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Melanocortins Mimic the Effects of Leptin to Restore Reproductive Function in Lean Hypogonadotropic Ewes.

Backholer K, Bowden M, Gamber K, Bjørbæk C, Iqbal J, Clarke IJ.

Neuroendocrinology. 2009 Nov 18. [Epub ahead of print]PMID: 19923792 [PubMed - as supplied by publisher]Related articles

Leptin-dependent control of glucose balance and locomotor activity by POMC neurons.

Huo L, Gamber K, Greeley S, Silva J, Huntoon N, Leng XH, Bjørbaek C.

Cell Metab. 2009 Jun;9(6):537-47.PMID: 19490908 [PubMed - indexed for MEDLINE]Related articles

Divergent leptin signaling in proglucagon neurons of the nucleus of the solitary tract in mice and rats.

Huo L, Gamber KM, Grill HJ, Bjørbaek C.

Endocrinology. 2008 Feb;149(2):492-7. Epub 2007 Nov 1.PMID: 17974623 [PubMed - indexed for MEDLINE]Related articlesFree article

Urocortin trafficking in cerebral microvessel endothelial cells.

Tu H, Kastin AJ, Bjorbaek C, Pan W.

J Mol Neurosci. 2007;31(2):171-81.PMID: 17478891 [PubMed - indexed for MEDLINE]Related articles

Mice lacking inhibitory leptin receptor signals are lean with normal endocrine function.

Björnholm M, Münzberg H, Leshan RL, Villanueva EC, Bates SH, Louis GW, Jones JC, Ishida-Takahashi R, Bjørbaek C, Myers MG Jr.

J Clin Invest. 2007 May;117(5):1354-60. Epub 2007 Apr 5.PMID: 17415414 [PubMed - indexed for MEDLINE]Related articlesFree article

Leptin and the control of food intake: neurons in the nucleus of the solitary tract are activated by both gastric distension and leptin.

Huo L, Maeng L, Bjørbaek C, Grill HJ.

Endocrinology. 2007 May;148(5):2189-97. Epub 2007 Feb 22.PMID: 17317774 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of suppressor of cytokine signaling 3 in adipose tissue causes local but not systemic insulin resistance.

Shi H, Cave B, Inouye K, Bjørbaek C, Flier JS.

Diabetes. 2006 Mar;55(3):699-707.PMID: 16505233 [PubMed - indexed for MEDLINE]Related articlesFree article

Divergent regulation of proopiomelanocortin neurons by leptin in the nucleus of the solitary tract and in the arcuate hypothalamic nucleus.

Huo L, Grill HJ, Bjørbaek C.

Diabetes. 2006 Mar;55(3):567-73.PMID: 16505217 [PubMed - indexed for MEDLINE]Related articlesFree article

Quantitative FRET imaging of leptin receptor oligomerization kinetics in single cells.

Biener E, Charlier M, Ramanujan VK, Daniel N, Eisenberg A, Bjørbaek C, Herman B, Gertler A, Djiane J.

Biol Cell. 2005 Dec;97(12):905-19.PMID: 15771593 [PubMed - indexed for MEDLINE]Related articles

Regulation of hypothalamic prohormone convertases 1 and 2 and effects on processing of prothyrotropin-releasing hormone.

Sanchez VC, Goldstein J, Stuart RC, Hovanesian V, Huo L, Munzberg H, Friedman TC, Bjorbaek C, Nillni EA.

J Clin Invest. 2004 Aug;114(3):357-69.PMID: 15286802 [PubMed - indexed for MEDLINE]Related articlesFree article

N-acetylation of hypothalamic alpha-melanocyte-stimulating hormone and regulation by leptin.

Guo L, Münzberg H, Stuart RC, Nillni EA, Bjørbaek C.

Proc Natl Acad Sci U S A. 2004 Aug 10;101(32):11797-802. Epub 2004 Jul 27.PMID: 15280541 [PubMed - indexed for MEDLINE]Related articlesFree article

Region-specific leptin resistance within the hypothalamus of diet-induced obese mice.

Münzberg H, Flier JS, Bjørbaek C.

Endocrinology. 2004 Nov;145(11):4880-9. Epub 2004 Jul 22.PMID: 15271881 [PubMed - indexed for MEDLINE]Related articlesFree article

Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3.

Howard JK, Cave BJ, Oksanen LJ, Tzameli I, Bjørbaek C, Flier JS.

Nat Med. 2004 Jul;10(7):734-8. Epub 2004 Jun 27.PMID: 15220914 [PubMed - indexed for MEDLINE]Related articles

Suppressor of cytokine signaling 3 is a physiological regulator of adipocyte insulin signaling.

Shi H, Tzameli I, Bjørbaek C, Flier JS.

J Biol Chem. 2004 Aug 13;279(33):34733-40. Epub 2004 Jun 4.PMID: 15181014 [PubMed - indexed for MEDLINE]Related articlesFree article

Ciliary neurotrophic factor and leptin induce distinct patterns of immediate early gene expression in the brain.

Kelly JF, Elias CF, Lee CE, Ahima RS, Seeley RJ, Bjørbaek C, Oka T, Saper CB, Flier JS, Elmquist JK.

Diabetes. 2004 Apr;53(4):911-20.PMID: 15047605 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification and characterization of melanocortin-4 receptor gene mutations in morbidly obese finnish children and adults.

Valli-Jaakola K, Lipsanen-Nyman M, Oksanen L, Hollenberg AN, Kontula K, Bjørbaek C, Schalin-Jäntti C.

J Clin Endocrinol Metab. 2004 Feb;89(2):940-5.PMID: 14764818 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of signal transducer and activator of transcription 3 in regulation of hypothalamic trh gene expression by leptin.

Huo L, Münzberg H, Nillni EA, Bjørbaek C.

Endocrinology. 2004 May;145(5):2516-23. Epub 2004 Feb 5.PMID: 14764629 [PubMed - indexed for MEDLINE]Related articlesFree article

Leptin signaling in the central nervous system and the periphery.

Bjørbaek C, Kahn BB.

Recent Prog Horm Res. 2004;59:305-31. Review.PMID: 14749508 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin resistance and lipodystrophy in mice lacking ribosomal S6 kinase 2.

El-Haschimi K, Dufresne SD, Hirshman MF, Flier JS, Goodyear LJ, Bjørbaek C.

Diabetes. 2003 Jun;52(6):1340-6.PMID: 12765942 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of signal transducer and activator of transcription 3 in regulation of hypothalamic proopiomelanocortin gene expression by leptin.

Münzberg H, Huo L, Nillni EA, Hollenberg AN, Bjørbaek C.

Endocrinology. 2003 May;144(5):2121-31.PMID: 12697721 [PubMed - indexed for MEDLINE]Related articlesFree article

Leptin and melanocortin signaling in the hypothalamus.

Bjørbaek C, Hollenberg AN.

Vitam Horm. 2002;65:281-311. Review.PMID: 12481551 [PubMed - indexed for MEDLINE]Related articles

Characterizaton of short isoforms of the leptin receptor in rat cerebral microvessels and of brain uptake of leptin in mouse models of obesity.

Hileman SM, Pierroz DD, Masuzaki H, Bjørbaek C, El-Haschimi K, Banks WA, Flier JS.

Endocrinology. 2002 Mar;143(3):775-83.PMID: 11861497 [PubMed - indexed for MEDLINE]Related articlesFree article

Altered extracellular signal-regulated kinase signaling and glycogen metabolism in skeletal muscle from p90 ribosomal S6 kinase 2 knockout mice.

Dufresne SD, Bjørbaek C, El-Haschimi K, Zhao Y, Aschenbach WG, Moller DE, Goodyear LJ.

Mol Cell Biol. 2001 Jan;21(1):81-7.PMID: 11113183 [PubMed - indexed for MEDLINE]Related articlesFree article

Divergent roles of SHP-2 in ERK activation by leptin receptors.

Bjørbaek C, Buchholz RM, Davis SM, Bates SH, Pierroz DD, Gu H, Neel BG, Myers MG Jr, Flier JS.

J Biol Chem. 2001 Feb 16;276(7):4747-55. Epub 2000 Nov 20.PMID: 11085989 [PubMed - indexed for MEDLINE]Related articlesFree article

Unlike leptin, ciliary neurotrophic factor does not reverse the starvation-induced changes of serum corticosterone and hypothalamic neuropeptide levels but induces expression of hypothalamic inhibitors of leptin signaling.

Ziotopoulou M, Erani DM, Hileman SM, Bjørbaek C, Mantzoros CS.

Diabetes. 2000 Nov;49(11):1890-6.PMID: 11078456 [PubMed - indexed for MEDLINE]Related articlesFree article

Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity.

El-Haschimi K, Pierroz DD, Hileman SM, Bjørbaek C, Flier JS.

J Clin Invest. 2000 Jun;105(12):1827-32.PMID: 10862798 [PubMed - indexed for MEDLINE]Related articlesFree article

Transcellular transport of leptin by the short leptin receptor isoform ObRa in Madin-Darby Canine Kidney cells.

Hileman SM, Tornøe J, Flier JS, Bjørbaek C.

Endocrinology. 2000 Jun;141(6):1955-61.PMID: 10830277 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of SOCS-3 in leptin signaling and leptin resistance.

Bjørbaek C, El-Haschimi K, Frantz JD, Flier JS.

J Biol Chem. 1999 Oct 15;274(42):30059-65.PMID: 10514492 [PubMed - indexed for MEDLINE]Related articlesFree article

Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area.

Elias CF, Aschkenasi C, Lee C, Kelly J, Ahima RS, Bjorbaek C, Flier JS, Saper CB, Elmquist JK.

Neuron. 1999 Aug;23(4):775-86.PMID: 10482243 [PubMed - indexed for MEDLINE]Related articles

Regulation of neuronal and glial proteins by leptin: implications for brain development.

Ahima RS, Bjorbaek C, Osei S, Flier JS.

Endocrinology. 1999 Jun;140(6):2755-62.PMID: 10342866 [PubMed - indexed for MEDLINE]Related articlesFree article

Functional properties of leptin receptor isoforms: internalization and degradation of leptin and ligand-induced receptor downregulation.

Uotani S, Bjørbaek C, Tornøe J, Flier JS.

Diabetes. 1999 Feb;48(2):279-86.PMID: 10334302 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of SOCS-3 messenger ribonucleic acid in the hypothalamus by ciliary neurotrophic factor.

Bjørbaek C, Elmquist JK, El-Haschimi K, Kelly J, Ahima RS, Hileman S, Flier JS.

Endocrinology. 1999 May;140(5):2035-43.PMID: 10218952 [PubMed - indexed for MEDLINE]Related articlesFree article

Targeting of constitutively active phosphoinositide 3-kinase to GLUT4-containing vesicles in 3T3-L1 adipocytes.

Frevert EU, Bjørbaek C, Venable CL, Keller SR, Kahn BB.

J Biol Chem. 1998 Sep 25;273(39):25480-7.PMID: 9738018 [PubMed - indexed for MEDLINE]Related articlesFree article

Functional properties of leptin receptor isoforms containing the gln-->pro extracellular domain mutation of the fatty rat.

da Silva BA, Bjørbaek C, Uotani S, Flier JS.

Endocrinology. 1998 Sep;139(9):3681-90.PMID: 9724018 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of leptin receptor isoforms in rat brain microvessels.

Bjørbaek C, Elmquist JK, Michl P, Ahima RS, van Bueren A, McCall AL, Flier JS.

Endocrinology. 1998 Aug;139(8):3485-91.PMID: 9681499 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of SOCS-3 as a potential mediator of central leptin resistance.

Bjørbaek C, Elmquist JK, Frantz JD, Shoelson SE, Flier JS.

Mol Cell. 1998 Mar;1(4):619-25.PMID: 9660946 [PubMed - indexed for MEDLINE]Related articles

Distributions of leptin receptor mRNA isoforms in the rat brain.

Elmquist JK, Bjørbaek C, Ahima RS, Flier JS, Saper CB.

J Comp Neurol. 1998 Jun 15;395(4):535-47.PMID: 9619505 [PubMed - indexed for MEDLINE]Related articles

Divergent signaling capacities of the long and short isoforms of the leptin receptor.

Bjørbaek C, Uotani S, da Silva B, Flier JS.

J Biol Chem. 1997 Dec 19;272(51):32686-95.PMID: 9405487 [PubMed - indexed for MEDLINE]Related articlesFree article

Ligand-independent activation domain in the N terminus of peroxisome proliferator-activated receptor gamma (PPARgamma). Differential activity of PPARgamma1 and -2 isoforms and influence of insulin.

Werman A, Hollenberg A, Solanes G, Bjorbaek C, Vidal-Puig AJ, Flier JS.

J Biol Chem. 1997 Aug 8;272(32):20230-5.PMID: 9242701 [PubMed - indexed for MEDLINE]Related articlesFree article

[Molecular genetics of non insulin dependent diabetes mellitus]

Vidal-Puig A, Bjørbaek C.

Med Clin (Barc). 1997 Jun 14;109(3):107-14. Review. Spanish. No abstract available. PMID: 9289511 [PubMed - indexed for MEDLINE]Related articles

Regulation and interaction of pp90(rsk) isoforms with mitogen-activated protein kinases.

Zhao Y, Bjorbaek C, Moller DE.

J Biol Chem. 1996 Nov 22;271(47):29773-9.PMID: 8939914 [PubMed - indexed for MEDLINE]Related articlesFree article

Candidate genes for insulin resistance.

Moller DE, Bjørbaek C, Vidal-Puig A.

Diabetes Care. 1996 Apr;19(4):396-400. Review.PMID: 8729172 [PubMed - indexed for MEDLINE]Related articles

Impaired activity and gene expression of hexokinase II in muscle from non-insulin-dependent diabetes mellitus patients.

Vestergaard H, Bjørbaek C, Hansen T, Larsen FS, Granner DK, Pedersen O.

J Clin Invest. 1995 Dec;96(6):2639-45.PMID: 8675629 [PubMed - indexed for MEDLINE]Related articlesFree article

Unchanged gene expression of glycogen synthase in muscle from patients with NIDDM following sulphonylurea-induced improvement of glycaemic control.

Vestergaard H, Lund S, Bjørbaek C, Pedersen O.

Diabetologia. 1995 Oct;38(10):1230-8.PMID: 8690177 [PubMed - indexed for MEDLINE]Related articles

Insulin resistance: interactions between obesity and a common variant of insulin receptor substrate-1.

Clausen JO, Hansen T, Bjørbaek C, Echwald SM, Urhammer SA, Rasmussen S, Andersen CB, Hansen L, Almind K, Winther K, et al.

Lancet. 1995 Aug 12;346(8972):397-402.PMID: 7623569 [PubMed - indexed for MEDLINE]Related articles

Divergent functional roles for p90rsk kinase domains.

Bjørbaek C, Zhao Y, Moller DE.

J Biol Chem. 1995 Aug 11;270(32):18848-52.PMID: 7642538 [PubMed - indexed for MEDLINE]Related articlesFree article

RSK3 encodes a novel pp90rsk isoform with a unique N-terminal sequence: growth factor-stimulated kinase function and nuclear translocation.

Zhao Y, Bjørbaek C, Weremowicz S, Morton CC, Moller DE.

Mol Cell Biol. 1995 Aug;15(8):4353-63.PMID: 7623830 [PubMed - indexed for MEDLINE]Related articlesFree article

A widespread amino acid polymorphism at codon 905 of the glycogen-associated regulatory subunit of protein phosphatase-1 is associated with insulin resistance and hypersecretion of insulin.

Hansen L, Hansen T, Vestergaard H, Bjørbaek C, Echwald SM, Clausen JO, Chen YH, Chen MX, Cohen PT, Pedersen O.

Hum Mol Genet. 1995 Aug;4(8):1313-20.PMID: 7581368 [PubMed - indexed for MEDLINE]Related articles

Severe insulin-resistant diabetes mellitus in patients with congenital muscle fiber type disproportion myopathy.

Vestergaard H, Klein HH, Hansen T, Müller J, Skovby F, Bjørbaek C, Røder ME, Pedersen O.

J Clin Invest. 1995 Apr;95(4):1925-32.PMID: 7706500 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of four amino acid substitutions in hexokinase II and studies of relationships to NIDDM, glucose effectiveness, and insulin sensitivity.

Echwald SM, Bjørbaek C, Hansen T, Clausen JO, Vestergaard H, Zierath JR, Printz RL, Granner DK, Pedersen O.

Diabetes. 1995 Mar;44(3):347-53.PMID: 7883123 [PubMed - indexed for MEDLINE]Related articles