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Molecular and genetic substrates linking stress and addiction.

Briand LA, Blendy JA.

Brain Res. 2009 Nov 10. [Epub ahead of print]PMID: 19900417 [PubMed - as supplied by publisher]Related articles

Stress-induced potentiation of cocaine reward: a role for CRF R1 and CREB.

Kreibich AS, Briand L, Cleck JN, Ecke L, Rice KC, Blendy JA.

Neuropsychopharmacology. 2009 Nov;34(12):2609-17. Epub 2009 Aug 12.PMID: 19675537 [PubMed - in process]Related articles

Assessment of NMDA receptor NR1 subunit hypofunction in mice as a model for schizophrenia.

Halene TB, Ehrlichman RS, Liang Y, Christian EP, Jonak GJ, Gur TL, Blendy JA, Dow HC, Brodkin ES, Schneider F, Gur RC, Siegel SJ.

Genes Brain Behav. 2009 Oct;8(7):661-75. Epub 2009 May 8.PMID: 19563516 [PubMed - in process]Related articlesFree article

Mouse model of OPRM1 (A118G) polymorphism has sex-specific effects on drug-mediated behavior.

Mague SD, Isiegas C, Huang P, Liu-Chen LY, Lerman C, Blendy JA.

Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10847-52. Epub 2009 Jun 15.PMID: 19528658 [PubMed - indexed for MEDLINE]Related articles

Sex differences in response to nicotine in C57Bl/6:129SvEv mice.

Isiegas C, Mague SD, Blendy JA.

Nicotine Tob Res. 2009 Jul;11(7):851-8. Epub 2009 May 29.PMID: 19483179 [PubMed - indexed for MEDLINE]Related articles

Effects of the histone deacetylase inhibitor sodium butyrate in models of depression and anxiety.

Gundersen BB, Blendy JA.

Neuropharmacology. 2009 Jul;57(1):67-74. Epub 2009 Apr 23.PMID: 19393671 [PubMed - indexed for MEDLINE]Related articles

Dysregulated editing of serotonin 2C receptor mRNAs results in energy dissipation and loss of fat mass.

Kawahara Y, Grimberg A, Teegarden S, Mombereau C, Liu S, Bale TL, Blendy JA, Nishikura K.

J Neurosci. 2008 Nov 26;28(48):12834-44.PMID: 19036977 [PubMed - indexed for MEDLINE]Related articlesFree article

Translating basic science to improve pharmacotherapy for nicotine dependence.

Phillips JM, Siegel SJ, Shields AE, Patterson F, Gould TJ, Strasser AA, Ray R, Pinto A, Audrain-McGovern J, Rukstalis M, Perkins KA, Blendy JA, Lerman C.

Nicotine Tob Res. 2007 Nov;9 Suppl 4:S583-98. Review.PMID: 18067034 [PubMed - indexed for MEDLINE]Related articles

Endocrine and gene expression changes following forced swim stress exposure during cocaine abstinence in mice.

Cleck JN, Ecke LE, Blendy JA.

Psychopharmacology (Berl). 2008 Nov;201(1):15-28. Epub 2008 Aug 3.PMID: 18677617 [PubMed - indexed for MEDLINE]Related articles

The role of transcription factors cyclic-AMP responsive element modulator (CREM) and inducible cyclic-AMP early repressor (ICER) in epileptogenesis.

Porter BE, Lund IV, Varodayan FP, Wallace RW, Blendy JA.

Neuroscience. 2008 Mar 27;152(3):829-36. Epub 2008 Jan 17.PMID: 18295410 [PubMed - indexed for MEDLINE]Related articlesFree article

Making a bad thing worse: adverse effects of stress on drug addiction.

Cleck JN, Blendy JA.

J Clin Invest. 2008 Feb;118(2):454-61. Review.PMID: 18246196 [PubMed - indexed for MEDLINE]Related articlesFree article

Requirement for the POZ/BTB protein NAC1 in acute but not chronic psychomotor stimulant response.

Mackler S, Pacchioni A, Degnan R, Homan Y, Conti AC, Kalivas P, Blendy JA.

Behav Brain Res. 2008 Feb 11;187(1):48-55. Epub 2007 Sep 2.PMID: 17945361 [PubMed - indexed for MEDLINE]Related articlesFree article

NAC1 regulates the recruitment of the proteasome complex into dendritic spines.

Shen H, Korutla L, Champtiaux N, Toda S, LaLumiere R, Vallone J, Klugmann M, Blendy JA, Mackler SA, Kalivas PW.

J Neurosci. 2007 Aug 15;27(33):8903-13.PMID: 17699672 [PubMed - indexed for MEDLINE]Related articlesFree article

cAMP response element-binding protein deficiency allows for increased neurogenesis and a rapid onset of antidepressant response.

Gur TL, Conti AC, Holden J, Bechtholt AJ, Hill TE, Lucki I, Malberg JE, Blendy JA.

J Neurosci. 2007 Jul 18;27(29):7860-8.PMID: 17634380 [PubMed - indexed for MEDLINE]Related articlesFree article

Pharmacogenomic evaluation of the antidepressant citalopram in the mouse tail suspension test.

Crowley JJ, Brodkin ES, Blendy JA, Berrettini WH, Lucki I.

Neuropsychopharmacology. 2006 Nov;31(11):2433-42. Epub 2006 Mar 22.PMID: 16554742 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of CREB in depression and antidepressant treatment.

Blendy JA.

Biol Psychiatry. 2006 Jun 15;59(12):1144-50. Epub 2006 Feb 2. Review.PMID: 16457782 [PubMed - indexed for MEDLINE]Related articles

Antidepressant action: to the nucleus and beyond.

Malberg JE, Blendy JA.

Trends Pharmacol Sci. 2005 Dec;26(12):631-8. Epub 2005 Oct 21. Review.PMID: 16246434 [PubMed - indexed for MEDLINE]Related articles

Strain-dependent antidepressant-like effects of citalopram in the mouse tail suspension test.

Crowley JJ, Blendy JA, Lucki I.

Psychopharmacology (Berl). 2005 Dec;183(2):257-64. Epub 2005 Nov 9.PMID: 16220334 [PubMed - indexed for MEDLINE]Related articles

The role of cAMP response element-binding proteins in mediating stress-induced vulnerability to drug abuse.

Kreibich AS, Blendy JA.

Int Rev Neurobiol. 2005;65:147-78. Review. No abstract available. PMID: 16140056 [PubMed - indexed for MEDLINE]Related articles

Mu-opioid receptor and CREB activation are required for nicotine reward.

Walters CL, Cleck JN, Kuo YC, Blendy JA.

Neuron. 2005 Jun 16;46(6):933-43.PMID: 15953421 [PubMed - indexed for MEDLINE]Related articles

Cyclic AMP response element-binding protein is required for normal maternal nurturing behavior.

Jin SH, Blendy JA, Thomas SA.

Neuroscience. 2005;133(3):647-55.PMID: 15893884 [PubMed - indexed for MEDLINE]Related articles

Reduced nicotine reward in obesity: cross-comparison in human and mouse.

Blendy JA, Strasser A, Walters CL, Perkins KA, Patterson F, Berkowitz R, Lerman C.

Psychopharmacology (Berl). 2005 Jul;180(2):306-15. Epub 2005 Feb 18.PMID: 15719224 [PubMed - indexed for MEDLINE]Related articles

CREB gene transcription factors: role in molecular mechanisms of alcohol and drug addiction.

Pandey SC, Chartoff EH, Carlezon WA Jr, Zou J, Zhang H, Kreibich AS, Blendy JA, Crews FT.

Alcohol Clin Exp Res. 2005 Feb;29(2):176-84.PMID: 15714041 [PubMed - indexed for MEDLINE]Related articles

Alterations in morphine-induced reward, locomotor activity, and thermoregulation in CREB-deficient mice.

Walters CL, Godfrey M, Li X, Blendy JA.

Brain Res. 2005 Jan 25;1032(1-2):193-9.PMID: 15680959 [PubMed - indexed for MEDLINE]Related articles

Regulation of antidepressant activity by cAMP response element binding proteins.

Conti AC, Blendy JA.

Mol Neurobiol. 2004 Oct;30(2):143-55. Review.PMID: 15475624 [PubMed - indexed for MEDLINE]Related articles

cAMP response element-binding protein is required for stress but not cocaine-induced reinstatement.

Kreibich AS, Blendy JA.

J Neurosci. 2004 Jul 28;24(30):6686-92.PMID: 15282271 [PubMed - indexed for MEDLINE]Related articlesFree article

Inducible cAMP early repressor regulates corticosterone suppression after tricyclic antidepressant treatment.

Conti AC, Kuo YC, Valentino RJ, Blendy JA.

J Neurosci. 2004 Feb 25;24(8):1967-75.PMID: 14985439 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential distribution of CREB in the mesolimbic dopamine reward pathway.

Walters CL, Kuo YC, Blendy JA.

J Neurochem. 2003 Dec;87(5):1237-44.PMID: 14622103 [PubMed - indexed for MEDLINE]Related articles

The mouse nac1 gene, encoding a cocaine-regulated Bric-a-brac Tramtrac Broad complex/Pox virus and Zinc finger protein, is regulated by AP1.

Mackler SA, Homan YX, Korutla L, Conti AC, Blendy JA.

Neuroscience. 2003;121(2):355-61.PMID: 14521994 [PubMed - indexed for MEDLINE]Related articles

alpha 1d Adrenoceptor signaling is required for stimulus induced locomotor activity.

Sadalge A, Coughlin L, Fu H, Wang B, Valladares O, Valentino R, Blendy JA.

Mol Psychiatry. 2003 Jul;8(7):664-72.PMID: 12874602 [PubMed - indexed for MEDLINE]Related articles

Augmented responses to morphine and cocaine in mice with a 12-lipoxygenase gene disruption.

Walters CL, Wang BC, Godfrey M, Sun D, Funk CD, Blendy JA.

Psychopharmacology (Berl). 2003 Nov;170(2):124-31. Epub 2003 Jul 4.PMID: 12845410 [PubMed - indexed for MEDLINE]Related articles

Genetic evidence for a role of CREB in sustained cortical arousal.

Graves LA, Hellman K, Veasey S, Blendy JA, Pack AI, Abel T.

J Neurophysiol. 2003 Aug;90(2):1152-9. Epub 2003 Apr 23.PMID: 12711709 [PubMed - indexed for MEDLINE]Related articlesFree article

cAMP response element-binding protein is essential for the upregulation of brain-derived neurotrophic factor transcription, but not the behavioral or endocrine responses to antidepressant drugs.

Conti AC, Cryan JF, Dalvi A, Lucki I, Blendy JA.

J Neurosci. 2002 Apr 15;22(8):3262-8.PMID: 11943827 [PubMed - indexed for MEDLINE]Related articlesFree article

Behavioral analysis of CREB alphadelta mutation on a B6/129 F1 hybrid background.

Graves L, Dalvi A, Lucki I, Blendy JA, Abel T.

Hippocampus. 2002;12(1):18-26.PMID: 11918283 [PubMed - indexed for MEDLINE]Related articles

Activating transcription factor 1 and CREB are important for cell survival during early mouse development.

Bleckmann SC, Blendy JA, Rudolph D, Monaghan AP, Schmid W, Schütz G.

Mol Cell Biol. 2002 Mar;22(6):1919-25.PMID: 11865068 [PubMed - indexed for MEDLINE]Related articlesFree article

Different requirements for cAMP response element binding protein in positive and negative reinforcing properties of drugs of abuse.

Walters CL, Blendy JA.

J Neurosci. 2001 Dec 1;21(23):9438-44.PMID: 11717377 [PubMed - indexed for MEDLINE]Related articlesFree article

Regional patterns of compensation following genetic deletion of either 5-hydroxytryptamine(1A) or 5-hydroxytryptamine(1B) receptor in the mouse.

Knobelman DA, Hen R, Blendy JA, Lucki I.

J Pharmacol Exp Ther. 2001 Sep;298(3):1092-100.PMID: 11504806 [PubMed - indexed for MEDLINE]Related articlesFree article

Loss of signaling through the G protein, Gz, results in abnormal platelet activation and altered responses to psychoactive drugs.

Yang J, Wu J, Kowalska MA, Dalvi A, Prevost N, O'Brien PJ, Manning D, Poncz M, Lucki I, Blendy JA, Brass LF.

Proc Natl Acad Sci U S A. 2000 Aug 29;97(18):9984-9.PMID: 10954748 [PubMed - indexed for MEDLINE]Related articlesFree article

Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neurons.

Riccio A, Ahn S, Davenport CM, Blendy JA, Ginty DD.

Science. 1999 Dec 17;286(5448):2358-61.PMID: 10600750 [PubMed - indexed for MEDLINE]Related articlesFree article

A cyclic AMP response element in the angiotensin-converting enzyme gene and the transcription factor CREM are required for transcription of the mRNA for the testicular isozyme.

Kessler SP, Rowe TM, Blendy JA, Erickson RP, Sen GC.

J Biol Chem. 1998 Apr 17;273(16):9971-5.PMID: 9545342 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic analysis of drug addiction: the role of cAMP response element binding protein.

Blendy JA, Maldonado R.

J Mol Med. 1998 Feb;76(2):104-10. Review.PMID: 9500675 [PubMed - indexed for MEDLINE]Related articles

Spaced training induces normal long-term memory in CREB mutant mice.

Kogan JH, Frankland PW, Blendy JA, Coblentz J, Marowitz Z, Schütz G, Silva AJ.

Curr Biol. 1997 Jan 1;7(1):1-11.PMID: 8999994 [PubMed - indexed for MEDLINE]Related articles

Reduction of morphine abstinence in mice with a mutation in the gene encoding CREB.

Maldonado R, Blendy JA, Tzavara E, Gass P, Roques BP, Hanoune J, Schütz G.

Science. 1996 Aug 2;273(5275):657-9.PMID: 8662559 [PubMed - indexed for MEDLINE]Related articles

Severe impairment of spermatogenesis in mice lacking the CREM gene.

Blendy JA, Kaestner KH, Weinbauer GF, Nieschlag E, Schütz G.

Nature. 1996 Mar 14;380(6570):162-5.PMID: 8600391 [PubMed - indexed for MEDLINE]Related articles

Targeting of the CREB gene leads to up-regulation of a novel CREB mRNA isoform.

Blendy JA, Kaestner KH, Schmid W, Gass P, Schutz G.

EMBO J. 1996 Mar 1;15(5):1098-106.PMID: 8605879 [PubMed - indexed for MEDLINE]Related articlesFree article

Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation.

Cole TJ, Blendy JA, Monaghan AP, Krieglstein K, Schmid W, Aguzzi A, Fantuzzi G, Hummler E, Unsicker K, Schütz G.

Genes Dev. 1995 Jul 1;9(13):1608-21.PMID: 7628695 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular genetic analysis of glucocorticoid signalling in development.

Schmid W, Cole TJ, Blendy JA, Schütz G.

J Steroid Biochem Mol Biol. 1995 Jun;53(1-6):33-5. Review.PMID: 7626475 [PubMed - indexed for MEDLINE]Related articles

Effects of kainic acid induced seizures on immediate early gene expression in mice with a targeted mutation of the CREB gene.

Blendy JA, Schmid W, Kiessling M, Schütz G, Gass P.

Brain Res. 1995 May 29;681(1-2):8-14.PMID: 7552295 [PubMed - indexed for MEDLINE]Related articles

Analysis of perinatal gene expression: hormone response elements mediate activation of a lacZ reporter gene in liver of transgenic mice.

Montoliu L, Blendy JA, Cole TJ, Schütz G.

Proc Natl Acad Sci U S A. 1995 May 9;92(10):4244-8.PMID: 7753790 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular genetic analysis of glucocorticoid signaling during mouse development.

Cole TJ, Blendy JA, Monaghan AP, Schmid W, Aguzzi A, Schütz G.

Steroids. 1995 Jan;60(1):93-6. Review.PMID: 7792824 [PubMed - indexed for MEDLINE]Related articles