PubMed

Regenerating pancreatic beta-cells: plasticity of adult pancreatic cells and the feasibility of in-vivo neogenesis.

Juhl K, Bonner-Weir S, Sharma A.

Curr Opin Organ Transplant. 2009 Nov 10. [Epub ahead of print]PMID: 19907327 [PubMed - as supplied by publisher]Related articles

OVO homologue-like 1 (Ovol1) transcription factor: a novel target of neurogenin-3 in rodent pancreas.

Vetere A, Li WC, Paroni F, Juhl K, Guo L, Nishimura W, Dai X, Bonner-Weir S, Sharma A.

Diabetologia. 2009 Oct 31. [Epub ahead of print]PMID: 19882138 [PubMed - as supplied by publisher]Related articles

Single pancreatic beta cells co-express multiple islet hormone genes in mice.

Katsuta H, Akashi T, Katsuta R, Nagaya M, Kim D, Arinobu Y, Hara M, Bonner-Weir S, Sharma AJ, Akashi K, Weir GC.

Diabetologia. 2009 Oct 23. [Epub ahead of print]PMID: 19851748 [PubMed - as supplied by publisher]Related articles

Towards better understanding of the contributions of overwork and glucotoxicity to the beta-cell inadequacy of type 2 diabetes.

Weir GC, Marselli L, Marchetti P, Katsuta H, Jung MH, Bonner-Weir S.

Diabetes Obes Metab. 2009 Nov;11 Suppl 4:82-90.PMID: 19817791 [PubMed - in process]Related articles

Mutations at the BLK locus linked to maturity onset diabetes of the young and beta-cell dysfunction.

Borowiec M, Liew CW, Thompson R, Boonyasrisawat W, Hu J, Mlynarski WM, El Khattabi I, Kim SH, Marselli L, Rich SS, Krolewski AS, Bonner-Weir S, Sharma A, Sale M, Mychaleckyj JC, Kulkarni RN, Doria A.

Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14460-5. Epub 2009 Aug 10.PMID: 19667185 [PubMed - indexed for MEDLINE]Related articles

Expression of MafA in pancreatic progenitors is detrimental for pancreatic development.

Nishimura W, Bonner-Weir S, Sharma A.

Dev Biol. 2009 Sep 1;333(1):108-20. Epub 2009 Jul 1.PMID: 19576197 [PubMed - indexed for MEDLINE]Related articles

Laser capture microdissection of human pancreatic beta-cells and RNA preparation for gene expression profiling.

Marselli L, Sgroi DC, Bonner-Weir S, Weir GC.

Methods Mol Biol. 2009;560:87-98.PMID: 19504246 [PubMed - in process]Related articles

p38 MAPK is a major regulator of MafA protein stability under oxidative stress.

Kondo T, El Khattabi I, Nishimura W, Laybutt DR, Geraldes P, Shah S, King G, Bonner-Weir S, Weir G, Sharma A.

Mol Endocrinol. 2009 Aug;23(8):1281-90. Epub 2009 Apr 30.PMID: 19407223 [PubMed - in process]Related articles

Developmental pathways during in vitro progression of human islet neogenesis.

Dodge R, Loomans C, Sharma A, Bonner-Weir S.

Differentiation. 2009 Feb;77(2):135-47. Epub 2008 Nov 6.PMID: 19281773 [PubMed - indexed for MEDLINE]Related articles

Differentiation of COPAS-sorted non-endocrine pancreatic cells into insulin-positive cells in the mouse.

Kikugawa R, Katsuta H, Akashi T, Yatoh S, Weir GC, Sharma A, Bonner-Weir S.

Diabetologia. 2009 Apr;52(4):645-52. Epub 2009 Jan 30.PMID: 19183938 [PubMed - indexed for MEDLINE]Related articles

Adult mouse intrahepatic biliary epithelial cells induced in vitro to become insulin-producing cells.

Nagaya M, Katsuta H, Kaneto H, Bonner-Weir S, Weir GC.

J Endocrinol. 2009 Apr;201(1):37-47. Epub 2009 Jan 23.PMID: 19168505 [PubMed - indexed for MEDLINE]Related articles

Porcine marginal mass islet autografts resist metabolic failure over time and are enhanced by early treatment with liraglutide.

Emamaullee JA, Merani S, Toso C, Kin T, Al-Saif F, Truong W, Pawlick R, Davis J, Edgar R, Lock J, Bonner-Weir S, Knudsen LB, Shapiro AM.

Endocrinology. 2009 May;150(5):2145-52. Epub 2009 Jan 8.PMID: 19131571 [PubMed - indexed for MEDLINE]Related articles

Carbonic anhydrase II-positive pancreatic cells are progenitors for both endocrine and exocrine pancreas after birth.

Inada A, Nienaber C, Katsuta H, Fujitani Y, Levine J, Morita R, Sharma A, Bonner-Weir S.

Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19915-9. Epub 2008 Dec 3.PMID: 19052237 [PubMed - indexed for MEDLINE]Related articlesFree article

Islets in type 2 diabetes: in honor of Dr. Robert C. Turner.

Bonner-Weir S, O'Brien TD.

Diabetes. 2008 Nov;57(11):2899-904. No abstract available. PMID: 18971437 [PubMed - indexed for MEDLINE]Related articlesFree article

Curative and beta cell regenerative effects of alpha1-antitrypsin treatment in autoimmune diabetic NOD mice.

Koulmanda M, Bhasin M, Hoffman L, Fan Z, Qipo A, Shi H, Bonner-Weir S, Putheti P, Degauque N, Libermann TA, Auchincloss H Jr, Flier JS, Strom TB.

Proc Natl Acad Sci U S A. 2008 Oct 21;105(42):16242-7. Epub 2008 Oct 13.PMID: 18852471 [PubMed - indexed for MEDLINE]Related articlesFree article

Bone marrow or foetal liver cells fail to induce islet regeneration in diabetic Akita mice.

Akashi T, Shigematsu H, Hamamoto Y, Iwasaki H, Yatoh S, Bonner-Weir S, Akashi K, Weir GC.

Diabetes Metab Res Rev. 2008 Oct;24(7):585-90.PMID: 18727153 [PubMed - indexed for MEDLINE]Related articles

Loss of Ncb5or results in impaired fatty acid desaturation, lipoatrophy, and diabetes.

Larade K, Jiang Z, Zhang Y, Wang W, Bonner-Weir S, Zhu H, Bunn HF.

J Biol Chem. 2008 Oct 24;283(43):29285-91. Epub 2008 Aug 5.PMID: 18682384 [PubMed - indexed for MEDLINE]Related articlesFree article

Transdifferentiation of pancreatic ductal cells to endocrine beta-cells.

Bonner-Weir S, Inada A, Yatoh S, Li WC, Aye T, Toschi E, Sharma A.

Biochem Soc Trans. 2008 Jun;36(Pt 3):353-6.PMID: 18481956 [PubMed - indexed for MEDLINE]Related articles

Preservation of beta-cell function by targeting beta-cell mass.

de Koning EJ, Bonner-Weir S, Rabelink TJ.

Trends Pharmacol Sci. 2008 Apr;29(4):218-27. Epub 2008 Mar 21. Review.PMID: 18359095 [PubMed - indexed for MEDLINE]Related articles

Preferential reduction of beta cells derived from Pax6-MafB pathway in MafB deficient mice.

Nishimura W, Rowan S, Salameh T, Maas RL, Bonner-Weir S, Sell SM, Sharma A.

Dev Biol. 2008 Feb 15;314(2):443-56. Epub 2007 Dec 23.PMID: 18199433 [PubMed - indexed for MEDLINE]Related articlesFree article

Gene expression of purified beta-cell tissue obtained from human pancreas with laser capture microdissection.

Marselli L, Thorne J, Ahn YB, Omer A, Sgroi DC, Libermann T, Otu HH, Sharma A, Bonner-Weir S, Weir GC.

J Clin Endocrinol Metab. 2008 Mar;93(3):1046-53. Epub 2007 Dec 11.PMID: 18073315 [PubMed - indexed for MEDLINE]Related articlesFree article

Modification of adverse inflammation is required to cure new-onset type 1 diabetic hosts.

Koulmanda M, Budo E, Bonner-Weir S, Qipo A, Putheti P, Degauque N, Shi H, Fan Z, Flier JS, Auchincloss H Jr, Zheng XX, Strom TB.

Proc Natl Acad Sci U S A. 2007 Aug 7;104(32):13074-9. Epub 2007 Aug 1.PMID: 17670937 [PubMed - indexed for MEDLINE]Related articlesFree article

Influence of diabetes on the loss of beta cell differentiation after islet transplantation in rats.

Laybutt DR, Hawkins YC, Lock J, Lebet J, Sharma A, Bonner-Weir S, Weir GC.

Diabetologia. 2007 Oct;50(10):2117-25. Epub 2007 Jul 20.PMID: 17641871 [PubMed - indexed for MEDLINE]Related articles

Normal relationship of beta- and non-beta-cells not needed for successful islet transplantation.

King AJ, Fernandes JR, Hollister-Lock J, Nienaber CE, Bonner-Weir S, Weir GC.

Diabetes. 2007 Sep;56(9):2312-8. Epub 2007 Jun 11.PMID: 17563059 [PubMed - indexed for MEDLINE]Related articlesFree article

Protein-tyrosine phosphatase 1B deficiency reduces insulin resistance and the diabetic phenotype in mice with polygenic insulin resistance.

Xue B, Kim YB, Lee A, Toschi E, Bonner-Weir S, Kahn CR, Neel BG, Kahn BB.

J Biol Chem. 2007 Aug 17;282(33):23829-40. Epub 2007 Jun 1.PMID: 17545163 [PubMed - indexed for MEDLINE]Related articlesFree article

Differentiation of affinity-purified human pancreatic duct cells to beta-cells.

Yatoh S, Dodge R, Akashi T, Omer A, Sharma A, Weir GC, Bonner-Weir S.

Diabetes. 2007 Jul;56(7):1802-9. Epub 2007 May 1.PMID: 17473224 [PubMed - indexed for MEDLINE]Related articlesFree article

In vivo multimodal imaging of transplanted pancreatic islets.

Medarova Z, Evgenov NV, Dai G, Bonner-Weir S, Moore A.

Nat Protoc. 2006;1(1):429-35.PMID: 17406265 [PubMed - indexed for MEDLINE]Related articles

Downregulation of GLP-1 and GIP receptor expression by hyperglycemia: possible contribution to impaired incretin effects in diabetes.

Xu G, Kaneto H, Laybutt DR, Duvivier-Kali VF, Trivedi N, Suzuma K, King GL, Weir GC, Bonner-Weir S.

Diabetes. 2007 Jun;56(6):1551-8. Epub 2007 Mar 14.PMID: 17360984 [PubMed - indexed for MEDLINE]Related articlesFree article

Induction of pancreatic stem/progenitor cells into insulin-producing cells by adenoviral-mediated gene transfer technology.

Noguchi H, Xu G, Matsumoto S, Kaneto H, Kobayashi N, Bonner-Weir S, Hayashi S.

Cell Transplant. 2006;15(10):929-38.PMID: 17299998 [PubMed - indexed for MEDLINE]Related articles

A dominant role for glucose in beta cell compensation of insulin resistance.

Weir GC, Bonner-Weir S.

J Clin Invest. 2007 Jan;117(1):81-3.PMID: 17200709 [PubMed - indexed for MEDLINE]Related articlesFree article

Changes in gene expression in beta cells after islet isolation and transplantation using laser-capture microdissection.

Ahn YB, Xu G, Marselli L, Toschi E, Sharma A, Bonner-Weir S, Sgroi DC, Weir GC.

Diabetologia. 2007 Feb;50(2):334-42. Epub 2006 Dec 16.PMID: 17180350 [PubMed - indexed for MEDLINE]Related articles

p16INK4a induces an age-dependent decline in islet regenerative potential.

Krishnamurthy J, Ramsey MR, Ligon KL, Torrice C, Koh A, Bonner-Weir S, Sharpless NE.

Nature. 2006 Sep 28;443(7110):453-7. Epub 2006 Sep 6.PMID: 16957737 [PubMed - indexed for MEDLINE]Related articles

In vivo imaging of immune rejection in transplanted pancreatic islets.

Evgenov NV, Medarova Z, Pratt J, Pantazopoulos P, Leyting S, Bonner-Weir S, Moore A.

Diabetes. 2006 Sep;55(9):2419-28.PMID: 16936189 [PubMed - indexed for MEDLINE]Related articlesFree article

Are there pancreatic progenitor cells from which new islets form after birth?

Bonner-Weir S, Sharma A.

Nat Clin Pract Endocrinol Metab. 2006 May;2(5):240-1. Review. No abstract available. PMID: 16932290 [PubMed - indexed for MEDLINE]Related articles

NeuroD and reaggregation induce beta-cell specific gene expression in cultured hepatocytes.

Yatoh S, Akashi T, Chan PP, Kaneto H, Sharma A, Bonner-Weir S, Weir GC.

Diabetes Metab Res Rev. 2007 Mar;23(3):239-49.PMID: 16921545 [PubMed - indexed for MEDLINE]Related articles

Evidence for a role of the ubiquitin-proteasome pathway in pancreatic islets.

López-Avalos MD, Duvivier-Kali VF, Xu G, Bonner-Weir S, Sharma A, Weir GC.

Diabetes. 2006 May;55(5):1223-31.PMID: 16644676 [PubMed - indexed for MEDLINE]Related articlesFree article

Timing and expression pattern of carbonic anhydrase II in pancreas.

Inada A, Nienaber C, Fonseca S, Bonner-Weir S.

Dev Dyn. 2006 Jun;235(6):1571-7.PMID: 16586439 [PubMed - indexed for MEDLINE]Related articlesFree article

A switch from MafB to MafA expression accompanies differentiation to pancreatic beta-cells.

Nishimura W, Kondo T, Salameh T, El Khattabi I, Dodge R, Bonner-Weir S, Sharma A.

Dev Biol. 2006 May 15;293(2):526-39. Epub 2006 Apr 3.PMID: 16580660 [PubMed - indexed for MEDLINE]Related articlesFree article

How can we get more beta cells?

Inada A, Bonner-Weir S, Toschi E.

Curr Diab Rep. 2006 Apr;6(2):96-101. Review.PMID: 16542618 [PubMed - indexed for MEDLINE]Related articles

Endogenous beta-galactosidase expression in murine pancreatic islets.

Inada A, Nienaber C, Bonner-Weir S.

Diabetologia. 2006 May;49(5):1120-2. Epub 2006 Mar 16. No abstract available. PMID: 16541278 [PubMed - indexed for MEDLINE]Related articles

GLP-1/exendin-4 facilitates beta-cell neogenesis in rat and human pancreatic ducts.

Xu G, Kaneto H, Lopez-Avalos MD, Weir GC, Bonner-Weir S.

Diabetes Res Clin Pract. 2006 Jul;73(1):107-10. Epub 2006 Jan 6. No abstract available. PMID: 16406191 [PubMed - indexed for MEDLINE]Related articles

In vivo imaging of islet transplantation.

Evgenov NV, Medarova Z, Dai G, Bonner-Weir S, Moore A.

Nat Med. 2006 Jan;12(1):144-8. Epub 2005 Dec 25.PMID: 16380717 [PubMed - indexed for MEDLINE]Related articles

Severe hypoglycaemia post-gastric bypass requiring partial pancreatectomy: evidence for inappropriate insulin secretion and pancreatic islet hyperplasia.

Patti ME, McMahon G, Mun EC, Bitton A, Holst JJ, Goldsmith J, Hanto DW, Callery M, Arky R, Nose V, Bonner-Weir S, Goldfine AB.

Diabetologia. 2005 Nov;48(11):2236-40. Epub 2005 Sep 30.PMID: 16195867 [PubMed - indexed for MEDLINE]Related articles

BETA2/NeuroD protein can be transduced into cells due to an arginine- and lysine-rich sequence.

Noguchi H, Bonner-Weir S, Wei FY, Matsushita M, Matsumoto S.

Diabetes. 2005 Oct;54(10):2859-66.PMID: 16186386 [PubMed - indexed for MEDLINE]Related articlesFree article

Islet transplantation outcomes in mice are better with fresh islets and exendin-4 treatment.

King A, Lock J, Xu G, Bonner-Weir S, Weir GC.

Diabetologia. 2005 Oct;48(10):2074-9. Epub 2005 Aug 23.PMID: 16132945 [PubMed - indexed for MEDLINE]Related articles

Establishment of a diabetic mouse model with progressive diabetic nephropathy.

Inada A, Nagai K, Arai H, Miyazaki J, Nomura K, Kanamori H, Toyokuni S, Yamada Y, Bonner-Weir S, Weir GC, Fukatsu A, Seino Y.

Am J Pathol. 2005 Aug;167(2):327-36.PMID: 16049320 [PubMed - indexed for MEDLINE]Related articlesFree article

New sources of pancreatic beta-cells.

Bonner-Weir S, Weir GC.

Nat Biotechnol. 2005 Jul;23(7):857-61. Review.PMID: 16003374 [PubMed - indexed for MEDLINE]Related articles

Imaging beta-cell death with a near-infrared probe.

Medarova Z, Bonner-Weir S, Lipes M, Moore A.

Diabetes. 2005 Jun;54(6):1780-8.PMID: 15919800 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanism of PDX-1 protein transduction.

Noguchi H, Matsushita M, Matsumoto S, Lu YF, Matsui H, Bonner-Weir S.

Biochem Biophys Res Commun. 2005 Jun 24;332(1):68-74.PMID: 15896300 [PubMed - indexed for MEDLINE]Related articles

Induced ICER Igamma down-regulates cyclin A expression and cell proliferation in insulin-producing beta cells.

Inada A, Weir GC, Bonner-Weir S.

Biochem Biophys Res Commun. 2005 Apr 15;329(3):925-9.PMID: 15752744 [PubMed - indexed for MEDLINE]Related articles