PubMed

Tuberous sclerosis complex suppression in cerebellar development and medulloblastoma: separate regulation of mammalian target of rapamycin activity and p27 Kip1 localization.

Bhatia B, Northcott PA, Hambardzumyan D, Govindarajan B, Brat DJ, Arbiser JL, Holland EC, Taylor MD, Kenney AM.

Cancer Res. 2009 Sep 15;69(18):7224-34. Epub 2009 Sep 8.PMID: 19738049 [PubMed - indexed for MEDLINE]Related articles

De novo germline TP53 mutation presenting with synchronous malignancies of the central nervous system.

Schniederjan MJ, Shehata B, Brat DJ, Esiashvili N, Janss AJ.

Pediatr Blood Cancer. 2009 Dec 15;53(7):1352-4.PMID: 19711436 [PubMed - indexed for MEDLINE]Related articles

Management of newly diagnosed glioblastoma: guidelines development, value and application.

Olson JJ, Fadul CE, Brat DJ, Mukundan S, Ryken TC.

J Neurooncol. 2009 May;93(1):1-23. Epub 2009 May 9. Review.PMID: 19430879 [PubMed - indexed for MEDLINE]Related articles

Epidermal growth factor receptor and PTEN modulate tissue factor expression in glioblastoma through JunD/activator protein-1 transcriptional activity.

Rong Y, Belozerov VE, Tucker-Burden C, Chen G, Durden DL, Olson JJ, Van Meir EG, Mackman N, Brat DJ.

Cancer Res. 2009 Mar 15;69(6):2540-9. Epub 2009 Mar 10.PMID: 19276385 [PubMed - indexed for MEDLINE]Related articles

Silencing of TMS1/ASC promotes resistance to anoikis in breast epithelial cells.

Parsons MJ, Patel P, Brat DJ, Colbert L, Vertino PM.

Cancer Res. 2009 Mar 1;69(5):1706-11. Epub 2009 Feb 17.PMID: 19223547 [PubMed - indexed for MEDLINE]Related articles

Distinguishing chordoid meningiomas from their histologic mimics: an immunohistochemical evaluation.

Sangoi AR, Dulai MS, Beck AH, Brat DJ, Vogel H.

Am J Surg Pathol. 2009 May;33(5):669-81.PMID: 19194275 [PubMed - indexed for MEDLINE]Related articles

Vasculostatin inhibits intracranial glioma growth and negatively regulates in vivo angiogenesis through a CD36-dependent mechanism.

Kaur B, Cork SM, Sandberg EM, Devi NS, Zhang Z, Klenotic PA, Febbraio M, Shim H, Mao H, Tucker-Burden C, Silverstein RL, Brat DJ, Olson JJ, Van Meir EG.

Cancer Res. 2009 Feb 1;69(3):1212-20. Epub 2009 Jan 27.PMID: 19176395 [PubMed - indexed for MEDLINE]Related articles

Human BRE1 is an E3 ubiquitin ligase for Ebp1 tumor suppressor.

Liu Z, Oh SM, Okada M, Liu X, Cheng D, Peng J, Brat DJ, Sun SY, Zhou W, Gu W, Ye K.

Mol Biol Cell. 2009 Feb;20(3):757-68. Epub 2008 Nov 26.PMID: 19037095 [PubMed - indexed for MEDLINE]Related articlesFree article

Diagnosis of malignant glioma: role of neuropathology.

Brat DJ, Prayson RA, Ryken TC, Olson JJ.

J Neurooncol. 2008 Sep;89(3):287-311. Epub 2008 Aug 20. No abstract available. PMID: 18712282 [PubMed - indexed for MEDLINE]Related articles

Galectin-3 expression is ubiquitous in tumors of the sellar region, nervous system, and mimics: an immunohistochemical and RT-PCR study.

Rodriguez FJ, Scheithauer BW, Roncaroli F, Silva AI, Kovacs K, Brat DJ, Jin L.

Am J Surg Pathol. 2008 Sep;32(9):1344-52.PMID: 18670355 [PubMed - indexed for MEDLINE]Related articles

Chordoid glioma: a case report and molecular characterization of five cases.

Horbinski C, Dacic S, McLendon RE, Cieply K, Datto M, Brat DJ, Chu CT.

Brain Pathol. 2009 Jul;19(3):439-48. Epub 2008 Jul 23.PMID: 18652591 [PubMed - indexed for MEDLINE]Related articles

Surgical neuropathology update: a review of changes introduced by the WHO classification of tumours of the central nervous system, 4th edition.

Brat DJ, Parisi JE, Kleinschmidt-DeMasters BK, Yachnis AT, Montine TJ, Boyer PJ, Powell SZ, Prayson RA, McLendon RE; Neuropathology Committee, College of American Pathologists.

Arch Pathol Lab Med. 2008 Jun;132(6):993-1007. Review.PMID: 18517285 [PubMed - indexed for MEDLINE]Related articles

Protocol for the examination of specimens from patients with tumors of the brain/spinal cord.

Parisi JE, Miller DV, Boyer PJ, Brat DJ, Cochran EJ, Cohen ML, Demasters BK, Dolinak D, McComb RD, McLendon RE, Powell SZ, Prayson RA, Vinters HV, Yachnis AT; Members of Cancer Committee, College of American Pathologists.

Arch Pathol Lab Med. 2008 Jun;132(6):907-12. No abstract available. PMID: 18517271 [PubMed - indexed for MEDLINE]Related articles

Intravascular thrombosis in central nervous system malignancies: a potential role in astrocytoma progression to glioblastoma.

Tehrani M, Friedman TM, Olson JJ, Brat DJ.

Brain Pathol. 2008 Apr;18(2):164-71. Epub 2007 Dec 17.PMID: 18093251 [PubMed - indexed for MEDLINE]Related articlesFree article

Depletion of peripheral macrophages and brain microglia increases brain tumor titers of oncolytic viruses.

Fulci G, Dmitrieva N, Gianni D, Fontana EJ, Pan X, Lu Y, Kaufman CS, Kaur B, Lawler SE, Lee RJ, Marsh CB, Brat DJ, van Rooijen N, Stemmer-Rachamimov AO, Hochberg FH, Weissleder R, Martuza RL, Chiocca EA.

Cancer Res. 2007 Oct 1;67(19):9398-406. Erratum in: Cancer Res. 2007 Nov 15;67(22):11092. Rachamimov, Anat Stemmer [corrected to Stemmer-Rachamimov, Anat O]. PMID: 17909049 [PubMed - indexed for MEDLINE]Related articlesFree article

Targeted cancer gene therapy using a hypoxia inducible factor dependent oncolytic adenovirus armed with interleukin-4.

Post DE, Sandberg EM, Kyle MM, Devi NS, Brat DJ, Xu Z, Tighiouart M, Van Meir EG.

Cancer Res. 2007 Jul 15;67(14):6872-81. Erratum in: Cancer Res. 2007 Sep 1;67(17):8422-3. PMID: 17638898 [PubMed - indexed for MEDLINE]Related articlesFree article

Newly codified glial neoplasms of the 2007 WHO Classification of Tumours of the Central Nervous System: angiocentric glioma, pilomyxoid astrocytoma and pituicytoma.

Brat DJ, Scheithauer BW, Fuller GN, Tihan T.

Brain Pathol. 2007 Jul;17(3):319-24.PMID: 17598825 [PubMed - indexed for MEDLINE]Related articles

Best cases from the AFIP: glioblastoma multiforme.

Altman DA, Atkinson DS Jr, Brat DJ.

Radiographics. 2007 May-Jun;27(3):883-8. No abstract available. PMID: 17495298 [PubMed - indexed for MEDLINE]Related articlesFree article

Congenital glioblastoma: a clinicopathologic and genetic analysis.

Brat DJ, Shehata BM, Castellano-Sanchez AA, Hawkins C, Yost RB, Greco C, Mazewski C, Janss A, Ohgaki H, Perry A.

Brain Pathol. 2007 Jul;17(3):276-81. Epub 2007 Apr 23.PMID: 17465990 [PubMed - indexed for MEDLINE]Related articles

An astroblastoma mimicking a cavernous malformation: case report.

Tumialán LM, Brat DJ, Fountain AJ, Barrow DL.

Neurosurgery. 2007 Mar;60(3):E569-70; discussion E570.PMID: 17327764 [PubMed - indexed for MEDLINE]Related articles

Antitumor effect of 2-methoxyestradiol in a rat orthotopic brain tumor model.

Kang SH, Cho HT, Devi S, Zhang Z, Escuin D, Liang Z, Mao H, Brat DJ, Olson JJ, Simons JW, Lavallee TM, Giannakakou P, Van Meir EG, Shim H.

Cancer Res. 2006 Dec 15;66(24):11991-7.PMID: 17178898 [PubMed - indexed for MEDLINE]Related articlesFree article

Attractin is elevated in the cerebrospinal fluid of patients with malignant astrocytoma and mediates glioma cell migration.

Khwaja FW, Duke-Cohan JS, Brat DJ, Van Meir EG.

Clin Cancer Res. 2006 Nov 1;12(21):6331-6.PMID: 17085642 [PubMed - indexed for MEDLINE]Related articlesFree article

Proteomic analysis of cerebrospinal fluid discriminates malignant and nonmalignant disease of the central nervous system and identifies specific protein markers.

Khwaja FW, Nolen JD, Mendrinos SE, Lewis MM, Olson JJ, Pohl J, Van Meir EG, Ritchie JC, Brat DJ.

Proteomics. 2006 Dec;6(23):6277-87.PMID: 17078017 [PubMed - indexed for MEDLINE]Related articles

Early growth response gene-1 regulates hypoxia-induced expression of tissue factor in glioblastoma multiforme through hypoxia-inducible factor-1-independent mechanisms.

Rong Y, Hu F, Huang R, Mackman N, Horowitz JM, Jensen RL, Durden DL, Van Meir EG, Brat DJ.

Cancer Res. 2006 Jul 15;66(14):7067-74.PMID: 16849552 [PubMed - indexed for MEDLINE]Related articlesFree article

'Pseudopalisading' necrosis in glioblastoma: a familiar morphologic feature that links vascular pathology, hypoxia, and angiogenesis.

Rong Y, Durden DL, Van Meir EG, Brat DJ.

J Neuropathol Exp Neurol. 2006 Jun;65(6):529-39. Review.PMID: 16783163 [PubMed - indexed for MEDLINE]Related articles

Special lecture: glial reactivity after damage: implications for scar formation and neuronal recovery.

Hamill CE, Goldshmidt A, Nicole O, McKeon RJ, Brat DJ, Traynelis SF.

Clin Neurosurg. 2005;52:29-44. No abstract available. PMID: 16626052 [PubMed - indexed for MEDLINE]Related articles

The elusive origin of chordoid glioma.

Brat DJ.

Arch Pathol Lab Med. 2006 Apr;130(4):437-8. No abstract available. PMID: 16594734 [PubMed - indexed for MEDLINE]Related articles

Proliferation (MIB-1 expression) in oligodendrogliomas: assessment of quantitative methods and prognostic significance.

Coleman KE, Brat DJ, Cotsonis GA, Lawson D, Cohen C.

Appl Immunohistochem Mol Morphol. 2006 Mar;14(1):109-14.PMID: 16540741 [PubMed - indexed for MEDLINE]Related articles

Spinal intradural clear cell meningioma following resection of a suprasellar clear cell meningioma. Case report and recommendations for management.

Dhall SS, Tumialán LM, Brat DJ, Barrow DL.

J Neurosurg. 2005 Sep;103(3):559-63.PMID: 16235691 [PubMed - indexed for MEDLINE]Related articles

Upregulation of hypoxia inducible factor is associated with attenuation of neuronal injury in neonatal piglets undergoing deep hypothermic circulatory arrest.

Kerendi F, Halkos ME, Kin H, Corvera JS, Brat DJ, Wagner MB, Vinten-Johansen J, Zhao ZQ, Forbess JM, Kanter KR, Kelley ME, Kirshbom PM.

J Thorac Cardiovasc Surg. 2005 Oct;130(4):1079.PMID: 16214523 [PubMed - indexed for MEDLINE]Related articles

Clarifying the diffuse gliomas: an update on the morphologic features and markers that discriminate oligodendroglioma from astrocytoma.

Gupta M, Djalilvand A, Brat DJ.

Am J Clin Pathol. 2005 Nov;124(5):755-68.PMID: 16203285 [PubMed - indexed for MEDLINE]Related articlesFree article

The neuronal PAS domain protein 3 transcription factor controls FGF-mediated adult hippocampal neurogenesis in mice.

Pieper AA, Wu X, Han TW, Estill SJ, Dang Q, Wu LC, Reece-Fincanon S, Dudley CA, Richardson JA, Brat DJ, McKnight SL.

Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):14052-7. Epub 2005 Sep 19.PMID: 16172381 [PubMed - indexed for MEDLINE]Related articlesFree article

Delivery systems and molecular targets of mechanism-based therapies for GBM.

Phuphanich S, Brat DJ, Olson JJ.

Expert Rev Neurother. 2004 Jul;4(4):649-63. Review.PMID: 15853584 [PubMed - indexed for MEDLINE]Related articles

Hypoxia and the hypoxia-inducible-factor pathway in glioma growth and angiogenesis.

Kaur B, Khwaja FW, Severson EA, Matheny SL, Brat DJ, Van Meir EG.

Neuro Oncol. 2005 Apr;7(2):134-53. Review.PMID: 15831232 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of interleukin-8 and its receptors in gliomagenesis and tumoral angiogenesis.

Brat DJ, Bellail AC, Van Meir EG.

Neuro Oncol. 2005 Apr;7(2):122-33. Review.PMID: 15831231 [PubMed - indexed for MEDLINE]Related articlesFree article

Vasculostatin, a proteolytic fragment of brain angiogenesis inhibitor 1, is an antiangiogenic and antitumorigenic factor.

Kaur B, Brat DJ, Devi NS, Van Meir EG.

Oncogene. 2005 May 19;24(22):3632-42.PMID: 15782143 [PubMed - indexed for MEDLINE]Related articles

PTEN and hypoxia regulate tissue factor expression and plasma coagulation by glioblastoma.

Rong Y, Post DE, Pieper RO, Durden DL, Van Meir EG, Brat DJ.

Cancer Res. 2005 Feb 15;65(4):1406-13.PMID: 15735028 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic and hypoxic regulation of angiogenesis in gliomas.

Kaur B, Tan C, Brat DJ, Post DE, Van Meir EG.

J Neurooncol. 2004 Nov;70(2):229-43. Review.PMID: 15674480 [PubMed - indexed for MEDLINE]Related articles

Anaplastic meningioma versus meningeal hemangiopericytoma: immunohistochemical and genetic markers.

Rajaram V, Brat DJ, Perry A.

Hum Pathol. 2004 Nov;35(11):1413-8.PMID: 15668900 [PubMed - indexed for MEDLINE]Related articles

Cancer therapy with a replicating oncolytic adenovirus targeting the hypoxic microenvironment of tumors.

Post DE, Devi NS, Li Z, Brat DJ, Kaur B, Nicholson A, Olson JJ, Zhang Z, Van Meir EG.

Clin Cancer Res. 2004 Dec 15;10(24):8603-12.PMID: 15623644 [PubMed - indexed for MEDLINE]Related articlesFree article

Transgenic expression of dominant negative tuberin through a strong constitutive promoter results in a tissue-specific tuberous sclerosis phenotype in the skin and brain.

Govindarajan B, Brat DJ, Csete M, Martin WD, Murad E, Litani K, Cohen C, Cerimele F, Nunnelley M, Lefkove B, Yamamoto T, Lee C, Arbiser JL.

J Biol Chem. 2005 Feb 18;280(7):5870-4. Epub 2004 Dec 2.PMID: 15576369 [PubMed - indexed for MEDLINE]Related articlesFree article

Notch1 and notch2 have opposite effects on embryonal brain tumor growth.

Fan X, Mikolaenko I, Elhassan I, Ni X, Wang Y, Ball D, Brat DJ, Perry A, Eberhart CG.

Cancer Res. 2004 Nov 1;64(21):7787-93.PMID: 15520184 [PubMed - indexed for MEDLINE]Related articlesFree article

Aberrant methylation and down-regulation of TMS1/ASC in human glioblastoma.

Stone AR, Bobo W, Brat DJ, Devi NS, Van Meir EG, Vertino PM.

Am J Pathol. 2004 Oct;165(4):1151-61.PMID: 15466382 [PubMed - indexed for MEDLINE]Related articlesFree article

Protease-activated receptor-1 in human brain: localization and functional expression in astrocytes.

Junge CE, Lee CJ, Hubbard KB, Zhang Z, Olson JJ, Hepler JR, Brat DJ, Traynelis SF.

Exp Neurol. 2004 Jul;188(1):94-103.PMID: 15191806 [PubMed - indexed for MEDLINE]Related articles

Analysis of 1p, 19q, 9p, and 10q as prognostic markers for high-grade astrocytomas using fluorescence in situ hybridization on tissue microarrays from Radiation Therapy Oncology Group trials.

Brat DJ, Seiferheld WF, Perry A, Hammond EH, Murray KJ, Schulsinger AR, Mehta MP, Curran WJ; Radiation Therapy Oncology Group.

Neuro Oncol. 2004 Apr;6(2):96-103.PMID: 15134623 [PubMed - indexed for MEDLINE]Related articlesFree article

Microregional extracellular matrix heterogeneity in brain modulates glioma cell invasion.

Bellail AC, Hunter SB, Brat DJ, Tan C, Van Meir EG.

Int J Biochem Cell Biol. 2004 Jun;36(6):1046-69. Review.PMID: 15094120 [PubMed - indexed for MEDLINE]Related articles

Pituicytoma: report of two cases and clues regarding histogenesis.

Ulm AJ, Yachnis AT, Brat DJ, Rhoton AL Jr.

Neurosurgery. 2004 Mar;54(3):753-7; discussion 757-8. Erratum in: Neurosurgery. 2004 May;54(5):1252. PMID: 15028154 [PubMed - indexed for MEDLINE]Related articles

Vaso-occlusive and prothrombotic mechanisms associated with tumor hypoxia, necrosis, and accelerated growth in glioblastoma.

Brat DJ, Van Meir EG.

Lab Invest. 2004 Apr;84(4):397-405. Review.PMID: 14990981 [PubMed - indexed for MEDLINE]Related articlesFree article

Primary central nervous system posttransplant lymphoproliferative disorders.

Castellano-Sanchez AA, Li S, Qian J, Lagoo A, Weir E, Brat DJ.

Am J Clin Pathol. 2004 Feb;121(2):246-53.PMID: 14983939 [PubMed - indexed for MEDLINE]Related articlesFree article

Pseudopalisades in glioblastoma are hypoxic, express extracellular matrix proteases, and are formed by an actively migrating cell population.

Brat DJ, Castellano-Sanchez AA, Hunter SB, Pecot M, Cohen C, Hammond EH, Devi SN, Kaur B, Van Meir EG.

Cancer Res. 2004 Feb 1;64(3):920-7.PMID: 14871821 [PubMed - indexed for MEDLINE]Related articlesFree article