PubMed

Physical inactivity, abdominal obesity and risk of coronary heart disease in apparently healthy men and women.

Arsenault BJ, Rana JS, Lemieux I, Després JP, Kastelein JJ, Boekholdt SM, Wareham NJ, Khaw KT.

Int J Obes (Lond). 2009 Nov 17. [Epub ahead of print]PMID: 19918249 [PubMed - as supplied by publisher]Related articles

Physical activity, the Framingham risk score and risk of coronary heart disease in men and women of the EPIC-Norfolk study.

Arsenault BJ, Rana JS, Lemieux I, Després JP, Wareham NJ, Kastelein JJ, Boekholdt SM, Khaw KT.

Atherosclerosis. 2009 Aug 31. [Epub ahead of print]PMID: 19772963 [PubMed - as supplied by publisher]Related articles

Both paraoxonase-1 genotype and activity do not predict the risk of future coronary artery disease; the EPIC-Norfolk Prospective Population Study.

Birjmohun RS, Vergeer M, Stroes ES, Sandhu MS, Ricketts SL, Tanck MW, Wareham NJ, Jukema JW, Kastelein JJ, Khaw KT, Boekholdt SM.

PLoS One. 2009 Aug 27;4(8):e6809.PMID: 19710913 [PubMed - in process]Related articlesFree article

Plasma levels of lecithin:cholesterol acyltransferase and risk of future coronary artery disease in apparently healthy men and women - a prospective case-control analysis nested in the EPIC-Norfolk population study.

Holleboom AG, Kuivenhoven JA, Vergeer M, Hovingh GK, van Miert JN, Wareham NJ, Kastelein JJ, Khaw KT, Boekholdt SM.

J Lipid Res. 2009 Aug 11. [Epub ahead of print]PMID: 19671930 [PubMed - as supplied by publisher]Related articlesFree article

Inflammatory biomarkers and the prediction of coronary events among people at intermediate risk: the EPIC-Norfolk prospective population study.

Rana JS, Cote M, Després JP, Sandhu MS, Talmud PJ, Ninio E, Wareham NJ, Kastelein JJ, Zwinderman AH, Khaw KT, Boekholdt SM.

Heart. 2009 Oct;95(20):1682-7. Epub 2009 Jul 8.PMID: 19587389 [PubMed - indexed for MEDLINE]Related articles

Metabolic dyslipidemia and risk of future coronary heart disease in apparently healthy men and women: The EPIC-Norfolk prospective population study.

Rana JS, Visser ME, Arsenault BJ, Després JP, Stroes ES, Kastelein JJ, Wareham NJ, Boekholdt SM, Khaw KT.

Int J Cardiol. 2009 Apr 24. [Epub ahead of print]PMID: 19394708 [PubMed - as supplied by publisher]Related articles

Osteoprotegerin and soluble receptor activator of nuclear factor-kappaB ligand and risk for coronary events: a nested case-control approach in the prospective EPIC-Norfolk population study 1993-2003.

Semb AG, Ueland T, Aukrust P, Wareham NJ, Luben R, Gullestad L, Kastelein JJ, Khaw KT, Boekholdt SM.

Arterioscler Thromb Vasc Biol. 2009 Jun;29(6):975-80. Epub 2009 Mar 26.PMID: 19325145 [PubMed - indexed for MEDLINE]Related articles

HDL particle size and the risk of coronary heart disease in apparently healthy men and women: the EPIC-Norfolk prospective population study.

Arsenault BJ, Lemieux I, Després JP, Gagnon P, Wareham NJ, Stroes ES, Kastelein JJ, Khaw KT, Boekholdt SM.

Atherosclerosis. 2009 Sep;206(1):276-81. Epub 2009 Feb 12.PMID: 19268944 [PubMed - in process]Related articles

Inflammatory biomarkers, physical activity, waist circumference, and risk of future coronary heart disease in healthy men and women.

Rana JS, Arsenault BJ, Després JP, Côté M, Talmud PJ, Ninio E, Jukema JW, Wareham NJ, Kastelein JJ, Khaw KT, Boekholdt SM.

Eur Heart J. 2009 Feb 18. [Epub ahead of print]PMID: 19224930 [PubMed - as supplied by publisher]Related articles

High-density lipoprotein particle size and concentration and coronary risk.

El Harchaoui K, Arsenault BJ, Franssen R, Després JP, Hovingh GK, Stroes ES, Otvos JD, Wareham NJ, Kastelein JJ, Khaw KT, Boekholdt SM.

Ann Intern Med. 2009 Jan 20;150(2):84-93.PMID: 19153411 [PubMed - indexed for MEDLINE]Related articlesFree article

ANGPTL4 E40K and T266M: effects on plasma triglyceride and HDL levels, postprandial responses, and CHD risk.

Talmud PJ, Smart M, Presswood E, Cooper JA, Nicaud V, Drenos F, Palmen J, Marmot MG, Boekholdt SM, Wareham NJ, Khaw KT, Kumari M, Humphries SE; EARSII Consortium; HIFMECH Consortium.

Arterioscler Thromb Vasc Biol. 2008 Dec;28(12):2319-25. Epub 2008 Oct 30.PMID: 18974381 [PubMed - indexed for MEDLINE]Related articles

Retinol-binding protein 4 and prediction of incident coronary events in healthy men and women.

Mallat Z, Simon T, Benessiano J, Clément K, Taleb S, Wareham NJ, Luben R, Khaw KT, Tedgui A, Boekholdt SM.

J Clin Endocrinol Metab. 2009 Jan;94(1):255-60. Epub 2008 Oct 14.PMID: 18854400 [PubMed - indexed for MEDLINE]Related articles

Inhibition of lipoprotein-associated phospholipase activity by darapladib: shifting gears in cardiovascular drug development: are antiinflammatory drugs the next frontier?

Boekholdt SM, de Winter RJ, Kastelein JJ.

Circulation. 2008 Sep 9;118(11):1120-2. No abstract available. PMID: 18779454 [PubMed - indexed for MEDLINE]Related articlesFree article

Major depression, C-reactive protein, and incident ischemic heart disease in healthy men and women.

Surtees PG, Wainwright NW, Boekholdt SM, Luben RN, Wareham NJ, Khaw KT.

Psychosom Med. 2008 Oct;70(8):850-5. Epub 2008 Aug 25.PMID: 18725428 [PubMed - indexed for MEDLINE]Related articles

Evaluation of the Framingham risk score in the European Prospective Investigation of Cancer-Norfolk cohort: does adding glycated hemoglobin improve the prediction of coronary heart disease events?

Simmons RK, Sharp S, Boekholdt SM, Sargeant LA, Khaw KT, Wareham NJ, Griffin SJ.

Arch Intern Med. 2008 Jun 9;168(11):1209-16.PMID: 18541829 [PubMed - indexed for MEDLINE]Related articlesFree article

Lipids, apolipoproteins, and their ratios in relation to cardiovascular events with statin treatment.

Kastelein JJ, van der Steeg WA, Holme I, Gaffney M, Cater NB, Barter P, Deedwania P, Olsson AG, Boekholdt SM, Demicco DA, Szarek M, LaRosa JC, Pedersen TR, Grundy SM; TNT Study Group; IDEAL Study Group.

Circulation. 2008 Jun 10;117(23):3002-9. Epub 2008 Jun 2.PMID: 18519851 [PubMed - indexed for MEDLINE]Related articlesFree article

High-density lipoprotein cholesterol, high-density lipoprotein particle size, and apolipoprotein A-I: significance for cardiovascular risk: the IDEAL and EPIC-Norfolk studies.

van der Steeg WA, Holme I, Boekholdt SM, Larsen ML, Lindahl C, Stroes ES, Tikkanen MJ, Wareham NJ, Faergeman O, Olsson AG, Pedersen TR, Khaw KT, Kastelein JJ.

J Am Coll Cardiol. 2008 Feb 12;51(6):634-42.PMID: 18261682 [PubMed - indexed for MEDLINE]Related articles

[The endocannabinoid system, overweight, and the CB1-endocannabinoid-receptor antagonist rimonabant]

Boekholdt SM, Jukema JW, Peters RJ.

Ned Tijdschr Geneeskd. 2007 Nov 24;151(47):2615-9. Review. Dutch. PMID: 18161262 [PubMed - indexed for MEDLINE]Related articles

Body fat distribution and risk of coronary heart disease in men and women in the European Prospective Investigation Into Cancer and Nutrition in Norfolk cohort: a population-based prospective study.

Canoy D, Boekholdt SM, Wareham N, Luben R, Welch A, Bingham S, Buchan I, Day N, Khaw KT.

Circulation. 2007 Dec 18;116(25):2933-43. Epub 2007 Dec 10.PMID: 18071080 [PubMed - indexed for MEDLINE]Related articlesFree article

Cholesterol levels in small LDL particles predict the risk of coronary heart disease in the EPIC-Norfolk prospective population study.

Arsenault BJ, Lemieux I, Després JP, Wareham NJ, Luben R, Kastelein JJ, Khaw KT, Boekholdt SM.

Eur Heart J. 2007 Nov;28(22):2770-7. Epub 2007 Oct 17.PMID: 17947216 [PubMed - indexed for MEDLINE]Related articlesFree article

Apolipoprotein A-II is inversely associated with risk of future coronary artery disease.

Birjmohun RS, Dallinga-Thie GM, Kuivenhoven JA, Stroes ES, Otvos JD, Wareham NJ, Luben R, Kastelein JJ, Khaw KT, Boekholdt SM.

Circulation. 2007 Oct 30;116(18):2029-35. Epub 2007 Oct 8.PMID: 17923573 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential leucocyte count and the risk of future coronary artery disease in healthy men and women: the EPIC-Norfolk Prospective Population Study.

Rana JS, Boekholdt SM, Ridker PM, Jukema JW, Luben R, Bingham SA, Day NE, Wareham NJ, Kastelein JJ, Khaw KT.

J Intern Med. 2007 Dec;262(6):678-89. Epub 2007 Oct 1.PMID: 17908163 [PubMed - indexed for MEDLINE]Related articles

Arterial thrombosis and the role of thrombophilia.

Boekholdt SM, Kramer MH.

Semin Thromb Hemost. 2007 Sep;33(6):588-96. Review.PMID: 17768691 [PubMed - indexed for MEDLINE]Related articles

Serum myeloperoxidase levels are associated with the future risk of coronary artery disease in apparently healthy individuals: the EPIC-Norfolk Prospective Population Study.

Meuwese MC, Stroes ES, Hazen SL, van Miert JN, Kuivenhoven JA, Schaub RG, Wareham NJ, Luben R, Kastelein JJ, Khaw KT, Boekholdt SM.

J Am Coll Cardiol. 2007 Jul 10;50(2):159-65. Epub 2007 Jun 21.PMID: 17616301 [PubMed - indexed for MEDLINE]Related articles

Role of the apolipoprotein B-apolipoprotein A-I ratio in cardiovascular risk assessment: a case-control analysis in EPIC-Norfolk.

van der Steeg WA, Boekholdt SM, Stein EA, El-Harchaoui K, Stroes ES, Sandhu MS, Wareham NJ, Jukema JW, Luben R, Zwinderman AH, Kastelein JJ, Khaw KT.

Ann Intern Med. 2007 May 1;146(9):640-8.PMID: 17470832 [PubMed - indexed for MEDLINE]Related articlesFree article

Circulating secretory phospholipase A2 activity and risk of incident coronary events in healthy men and women: the EPIC-Norfolk study.

Mallat Z, Benessiano J, Simon T, Ederhy S, Sebella-Arguelles C, Cohen A, Huart V, Wareham NJ, Luben R, Khaw KT, Tedgui A, Boekholdt SM.

Arterioscler Thromb Vasc Biol. 2007 May;27(5):1177-83. Epub 2007 Feb 15.PMID: 17303774 [PubMed - indexed for MEDLINE]Related articlesFree article

Value of low-density lipoprotein particle number and size as predictors of coronary artery disease in apparently healthy men and women: the EPIC-Norfolk Prospective Population Study.

El Harchaoui K, van der Steeg WA, Stroes ES, Kuivenhoven JA, Otvos JD, Wareham NJ, Hutten BA, Kastelein JJ, Khaw KT, Boekholdt SM.

J Am Coll Cardiol. 2007 Feb 6;49(5):547-53. Epub 2007 Jan 22.PMID: 17276177 [PubMed - indexed for MEDLINE]Related articles

Triglycerides and the risk of coronary heart disease: 10,158 incident cases among 262,525 participants in 29 Western prospective studies.

Sarwar N, Danesh J, Eiriksdottir G, Sigurdsson G, Wareham N, Bingham S, Boekholdt SM, Khaw KT, Gudnason V.

Circulation. 2007 Jan 30;115(4):450-8. Epub 2006 Dec 26.PMID: 17190864 [PubMed - indexed for MEDLINE]Related articlesFree article

Physical activity, C-reactive protein levels and the risk of future coronary artery disease in apparently healthy men and women: the EPIC-Norfolk prospective population study.

Boekholdt SM, Sandhu MS, Day NE, Luben R, Bingham SA, Peters RJ, Wareham NJ, Khaw KT.

Eur J Cardiovasc Prev Rehabil. 2006 Dec;13(6):970-6.PMID: 17143130 [PubMed - indexed for MEDLINE]Related articles

Plasma levels of plant sterols and the risk of coronary artery disease: the prospective EPIC-Norfolk Population Study.

Pinedo S, Vissers MN, von Bergmann K, Elharchaoui K, Lütjohann D, Luben R, Wareham NJ, Kastelein JJ, Khaw KT, Boekholdt SM.

J Lipid Res. 2007 Jan;48(1):139-44. Epub 2006 Oct 30.PMID: 17074925 [PubMed - indexed for MEDLINE]Related articlesFree article

Tissue factor serum levels and the risk of future coronary artery disease in apparently healthy men and women: the EPIC-Norfolk prospective population study.

Keller TT, Choi D, Nagel C, Te Velthuis H, Gerdes VE, Wareham NJ, Bingham SA, Luben R, Hack CE, Reitsma PH, Levi M, Khaw KT, Boekholdt SM.

J Thromb Haemost. 2006 Nov;4(11):2391-6. Epub 2006 Aug 28. Erratum in: J Thromb Haemost. 2006 Dec;4(12):2742. Choi, D [added]. PMID: 16938131 [PubMed - indexed for MEDLINE]Related articles

Plasma concentrations of ascorbic acid and C-reactive protein, and risk of future coronary artery disease, in apparently healthy men and women: the EPIC-Norfolk prospective population study.

Boekholdt SM, Meuwese MC, Day NE, Luben R, Welch A, Wareham NJ, Khaw KT.

Br J Nutr. 2006 Sep;96(3):516-22.PMID: 16925857 [PubMed - indexed for MEDLINE]Related articles

Serum levels of mannose-binding lectin and the risk of future coronary artery disease in apparently healthy men and women.

Keller TT, van Leuven SI, Meuwese MC, Wareham NJ, Luben R, Stroes ES, Hack CE, Levi M, Khaw KT, Boekholdt SM.

Arterioscler Thromb Vasc Biol. 2006 Oct;26(10):2345-50. Epub 2006 Aug 10.PMID: 16902159 [PubMed - indexed for MEDLINE]Related articlesFree article

Fibrinogen plasma levels modify the association between the factor XIII Val34Leu variant and risk of coronary artery disease: the EPIC-Norfolk prospective population study.

Boekholdt SM, Sandhu MS, Wareham NJ, Luben R, Reitsma PH, Khaw KT.

J Thromb Haemost. 2006 Oct;4(10):2204-9. Epub 2006 Aug 1.PMID: 16881935 [PubMed - indexed for MEDLINE]Related articles

Apolipoprotein A-V, triglycerides and risk of coronary artery disease: the prospective Epic-Norfolk Population Study.

Vaessen SF, Schaap FG, Kuivenhoven JA, Groen AK, Hutten BA, Boekholdt SM, Hattori H, Sandhu MS, Bingham SA, Luben R, Palmen JA, Wareham NJ, Humphries SE, Kastelein JJ, Talmud PJ, Khaw KT.

J Lipid Res. 2006 Sep;47(9):2064-70. Epub 2006 Jun 12.PMID: 16769999 [PubMed - indexed for MEDLINE]Related articlesFree article

Common variants of multiple genes that control reverse cholesterol transport together explain only a minor part of the variation of HDL cholesterol levels.

Boekholdt SM, Souverein OW, Tanck MW, Hovingh GK, Kuivenhoven JA, Peters RI, Jansen H, Schiffers PM, van der Wall EE, Doevendans PA, Reitsma PH, Zwinderman AH, Kastelein JJ, Jukema JW.

Clin Genet. 2006 Mar;69(3):263-70.PMID: 16542392 [PubMed - indexed for MEDLINE]Related articles

Cholesteryl ester transfer protein (CETP) inhibition beyond raising high-density lipoprotein cholesterol levels: pathways by which modulation of CETP activity may alter atherogenesis.

Klerkx AH, El Harchaoui K, van der Steeg WA, Boekholdt SM, Stroes ES, Kastelein JJ, Kuivenhoven JA.

Arterioscler Thromb Vasc Biol. 2006 Apr;26(4):706-15. Epub 2006 Jan 26. Review.PMID: 16439711 [PubMed - indexed for MEDLINE]Related articlesFree article

Serum lipoprotein lipase concentration and risk for future coronary artery disease: the EPIC-Norfolk prospective population study.

Rip J, Nierman MC, Wareham NJ, Luben R, Bingham SA, Day NE, van Miert JN, Hutten BA, Kastelein JJ, Kuivenhoven JA, Khaw KT, Boekholdt SM.

Arterioscler Thromb Vasc Biol. 2006 Mar;26(3):637-42. Epub 2005 Dec 22.PMID: 16373616 [PubMed - indexed for MEDLINE]Related articlesFree article

C-reactive protein levels and coronary artery disease incidence and mortality in apparently healthy men and women: the EPIC-Norfolk prospective population study 1993-2003.

Boekholdt SM, Hack CE, Sandhu MS, Luben R, Bingham SA, Wareham NJ, Peters RJ, Jukema JW, Day NE, Kastelein JJ, Khaw KT.

Atherosclerosis. 2006 Aug;187(2):415-22. Epub 2005 Oct 28.PMID: 16257408 [PubMed - indexed for MEDLINE]Related articles

Genetic determinants of plasma HDL-cholesterol levels in familial hypercholesterolemia.

van Aalst-Cohen ES, Jansen AC, Boekholdt SM, Tanck MW, Fontecha MR, Cheng S, Li J, Defesche JC, Kuivenhoven JA, Kastelein JJ.

Eur J Hum Genet. 2005 Oct;13(10):1137-42.PMID: 16030523 [PubMed - indexed for MEDLINE]Related articlesFree article

Inherited disorders of HDL metabolism and atherosclerosis.

Hovingh GK, de Groot E, van der Steeg W, Boekholdt SM, Hutten BA, Kuivenhoven JA, Kastelein JJ.

Curr Opin Lipidol. 2005 Apr;16(2):139-45. Review.PMID: 15767853 [PubMed - indexed for MEDLINE]Related articles

Serum levels of type II secretory phospholipase A2 and the risk of future coronary artery disease in apparently healthy men and women: the EPIC-Norfolk Prospective Population Study.

Boekholdt SM, Keller TT, Wareham NJ, Luben R, Bingham SA, Day NE, Sandhu MS, Jukema JW, Kastelein JJ, Hack CE, Khaw KT.

Arterioscler Thromb Vasc Biol. 2005 Apr;25(4):839-46. Epub 2005 Feb 3.PMID: 15692105 [PubMed - indexed for MEDLINE]Related articlesFree article

Polymorphisms in APOA1 and LPL genes are statistically independently associated with fasting TG in men with CAD.

Souverein OW, Jukema JW, Boekholdt SM, Zwinderman AH, Tanck MW.

Eur J Hum Genet. 2005 Apr;13(4):445-51.PMID: 15657615 [PubMed - indexed for MEDLINE]Related articlesFree article

Cholesteryl ester transfer protein TaqIB variant, high-density lipoprotein cholesterol levels, cardiovascular risk, and efficacy of pravastatin treatment: individual patient meta-analysis of 13,677 subjects.

Boekholdt SM, Sacks FM, Jukema JW, Shepherd J, Freeman DJ, McMahon AD, Cambien F, Nicaud V, de Grooth GJ, Talmud PJ, Humphries SE, Miller GJ, Eiriksdottir G, Gudnason V, Kauma H, Kakko S, Savolainen MJ, Arca M, Montali A, Liu S, Lanz HJ, Zwinderman AH, Kuivenhoven JA, Kastelein JJ.

Circulation. 2005 Jan 25;111(3):278-87. Epub 2005 Jan 17.PMID: 15655129 [PubMed - indexed for MEDLINE]Related articlesFree article

Relationship between in vitro lipopolysaccharide-induced cytokine response in whole blood, angiographic in-stent restenosis, and toll-like receptor 4 gene polymorphisms.

Rittersma SZ, Kremer Hovinga JA, Koch KT, Boekholdt SM, van Aken BE, Scheepmaker A, Bax M, Schotborgh CE, Piek JJ, Tijssen JG, Reitsma PH, de Winter RJ.

Clin Chem. 2005 Mar;51(3):516-21. Epub 2005 Jan 13.PMID: 15650037 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of CETP inhibitors in the treatment of dyslipidemia.

van der Steeg WA, Kuivenhoven JA, Klerkx AH, Boekholdt SM, Hovingh GK, Kastelein JJ.

Curr Opin Lipidol. 2004 Dec;15(6):631-6. Review.PMID: 15529021 [PubMed - indexed for MEDLINE]Related articles

Macrophage migration inhibitory factor and the risk of myocardial infarction or death due to coronary artery disease in adults without prior myocardial infarction or stroke: the EPIC-Norfolk Prospective Population study.

Boekholdt SM, Peters RJ, Day NE, Luben R, Bingham SA, Wareham NJ, Hack CE, Reitsma PH, Khaw KT.

Am J Med. 2004 Sep 15;117(6):390-7.PMID: 15380495 [PubMed - indexed for MEDLINE]Related articles

Plasma levels of cholesteryl ester transfer protein and the risk of future coronary artery disease in apparently healthy men and women: the prospective EPIC (European Prospective Investigation into Cancer and nutrition)-Norfolk population study.

Boekholdt SM, Kuivenhoven JA, Wareham NJ, Peters RJ, Jukema JW, Luben R, Bingham SA, Day NE, Kastelein JJ, Khaw KT.

Circulation. 2004 Sep 14;110(11):1418-23. Epub 2004 Aug 30.PMID: 15337694 [PubMed - indexed for MEDLINE]Related articlesFree article

CETP gene variation: relation to lipid parameters and cardiovascular risk.

Boekholdt SM, Kuivenhoven JA, Hovingh GK, Jukema JW, Kastelein JJ, van Tol A.

Curr Opin Lipidol. 2004 Aug;15(4):393-8. Review.PMID: 15243211 [PubMed - indexed for MEDLINE]Related articles

IL-8 plasma concentrations and the risk of future coronary artery disease in apparently healthy men and women: the EPIC-Norfolk prospective population study.

Boekholdt SM, Peters RJ, Hack CE, Day NE, Luben R, Bingham SA, Wareham NJ, Reitsma PH, Khaw KT.

Arterioscler Thromb Vasc Biol. 2004 Aug;24(8):1503-8. Epub 2004 Jun 3.PMID: 15178568 [PubMed - indexed for MEDLINE]Related articlesFree article