PubMed

Synthesis and in-vitro antitumour activity of new naphthyridine derivatives on human pancreatic cancer cells.

Banti I, Nencetti S, Orlandini E, Lapucci A, Breschi MC, Fogli S.

J Pharm Pharmacol. 2009 Aug;61(8):1057-66.PMID: 19703350 [PubMed - indexed for MEDLINE]Related articles

Anti-ischemic properties of a new spiro-cyclic benzopyran activator of the cardiac mito-K(ATP) channel.

Calderone V, Testai L, Martelli A, Rapposelli S, Digiacomo M, Balsamo A, Breschi MC.

Biochem Pharmacol. 2010 Jan 1;79(1):39-47. Epub 2009 Aug 4.PMID: 19660436 [PubMed - in process]Related articles

NO-glibenclamide derivatives: prototypes of a new class of nitric oxide-releasing anti-diabetic drugs.

Calderone V, Rapposelli S, Martelli A, Digiacomo M, Testai L, Torri S, Marchetti P, Breschi MC, Balsamo A.

Bioorg Med Chem. 2009 Aug 1;17(15):5426-32. Epub 2009 Jun 27.PMID: 19595600 [PubMed - indexed for MEDLINE]Related articles

Synthesis, characterization and evaluation of thiolated quaternary ammonium-chitosan conjugates for enhanced intestinal drug permeation.

Zambito Y, Fogli S, Zaino C, Stefanelli F, Breschi MC, Di Colo G.

Eur J Pharm Sci. 2009 Sep 10;38(2):112-20. Epub 2009 Jul 2.PMID: 19576984 [PubMed - indexed for MEDLINE]Related articles

New chitosan derivatives for the preparation of rokitamycin loaded microspheres designed for ocular or nasal administration.

Rassu G, Gavini E, Jonassen H, Zambito Y, Fogli S, Breschi MC, Giunchedi P.

J Pharm Sci. 2009 Dec;98(12):4852-65.PMID: 19479981 [PubMed - in process]Related articles

Pharmacodynamic hybrids coupling established cardiovascular mechanisms of action with additional nitric oxide releasing properties.

Martelli A, Breschi MC, Calderone V.

Curr Pharm Des. 2009;15(6):614-36. Review.PMID: 19199986 [PubMed - indexed for MEDLINE]Related articles

Spirocyclic benzopyran-based derivatives as new anti-ischemic activators of mitochondrial ATP-sensitive potassium channel.

Breschi MC, Calderone V, Digiacomo M, Manganaro M, Martelli A, Minutolo F, Rapposelli S, Testai L, Tonelli F, Balsamo A.

J Med Chem. 2008 Nov 13;51(21):6945-54. Epub 2008 Oct 17.PMID: 18925735 [PubMed - indexed for MEDLINE]Related articles

Total plasma homocysteine correlates in women with gestational diabetes.

Idzior-Waluś B, Cyganek K, Sztefko K, Seghieri G, Breschi MC, Waluś-Miarka M, Kawalec E, Seretny M, Sieradzki J.

Arch Gynecol Obstet. 2008 Oct;278(4):309-13. Epub 2008 Jan 31.PMID: 18236055 [PubMed - indexed for MEDLINE]Related articles

In vivo adenosine A(2B) receptor desensitization in guinea-pig airway smooth muscle: implications for asthma.

Breschi MC, Blandizzi C, Fogli S, Martinelli C, Adinolfi B, Calderone V, Camici M, Martinotti E, Nieri P.

Eur J Pharmacol. 2007 Dec 1;575(1-3):149-57. Epub 2007 Aug 1.PMID: 17716655 [PubMed - indexed for MEDLINE]Related articles

Inhibition of adenosine deaminase attenuates inflammation in experimental colitis.

Antonioli L, Fornai M, Colucci R, Ghisu N, Da Settimo F, Natale G, Kastsiuchenka O, Duranti E, Virdis A, Vassalle C, La Motta C, Mugnaini L, Breschi MC, Blandizzi C, Del Taca M.

J Pharmacol Exp Ther. 2007 Aug;322(2):435-42. Epub 2007 May 8.PMID: 17488880 [PubMed - indexed for MEDLINE]Related articlesFree article

QT prolongation in guinea pigs for preliminary screening of torsadogenicity of drugs and drug-candidates. II.

Testai L, Breschi MC, Martinotti E, Calderone V.

J Appl Toxicol. 2007 May-Jun;27(3):270-5.PMID: 17265420 [PubMed - indexed for MEDLINE]Related articles

Functional contribution of the endothelial component to the vasorelaxing effect of resveratrol and NS 1619, activators of the large-conductance calcium-activated potassium channels.

Calderone V, Martelli A, Testai L, Martinotti E, Breschi MC.

Naunyn Schmiedebergs Arch Pharmacol. 2007 Mar;375(1):73-80. Epub 2007 Jan 4.PMID: 17203288 [PubMed - indexed for MEDLINE]Related articles

New benzopyran-based openers of the mitochondrial ATP-sensitive potassium channel with potent anti-ischemic properties.

Breschi MC, Calderone V, Martelli A, Minutolo F, Rapposelli S, Testai L, Tonelli F, Balsamo A.

J Med Chem. 2006 Dec 28;49(26):7600-2.PMID: 17181142 [PubMed - indexed for MEDLINE]Related articles

Sequence characterized amplified region (SCAR) analysis on DNA from the three medicinal Echinacea species.

Adinolfi B, Chicca A, Martinotti E, Breschi MC, Nieri P.

Fitoterapia. 2007 Jan;78(1):43-5. Epub 2006 Sep 23.PMID: 17067760 [PubMed - indexed for MEDLINE]Related articles

Cytotoxic effects of Echinacea root hexanic extracts on human cancer cell lines.

Chicca A, Adinolfi B, Martinotti E, Fogli S, Breschi MC, Pellati F, Benvenuti S, Nieri P.

J Ethnopharmacol. 2007 Mar 1;110(1):148-53. Epub 2006 Sep 23.PMID: 17052874 [PubMed - indexed for MEDLINE]Related articles

Role of cyclooxygenase isoforms and nitric-oxide synthase in the modulation of tracheal motor responsiveness in normal and antigen-sensitized Guinea pigs.

Nieri P, Martinelli C, Blandizzi C, Bernardini N, Greco R, Ippolito C, Del Tacca M, Breschi MC.

J Pharmacol Exp Ther. 2006 Nov;319(2):648-56. Epub 2006 Aug 22.PMID: 16926267 [PubMed - indexed for MEDLINE]Related articlesFree article

New NO-releasing pharmacodynamic hybrids of losartan and its active metabolite: design, synthesis, and biopharmacological properties.

Breschi MC, Calderone V, Digiacomo M, Macchia M, Martelli A, Martinotti E, Minutolo F, Rapposelli S, Rossello A, Testai L, Balsamo A.

J Med Chem. 2006 Apr 20;49(8):2628-39.PMID: 16610806 [PubMed - indexed for MEDLINE]Related articles

Cannabinoid derivatives induce cell death in pancreatic MIA PaCa-2 cells via a receptor-independent mechanism.

Fogli S, Nieri P, Chicca A, Adinolfi B, Mariotti V, Iacopetti P, Breschi MC, Pellegrini S.

FEBS Lett. 2006 Mar 20;580(7):1733-9. Epub 2006 Feb 20.PMID: 16500647 [PubMed - indexed for MEDLINE]Related articles

Does parity increase insulin resistance during pregnancy?

Seghieri G, De Bellis A, Anichini R, Alviggi L, Franconi F, Breschi MC.

Diabet Med. 2005 Nov;22(11):1574-80.PMID: 16241924 [PubMed - indexed for MEDLINE]Related articles

Drug-induced block of cardiac HERG potassium channels and development of torsade de pointes arrhythmias: the case of antipsychotics.

Calderone V, Testai L, Martinotti E, Del Tacca M, Breschi MC.

J Pharm Pharmacol. 2005 Feb;57(2):151-61. Review.PMID: 15720777 [PubMed - indexed for MEDLINE]Related articles

Gastrin promotes human colon cancer cell growth via CCK-2 receptor-mediated cyclooxygenase-2 induction and prostaglandin E2 production.

Colucci R, Blandizzi C, Tanini M, Vassalle C, Breschi MC, Del Tacca M.

Br J Pharmacol. 2005 Feb;144(3):338-48.PMID: 15655524 [PubMed - indexed for MEDLINE]Related articlesFree article

Torsadogenic cardiotoxicity of antipsychotic drugs: a structural feature, potentially involved in the interaction with cardiac HERG potassium channels.

Testai L, Bianucci AM, Massarelli I, Breschi MC, Martinotti E, Calderone V.

Curr Med Chem. 2004 Oct;11(20):2691-706. Review.PMID: 15544470 [PubMed - indexed for MEDLINE]Related articles

NO-sartans: a new class of pharmacodynamic hybrids as cardiovascular drugs.

Breschi MC, Calderone V, Digiacomo M, Martelli A, Martinotti E, Minutolo F, Rapposelli S, Balsamo A.

J Med Chem. 2004 Nov 4;47(23):5597-600.PMID: 15509155 [PubMed - indexed for MEDLINE]Related articles

Vasorelaxing effects of flavonoids: investigation on the possible involvement of potassium channels.

Calderone V, Chericoni S, Martinelli C, Testai L, Nardi A, Morelli I, Breschi MC, Martinotti E.

Naunyn Schmiedebergs Arch Pharmacol. 2004 Oct;370(4):290-8. Epub 2004 Sep 17.PMID: 15378228 [PubMed - indexed for MEDLINE]Related articles

QT prolongation in anaesthetized guinea-pigs: an experimental approach for preliminary screening of torsadogenicity of drugs and drug candidates.

Testai L, Calderone V, Salvadori A, Breschi MC, Nieri P, Martinotti E.

J Appl Toxicol. 2004 May-Jun;24(3):217-22.PMID: 15211616 [PubMed - indexed for MEDLINE]Related articles

The role of nitric oxide in anthracycline toxicity and prospects for pharmacologic prevention of cardiac damage.

Fogli S, Nieri P, Breschi MC.

FASEB J. 2004 Apr;18(6):664-75. Review.PMID: 15054088 [PubMed - indexed for MEDLINE]Related articlesFree article

CB1- and CB2-cannabinoid receptor-independent lipolysis induced by WIN 55,212-2 in male rat adipocytes.

Nieri P, Greco R, Adinolfi B, Breschi MC, Martinotti E, Nannetti C, Podestà A.

Naunyn Schmiedebergs Arch Pharmacol. 2003 Nov;368(5):352-9. Epub 2003 Oct 18.PMID: 14566452 [PubMed - indexed for MEDLINE]Related articles

Effects of cannabinoids on non-adrenergic non-cholinergic-mediated relaxation in guinea-pig trachea.

Nieri P, Martinotti E, Testai L, Martinelli C, Breschi MC.

Eur J Pharmacol. 2003 Aug 15;475(1-3):115-8.PMID: 12954367 [PubMed - indexed for MEDLINE]Related articles

Genetic characterization of the three medicinal Echinacea species using RAPD analysis.

Nieri P, Adinolfi B, Morelli I, Breschi MC, Simoni G, Martinotti E.

Planta Med. 2003 Jul;69(7):685-6.PMID: 12898432 [PubMed - indexed for MEDLINE]Related articles

Serum homocysteine levels are increased in women with gestational diabetes mellitus.

Seghieri G, Breschi MC, Anichini R, De Bellis A, Alviggi L, Maida I, Franconi F.

Metabolism. 2003 Jun;52(6):720-3.PMID: 12800097 [PubMed - indexed for MEDLINE]Related articles

Altered prejunctional modulation of intestinal cholinergic and noradrenergic pathways by alpha2-adrenoceptors in the presence of experimental colitis.

Blandizzi C, Fornai M, Colucci R, Baschiera F, Barbara G, De Giorgio R, De Ponti F, Breschi MC, Del Tacca M.

Br J Pharmacol. 2003 May;139(2):309-20.PMID: 12770936 [PubMed - indexed for MEDLINE]Related articlesFree article

R+-methanandamide inhibits tracheal response to endogenously released acetylcholine via capsazepine-sensitive receptors.

Nieri P, Martinotti E, Testai L, Adinolfi B, Calderone V, Breschi MC.

Eur J Pharmacol. 2003 Jan 10;459(1):75-81.PMID: 12505536 [PubMed - indexed for MEDLINE]Related articles

Relationship between gestational diabetes mellitus and low maternal birth weight.

Seghieri G, Anichini R, De Bellis A, Alviggi L, Franconi F, Breschi MC.

Diabetes Care. 2002 Oct;25(10):1761-5.PMID: 12351474 [PubMed - indexed for MEDLINE]Related articlesFree article

Spirotetrahydronaphthalene analogues of sympathomimetic catecholamines. Synthesis and adrenergic activity of 5,6- and 6,7-dihydroxy-3,4-dihydrospiro[naphthalen-1 (2H)-3'-piperidines].

Macchia B, Manera C, Martinelli A, Nencetti S, Orlandini E, Breschi MC, Martini C, Martinotti E.

J Pharm Pharmacol. 2002 May;54(5):649-60.PMID: 12005360 [PubMed - indexed for MEDLINE]Related articles

Hormonal influence on the release of endothelial nitric oxide: gender-related dimorphic sensitivity of rat aorta for noradrenaline.

Calderone V, Baragatti B, Breschi MC, Nieri P, Martinotti E.

J Pharm Pharmacol. 2002 Apr;54(4):523-8.PMID: 11999130 [PubMed - indexed for MEDLINE]Related articles

Protective effect of silymarin in antigen challenge- and histamine-induced bronchoconstriction in in vivo guinea-pigs.

Breschi MC, Martinotti E, Apostoliti F, Nieri P.

Eur J Pharmacol. 2002 Feb 15;437(1-2):91-5.PMID: 11864645 [PubMed - indexed for MEDLINE]Related articles

Adenosine-mediated hypotension in in vivo guinea-pig: receptors involved and role of NO.

Nieri P, Martinotti E, Calderone V, Breschi MC.

Br J Pharmacol. 2001 Oct;134(4):745-52.PMID: 11606314 [PubMed - indexed for MEDLINE]Related articlesFree article

Experimental and theoretical comparisons between the classical Schild analysis and a new alternative method to evaluate the pA2 of competitive antagonists.

Calderone V, Baragatti B, Breschi MC, Martinotti E.

Naunyn Schmiedebergs Arch Pharmacol. 1999 Nov;360(5):477-87.PMID: 10598787 [PubMed - indexed for MEDLINE]Related articles

Vascular effects of aqueous crude extracts of Artemisia verlotorum Lamotte (Compositae): in vivo and in vitro pharmacological studies in rats.

Calderone V, Martinotti E, Baragatti B, Breschi MC, Morelli I.

Phytother Res. 1999 Dec;13(8):645-8.PMID: 10594931 [PubMed - indexed for MEDLINE]Related articles

Role of peptidase and cyclooxygenase inhibitors in the guinea-pig bronchial response to the synthetic endothelin ET(B) agonist IRL 1620 and antagonist BQ-788.

Lazzeri N, Nieri P, Lenzi P, Ratti C, Breschi MC.

J Auton Pharmacol. 1999 Aug;19(4):201-7.PMID: 10589970 [PubMed - indexed for MEDLINE]Related articles

Suc-[Glu9,Ala11,15]-endothelin-1 (8-21), IRL 1620, identifies two populations of ET(B) receptors in guinea-pig bronchus.

Mazzoni MR, Breschi MC, Ceccarelli F, Lazzeri N, Giusti L, Nieri P, Lucacchini A.

Br J Pharmacol. 1999 Jul;127(6):1406-14.PMID: 10455290 [PubMed - indexed for MEDLINE]Related articlesFree article

Synthesis and beta-adrenergic properties of (Z)-N-[3-(alkylamino)-2-hydroxypropylidene](aryl-methyloxy)amines: effects of the configuration around the methyloxyiminomethyl (MOIM) double bond on the biopharmacological properties of MOIM-type beta-blocking agents.

Balsamo A, Breschi MC, Chiellini G, Lapucci A, Lazzeri N, Macchia M, Martinelli A, Micali E, Nencetti S, Rossello A.

Bioorg Med Chem. 1998 Nov;6(11):2151-60.PMID: 9881105 [PubMed - indexed for MEDLINE]Related articles

Different bronchial responsiveness to Ach between normal and OA-sensitized guinea pigs after acoustic stress: a role for adenosine.

Nieri P, Lazzeri N, Greco R, Breschi MC.

Immunopharmacology. 1998 Jun;39(3):235-42.PMID: 9754909 [PubMed - indexed for MEDLINE]Related articles

Effects of noise stress on EFS-mediated cholinergic and inhibitory NANC responses in tracheae from normal and sensitized guinea-pigs.

Breschi MC, Nieri P, Lazzeri N, Martinotti E.

J Auton Pharmacol. 1997 Dec;17(6):353-63.PMID: 9610430 [PubMed - indexed for MEDLINE]Related articles

Histaminic bronchospasm potentiated by adenosine: investigation of the mechanisms.

Nieri P, Lazzeri N, Martinotti E, Breschi MC.

Eur J Pharmacol. 1997 Jul 23;331(2-3):205-12.PMID: 9274981 [PubMed - indexed for MEDLINE]Related articles

A modified aortic multiple-ring preparation for functional studies.

Calderone V, Martinotti E, Scatizzi R, Pellegrini A, Breschi MC.

J Pharmacol Toxicol Methods. 1996 Jun;35(3):131-8.PMID: 8782090 [PubMed - indexed for MEDLINE]Related articles

Acetylcholine-induced bronchoconstriction modified by noise exposure in normal but not in sensitized guinea-pigs.

Nieri P, Lazzeri N, Martinotti E, Scatizzi R, Breschi MC.

J Auton Pharmacol. 1996 Apr;16(2):55-62.PMID: 8842865 [PubMed - indexed for MEDLINE]Related articles

Effects of adenosine on NANC bronchoconstriction in anaesthetized guinea-pigs.

Nieri P, Martinotti L, Lazzeri N, Breschi MC.

J Pharm Pharmacol. 1996 Apr;48(4):422-8.PMID: 8794995 [PubMed - indexed for MEDLINE]Related articles

Relaxing activity of two linear diterpenes from Cystoseira brachycarpa var. balearica on the contractions of intestinal preparations.

Pietà FD, Breschi MC, Scatizzi R, Cinelli F.

Planta Med. 1995 Dec;61(6):493-6.PMID: 8824939 [PubMed - indexed for MEDLINE]Related articles

Effects of idrapril calcium on tissue angiotensin-converting enzyme in rats.

Becagli P, Lippi A, Criscuoli M, Breschi MC, Subissi A.

J Cardiovasc Pharmacol. 1995 Jul;26(1):27-32.PMID: 7564361 [PubMed - indexed for MEDLINE]Related articles