PubMed

Synthesis and biological evaluation of novel thiocolchicine-podophyllotoxin conjugates.

Passarella D, Peretto B, Blasco Y Yepes R, Cappelletti G, Cartelli D, Ronchi C, Snaith J, Fontana G, Danieli B, Borlak J.

Eur J Med Chem. 2009 Oct 6. [Epub ahead of print]PMID: 19880222 [PubMed - as supplied by publisher]Related articles

Cancer genomics identifies regulatory gene networks associated with the transition from dysplasia to advanced lung adenocarcinomas induced by c-Raf-1.

Rohrbeck A, Borlak J.

PLoS One. 2009 Oct 8;4(10):e7315.PMID: 19812696 [PubMed - in process]Related articlesFree article

Synthesis and biological evaluation of epothilone A dimeric compounds.

Passarella D, Comi D, Cappelletti G, Cartelli D, Gertsch J, Quesada AR, Borlak J, Altmann KH.

Bioorg Med Chem. 2009 Nov 1;17(21):7435-40. Epub 2009 Sep 20.PMID: 19804980 [PubMed - in process]Related articles

Toxicogenomics applied to cultures of human hepatocytes enabled an identification of novel petasites hybridus extracts for the treatment of migraine with improved hepatobiliary safety.

Anderson N, Meier T, Borlak J.

Toxicol Sci. 2009 Dec;112(2):507-20. Epub 2009 Sep 21.PMID: 19770483 [PubMed - in process]Related articles

An update on the mouse liver proteome.

Gazzana G, Borlak J.

Proteome Sci. 2009 Sep 8;7:35.PMID: 19737410 [PubMed - in process]Related articlesFree article

3.3 Trovafloxacin: a case study of idiosyncratic or iatrogenic liver toxicity - molecular mechanisms and lessons for pharmacotoxicity.

Borlak J.

Hum Exp Toxicol. 2009 Feb;28(2-3):119-21. No abstract available. PMID: 19713375 [PubMed - in process]Related articles

The risk of exaggerated risk aversion-a life and death struggle for molecular imaging.

Långström B, Grahnen A, Honoré PH, Borlak J, Bergstrom M, Nielsen B, Vanderheyden J, Watanabe Y, Josephsson R, Høilund-Carlsen PF, Schwaiger M, Larson SM, Goldenberg DM, Melzer A, Engler H, Hicks R, Sundin A, Seppänen M, Hedenstierna G, Nordberg A, Brooks D.

Eur J Nucl Med Mol Imaging. 2009 Oct;36(10):1693-4. No abstract available. PMID: 19618184 [PubMed - in process]Related articlesFree article

A functional genetic study identifies HAND1 mutations in septation defects of the human heart.

Reamon-Buettner SM, Ciribilli Y, Traverso I, Kuhls B, Inga A, Borlak J.

Hum Mol Genet. 2009 Oct 1;18(19):3567-78. Epub 2009 Jul 7.PMID: 19586923 [PubMed - indexed for MEDLINE]Related articles

Deferoxamine-induced neurite outgrowth and synapse formation in postnatal rat dorsal root ganglion (DRG) cell cultures.

Nowicki M, Kosacka J, Spanel-Borowski K, Borlak J.

Eur J Cell Biol. 2009 Oct;88(10):551-62. Epub 2009 Jul 5.PMID: 19581022 [PubMed - in process]Related articles

Expression of HNF4alpha in the human and rat choroid plexus: implications for drug transport across the blood-cerebrospinal-fluid (CSF) barrier.

Niehof M, Borlak J.

BMC Mol Biol. 2009 Jul 3;10:68.PMID: 19575803 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular characterization of lung dysplasia induced by c-Raf-1.

Rohrbeck A, Müller VS, Borlak J.

PLoS One. 2009 May 20;4(5):e5637.PMID: 19529782 [PubMed - indexed for MEDLINE]Related articlesFree article

Apolipoproteins D and E3 exert neurotrophic and synaptogenic effects in dorsal root ganglion cell cultures.

Kosacka J, Gericke M, Nowicki M, Kacza J, Borlak J, Spanel-Borowski K.

Neuroscience. 2009 Aug 18;162(2):282-91. Epub 2009 May 3.PMID: 19414061 [PubMed - indexed for MEDLINE]Related articles

Combined microPET/CT for imaging of hepatocellular carcinoma in mice.

von Falck C, Rodt T, Halter R, Spanel R, Galanski M, Borlak J.

Front Biosci. 2009 Jan 1;14:2193-202.PMID: 19273193 [PubMed - indexed for MEDLINE]Related articles

In vivo microCT quantification of lung tumor growth in SPC-raf transgenic mice.

Rodt T, von Falck C, Halter R, Ringe K, Shin HO, Galanski M, Borlak J.

Front Biosci. 2009 Jan 1;14:1939-44.PMID: 19273175 [PubMed - indexed for MEDLINE]Related articles

HNF4alpha and HNF1alpha dysfunction as a molecular rational for cyclosporine induced posttransplantation diabetes mellitus.

Borlak J, Niehof M.

PLoS One. 2009;4(3):e4662. Epub 2009 Mar 2.PMID: 19252740 [PubMed - indexed for MEDLINE]Related articlesFree article

A 2-DE MALDI-TOF study to identify disease regulated serum proteins in lung cancer of c-myc transgenic mice.

Chatterji B, Borlak J.

Proteomics. 2009 Feb;9(4):1044-56.PMID: 19180532 [PubMed - indexed for MEDLINE]Related articles

Increase of pro-inflammatory cytokine expression in non-demyelinating early cerebral lesions in nervous canine distemper.

Beineke A, Markus S, Borlak J, Thum T, Baumgärtner W.

Viral Immunol. 2008 Dec;21(4):401-10.PMID: 19115929 [PubMed - indexed for MEDLINE]Related articles

A genome-wide expression analysis identifies a network of EpCAM-induced cell cycle regulators.

Maaser K, Borlak J.

Br J Cancer. 2008 Nov 18;99(10):1635-43. Epub 2008 Oct 28.PMID: 19002182 [PubMed - indexed for MEDLINE]Related articlesFree article

Clinical versatility of porcine hepatocytes in the light of interspecies differences in cytochrome P450 regulation and expression.

Kleine M, Schrem H, Borlak J, Klempnauer J.

Xenotransplantation. 2008 Jul;15(4):208-17.PMID: 18957043 [PubMed - indexed for MEDLINE]Related articles

Molecular mechanisms and therapeutic targets in steatosis and steatohepatitis.

Anderson N, Borlak J.

Pharmacol Rev. 2008 Sep;60(3):311-57. Review.PMID: 18922966 [PubMed - indexed for MEDLINE]Related articlesFree article

Epigenetic silencing of cell adhesion molecule 1 in different cancer progenitor cells of transgenic c-Myc and c-Raf mouse lung tumors.

Reamon-Buettner SM, Borlak J.

Cancer Res. 2008 Sep 15;68(18):7587-96.PMID: 18794147 [PubMed - indexed for MEDLINE]Related articlesFree article

A simple and reliable protocol for mouse serum proteome profiling studies by use of two-dimensional electrophoresis and MALDI TOF/TOF mass spectrometry.

Ritorto MS, Borlak J.

Proteome Sci. 2008 Sep 12;6:25.PMID: 18789141 [PubMed - in process]Related articlesFree article

Cross-talk between aryl hydrocarbon receptor and mitogen-activated protein kinase signaling pathway in liver cancer through c-raf transcriptional regulation.

Borlak J, Jenke HS.

Mol Cancer Res. 2008 Aug;6(8):1326-36.PMID: 18708364 [PubMed - indexed for MEDLINE]Related articlesFree article

Gender-incompatible liver transplantation is not a risk factor for patient survival.

Lehner F, Becker T, Klempnauer J, Borlak J.

Liver Int. 2009 Feb;29(2):196-202. Epub 2008 Jul 29.PMID: 18673439 [PubMed - indexed for MEDLINE]Related articles

Topoisomerase II inhibition involves characteristic chromosomal expression patterns.

Reymann S, Borlak J.

BMC Genomics. 2008 Jul 8;9:324.PMID: 18611269 [PubMed - indexed for MEDLINE]Related articlesFree article

Matrix layer sample preparation: an improved MALDI-MS peptide analysis method for proteomic studies.

Garaguso I, Borlak J.

Proteomics. 2008 Jul;8(13):2583-95.PMID: 18546159 [PubMed - indexed for MEDLINE]Related articles

Transcription profiling of lung adenocarcinomas of c-myc-transgenic mice: identification of the c-myc regulatory gene network.

Reymann S, Borlak J.

BMC Syst Biol. 2008 May 22;2:46.PMID: 18498649 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibitors of tubulin polymerization: synthesis and biological evaluation of hybrids of vindoline, anhydrovinblastine and vinorelbine with thiocolchicine, podophyllotoxin and baccatin III.

Passarella D, Giardini A, Peretto B, Fontana G, Sacchetti A, Silvani A, Ronchi C, Cappelletti G, Cartelli D, Borlak J, Danieli B.

Bioorg Med Chem. 2008 Jun 1;16(11):6269-85. Epub 2008 May 28.PMID: 18468444 [PubMed - indexed for MEDLINE]Related articles

EPS15R, TASP1, and PRPF3 are novel disease candidate genes targeted by HNF4alpha splice variants in hepatocellular carcinomas.

Niehof M, Borlak J.

Gastroenterology. 2008 Apr;134(4):1191-202. Epub 2008 Jan 17.PMID: 18395097 [PubMed - indexed for MEDLINE]Related articles

Nuclear factor-eythroid 2-related factor 2 prevents alcohol-induced fulminant liver injury.

Lamlé J, Marhenke S, Borlak J, von Wasielewski R, Eriksson CJ, Geffers R, Manns MP, Yamamoto M, Vogel A.

Gastroenterology. 2008 Apr;134(4):1159-68. Epub 2008 Jan 11.PMID: 18395094 [PubMed - indexed for MEDLINE]Related articles

LOX-1 receptor blockade abrogates oxLDL-induced oxidative DNA damage and prevents activation of the transcriptional repressor Oct-1 in human coronary arterial endothelium.

Thum T, Borlak J.

J Biol Chem. 2008 Jul 11;283(28):19456-64. Epub 2008 Apr 7.PMID: 18390905 [PubMed - indexed for MEDLINE]Related articlesFree article

The next innovation cycle in toxicogenomics: environmental epigenetics.

Reamon-Buettner SM, Mutschler V, Borlak J.

Mutat Res. 2008 Jul-Aug;659(1-2):158-65. Epub 2008 Jan 19. Review.PMID: 18342568 [PubMed - indexed for MEDLINE]Related articles

Graft rejection: pharmacogenetic analysis or drug anamnesis?

Pham VV, Stichtenoth DO, Borlak J.

Br J Clin Pharmacol. 2008 Jun;65(6):959-60. Epub 2008 Mar 13.PMID: 18341681 [PubMed - indexed for MEDLINE]Related articlesFree article

Genome wide prediction of HNF4alpha functional binding sites by the use of local and global sequence context.

Kel AE, Niehof M, Matys V, Zemlin R, Borlak J.

Genome Biol. 2008;9(2):R36. Epub 2008 Feb 21.PMID: 18291023 [PubMed - indexed for MEDLINE]Related articlesFree article

A loss-of-function mutation in the binding domain of HAND1 predicts hypoplasia of the human hearts.

Reamon-Buettner SM, Ciribilli Y, Inga A, Borlak J.

Hum Mol Genet. 2008 May 15;17(10):1397-405. Epub 2008 Feb 14.PMID: 18276607 [PubMed - indexed for MEDLINE]Related articlesFree article

Mapping of the serum proteome of hepatocellular carcinoma induced by targeted overexpression of epidermal growth factor to liver cells of transgenic mice.

Gazzana G, Borlak J.

J Proteome Res. 2008 Mar;7(3):928-37. Epub 2008 Jan 17.PMID: 18198842 [PubMed - indexed for MEDLINE]Related articles

HNF4 alpha and the Ca-channel TRPC1 are novel disease candidate genes in diabetic nephropathy.

Niehof M, Borlak J.

Diabetes. 2008 Apr;57(4):1069-77. Epub 2008 Jan 9.PMID: 18184923 [PubMed - indexed for MEDLINE]Related articlesFree article

Quantitative mass spectrometry to investigate epidermal growth factor receptor phosphorylation dynamics.

Schuchardt S, Borlak J.

Mass Spectrom Rev. 2008 Jan-Feb;27(1):51-65. Review.PMID: 18023079 [PubMed - indexed for MEDLINE]Related articles

Serum proteomics of lung adenocarcinomas induced by targeted overexpression of c-raf in alveolar epithelium identifies candidate biomarkers.

Chatterji B, Borlak J.

Proteomics. 2007 Nov;7(21):3980-91.PMID: 17902193 [PubMed - indexed for MEDLINE]Related articles

Detection of early signals of hepatotoxicity by gene expression profiling studies with cultures of metabolically competent human hepatocytes.

Thum T, Borlak J.

Arch Toxicol. 2008 Feb;82(2):89-101. Epub 2007 Sep 13.PMID: 17851650 [PubMed - indexed for MEDLINE]Related articles

The myelin-associated glycoprotein inhibitor BENZ induces outgrowth and survival of rat dorsal root ganglion cell cultures.

Nowicki M, Kosacka J, Brossmer R, Spanel-Borowski K, Borlak J.

J Neurosci Res. 2007 Nov 1;85(14):3053-63.PMID: 17722062 [PubMed - indexed for MEDLINE]Related articles

Transcriptomics does not show adverse effects of beta-carotene in A/J mice exposed to smoke for 2 weeks.

Kuntz E, Borlak J, Riss G, Aebischer CP, Bachmann H, Seifert N, Hunziker PB, Sölle D, Hunziker W, Goralczyk R, Wertz K.

Arch Biochem Biophys. 2007 Sep 15;465(2):336-46. Epub 2007 Jul 18.PMID: 17707332 [PubMed - indexed for MEDLINE]Related articles

No upregulation of lectin-like oxidized low-density lipoprotein receptor-1 in serum-deprived EA.hy926 endothelial cells under oxLDL exposure, but increase in autophagy.

Nowicki M, Zabirnyk O, Duerrschmidt N, Borlak J, Spanel-Borowski K.

Eur J Cell Biol. 2007 Oct;86(10):605-16. Epub 2007 Jul 23.PMID: 17643551 [PubMed - indexed for MEDLINE]Related articles

MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure.

Thum T, Galuppo P, Wolf C, Fiedler J, Kneitz S, van Laake LW, Doevendans PA, Mummery CL, Borlak J, Haverich A, Gross C, Engelhardt S, Ertl G, Bauersachs J.

Circulation. 2007 Jul 17;116(3):258-67. Epub 2007 Jul 2. Erratum in: Circulation. 2007 Jul 17;116(3):e135. PMID: 17606841 [PubMed - indexed for MEDLINE]Related articlesFree article

A new paradigm in toxicology and teratology: altering gene activity in the absence of DNA sequence variation.

Reamon-Buettner SM, Borlak J.

Reprod Toxicol. 2007 Jul;24(1):20-30. Epub 2007 May 22. Review.PMID: 17596910 [PubMed - indexed for MEDLINE]Related articles

Mutations in the 3'-untranslated region of GATA4 as molecular hotspots for congenital heart disease (CHD).

Reamon-Buettner SM, Cho SH, Borlak J.

BMC Med Genet. 2007 Jun 25;8:38.PMID: 17592645 [PubMed - indexed for MEDLINE]Related articlesFree article

Improved method for proteome mapping of the liver by 2-DE MALDI-TOF MS.

Gazzana G, Borlak J.

J Proteome Res. 2007 Aug;6(8):3143-51. Epub 2007 Jun 19.PMID: 17579388 [PubMed - indexed for MEDLINE]Related articles

The environmental carcinogen 3-nitrobenzanthrone and its main metabolite 3-aminobenzanthrone enhance formation of reactive oxygen intermediates in human A549 lung epithelial cells.

Hansen T, Seidel A, Borlak J.

Toxicol Appl Pharmacol. 2007 Jun 1;221(2):222-34. Epub 2007 Mar 23.PMID: 17477947 [PubMed - indexed for MEDLINE]Related articles

The hepatocyte nuclear factor 6 (HNF6) and FOXA2 are key regulators in colorectal liver metastases.

Lehner F, Kulik U, Klempnauer J, Borlak J.

FASEB J. 2007 May;21(7):1445-62. Epub 2007 Feb 5.PMID: 17283222 [PubMed - indexed for MEDLINE]Related articlesFree article

Age-dependent impairment of endothelial progenitor cells is corrected by growth-hormone-mediated increase of insulin-like growth-factor-1.

Thum T, Hoeber S, Froese S, Klink I, Stichtenoth DO, Galuppo P, Jakob M, Tsikas D, Anker SD, Poole-Wilson PA, Borlak J, Ertl G, Bauersachs J.

Circ Res. 2007 Feb 16;100(3):434-43. Epub 2007 Jan 18.PMID: 17234973 [PubMed - indexed for MEDLINE]Related articlesFree article