendel MD.

Langenbecks Arch Surg. 2007 May;392(3):239-53. Epub 2007 Mar 28.PMID: 17393180 [PubMed - indexed for MEDLINE]Related articles

Endoscopic sphincterotomy in patients with stenosis of ampulla of Vater: three-year follow-up of exocrine pancreatic function and clinical symptoms.

Ewald N, Marzeion AM, Bretzel RG, Kloer HU, Hardt PD.

World J Gastroenterol. 2007 Feb 14;13(6):901-5.PMID: 17352020 [PubMed - indexed for MEDLINE]Related articlesFree article

When basal insulin therapy in type 2 diabetes mellitus is not enough--what next?

Raccah D, Bretzel RG, Owens D, Riddle M.

Diabetes Metab Res Rev. 2007 May;23(4):257-64. Review.PMID: 17315242 [PubMed - indexed for MEDLINE]Related articles

[Sandfly fever Naples virus (serotype Toscana) infection with meningeal involvement after a vacation in Italy]

Imirzalioglu C, Schaller M, Bretzel RG.

Dtsch Med Wochenschr. 2006 Dec 15;131(50):2838-40. German. PMID: 17160766 [PubMed - indexed for MEDLINE]Related articles

Isolated pancreatic islets in three-dimensional matrices are responsive to stimulators and inhibitors of angiogenesis.

Kidszun A, Schneider D, Erb D, Hertl G, Schmidt V, Eckhard M, Preissner KT, Breier G, Bretzel RG, Linn T.

Cell Transplant. 2006;15(6):489-97.PMID: 17121160 [PubMed - indexed for MEDLINE]Related articles

Characterization of somatostatin receptor subtype-specific regulation of insulin and glucagon secretion: an in vitro study on isolated human pancreatic islets.

Singh V, Brendel MD, Zacharias S, Mergler S, Jahr H, Wiedenmann B, Bretzel RG, Plöckinger U, Strowski MZ.

J Clin Endocrinol Metab. 2007 Feb;92(2):673-80. Epub 2006 Nov 14.PMID: 17105845 [PubMed - indexed for MEDLINE]Related articlesFree article

Pancreatin therapy in patients with insulin-treated diabetes mellitus and exocrine pancreatic insufficiency according to low fecal elastase 1 concentrations. Results of a prospective multi-centre trial.

Ewald N, Bretzel RG, Fantus IG, Hollenhorst M, Kloer HU, Hardt PD; S-2453110 Study Group.

Diabetes Metab Res Rev. 2007 Jul;23(5):386-91.PMID: 17103488 [PubMed - indexed for MEDLINE]Related articles

International trial of the Edmonton protocol for islet transplantation.

Shapiro AM, Ricordi C, Hering BJ, Auchincloss H, Lindblad R, Robertson RP, Secchi A, Brendel MD, Berney T, Brennan DC, Cagliero E, Alejandro R, Ryan EA, DiMercurio B, Morel P, Polonsky KS, Reems JA, Bretzel RG, Bertuzzi F, Froud T, Kandaswamy R, Sutherland DE, Eisenbarth G, Segal M, Preiksaitis J, Korbutt GS, Barton FB, Viviano L, Seyfert-Margolis V, Bluestone J, Lakey JR.

N Engl J Med. 2006 Sep 28;355(13):1318-30.PMID: 17005949 [PubMed - indexed for MEDLINE]Related articlesFree article

Pancreas storage in oxygenated perfluorodecalin does not restore post-transplant function of isolated pig islets pre-damaged by warm ischemia.

Brandhorst D, Iken M, Bretzel RG, Brandhorst H.

Xenotransplantation. 2006 Sep;13(5):465-70.PMID: 16925671 [PubMed - indexed for MEDLINE]Related articles

Porcine islet graft function is affected by pretreatment with a caspase-3 inhibitor.

Brandhorst D, Kumarasamy V, Maatoui A, Alt A, Bretzel RG, Brandhorst H.

Cell Transplant. 2006;15(4):311-7.PMID: 16898224 [PubMed - indexed for MEDLINE]Related articles

Glucose-dependent expansion of pancreatic beta-cells by the protein p8 in vitro and in vivo.

Päth G, Opel A, Gehlen M, Rothhammer V, Niu X, Limbert C, Romfeld L, Hügl S, Knoll A, Brendel MD, Bretzel RG, Seufert J.

Am J Physiol Endocrinol Metab. 2006 Dec;291(6):E1168-76. Epub 2006 Jul 5.PMID: 16822955 [PubMed - indexed for MEDLINE]Related articlesFree article

Diagnosis of mixed Plasmodium malariae and P. vivax infection in a development aid volunteer by examination of bone-marrow specimens by real-time PCR.

Imirzalioglu C, Soydan N, Schaller M, Bretzel RG, Chakraborty T, Domann E.

J Clin Microbiol. 2006 Jun;44(6):2307-10.PMID: 16757648 [PubMed - indexed for MEDLINE]Related articlesFree article

High prevalence of vitamin D deficiency, secondary hyperparathyroidism and generalized bone pain in Turkish immigrants in Germany: identification of risk factors.

Erkal MZ, Wilde J, Bilgin Y, Akinci A, Demir E, Bödeker RH, Mann M, Bretzel RG, Stracke H, Holick MF.

Osteoporos Int. 2006;17(8):1133-40. Epub 2006 May 23.PMID: 16718398 [PubMed - indexed for MEDLINE]Related articles

Ischaemia is linked to inflammation and induction of angiogenesis in pancreatic islets.

Linn T, Schmitz J, Hauck-Schmalenberger I, Lai Y, Bretzel RG, Brandhorst H, Brandhorst D.

Clin Exp Immunol. 2006 May;144(2):179-87. Review.PMID: 16634789 [PubMed - indexed for MEDLINE]Related articlesFree article

[Islet transplantation, stem cell transfer and regenerative therapy in diabetes mellitus]

Bretzel RG, Eckhard M, Jahr H, Brendel MD.

Dtsch Med Wochenschr. 2006 Apr 21;131(16):903-6. German. No abstract available. PMID: 16625486 [PubMed - indexed for MEDLINE]Related articles

[Therapy of diabetes mellitus. Pancreas transplantation, islet transplantation, stem cell and gene therapy]

Dieterle C, Brendel MD, Seissler J, Eckhard M, Bretzel RG, Landgraf R.

Internist (Berl). 2006 May;47(5):489-96, 498-501. German. PMID: 16575611 [PubMed - indexed for MEDLINE]Related articles

[Pyruvate kinase M2 (tumor M2-PK) as a screening tool for colorectal cancer (CRC). A review of current published data]

Ewald N, Toepler M, Akinci A, Kloer HU, Bretzel RG, Hardt PD.

Z Gastroenterol. 2005 Dec;43(12):1313-7. Review. German. PMID: 16315127 [PubMed - indexed for MEDLINE]Related articles

Effect of stable glutamine compounds on porcine islet culture.

Brandhorst H, Duan Y, Iken M, Bretzel RG, Brandhorst D.

Transplant Proc. 2005 Oct;37(8):3519-20.PMID: 16298648 [PubMed - indexed for MEDLINE]Related articles

Adjustment of the ratio between collagenase class II and I improves islet isolation outcome.

Brandhorst D, Huettler S, Alt A, Raemsch-Guenther N, Kurfuerst M, Bretzel RG, Brandhorst H.

Transplant Proc. 2005 Oct;37(8):3450-1.PMID: 16298625 [PubMed - indexed for MEDLINE]Related articles

Adiponectin is functionally active in human islets but does not affect insulin secretory function or beta-cell lipoapoptosis.

Staiger K, Stefan N, Staiger H, Brendel MD, Brandhorst D, Bretzel RG, Machicao F, Kellerer M, Stumvoll M, Fritsche A, Häring HU.

J Clin Endocrinol Metab. 2005 Dec;90(12):6707-13. Epub 2005 Oct 4.PMID: 16204361 [PubMed - indexed for MEDLINE]Related articlesFree article

Pancreas divisum--an underestimated cause of chronic pancreatitis and relapsing episodes of acute pancreatitis?

Ewald N, Kloer HU, Bretzel RG, Hardt PD.

Dig Dis Sci. 2005 Oct;50(10):1857-9. No abstract available. PMID: 16187187 [PubMed - indexed for MEDLINE]Related articles

A potential important role of skeletal muscle in human counterregulation of hypoglycemia.

Meyer C, Saar P, Soydan N, Eckhard M, Bretzel RG, Gerich J, Linn T.

J Clin Endocrinol Metab. 2005 Nov;90(11):6244-50. Epub 2005 Sep 6. Erratum in: J Clin Endocrinol Metab. 2006 Jan;91(1):27. PMID: 16144954 [PubMed - indexed for MEDLINE]Related articlesFree article

Vascular endothelial growth factor increases functional beta-cell mass by improvement of angiogenesis of isolated human and murine pancreatic islets.

Lai Y, Schneider D, Kidszun A, Hauck-Schmalenberger I, Breier G, Brandhorst D, Brandhorst H, Iken M, Brendel MD, Bretzel RG, Linn T.

Transplantation. 2005 Jun 15;79(11):1530-6.PMID: 15940042 [PubMed - indexed for MEDLINE]Related articles

Adaption of neutral protease activity for islet isolation from the long-term two-layer method-stored pig pancreas.

Brandhorst D, Iken M, Brendel MD, Bretzel RG, Brandhorst H.

Transplant Proc. 2005 Jan-Feb;37(1):458-9.PMID: 15808675 [PubMed - indexed for MEDLINE]Related articles

Influence of neutral protease activity on human islet isolation outcome.

Brandhorst H, Brendel MD, Eckhard M, Bretzel RG, Brandhorst D.

Transplant Proc. 2005 Jan-Feb;37(1):241-2.PMID: 15808607 [PubMed - indexed for MEDLINE]Related articles

Timing of hyperthermic preconditioning affects islet resistance against inflammation.

Brandhorst D, Olbrich M, Alt A, Bretzel RG, Brandhorst H.

Transplant Proc. 2005 Jan-Feb;37(1):231-2.PMID: 15808604 [PubMed - indexed for MEDLINE]Related articles

Long-term preservation of the pig pancreas by a one-layer method for successful islet isolation.

Brandhorst D, Iken M, Brendel MD, Bretzel RG, Brandhorst H.

Transplant Proc. 2005 Jan-Feb;37(1):229-30.PMID: 15808603 [PubMed - indexed for MEDLINE]Related articles