PubMed

Global challenges for clinical pharmacology in the developing world.

Blaschke TF.

Clin Pharmacol Ther. 2009 Jun;85(6):579-81.PMID: 19451910 [PubMed - indexed for MEDLINE]Related articles

Variable adherence to prescribed dosing regimens for protease inhibitors: scope and outcomes.

Blaschke TF.

Curr Opin HIV AIDS. 2008 Nov;3(6):603-7.PMID: 19373030 [PubMed - in process]Related articles

Increased vascular alpha1-adrenergic sensitivity in patients with renal failure: receiving recombinant erythropoeitin.

Abiose AK, Aronow WS, Moreno H Jr, Nair CK, Blaschke TF, Hoffman BB.

Am J Ther. 2007 Sep-Oct;14(5):427-34.PMID: 17890929 [PubMed - indexed for MEDLINE]Related articles

Improving data reliability using a non-compliance detection method versus using pharmacokinetic criteria.

Kshirsagar SA, Blaschke TF, Sheiner LB, Krygowski M, Acosta EP, Verotta D.

J Pharmacokinet Pharmacodyn. 2007 Feb;34(1):35-55. Epub 2006 Sep 27.PMID: 17004125 [PubMed - indexed for MEDLINE]Related articles

Characterization of nelfinavir binding to plasma proteins and the lack of drug displacement interactions.

Motoya T, Thevanayagam LN, Blaschke TF, Au S, Stone JA, Jayewardene AL, Chi J, Aweeka FT.

HIV Med. 2006 Mar;7(2):122-8.PMID: 16420257 [PubMed - indexed for MEDLINE]Related articles

Sex differences in pharmacokinetics and pharmacodynamics.

Gandhi M, Aweeka F, Greenblatt RM, Blaschke TF.

Annu Rev Pharmacol Toxicol. 2004;44:499-523. Review.PMID: 14744256 [PubMed - indexed for MEDLINE]Related articles

Protein binding in antiretroviral therapies.

Boffito M, Back DJ, Blaschke TF, Rowland M, Bertz RJ, Gerber JG, Miller V.

AIDS Res Hum Retroviruses. 2003 Sep;19(9):825-35. Review.PMID: 14585213 [PubMed - indexed for MEDLINE]Related articles

Effect of simultaneous versus staggered dosing on pharmacokinetic interactions of protease inhibitors.

Washington CB, Flexner C, Sheiner LB, Rosenkranz SL, Segal Y, Aberg JA, Blaschke TF; AIDS Clinical Trials Group Protocol (ACTG 378) Study Team.

Clin Pharmacol Ther. 2003 May;73(5):406-16.PMID: 12732841 [PubMed - indexed for MEDLINE]Related articles

Model-based analysis of the pharmacokinetic interactions between ritonavir, nelfinavir, and saquinavir after simultaneous and staggered oral administration.

Lu JF, Blaschke TF, Flexner C, Rosenkranz SL, Sheiner LB; AIDS Clinical Trials Group Protocol 378 Investigators.

Drug Metab Dispos. 2002 Dec;30(12):1455-61.PMID: 12433819 [PubMed - indexed for MEDLINE]Related articlesFree article

Determination of nelfinavir free drug concentrations in plasma by equilibrium dialysis and liquid chromatography/tandem mass spectrometry: important factors for method optimization.

Herforth C, Stone JA, Jayewardene AL, Blaschke TF, Fang F, Motoya T, Aweeka FT.

Eur J Pharm Sci. 2002 Mar;15(2):185-95.PMID: 11849916 [PubMed - indexed for MEDLINE]Related articles

Optimizing the science of drug development: opportunities for better candidate selection and accelerated evaluation in humans.

Lesko LJ, Rowland M, Peck CC, Blaschke TF.

Pharm Res. 2000 Nov;17(11):1335-44. Review. No abstract available. PMID: 11205725 [PubMed - indexed for MEDLINE]Related articles

Optimizing the science of drug development: opportunities for better candidate selection and accelerated evaluation in humans.

Lesko LJ, Rowland M, Peck CC, Blaschke TF, Breimer D, de Jong HJ, Grahnen A, Kuhlmann JJ, Stewart B.

Eur J Pharm Sci. 2000;10(4):iv-xiv. No abstract available. PMID: 11023342 [PubMed - indexed for MEDLINE]Related articles

The disposition of saquinavir in normal and P-glycoprotein deficient mice, rats, and in cultured cells.

Washington CB, Wiltshire HR, Man M, Moy T, Harris SR, Worth E, Weigl P, Liang Z, Hall D, Marriott L, Blaschke TF.

Drug Metab Dispos. 2000 Sep;28(9):1058-62.PMID: 10950849 [PubMed - indexed for MEDLINE]Related articlesFree article

Optimizing the science of drug development: opportunities for better candidate selection and accelerated evaluation in humans.

Lesko LJ, Rowland M, Peck CC, Blaschke TF.

J Clin Pharmacol. 2000 Aug;40(8):803-14.PMID: 10934664 [PubMed - indexed for MEDLINE]Related articles

Nicotine impairs endothelium-dependent dilatation in human veins in vivo.

Chalon S, Moreno H Jr, Benowitz NL, Hoffman BB, Blaschke TF.

Clin Pharmacol Ther. 2000 Apr;67(4):391-7.PMID: 10801248 [PubMed - indexed for MEDLINE]Related articles

Asymmetric dimethylarginine increases mononuclear cell adhesiveness in hypercholesterolemic humans.

Chan JR, Böger RH, Bode-Böger SM, Tangphao O, Tsao PS, Blaschke TF, Cooke JP.

Arterioscler Thromb Vasc Biol. 2000 Apr;20(4):1040-6.PMID: 10764670 [PubMed - indexed for MEDLINE]Related articlesFree article

Interactions of HIV protease inhibitors with a human organic cation transporter in a mammalian expression system.

Zhang L, Gorset W, Washington CB, Blaschke TF, Kroetz DL, Giacomini KM.

Drug Metab Dispos. 2000 Mar;28(3):329-34.PMID: 10681378 [PubMed - indexed for MEDLINE]Related articlesFree article

Vascular reactivity in obstructive sleep apnea syndrome.

Duchna HW, Guilleminault C, Stoohs RA, Faul JL, Moreno H, Hoffman BB, Blaschke TF.

Am J Respir Crit Care Med. 2000 Jan;161(1):187-91.PMID: 10619819 [PubMed - indexed for MEDLINE]Related articlesFree article

Heparin-induced vasodilation in human hand veins.

Tangphao O, Chalon S, Moreno HJ Jr, Abiose AK, Blaschke TF, Hoffman BB.

Clin Pharmacol Ther. 1999 Sep;66(3):232-8.PMID: 10511058 [PubMed - indexed for MEDLINE]Related articles

L-arginine and nitric oxide-related compounds in plasma: comparison of normal and arginine-free diets in a 24-h crossover study.

Tangphao O, Chalon S, Coulston AM, Moreno H Jr, Chan JR, Cooke JP, Hoffman BB, Blaschke TF.

Vasc Med. 1999;4(1):27-32.PMID: 10355867 [PubMed - indexed for MEDLINE]Related articles

Pharmacokinetics of intravenous and oral L-arginine in normal volunteers.

Tangphao O, Grossmann M, Chalon S, Hoffman BB, Blaschke TF.

Br J Clin Pharmacol. 1999 Mar;47(3):261-6.PMID: 10215749 [PubMed - indexed for MEDLINE]Related articlesFree article

Angiotensin-converting enzyme inhibition improves venous endothelial dysfunction in chronic smokers.

Chalon S, Moreno H Jr, Hoffman BB, Blaschke TF.

Clin Pharmacol Ther. 1999 Mar;65(3):295-303.PMID: 10096262 [PubMed - indexed for MEDLINE]Related articles

Role of nitric oxide in isoprenaline and sodium nitroprusside-induced relaxation in human hand veins.

Chalon S, Tejura B, Moreno H Jr, Urae A, Blaschke TF, Hoffman BB.

Br J Clin Pharmacol. 1999 Jan;47(1):91-8.PMID: 10073745 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of angiotensin-converting enzyme in human hand veins.

Chalon S, Bedarida GV, Moreno H Jr, Tejura B, Urae A, Hoffman BB, Blaschke TF.

Clin Pharmacol Ther. 1999 Jan;65(1):58-65.PMID: 9951431 [PubMed - indexed for MEDLINE]Related articles

Pharmacokinetics of L-arginine during chronic administration to patients with hypercholesterolaemia.

Tangphao O, Chalon S, Moreno H Jr, Hoffman BB, Blaschke TF.

Clin Sci (Lond). 1999 Feb;96(2):199-207.PMID: 9918901 [PubMed - indexed for MEDLINE]Related articles

The extent of non-adherence in a large AIDS clinical trial using plasma dideoxynucleoside concentrations as a marker.

Kastrissios H, Suárez JR, Hammer S, Katzenstein D, Blaschke TF.

AIDS. 1998 Dec 3;12(17):2305-11.PMID: 9863873 [PubMed - indexed for MEDLINE]Related articles

Characterizing patterns of drug-taking behavior with a multiple drug regimen in an AIDS clinical trial.

Kastrissios H, Suárez JR, Katzenstein D, Girard P, Sheiner LB, Blaschke TF.

AIDS. 1998 Dec 3;12(17):2295-303.PMID: 9863872 [PubMed - indexed for MEDLINE]Related articles

A Markov mixed effect regression model for drug compliance.

Girard P, Blaschke TF, Kastrissios H, Sheiner LB.

Stat Med. 1998 Oct 30;17(20):2313-33.PMID: 9819830 [PubMed - indexed for MEDLINE]Related articles

Interaction of anti-HIV protease inhibitors with the multidrug transporter P-glycoprotein (P-gp) in human cultured cells.

Washington CB, Duran GE, Man MC, Sikic BI, Blaschke TF.

J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Nov 1;19(3):203-9.PMID: 9803961 [PubMed - indexed for MEDLINE]Related articles

Asymmetric dimethylarginine (ADMA): a novel risk factor for endothelial dysfunction: its role in hypercholesterolemia.

Böger RH, Bode-Böger SM, Szuba A, Tsao PS, Chan JR, Tangphao O, Blaschke TF, Cooke JP.

Circulation. 1998 Nov 3;98(18):1842-7.PMID: 9799202 [PubMed - indexed for MEDLINE]Related articlesFree article

Endothelial dysfunction in human hand veins is rapidly reversible after smoking cessation.

Moreno H Jr, Chalon S, Urae A, Tangphao O, Abiose AK, Hoffman BB, Blaschke TF.

Am J Physiol. 1998 Sep;275(3 Pt 2):H1040-5.PMID: 9724311 [PubMed - indexed for MEDLINE]Related articlesFree article

A semiparametric method for describing noisy population pharmacokinetic data.

Park K, Verotta D, Blaschke TF, Sheiner LB.

J Pharmacokinet Biopharm. 1997 Oct;25(5):615-42.PMID: 9679225 [PubMed - indexed for MEDLINE]Related articles

Exposure-response relationships for saquinavir, zidovudine, and zalcitabine in combination therapy.

Vanhove GF, Gries JM, Verotta D, Sheiner LB, Coombs R, Collier AC, Blaschke TF.

Antimicrob Agents Chemother. 1997 Nov;41(11):2433-8.PMID: 9371346 [PubMed - indexed for MEDLINE]Related articlesFree article

Pharmacokinetics of saquinavir, zidovudine, and zalcitabine in combination therapy.

Vanhove GF, Kastrissios H, Gries JM, Verotta D, Park K, Collier AC, Squires K, Sheiner LB, Blaschke TF.

Antimicrob Agents Chemother. 1997 Nov;41(11):2428-32.PMID: 9371345 [PubMed - indexed for MEDLINE]Related articlesFree article

Chloroquine-induced venodilation in human hand veins.

Abiose AK, Grossmann M, Tangphao O, Hoffman BB, Blaschke TF.

Clin Pharmacol Ther. 1997 Jun;61(6):677-83.PMID: 9209251 [PubMed - indexed for MEDLINE]Related articles

Medication compliance as a feature in drug development.

Kastrissios H, Blaschke TF.

Annu Rev Pharmacol Toxicol. 1997;37:451-75. Review.PMID: 9131261 [PubMed - indexed for MEDLINE]Related articles

Patient compliance and drug failure in protease inhibitor monotherapy.

Vanhove GF, Schapiro JM, Winters MA, Merigan TC, Blaschke TF.

JAMA. 1996 Dec 25;276(24):1955-6. No abstract available. PMID: 8971062 [PubMed - indexed for MEDLINE]Related articles

Morphine-induced venodilation in humans.

Grossmann M, Abiose A, Tangphao O, Blaschke TF, Hoffman BB.

Clin Pharmacol Ther. 1996 Nov;60(5):554-60.PMID: 8941028 [PubMed - indexed for MEDLINE]Related articles

High-performance liquid chromatographic assay for the quantitation of L-arginine in human plasma.

Gopalakrishnan V, Burton PJ, Blaschke TF.

Anal Chem. 1996 Oct 1;68(19):3520-3.PMID: 8843144 [PubMed - indexed for MEDLINE]Related articles

Do we need full compliance data for population pharmacokinetic analysis?

Girard P, Sheiner LB, Kastrissios H, Blaschke TF.

J Pharmacokinet Biopharm. 1996 Jun;24(3):265-82.PMID: 8970015 [PubMed - indexed for MEDLINE]Related articles

Introducing medical students to medication noncompliance.

Kastrissios H, Flowers NT, Blaschke TF.

Clin Pharmacol Ther. 1996 May;59(5):577-82.PMID: 8646829 [PubMed - indexed for MEDLINE]Related articles

The clinical pharmacokinetics of rifabutin.

Blaschke TF, Skinner MH.

Clin Infect Dis. 1996 Apr;22 Suppl 1:S15-21; discussion S21-2. Review.PMID: 8785251 [PubMed - indexed for MEDLINE]Related articles

Pharmacokinetics of high-dose oral CCNU in bone marrow transplant patients.

Kastrissios H, Chao NJ, Blaschke TF.

Cancer Chemother Pharmacol. 1996;38(5):425-30.PMID: 8765435 [PubMed - indexed for MEDLINE]Related articles

H1- and H2-histamine receptor-mediated vasodilation varies with aging in humans.

Bedarida G, Bushell E, Blaschke TF, Hoffman BB.

Clin Pharmacol Ther. 1995 Jul;58(1):73-80.PMID: 7628185 [PubMed - indexed for MEDLINE]Related articles

A new preparatory regimen for autologous bone marrow transplantation for patients with lymphoma.

Chao NJ, Kastrissios H, Long GD, Negrin RS, Horning SJ, Wong RM, Blaschke TF, Blume KG.

Cancer. 1995 Mar 15;75(6):1354-9.PMID: 7882286 [PubMed - indexed for MEDLINE]Related articles

Clinical pharmacokinetics of rifabutin.

Skinner MH, Blaschke TF.

Clin Pharmacokinet. 1995 Feb;28(2):115-25. Review.PMID: 7736687 [PubMed - indexed for MEDLINE]Related articles

Effect of aging on beta 2-adrenergic receptor-stimulated flux of K+, PO4, FFA, and glycerol in human forearms.

Ford GA, Dachman WD, Blaschke TF, Hoffman BB.

J Appl Physiol. 1995 Jan;78(1):172-8.PMID: 7713808 [PubMed - indexed for MEDLINE]Related articles

Histamine-induced venodilation in human beings involves both H1 and H2 receptor subtypes.

Dachman WD, Bedarida G, Blaschke TF, Hoffman BB.

J Allergy Clin Immunol. 1994 Mar;93(3):606-14.PMID: 8151062 [PubMed - indexed for MEDLINE]Related articles

Characterization of an inhibitor of nitric oxide synthase in human-hand veins.

Bedarida GV, Kim D, Blaschke TF, Hoffman BB.

Horm Metab Res. 1994 Feb;26(2):109-12.PMID: 7515369 [PubMed - indexed for MEDLINE]Related articles

Venodilation in Raynaud's disease.

Bedarida G, Kim D, Blaschke TF, Hoffman BB.

Lancet. 1993 Dec 11;342(8885):1451-4.PMID: 7902481 [PubMed - indexed for MEDLINE]Related articles