PubMed

Defective phagocytosis of apoptotic cells by macrophages in atherosclerotic lesions of ob/ob mice and reversal by a fish oil diet.

Li S, Sun Y, Liang CP, Thorp EB, Han S, Jehle AW, Saraswathi V, Pridgen B, Kanter JE, Li R, Welch CL, Hasty AH, Bornfeldt KE, Breslow JL, Tabas I, Tall AR.

Circ Res. 2009 Nov 20;105(11):1072-82. Epub 2009 Oct 15.PMID: 19834009 [PubMed - in process]Related articles

Lipids versus glucose in inflammation and the pathogenesis of macrovascular disease in diabetes.

Averill MM, Bornfeldt KE.

Curr Diab Rep. 2009 Feb;9(1):18-25. Review.PMID: 19192420 [PubMed - indexed for MEDLINE]Related articles

Diabetes and atherosclerosis: is there a role for hyperglycemia?

Chait A, Bornfeldt KE.

J Lipid Res. 2009 Apr;50 Suppl:S335-9. Epub 2008 Nov 23. Review.PMID: 19029122 [PubMed - indexed for MEDLINE]Related articles

Diabetes-accelerated atherosclerosis and inflammation.

Kanter JE, Averill MM, Leboeuf RC, Bornfeldt KE.

Circ Res. 2008 Oct 10;103(8):e116-7. No abstract available. PMID: 18845812 [PubMed - indexed for MEDLINE]Related articlesFree article

An inducible and reversible mouse genetic rescue system.

Zeng H, Horie K, Madisen L, Pavlova MN, Gragerova G, Rohde AD, Schimpf BA, Liang Y, Ojala E, Kramer F, Roth P, Slobodskaya O, Dolka I, Southon EA, Tessarollo L, Bornfeldt KE, Gragerov A, Pavlakis GN, Gaitanaris GA.

PLoS Genet. 2008 May 9;4(5):e1000069.PMID: 18464897 [PubMed - indexed for MEDLINE]Related articlesFree article

Type 1 diabetes promotes disruption of advanced atherosclerotic lesions in LDL receptor-deficient mice.

Johansson F, Kramer F, Barnhart S, Kanter JE, Vaisar T, Merrill RD, Geng L, Oka K, Chan L, Chait A, Heinecke JW, Bornfeldt KE.

Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):2082-7. Epub 2008 Feb 5.PMID: 18252823 [PubMed - indexed for MEDLINE]Related articlesFree article

Do glucose and lipids exert independent effects on atherosclerotic lesion initiation or progression to advanced plaques?

Kanter JE, Johansson F, LeBoeuf RC, Bornfeldt KE.

Circ Res. 2007 Mar 30;100(6):769-81. Review.PMID: 17395883 [PubMed - indexed for MEDLINE]Related articlesFree article

Mouse models for studies of cardiovascular complications of type 1 diabetes.

Shen X, Bornfeldt KE.

Ann N Y Acad Sci. 2007 Apr;1103:202-17. Epub 2007 Mar 21.PMID: 17376839 [PubMed - indexed for MEDLINE]Related articles

Rosiglitazone inhibits acyl-CoA synthetase activity and fatty acid partitioning to diacylglycerol and triacylglycerol via a peroxisome proliferator-activated receptor-gamma-independent mechanism in human arterial smooth muscle cells and macrophages.

Askari B, Kanter JE, Sherrid AM, Golej DL, Bender AT, Liu J, Hsueh WA, Beavo JA, Coleman RA, Bornfeldt KE.

Diabetes. 2007 Apr;56(4):1143-52. Epub 2007 Jan 26.PMID: 17259370 [PubMed - indexed for MEDLINE]Related articlesFree article

A single second messenger: several possible cellular responses depending on distinct subcellular pools.

Bornfeldt KE.

Circ Res. 2006 Oct 13;99(8):790-2. Review. No abstract available. PMID: 17038646 [PubMed - indexed for MEDLINE]Related articlesFree article

Aggressive very low-density lipoprotein (VLDL) and LDL lowering by gene transfer of the VLDL receptor combined with a low-fat diet regimen induces regression and reduces macrophage content in advanced atherosclerotic lesions in LDL receptor-deficient mice.

MacDougall ED, Kramer F, Polinsky P, Barnhart S, Askari B, Johansson F, Varon R, Rosenfeld ME, Oka K, Chan L, Schwartz SM, Bornfeldt KE.

Am J Pathol. 2006 Jun;168(6):2064-73.PMID: 16723719 [PubMed - indexed for MEDLINE]Related articlesFree article

Nuclear signaling in smooth muscle cells: cyclic nucleotide phosphodiesterase 1A moves in.

Bornfeldt KE.

Circ Res. 2006 Mar 31;98(6):720-2. No abstract available. PMID: 16574912 [PubMed - indexed for MEDLINE]Related articlesFree article

IGF-I/insulin hybrid receptors in human endothelial cells.

Nitert MD, Chisalita SI, Olsson K, Bornfeldt KE, Arnqvist HJ.

Mol Cell Endocrinol. 2005 Jan 14;229(1-2):31-7.PMID: 15607526 [PubMed - indexed for MEDLINE]Related articles

Hyperlipidemia in concert with hyperglycemia stimulates the proliferation of macrophages in atherosclerotic lesions: potential role of glucose-oxidized LDL.

Lamharzi N, Renard CB, Kramer F, Pennathur S, Heinecke JW, Chait A, Bornfeldt KE.

Diabetes. 2004 Dec;53(12):3217-25.PMID: 15561953 [PubMed - indexed for MEDLINE]Related articlesFree article

Diabetes and diabetes-associated lipid abnormalities have distinct effects on initiation and progression of atherosclerotic lesions.

Renard CB, Kramer F, Johansson F, Lamharzi N, Tannock LR, von Herrath MG, Chait A, Bornfeldt KE.

J Clin Invest. 2004 Sep;114(5):659-68.PMID: 15343384 [PubMed - indexed for MEDLINE]Related articlesFree article

Revised nomenclature for the mammalian long-chain acyl-CoA synthetase gene family.

Mashek DG, Bornfeldt KE, Coleman RA, Berger J, Bernlohr DA, Black P, DiRusso CC, Farber SA, Guo W, Hashimoto N, Khodiyar V, Kuypers FA, Maltais LJ, Nebert DW, Renieri A, Schaffer JE, Stahl A, Watkins PA, Vasiliou V, Yamamoto TT.

J Lipid Res. 2004 Oct;45(10):1958-61. Epub 2004 Aug 1.PMID: 15292367 [PubMed - indexed for MEDLINE]Related articlesFree article

Direct effects of long-chain non-esterified fatty acids on vascular cells and their relevance to macrovascular complications of diabetes.

Oram JF, Bornfeldt KE.

Front Biosci. 2004 May 1;9:1240-53. Review.PMID: 14977541 [PubMed - indexed for MEDLINE]Related articles

Oleate, not ligands of the receptor for advanced glycation end-products, promotes proliferation of human arterial smooth muscle cells.

Renard CB, Askari B, Suzuki LA, Kramer F, Bornfeldt KE.

Diabetologia. 2003 Dec;46(12):1676-87. Epub 2003 Nov 1.PMID: 14595542 [PubMed - indexed for MEDLINE]Related articles

How does diabetes accelerate atherosclerotic plaque rupture and arterial occlusion?

Schwartz SM, Bornfeldt KE.

Front Biosci. 2003 Sep 1;8:s1371-83. Review.PMID: 12957842 [PubMed - indexed for MEDLINE]Related articles

Cyclic GMP phosphodiesterases and regulation of smooth muscle function.

Rybalkin SD, Yan C, Bornfeldt KE, Beavo JA.

Circ Res. 2003 Aug 22;93(4):280-91. Review.PMID: 12933699 [PubMed - indexed for MEDLINE]Related articlesFree article

The cyclin-dependent kinase pathway moves forward.

Bornfeldt KE.

Circ Res. 2003 Mar 7;92(4):345-7. No abstract available. PMID: 12623871 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of protein kinase C on the expression of platelet-derived growth factor and endothelin-1 in the retina of diabetic rats and cultured retinal capillary pericytes.

Yokota T, Ma RC, Park JY, Isshiki K, Sotiropoulos KB, Rauniyar RK, Bornfeldt KE, King GL.

Diabetes. 2003 Mar;52(3):838-45.PMID: 12606528 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of smooth muscle cell accumulation in diabetes-accelerated atherosclerosis.

Askari B, Renard CB, Bornfeldt KE.

Histol Histopathol. 2002 Oct;17(4):1317-28. Review.PMID: 12371156 [PubMed - indexed for MEDLINE]Related articles

Oleate and linoleate enhance the growth-promoting effects of insulin-like growth factor-I through a phospholipase D-dependent pathway in arterial smooth muscle cells.

Askari B, Carroll MA, Capparelli M, Kramer F, Gerrity RG, Bornfeldt KE.

J Biol Chem. 2002 Sep 27;277(39):36338-44. Epub 2002 Jul 22.PMID: 12138107 [PubMed - indexed for MEDLINE]Related articlesFree article

Cyclic nucleotide phosphodiesterase 1C promotes human arterial smooth muscle cell proliferation.

Rybalkin SD, Rybalkina I, Beavo JA, Bornfeldt KE.

Circ Res. 2002 Feb 8;90(2):151-7.PMID: 11834707 [PubMed - indexed for MEDLINE]Related articlesFree article

Cyclic AMP-specific phosphodiesterase 4 inhibitors promote ABCA1 expression and cholesterol efflux.

Lin G, Bornfeldt KE.

Biochem Biophys Res Commun. 2002 Jan 18;290(2):663-9.PMID: 11785950 [PubMed - indexed for MEDLINE]Related articles

Human arterial smooth muscle cells rapidly deplete cell culture media of glucose.

Renard CB, Bornfeldt KE.

Diabetologia. 2001 Aug;44(8):1067-8. No abstract available. PMID: 11484090 [PubMed - indexed for MEDLINE]Related articles

Adenylyl cyclase 3 mediates prostaglandin E(2)-induced growth inhibition in arterial smooth muscle cells.

Wong ST, Baker LP, Trinh K, Hetman M, Suzuki LA, Storm DR, Bornfeldt KE.

J Biol Chem. 2001 Sep 7;276(36):34206-12. Epub 2001 Jun 29.PMID: 11432866 [PubMed - indexed for MEDLINE]Related articlesFree article

Diabetes accelerates smooth muscle accumulation in lesions of atherosclerosis: lack of direct growth-promoting effects of high glucose levels.

Suzuki LA, Poot M, Gerrity RG, Bornfeldt KE.

Diabetes. 2001 Apr;50(4):851-60.PMID: 11289052 [PubMed - indexed for MEDLINE]Related articlesFree article

Leptin induces insulin-like signaling that antagonizes cAMP elevation by glucagon in hepatocytes.

Zhao AZ, Shinohara MM, Huang D, Shimizu M, Eldar-Finkelman H, Krebs EG, Beavo JA, Bornfeldt KE.

J Biol Chem. 2000 Apr 14;275(15):11348-54.PMID: 10753948 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular pathways of cyclic nucleotide-induced inhibition of arterial smooth muscle cell proliferation.

Koyama H, Bornfeldt KE, Fukumoto S, Nishizawa Y.

J Cell Physiol. 2001 Jan;186(1):1-10. Review.PMID: 11147803 [PubMed - indexed for MEDLINE]Related articles

Stressing Rac, Ras, and downstream heat shock protein 70.

Bornfeldt KE.

Circ Res. 2000 Jun 9;86(11):1101-3. Review. No abstract available. PMID: 10850958 [PubMed - indexed for MEDLINE]Related articlesFree article

Cyclic nucleotide phosphodiesterases and human arterial smooth muscle cell proliferation.

Rybalkin SD, Bornfeldt KE.

Thromb Haemost. 1999 Aug;82(2):424-34. Review. No abstract available. PMID: 10605733 [PubMed - indexed for MEDLINE]Related articles

Sparing effect of leptin on liver glycogen stores in rats during the fed-to-fasted transition.

O'Doherty RM, Anderson PR, Zhao AZ, Bornfeldt KE, Newgard CB.

Am J Physiol. 1999 Sep;277(3 Pt 1):E544-50.PMID: 10484368 [PubMed - indexed for MEDLINE]Related articlesFree article

Crosstalk between protein kinase A and growth factor receptor signaling pathways in arterial smooth muscle.

Bornfeldt KE, Krebs EG.

Cell Signal. 1999 Jul;11(7):465-77. Review.PMID: 10405757 [PubMed - indexed for MEDLINE]Related articles

Leptin inhibits insulin secretion by activation of phosphodiesterase 3B.

Zhao AZ, Bornfeldt KE, Beavo JA.

J Clin Invest. 1998 Sep 1;102(5):869-73.PMID: 9727054 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification, quantitation, and cellular localization of PDE1 calmodulin-stimulated cyclic nucleotide phosphodiesterases.

Sonnenburg WK, Rybalkin SD, Bornfeldt KE, Kwak KS, Rybalkina IG, Beavo JA.

Methods. 1998 Jan;14(1):3-19.PMID: 9500854 [PubMed - indexed for MEDLINE]Related articles

Calmodulin-stimulated cyclic nucleotide phosphodiesterase (PDE1C) is induced in human arterial smooth muscle cells of the synthetic, proliferative phenotype.

Rybalkin SD, Bornfeldt KE, Sonnenburg WK, Rybalkina IG, Kwak KS, Hanson K, Krebs EG, Beavo JA.

J Clin Invest. 1997 Nov 15;100(10):2611-21.PMID: 9366577 [PubMed - indexed for MEDLINE]Related articlesFree article

The mitogen-activated protein kinase pathway can mediate growth inhibition and proliferation in smooth muscle cells. Dependence on the availability of downstream targets.

Bornfeldt KE, Campbell JS, Koyama H, Argast GM, Leslie CC, Raines EW, Krebs EG, Ross R.

J Clin Invest. 1997 Aug 15;100(4):875-85.PMID: 9259587 [PubMed - indexed for MEDLINE]Related articlesFree article

Historical perspectives and new insights involving the MAP kinase cascades.

Graves LM, Bornfeldt KE, Krebs EG.

Adv Second Messenger Phosphoprotein Res. 1997;31:49-62. Review. No abstract available. PMID: 9344241 [PubMed - indexed for MEDLINE]Related articles

Fibrillar collagen inhibits arterial smooth muscle proliferation through regulation of Cdk2 inhibitors.

Koyama H, Raines EW, Bornfeldt KE, Roberts JM, Ross R.

Cell. 1996 Dec 13;87(6):1069-78.PMID: 8978611 [PubMed - indexed for MEDLINE]Related articles

Platelet-derived growth factor stimulates protein kinase A through a mitogen-activated protein kinase-dependent pathway in human arterial smooth muscle cells.

Graves LM, Bornfeldt KE, Sidhu JS, Argast GM, Raines EW, Ross R, Leslie CC, Krebs EG.

J Biol Chem. 1996 Jan 5;271(1):505-11.PMID: 8550611 [PubMed - indexed for MEDLINE]Related articlesFree article

The insulin-like growth factor system in vascular smooth muscle: interaction with insulin and growth factors.

Arnqvist HJ, Bornfeldt KE, Chen Y, Lindström T.

Metabolism. 1995 Oct;44(10 Suppl 4):58-66. Review.PMID: 7476313 [PubMed - indexed for MEDLINE]Related articles

Platelet-derived growth factor. Distinct signal transduction pathways associated with migration versus proliferation.

Bornfeldt KE, Raines EW, Graves LM, Skinner MP, Krebs EG, Ross R.

Ann N Y Acad Sci. 1995 Sep 7;766:416-30. Review.PMID: 7486687 [PubMed - indexed for MEDLINE]Related articles

cAMP- and rapamycin-sensitive regulation of the association of eukaryotic initiation factor 4E and the translational regulator PHAS-I in aortic smooth muscle cells.

Graves LM, Bornfeldt KE, Argast GM, Krebs EG, Kong X, Lin TA, Lawrence JC Jr.

Proc Natl Acad Sci U S A. 1995 Aug 1;92(16):7222-6.PMID: 7638171 [PubMed - indexed for MEDLINE]Related articlesFree article

Sphingosine-1-phosphate inhibits PDGF-induced chemotaxis of human arterial smooth muscle cells: spatial and temporal modulation of PDGF chemotactic signal transduction.

Bornfeldt KE, Graves LM, Raines EW, Igarashi Y, Wayman G, Yamamura S, Yatomi Y, Sidhu JS, Krebs EG, Hakomori S, et al.

J Cell Biol. 1995 Jul;130(1):193-206.PMID: 7790372 [PubMed - indexed for MEDLINE]Related articlesFree article

Development of smooth muscle hypertrophy is closely associated with increased gene expression of insulin-like growth factor binding protein-2 and -4.

Chen Y, Arner A, Bornfeldt KE, Uvelius B, Arnqvist HJ.

Growth Regul. 1995 Mar;5(1):45-52.PMID: 7538370 [PubMed - indexed for MEDLINE]Related articles

Negative cooperativity in the insulin-like growth factor-I receptor and a chimeric IGF-I/insulin receptor.

Christoffersen CT, Bornfeldt KE, Rotella CM, Gonzales N, Vissing H, Shymko RM, ten Hoeve J, Groffen J, Heisterkamp N, De Meyts P.

Endocrinology. 1994 Jul;135(1):472-5.PMID: 8013387 [PubMed - indexed for MEDLINE]Related articles

Insulin-like growth factor-I and platelet-derived growth factor-BB induce directed migration of human arterial smooth muscle cells via signaling pathways that are distinct from those of proliferation.

Bornfeldt KE, Raines EW, Nakano T, Graves LM, Krebs EG, Ross R.

J Clin Invest. 1994 Mar;93(3):1266-74.PMID: 8132765 [PubMed - indexed for MEDLINE]Related articlesFree article

Increase in insulin-like growth factor I in hypertrophying smooth muscle.

Chen Y, Bornfeldt KE, Arner A, Jennische E, Malmqvist U, Uvelius B, Arnqvist HJ.

Am J Physiol. 1994 Feb;266(2 Pt 1):E224-9.PMID: 7511339 [PubMed - indexed for MEDLINE]Related articles