PubMed

Autoimmunity.

Bluestone JA, Kuchroo V.

Curr Opin Immunol. 2009 Dec;21(6):579-81. Epub 2009 Oct 30. No abstract available. PMID: 19879742 [PubMed - in process]Related articles

Is antigen specificity of autoreactive T cells the key to islet entry?

Penaranda C, Bluestone JA.

Immunity. 2009 Oct 16;31(4):534-6.PMID: 19833083 [PubMed - indexed for MEDLINE]Related articles

The functional plasticity of T cell subsets.

Bluestone JA, Mackay CR, O'Shea JJ, Stockinger B.

Nat Rev Immunol. 2009 Nov;9(11):811-6. Epub 2009 Oct 7.PMID: 19809471 [PubMed - indexed for MEDLINE]Related articles

Regulatory T cells as therapeutic targets in rheumatoid arthritis.

Esensten JH, Wofsy D, Bluestone JA.

Nat Rev Rheumatol. 2009 Oct;5(10):560-5.PMID: 19798031 [PubMed - in process]Related articles

Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR-induced stop signal.

Fife BT, Pauken KE, Eagar TN, Obu T, Wu J, Tang Q, Azuma M, Krummel MF, Bluestone JA.

Nat Immunol. 2009 Nov;10(11):1185-92. Epub 2009 Sep 27.PMID: 19783989 [PubMed - indexed for MEDLINE]Related articles

How suppressor cells led to anergy, costimulation, and beyond.

Bour-Jordan H, Bluestone JA.

J Immunol. 2009 Oct 1;183(7):4147-9. No abstract available. PMID: 19767564 [PubMed - indexed for MEDLINE]Related articles

Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo.

Zhou X, Bailey-Bucktrout SL, Jeker LT, Penaranda C, Martínez-Llordella M, Ashby M, Nakayama M, Rosenthal W, Bluestone JA.

Nat Immunol. 2009 Sep;10(9):1000-7. Epub 2009 Jul 26.PMID: 19633673 [PubMed - indexed for MEDLINE]Related articles

Insulin receptor substrate-2 in beta-cells decreases diabetes in nonobese diabetic mice.

Norquay LD, D'Aquino KE, Opare-Addo LM, Kuznetsova A, Haas M, Bluestone JA, White MF.

Endocrinology. 2009 Oct;150(10):4531-40. Epub 2009 Jul 2.PMID: 19574401 [PubMed - indexed for MEDLINE]Related articles

Lethal effect of CD3-specific antibody in mice deficient in TGF-beta1 by uncontrolled flu-like syndrome.

Perruche S, Zhang P, Maruyama T, Bluestone JA, Saas P, Chen W.

J Immunol. 2009 Jul 15;183(2):953-61. Epub 2009 Jun 26.PMID: 19561097 [PubMed - indexed for MEDLINE]Related articles

T-bet-deficient NOD mice are protected from diabetes due to defects in both T cell and innate immune system function.

Esensten JH, Lee MR, Glimcher LH, Bluestone JA.

J Immunol. 2009 Jul 1;183(1):75-82. Epub 2009 Jun 17.PMID: 19535634 [PubMed - indexed for MEDLINE]Related articles

Anti-CTLA-4 treatment induces IL-10-producing ICOS+ regulatory T cells displaying IDO-dependent anti-inflammatory properties in a mouse model of colitis.

Coquerelle C, Oldenhove G, Acolty V, Denoeud J, Vansanten G, Verdebout JM, Mellor A, Bluestone JA, Moser M.

Gut. 2009 Oct;58(10):1363-73. Epub 2009 Jun 7.PMID: 19505881 [PubMed - indexed for MEDLINE]Related articles

Plasticity of CD4(+) FoxP3(+) T cells.

Zhou X, Bailey-Bucktrout S, Jeker LT, Bluestone JA.

Curr Opin Immunol. 2009 Jun;21(3):281-5. Epub 2009 Jun 6. Review.PMID: 19500966 [PubMed - indexed for MEDLINE]Related articles

Treatment of patients with new onset Type 1 diabetes with a single course of anti-CD3 mAb Teplizumab preserves insulin production for up to 5 years.

Herold KC, Gitelman S, Greenbaum C, Puck J, Hagopian W, Gottlieb P, Sayre P, Bianchine P, Wong E, Seyfert-Margolis V, Bourcier K, Bluestone JA; Immune Tolerance Network ITN007AI Study Group.

Clin Immunol. 2009 Aug;132(2):166-73. Epub 2009 May 14.PMID: 19443276 [PubMed - indexed for MEDLINE]Related articles

Regulating the regulators: costimulatory signals control the homeostasis and function of regulatory T cells.

Bour-Jordan H, Bluestone JA.

Immunol Rev. 2009 May;229(1):41-66. Review.PMID: 19426214 [PubMed - indexed for MEDLINE]Related articles

A novel myelin P0-specific T cell receptor transgenic mouse develops a fulminant autoimmune peripheral neuropathy.

Louvet C, Kabre BG, Davini DW, Martinier N, Su MA, DeVoss JJ, Rosenthal WL, Anderson MS, Bour-Jordan H, Bluestone JA.

J Exp Med. 2009 Mar 16;206(3):507-14. Epub 2009 Feb 16.PMID: 19221395 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of X-linked FOXP3 in the autoimmune susceptibility of Turner Syndrome patients.

Su MA, Stenerson M, Liu W, Putnam A, Conte F, Bluestone JA, Anderson MS.

Clin Immunol. 2009 Apr;131(1):139-44. Epub 2009 Jan 15.PMID: 19150256 [PubMed - indexed for MEDLINE]Related articles

Expansion of human regulatory T-cells from patients with type 1 diabetes.

Putnam AL, Brusko TM, Lee MR, Liu W, Szot GL, Ghosh T, Atkinson MA, Bluestone JA.

Diabetes. 2009 Mar;58(3):652-62. Epub 2008 Dec 15.PMID: 19074986 [PubMed - indexed for MEDLINE]Related articlesFree article

Tyrosine kinase inhibitors reverse type 1 diabetes in nonobese diabetic mice.

Louvet C, Szot GL, Lang J, Lee MR, Martinier N, Bollag G, Zhu S, Weiss A, Bluestone JA.

Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18895-900. Epub 2008 Nov 17.PMID: 19015530 [PubMed - indexed for MEDLINE]Related articlesFree article

Transplantation of pancreatic islets into the kidney capsule of diabetic mice.

Szot GL, Koudria P, Bluestone JA.

J Vis Exp. 2007;(9):404. Epub 2007 Oct 31.PMID: 18989445 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulatory T cells: therapeutic potential for treating transplant rejection and type I diabetes.

Bluestone JA.

J Vis Exp. 2007;(7):257. Epub 2007 Aug 20. No abstract available. PMID: 18989429 [PubMed - indexed for MEDLINE]Related articlesFree article

Murine pancreatic islet isolation.

Szot GL, Koudria P, Bluestone JA.

J Vis Exp. 2007;(7):255. Epub 2007 Aug 22. No abstract available. PMID: 18989427 [PubMed - indexed for MEDLINE]Related articlesFree article

The effect of costimulatory and interleukin 2 receptor blockade on regulatory T cells in renal transplantation.

Bluestone JA, Liu W, Yabu JM, Laszik ZG, Putnam A, Belingheri M, Gross DM, Townsend RM, Vincenti F.

Am J Transplant. 2008 Oct;8(10):2086-96.PMID: 18828769 [PubMed - indexed for MEDLINE]Related articles

Innate immunity and intestinal microbiota in the development of Type 1 diabetes.

Wen L, Ley RE, Volchkov PY, Stranges PB, Avanesyan L, Stonebraker AC, Hu C, Wong FS, Szot GL, Bluestone JA, Gordon JI, Chervonsky AV.

Nature. 2008 Oct 23;455(7216):1109-13. Epub 2008 Sep 21.PMID: 18806780 [PubMed - indexed for MEDLINE]Related articlesFree article

Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways.

Fife BT, Bluestone JA.

Immunol Rev. 2008 Aug;224:166-82. Review.PMID: 18759926 [PubMed - indexed for MEDLINE]Related articles

Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity.

Zhou X, Jeker LT, Fife BT, Zhu S, Anderson MS, McManus MT, Bluestone JA.

J Exp Med. 2008 Sep 1;205(9):1983-91. Epub 2008 Aug 25.PMID: 18725525 [PubMed - indexed for MEDLINE]Related articlesFree article

T regulatory cells in autoimmune diabetes: past challenges, future prospects.

Bluestone JA, Tang Q, Sedwick CE.

J Clin Immunol. 2008 Nov;28(6):677-84. Epub 2008 Aug 21. Review.PMID: 18716861 [PubMed - indexed for MEDLINE]Related articles

Human regulatory T cells: role in autoimmune disease and therapeutic opportunities.

Brusko TM, Putnam AL, Bluestone JA.

Immunol Rev. 2008 Jun;223:371-90. Review. Erratum in: Immunol Rev. 2009 May;229(1):388. PMID: 18613848 [PubMed - indexed for MEDLINE]Related articles

Spontaneous development of a pancreatic exocrine disease in CD28-deficient NOD mice.

Meagher C, Tang Q, Fife BT, Bour-Jordan H, Wu J, Pardoux C, Bi M, Melli K, Bluestone JA.

J Immunol. 2008 Jun 15;180(12):7793-803.PMID: 18523243 [PubMed - indexed for MEDLINE]Related articlesFree article

Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction.

Tang Q, Adams JY, Penaranda C, Melli K, Piaggio E, Sgouroudis E, Piccirillo CA, Salomon BL, Bluestone JA.

Immunity. 2008 May;28(5):687-97. Epub 2008 May 8.PMID: 18468463 [PubMed - indexed for MEDLINE]Related articlesFree article

CD3-specific antibody-induced immune tolerance involves transforming growth factor-beta from phagocytes digesting apoptotic T cells.

Perruche S, Zhang P, Liu Y, Saas P, Bluestone JA, Chen W.

Nat Med. 2008 May;14(5):528-35. Epub 2008 Apr 27.PMID: 18438416 [PubMed - indexed for MEDLINE]Related articles

The Foxp3+ regulatory T cell: a jack of all trades, master of regulation.

Tang Q, Bluestone JA.

Nat Immunol. 2008 Mar;9(3):239-44. Review.PMID: 18285775 [PubMed - indexed for MEDLINE]Related articles

Safer, longer-lasting regulatory T cells with beta-catenin.

Bluestone JA, Hebrok M.

Nat Med. 2008 Feb;14(2):118-9. No abstract available. PMID: 18256611 [PubMed - indexed for MEDLINE]Related articles

Regulated beta-cell regeneration in the adult mouse pancreas.

Cano DA, Rulifson IC, Heiser PW, Swigart LB, Pelengaris S, German M, Evan GI, Bluestone JA, Hebrok M.

Diabetes. 2008 Apr;57(4):958-66. Epub 2007 Dec 14.PMID: 18083786 [PubMed - indexed for MEDLINE]Related articlesFree article

B cell depletion: a novel therapy for autoimmune diabetes?

Bour-Jordan H, Bluestone JA.

J Clin Invest. 2007 Dec;117(12):3642-5.PMID: 18060022 [PubMed - indexed for MEDLINE]Related articlesFree article

Loss of integrin alpha(v)beta8 on dendritic cells causes autoimmunity and colitis in mice.

Travis MA, Reizis B, Melton AC, Masteller E, Tang Q, Proctor JM, Wang Y, Bernstein X, Huang X, Reichardt LF, Bluestone JA, Sheppard D.

Nature. 2007 Sep 20;449(7160):361-5. Epub 2007 Aug 12.PMID: 17694047 [PubMed - indexed for MEDLINE]Related articlesFree article

Exendin-4 improves reversal of diabetes in NOD mice treated with anti-CD3 monoclonal antibody by enhancing recovery of beta-cells.

Sherry NA, Chen W, Kushner JA, Glandt M, Tang Q, Tsai S, Santamaria P, Bluestone JA, Brillantes AM, Herold KC.

Endocrinology. 2007 Nov;148(11):5136-44. Epub 2007 Aug 2.PMID: 17673522 [PubMed - indexed for MEDLINE]Related articlesFree article

What does the future hold for cell-based tolerogenic therapy?

Bluestone JA, Thomson AW, Shevach EM, Weiner HL.

Nat Rev Immunol. 2007 Aug;7(8):650-4.PMID: 17653127 [PubMed - indexed for MEDLINE]Related articles

CD3-specific antibodies: a portal to the treatment of autoimmunity.

Chatenoud L, Bluestone JA.

Nat Rev Immunol. 2007 Aug;7(8):622-32. Epub 2007 Jul 20. Review.PMID: 17641665 [PubMed - indexed for MEDLINE]Related articles

Mechanisms of PDL1-mediated regulation of autoimmune diabetes.

Guleria I, Gubbels Bupp M, Dada S, Fife B, Tang Q, Ansari MJ, Trikudanathan S, Vadivel N, Fiorina P, Yagita H, Azuma M, Atkinson M, Bluestone JA, Sayegh MH.

Clin Immunol. 2007 Oct;125(1):16-25. Epub 2007 Jul 12.PMID: 17627890 [PubMed - indexed for MEDLINE]Related articles

Constitutive expression of B7-1 on B cells uncovers autoimmunity toward the B cell compartment in the nonobese diabetic mouse.

Bour-Jordan H, Salomon BL, Thompson HL, Santos R, Abbas AK, Bluestone JA.

J Immunol. 2007 Jul 15;179(2):1004-12.PMID: 17617592 [PubMed - indexed for MEDLINE]Related articlesFree article

CD4+CD25+ regulatory T cells in transplantation: progress, challenges and prospects.

Kang SM, Tang Q, Bluestone JA.

Am J Transplant. 2007 Jun;7(6):1457-63. Review.PMID: 17511675 [PubMed - indexed for MEDLINE]Related articles

Differential roles of costimulatory signaling pathways in type 1 diabetes mellitus.

Boehm BO, Bluestone JA.

Rev Diabet Stud. 2004 Winter;1(4):156-64. Epub 2005 Feb 10. No abstract available. PMID: 17491700 [PubMed]Related articlesFree article

Expression of CTLA-4 and FOXP3 in cis protects from lethal lymphoproliferative disease.

Chikuma S, Bluestone JA.

Eur J Immunol. 2007 May;37(5):1285-9.PMID: 17429849 [PubMed - indexed for MEDLINE]Related articles

Adaptive TGF-beta-dependent regulatory T cells control autoimmune diabetes and are a privileged target of anti-CD3 antibody treatment.

You S, Leforban B, Garcia C, Bach JF, Bluestone JA, Chatenoud L.

Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6335-40. Epub 2007 Mar 26.PMID: 17389382 [PubMed - indexed for MEDLINE]Related articlesFree article

Sensory neurons link the nervous system and autoimmune diabetes.

Bour-Jordan H, Bluestone JA.

Cell. 2006 Dec 15;127(6):1097-9.PMID: 17174888 [PubMed - indexed for MEDLINE]Related articles

Insulin-induced remission in new-onset NOD mice is maintained by the PD-1-PD-L1 pathway.

Fife BT, Guleria I, Gubbels Bupp M, Eagar TN, Tang Q, Bour-Jordan H, Yagita H, Azuma M, Sayegh MH, Bluestone JA.

J Exp Med. 2006 Nov 27;203(12):2737-47. Epub 2006 Nov 20.PMID: 17116737 [PubMed - indexed for MEDLINE]Related articlesFree article

Analysis of T-cell assays to measure autoimmune responses in subjects with type 1 diabetes: results of a blinded controlled study.

Seyfert-Margolis V, Gisler TD, Asare AL, Wang RS, Dosch HM, Brooks-Worrell B, Eisenbarth GS, Palmer JP, Greenbaum CJ, Gitelman SE, Nepom GT, Bluestone JA, Herold KC.

Diabetes. 2006 Sep;55(9):2588-94.PMID: 16936208 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulatory T-cell physiology and application to treat autoimmunity.

Tang Q, Bluestone JA.

Immunol Rev. 2006 Aug;212:217-37. Review.PMID: 16903917 [PubMed - indexed for MEDLINE]Related articles

Inhibition of T cell activation and autoimmune diabetes using a B cell surface-linked CTLA-4 agonist.

Fife BT, Griffin MD, Abbas AK, Locksley RM, Bluestone JA.

J Clin Invest. 2006 Aug;116(8):2252-61.PMID: 16886063 [PubMed - indexed for MEDLINE]Related articlesFree article

Suppression of disease in New Zealand Black/New Zealand White lupus-prone mice by adoptive transfer of ex vivo expanded regulatory T cells.

Scalapino KJ, Tang Q, Bluestone JA, Bonyhadi ML, Daikh DI.

J Immunol. 2006 Aug 1;177(3):1451-9.PMID: 16849451 [PubMed - indexed for MEDLINE]Related articlesFree article