PubMed

Long-Term Controlled Normoglycemia in Diabetic Non-Human Primates After Transplantation with hCD46 Transgenic Porcine Islets.

van der Windt DJ, Bottino R, Casu A, Campanile N, Smetanka C, He J, Murase N, Hara H, Ball S, Loveland BE, Ayares D, Lakkis FG, Cooper DK, Trucco M.

Am J Transplant. 2009 Oct 21. [Epub ahead of print]PMID: 19845582 [PubMed - as supplied by publisher]Related articles

Endoscopic gastric submucosal transplantation of islets (ENDO-STI): technique and initial results in diabetic pigs.

Echeverri GJ, McGrath K, Bottino R, Hara H, Dons EM, van der Windt DJ, Ekser B, Casu A, Houser S, Ezzelarab M, Wagner R, Trucco M, Lakkis FG, Cooper DK.

Am J Transplant. 2009 Nov;9(11):2485-96. Epub 2009 Sep 22.PMID: 19775318 [PubMed - in process]Related articles

Polycomb protein Ezh2 regulates pancreatic beta-cell Ink4a/Arf expression and regeneration in diabetes mellitus.

Chen H, Gu X, Su IH, Bottino R, Contreras JL, Tarakhovsky A, Kim SK.

Genes Dev. 2009 Apr 15;23(8):975-85.PMID: 19390090 [PubMed - indexed for MEDLINE]Related articlesFree article

Recovery of endogenous beta-cell function in nonhuman primates after chemical diabetes induction and islet transplantation.

Bottino R, Criscimanna A, Casu A, He J, Van der Windt DJ, Rudert WA, Giordano C, Trucco M.

Diabetes. 2009 Feb;58(2):442-7. Epub 2008 Nov 10.PMID: 19001183 [PubMed - indexed for MEDLINE]Related articlesFree article

A new immunodeficient hyperglycaemic mouse model based on the Ins2Akita mutation for analyses of human islet and beta stem and progenitor cell function.

Pearson T, Shultz LD, Lief J, Burzenski L, Gott B, Chase T, Foreman O, Rossini AA, Bottino R, Trucco M, Greiner DL.

Diabetologia. 2008 Aug;51(8):1449-56. Epub 2008 Jun 19.PMID: 18563383 [PubMed - indexed for MEDLINE]Related articlesFree article

Islet xenotransplantation: the pig-to-non-human primate model.

Bottino R, Cooper DK.

Xenotransplantation. 2008 Mar;15(2):104-6. No abstract available. PMID: 18447880 [PubMed - indexed for MEDLINE]Related articles

Safe induction of diabetes by high-dose streptozotocin in pigs.

Hara H, Lin YJ, Zhu X, Tai HC, Ezzelarab M, Balamurugan AN, Bottino R, Houser SL, Cooper DK.

Pancreas. 2008 Jan;36(1):31-8. Erratum in: Pancreas. 2008 Apr;36(3):328. Balamarugan, A N [corrected to Balamurugan, A N]. PMID: 18192878 [PubMed - indexed for MEDLINE]Related articles

A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene.

King M, Pearson T, Shultz LD, Leif J, Bottino R, Trucco M, Atkinson MA, Wasserfall C, Herold KC, Woodland RT, Schmidt MR, Woda BA, Thompson MJ, Rossini AA, Greiner DL.

Clin Immunol. 2008 Mar;126(3):303-14. Epub 2007 Dec 21.PMID: 18096436 [PubMed - indexed for MEDLINE]Related articles

Metabolic aspects of pig-to-monkey (Macaca fascicularis) islet transplantation: implications for translation into clinical practice.

Casu A, Bottino R, Balamurugan AN, Hara H, van der Windt DJ, Campanile N, Smetanka C, Cooper DK, Trucco M.

Diabetologia. 2008 Jan;51(1):120-9. Epub 2007 Oct 25.PMID: 17960359 [PubMed - indexed for MEDLINE]Related articles

The pig as the donor of pancreatic islets for men.

Trucco M, Casu A, Bottino R.

Vet Res Commun. 2007 Aug;31 Suppl 1:27-33.PMID: 17682843 [PubMed - indexed for MEDLINE]Related articles

Rapid loss of intraportally transplanted islets: an overview of pathophysiology and preventive strategies.

van der Windt DJ, Bottino R, Casu A, Campanile N, Cooper DK.

Xenotransplantation. 2007 Jul;14(4):288-97. Review.PMID: 17669170 [PubMed - indexed for MEDLINE]Related articles

Angiopoietin-1 production in islets improves islet engraftment and protects islets from cytokine-induced apoptosis.

Su D, Zhang N, He J, Qu S, Slusher S, Bottino R, Bertera S, Bromberg J, Dong HH.

Diabetes. 2007 Sep;56(9):2274-83. Epub 2007 Jun 27.PMID: 17596403 [PubMed - indexed for MEDLINE]Related articlesFree article

Acute gastric dilatation after porcine islet transplantation in a cynomolgus monkey - case history and review of the literature.

Campanile N, Rood PP, Yeh P, Casu A, Bottino R, Cooper DK.

Xenotransplantation. 2007 May;14(3):265-70. Review.PMID: 17489868 [PubMed - indexed for MEDLINE]Related articles

Antidiabetic sulfonylurea stimulates insulin secretion independently of plasma membrane KATP channels.

Geng X, Li L, Bottino R, Balamurugan AN, Bertera S, Densmore E, Su A, Chang Y, Trucco M, Drain P.

Am J Physiol Endocrinol Metab. 2007 Jul;293(1):E293-301. Epub 2007 Apr 3.PMID: 17405830 [PubMed - indexed for MEDLINE]Related articlesFree article

Development of new-generation HU-PBMC-NOD/SCID mice to study human islet alloreactivity.

King M, Pearson T, Shultz LD, Leif J, Bottino R, Trucco M, Atkinson M, Wasserfall C, Herold K, Mordes JP, Rossini AA, Greiner DL.

Ann N Y Acad Sci. 2007 Apr;1103:90-3. Epub 2007 Mar 21.PMID: 17376822 [PubMed - indexed for MEDLINE]Related articles

Gene therapy for type 1 diabetes: is it ready for the clinic?

D'Anneo A, Rood P, Bottino R, Balamurugan AN, He J, Giannoukakis N.

Immunol Res. 2006;36(1-3):83-9. Review.PMID: 17337769 [PubMed - indexed for MEDLINE]Related articles

Reduction of early graft loss after intraportal porcine islet transplantation in monkeys.

Rood PP, Bottino R, Balamurugan AN, Smetanka C, Ayares D, Groth CG, Murase N, Cooper DK, Trucco M.

Transplantation. 2007 Jan 27;83(2):202-10.PMID: 17264817 [PubMed - indexed for MEDLINE]Related articles

Isolation outcome and functional characteristics of young and adult pig pancreatic islets for transplantation studies.

Bottino R, Balamurugan AN, Smetanka C, Bertera S, He J, Rood PP, Cooper DK, Trucco M.

Xenotransplantation. 2007 Jan;14(1):74-82.PMID: 17214707 [PubMed - indexed for MEDLINE]Related articles

Induction of diabetes in cynomolgus monkeys with high-dose streptozotocin: adverse effects and early responses.

Rood PP, Bottino R, Balamurugan AN, Smetanka C, Ezzelarab M, Busch J, Hara H, Trucco M, Cooper DK.

Pancreas. 2006 Oct;33(3):287-92.PMID: 17003651 [PubMed - indexed for MEDLINE]Related articles

Sirolimus is associated with reduced islet engraftment and impaired beta-cell function.

Zhang N, Su D, Qu S, Tse T, Bottino R, Balamurugan AN, Xu J, Bromberg JS, Dong HH.

Diabetes. 2006 Sep;55(9):2429-36.PMID: 16936190 [PubMed - indexed for MEDLINE]Related articlesFree article

Suitability of human juvenile pancreatic islets for clinical use.

Balamurugan AN, Chang Y, Bertera S, Sands A, Shankar V, Trucco M, Bottino R.

Diabetologia. 2006 Aug;49(8):1845-54. Epub 2006 Jun 17.PMID: 16783471 [PubMed - indexed for MEDLINE]Related articles

Pig-to-nonhuman primate islet xenotransplantation: a review of current problems.

Rood PP, Buhler LH, Bottino R, Trucco M, Cooper DK.

Cell Transplant. 2006;15(2):89-104. Review.PMID: 16719044 [PubMed - indexed for MEDLINE]Related articles

Prospective and challenges of islet transplantation for the therapy of autoimmune diabetes.

Balamurugan AN, Bottino R, Giannoukakis N, Smetanka C.

Pancreas. 2006 Apr;32(3):231-43. Review.PMID: 16628077 [PubMed - indexed for MEDLINE]Related articles

HLA-A*0201-restricted T cells from humanized NOD mice recognize autoantigens of potential clinical relevance to type 1 diabetes.

Takaki T, Marron MP, Mathews CE, Guttmann ST, Bottino R, Trucco M, DiLorenzo TP, Serreze DV.

J Immunol. 2006 Mar 1;176(5):3257-65.PMID: 16493087 [PubMed - indexed for MEDLINE]Related articlesFree article

Facilitating physiologic self-regeneration: a step beyond islet cell replacement.

Rood PP, Bottino R, Balamurugan AN, Fan Y, Cooper DK, Trucco M.

Pharm Res. 2006 Feb;23(2):227-42. Epub 2006 Jan 1. Review.PMID: 16323065 [PubMed - indexed for MEDLINE]Related articles

Multifaceted therapeutic approaches for a multigenic disease.

Bottino R, Trucco M.

Diabetes. 2005 Dec;54 Suppl 2:S79-86. Review.PMID: 16306345 [PubMed - indexed for MEDLINE]Related articlesFree article

Harmful delayed effects of exogenous isolation enzymes on isolated human islets: relevance to clinical transplantation.

Balamurugan AN, He J, Guo F, Stolz DB, Bertera S, Geng X, Ge X, Trucco M, Bottino R.

Am J Transplant. 2005 Nov;5(11):2671-81.PMID: 16212626 [PubMed - indexed for MEDLINE]Related articles

A randomised, double blind, placebo controlled trial of the effect of theophylline in prevention of vasomotor nephropathy in very preterm neonates with respiratory distress syndrome.

Cattarelli D, Spandrio M, Gasparoni A, Bottino R, Offer C, Chirico G.

Arch Dis Child Fetal Neonatal Ed. 2006 Mar;91(2):F80-4. Epub 2005 Oct 4.PMID: 16204359 [PubMed - indexed for MEDLINE]Related articlesFree article

Gene transfer of constitutively active Akt markedly improves human islet transplant outcomes in diabetic severe combined immunodeficient mice.

Rao P, Roccisana J, Takane KK, Bottino R, Zhao A, Trucco M, García-Ocaña A.

Diabetes. 2005 Jun;54(6):1664-75.PMID: 15919787 [PubMed - indexed for MEDLINE]Related articlesFree article

Efficient gene delivery to human and rodent islets with double-stranded (ds) AAV-based vectors.

Rehman KK, Wang Z, Bottino R, Balamurugan AN, Trucco M, Li J, Xiao X, Robbins PD.

Gene Ther. 2005 Sep;12(17):1313-23.PMID: 15858610 [PubMed - indexed for MEDLINE]Related articles

Response of human islets to isolation stress and the effect of antioxidant treatment.

Bottino R, Balamurugan AN, Tse H, Thirunavukkarasu C, Ge X, Profozich J, Milton M, Ziegenfuss A, Trucco M, Piganelli JD.

Diabetes. 2004 Oct;53(10):2559-68.PMID: 15448084 [PubMed - indexed for MEDLINE]Related articlesFree article

Prolongation of islet allograft survival following ex vivo transduction with adenovirus encoding a soluble type 1 TNF receptor-Ig fusion decoy.

Machen J, Bertera S, Chang Y, Bottino R, Balamurugan AN, Robbins PD, Trucco M, Giannoukakis N.

Gene Ther. 2004 Oct;11(20):1506-14.PMID: 15229635 [PubMed - indexed for MEDLINE]Related articles

Islet/pancreas transplantation: challenges for pediatrics.

Bottino R, Balamurugan AN, Giannoukakis N, Trucco M.

Pediatr Diabetes. 2002 Dec;3(4):210-23.PMID: 15016150 [PubMed]Related articles

High-frequency partial liquid ventilation in two infants.

Migliori C, Bottino R, Angeli A, Cattarelli D, Chirico G.

J Perinatol. 2004 Feb;24(2):118-20.PMID: 14762454 [PubMed - indexed for MEDLINE]Related articles

Induction of beta-cell proliferation and retinoblastoma protein phosphorylation in rat and human islets using adenovirus-mediated transfer of cyclin-dependent kinase-4 and cyclin D1.

Cozar-Castellano I, Takane KK, Bottino R, Balamurugan AN, Stewart AF.

Diabetes. 2004 Jan;53(1):149-59.PMID: 14693709 [PubMed - indexed for MEDLINE]Related articlesFree article

Body window-enabled in vivo multicolor imaging of transplanted mouse islets expressing an insulin-Timer fusion protein.

Bertera S, Geng X, Tawadrous Z, Bottino R, Balamurugan AN, Rudert WA, Drain P, Watkins SC, Trucco M.

Biotechniques. 2003 Oct;35(4):718-22.PMID: 14579736 [PubMed - indexed for MEDLINE]Related articles

Flexible management of enzymatic digestion improves human islet isolation outcome from sub-optimal donor pancreata.

Balamurugan AN, Chang Y, Fung JJ, Trucco M, Bottino R.

Am J Transplant. 2003 Sep;3(9):1135-42.PMID: 12919094 [PubMed - indexed for MEDLINE]Related articles

Early use of Nasal-BiPAP in two infants with Congenital Central Hypoventilation syndrome.

Migliori C, Cavazza A, Motta M, Bottino R, Chirico G.

Acta Paediatr. 2003 Jul;92(7):823-6.PMID: 12892162 [PubMed - indexed for MEDLINE]Related articles

Recovery of the endogenous beta cell function in the NOD model of autoimmune diabetes.

Zorina TD, Subbotin VM, Bertera S, Alexander AM, Haluszczak C, Gambrell B, Bottino R, Styche AJ, Trucco M.

Stem Cells. 2003;21(4):377-88. Review.PMID: 12832692 [PubMed - indexed for MEDLINE]Related articlesFree article

Gene- and cell-based therapeutics for type I diabetes mellitus.

Bottino R, Lemarchand P, Trucco M, Giannoukakis N.

Gene Ther. 2003 May;10(10):875-89. Review.PMID: 12732873 [PubMed - indexed for MEDLINE]Related articles

Protection of islets by in situ peptide-mediated transduction of the Ikappa B kinase inhibitor Nemo-binding domain peptide.

Rehman KK, Bertera S, Bottino R, Balamurugan AN, Mai JC, Mi Z, Trucco M, Robbins PD.

J Biol Chem. 2003 Mar 14;278(11):9862-8. Epub 2003 Jan 9.PMID: 12524423 [PubMed - indexed for MEDLINE]Related articlesFree article

Production of alpha 1,3-galactosyltransferase-deficient pigs.

Phelps CJ, Koike C, Vaught TD, Boone J, Wells KD, Chen SH, Ball S, Specht SM, Polejaeva IA, Monahan JA, Jobst PM, Sharma SB, Lamborn AE, Garst AS, Moore M, Demetris AJ, Rudert WA, Bottino R, Bertera S, Trucco M, Starzl TE, Dai Y, Ayares DL.

Science. 2003 Jan 17;299(5605):411-4. Epub 2002 Dec 19.PMID: 12493821 [PubMed - indexed for MEDLINE]Related articlesFree article

Preservation of human islet cell functional mass by anti-oxidative action of a novel SOD mimic compound.

Bottino R, Balamurugan AN, Bertera S, Pietropaolo M, Trucco M, Piganelli JD.

Diabetes. 2002 Aug;51(8):2561-7. Erratum in: Diabetes. 2004 Aug;53(8):2177. PMID: 12145171 [PubMed - indexed for MEDLINE]Related articlesFree article

Pancreas and islet cell transplantation.

Bottino R, Trucco M, Balamurugan AN, Starzl TE.

Best Pract Res Clin Gastroenterol. 2002 Jun;16(3):457-74. Review.PMID: 12079269 [PubMed - indexed for MEDLINE]Related articles

Effect of general and epidural anaesthesia on thyroid hormones and immunity in neonates.

Gasparoni A, Ciardelli L, De Amici D, Castellazzi AM, Autelli M, Bottino R, Polito E, Bartoli A, Rondini G, Chirico G.

Paediatr Anaesth. 2002 Jan;12(1):59-64.PMID: 11849577 [PubMed - indexed for MEDLINE]Related articles

Transplantation of islets of Langerhans in patients with insulin-requiring diabetes mellitus undergoing orthotopic liver transplantation--the Miami experience.

Angelico MC, Alejandro R, Nery J, Webb M, Bottino R, Kong SS, Karatzas T, Olson L, Tzakis AG, Ricordi C.

J Mol Med. 1999 Jan;77(1):144-7.PMID: 9930950 [PubMed - indexed for MEDLINE]Related articles

Evaluation of islet isolation by a new automated method (Coulter Multisizer Ile) and manual counting.

Lehmann R, Fernandez LA, Bottino R, Szabo S, Ricordi C, Alejandro R, Kenyon NS.

Transplant Proc. 1998 Mar;30(2):373-4. No abstract available. PMID: 9532086 [PubMed - indexed for MEDLINE]Related articles

Transplantation of allogeneic islets of Langerhans in the rat liver: effects of macrophage depletion on graft survival and microenvironment activation.

Bottino R, Fernandez LA, Ricordi C, Lehmann R, Tsan MF, Oliver R, Inverardi L.

Diabetes. 1998 Mar;47(3):316-23.PMID: 9519734 [PubMed - indexed for MEDLINE]Related articlesFree article

Improved human islet isolation using a new enzyme blend, liberase.

Linetsky E, Bottino R, Lehmann R, Alejandro R, Inverardi L, Ricordi C.

Diabetes. 1997 Jul;46(7):1120-3.PMID: 9200645 [PubMed - indexed for MEDLINE]Related articles

Liver-islet transplantation in type 2 diabetes.

Ricordi C, Angelico MC, Alejandro R, Nery J, Webb M, Bottino R, Kong SS, Karatzas T, Olson L, Mintz DH, Tzakis AG.

Transplant Proc. 1997 Jun;29(4):2240. No abstract available. PMID: 9193608 [PubMed - indexed for MEDLINE]Related articles